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  1. Article ; Online: Clostridium difficile and the Consequences of Progress.

    Sepkowitz, Kent A

    Journal of oncology practice

    2017  Volume 13, Issue 1, Page(s) 33–34

    MeSH term(s) Clostridium difficile
    Language English
    Publishing date 2017-08-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2236338-5
    ISSN 1935-469X ; 1554-7477
    ISSN (online) 1935-469X
    ISSN 1554-7477
    DOI 10.1200/JOP.2016.019166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clostridium difficile leaves the hospital--what's next?

    Sepkowitz, Kent A

    JAMA internal medicine

    2013  Volume 173, Issue 14, Page(s) 1367–1368

    MeSH term(s) Clostridium difficile/isolation & purification ; Enterocolitis, Pseudomembranous/epidemiology ; Female ; Humans ; Male ; Population Surveillance
    Language English
    Publishing date 2013-07-22
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2013.7940
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  3. Article ; Online: Energy drinks and caffeine-related adverse effects.

    Sepkowitz, Kent A

    JAMA

    2013  Volume 309, Issue 3, Page(s) 243–244

    MeSH term(s) Caffeine/adverse effects ; Caffeine/pharmacokinetics ; Caffeine/poisoning ; Cause of Death ; Central Nervous System Stimulants/adverse effects ; Central Nervous System Stimulants/pharmacokinetics ; Central Nervous System Stimulants/poisoning ; Dietary Supplements ; Energy Drinks/adverse effects ; Humans ; Male ; Mortality/trends ; Prescription Drug Misuse ; Product Labeling ; United States/epidemiology ; United States Food and Drug Administration
    Chemical Substances Central Nervous System Stimulants ; Caffeine (3G6A5W338E)
    Language English
    Publishing date 2013-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2012.173526
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  4. Article ; Online: Why doesn't hand hygiene work better?

    Sepkowitz, Kent A

    The Lancet. Infectious diseases

    2012  Volume 12, Issue 2, Page(s) 96–97

    MeSH term(s) Communicable Disease Control/methods ; Communicable Diseases/epidemiology ; Humans ; Hygiene ; Public Health/methods
    Language English
    Publishing date 2012-02
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(11)70349-8
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  5. Article ; Online: Finland, Weinstein, and the birth of antibiotic regret.

    Sepkowitz, Kent A

    The New England journal of medicine

    2012  Volume 367, Issue 2, Page(s) 102–103

    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/history ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Microbial ; Health Services Misuse ; History, 20th Century ; Humans ; Treatment Refusal
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2012-07-12
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp1205847
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  6. Article ; Online: Management of a major varicella zoster exposure in a pediatric oncology population.

    Rossetto, Carol / Sepkowitz, Kent / Ackerman, Jill / Corke, Rachel / Pickett, Nina J / Cudjoe, Wini / Eagan, Janet / Kamboj, Mini / O'Reilly, Richard J / Boulad, Farid

    Pediatric hematology and oncology

    2024  , Page(s) 1–11

    Abstract: Management of the exposure of pediatric oncology patients to varicella zoster virus (VZV) is controversial. We report the exposure of 56 patients to a single child with chicken pox at a pediatric cancer housing facility and describe our strategic ... ...

    Abstract Management of the exposure of pediatric oncology patients to varicella zoster virus (VZV) is controversial. We report the exposure of 56 patients to a single child with chicken pox at a pediatric cancer housing facility and describe our strategic approach for their management. We reviewed the immune and clinical status of 56 children with cancer receiving ongoing treatment at Memorial Sloan Kettering Cancer Center (MSK) who, while living at a pediatric cancer housing facility, were exposed to the index patient. The management of patients exposed included: (1) determination of immune status, (2) availability of vaccination history or VZV disease prophylaxis, (3) exposure status and subsequent isolation during the period of incubation, and (4) VZV disease prophylaxis. In addition to the 56 patients exposed to the index case, eight children with cancer treated at other facilities and 11 healthy siblings living in the facility were exposed. Of the 56 MSK patients, 21 were classified as immunosuppressed and received varicella zoster immune globulin (human), intravenous standard immune globulin, or acyclovir based on serostatus and immune function. The cohort was followed for 4 weeks after the exposure and no secondary infections were diagnosed. We performed a risk assessment and created a management plan to control and prevent further exposure and development of disease. No secondary cases developed. This strategic approach could serve as a model for the management of VZV exposure for other pediatric oncology centers.
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 632914-7
    ISSN 1521-0669 ; 0888-0018
    ISSN (online) 1521-0669
    ISSN 0888-0018
    DOI 10.1080/08880018.2024.2315456
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  7. Article: Dignity in dying.

    Sepkowitz, Kent

    Newsweek

    2009  Volume 154, Issue 14, Page(s) 13

    MeSH term(s) Home Care Services ; Humans ; Right to Die
    Language English
    Publishing date 2009-10-05
    Publishing country United States
    Document type News
    ISSN 0028-9604
    ISSN 0028-9604
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  8. Article ; Online: One hundred years of Salvarsan.

    Sepkowitz, Kent A

    The New England journal of medicine

    2011  Volume 365, Issue 4, Page(s) 291–293

    MeSH term(s) Antitreponemal Agents/history ; Antitreponemal Agents/therapeutic use ; Arsphenamine/history ; Arsphenamine/therapeutic use ; History, 20th Century ; Humans ; Syphilis/drug therapy ; Syphilis/history
    Chemical Substances Antitreponemal Agents ; Arsphenamine (139-93-5)
    Language English
    Publishing date 2011-07-28
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp1105345
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  9. Article ; Online: Recognizing therapeutic failure.

    Sepkowitz, Kent A

    Medical mycology

    2009  Volume 47 Suppl 1, Page(s) S382–6

    Abstract: Cases are presented that raise the issue of how to recognize treatment failure, including radiologic, serologic, and/or clinical definitions with special attention to assessment when available information is conflicting or ambiguous. Just as the ... ...

    Abstract Cases are presented that raise the issue of how to recognize treatment failure, including radiologic, serologic, and/or clinical definitions with special attention to assessment when available information is conflicting or ambiguous. Just as the diagnosis of invasive aspergillus (IA) remains difficult to secure for many patients, so too is the assessment of a patient for possible treatment failure. Specifically the absence of a sensitive surrogate marker to monitor response leaves clinicians with several insensitive, non-specific and often conflicting pieces of information. For example, CT evidence of response is well-described to lag at least a week behind patient improvement and so this modality cannot be relied upon to assess daily or even weekly patient response. The clinical assessment of the patient is complicated by the presence or absence of neutropenia since patients may appear to worsen as their neutropenia recovers; conversely, patients with advanced infection may exhibit only subtle signs of IA if profoundly immunosuppressed. Finally, IA does not respond to any antifungal quickly; thus the clinician must patiently wait longer than is typical for a bacterial infection to determine whether the response is slow or simply not present. Assessment of a patient with IA for treatment failure is a complicated determination that requires the clinician to synthesize incomplete and often conflicting information. Further adding to the difficulty are the morbidity and mortality of the disease and the relative lack of effectiveness of the available antifungal agents.
    MeSH term(s) Antifungal Agents/therapeutic use ; Aspergillosis/drug therapy ; Child ; Drug Monitoring/methods ; Female ; Humans ; Middle Aged ; Radiography, Thoracic ; Sensitivity and Specificity ; Treatment Failure
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2009
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1421796-x
    ISSN 1460-2709 ; 1369-3786
    ISSN (online) 1460-2709
    ISSN 1369-3786
    DOI 10.1080/13693780802546533
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  10. Article ; Online: Forever unprepared--the predictable unpredictability of pathogens.

    Sepkowitz, Kent A

    The New England journal of medicine

    2009  Volume 361, Issue 2, Page(s) 120–121

    MeSH term(s) Animals ; Anti-Bacterial Agents/therapeutic use ; Birds ; Disease Outbreaks ; Drug Resistance, Viral ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza in Birds/epidemiology ; Influenza in Birds/virology ; Influenza, Human/drug therapy ; Influenza, Human/epidemiology ; Influenza, Human/virology ; Methicillin-Resistant Staphylococcus aureus ; Oseltamivir/therapeutic use ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/transmission ; Unnecessary Procedures
    Chemical Substances Anti-Bacterial Agents ; Oseltamivir (20O93L6F9H)
    Language English
    Publishing date 2009-07-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp0902373
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