LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Correction: Antibody-Peptide Epitope Conjugates for Personalized Cancer Therapy.

    Zhang, Songfa / Yan, Chuan / Millar, David G / Yang, Qiqi / Heather, James M / Langenbucher, Adam / Morton, Laura T / Sepulveda, Sean / Alpert, Eric / Whelton, Lauren R / Zarrella, Dominique T / Guo, Mei / Minogue, Eleanor / Lawrence, Michael S / Rueda, Bo R / Spriggs, David R / Lu, Weiguo / Langenau, David M / Cobbold, Mark

    Cancer research

    2024  Volume 84, Issue 9, Page(s) 1534

    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-24-0718
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.135/5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Expansion of endogenous T cells in CSF of pediatric CNS tumor patients undergoing locoregional delivery of IL13R〿2-targeting CAR T cells: an interim analysis.

    Wang, Leo / Oill, Angela Taravella / Blanchard, M / Wu, Melody / Hibbard, Jonathan / Sepulveda, Sean / Peter, Lance / Kilpatrick, Julie / Munoz, Margarita / Stiller, Tracey / Shulkin, Noah / Wagner, Jamie / Dolatabadi, Ally / Nisis, Monica / Shepphird, Jennifer / Sanchez, Gabriela / Lingaraju, Chetan / Manchanda, Mishika / Natri, Heini /
    Kouakanou, Léonce / Sun, Grace / Oliver-Cervantes, Cheryl / Georges, Joseph / Aftabizadeh, Maryam / Forman, Stephen / Priceman, Saul / Ressler, Julie / Arvanitis, Leonidas / Cotter, Jennifer / D'Apuzzo, Massimo / Tamrazi, Benita / Badie, Behnam / Davidson, Tom / Banovich, Nicholas / Brown, Christine

    Research square

    2023  

    Abstract: Outcomes for pediatric brain tumor patients remain poor, and there is optimism that chimeric antigen receptor (CAR) T cell therapy can improve prognosis. Here, we present interim results from the first six pediatric patients treated on an ongoing phase I ...

    Abstract Outcomes for pediatric brain tumor patients remain poor, and there is optimism that chimeric antigen receptor (CAR) T cell therapy can improve prognosis. Here, we present interim results from the first six pediatric patients treated on an ongoing phase I clinical trial (NCT04510051) of IL13BBζ-CAR T cells delivered weekly into the lateral cerebral ventricles, identifying clonal expansion of endogenous CAR-negative CD8
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3454977/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Antibody-Peptide Epitope Conjugates for Personalized Cancer Therapy.

    Zhang, Songfa / Yan, Chuan / Millar, David G / Yang, Qiqi / Heather, James M / Langenbucher, Adam / Morton, Laura T / Sepulveda, Sean / Alpert, Eric / Whelton, Lauren R / Zarrella, Dominique T / Guo, Mei / Minogue, Eleanor / Lawrence, Michael S / Rueda, Bo R / Spriggs, David R / Lu, Weiguo / Langenau, David M / Cobbold, Mark

    Cancer research

    2021  Volume 82, Issue 5, Page(s) 773–784

    Abstract: Antibody-peptide epitope conjugates (APEC) are a new class of modified antibody-drug conjugates that redirect T-cell viral immunity against tumor cells. APECs contain a tumor-specific protease cleavage site linked to a patient-specific viral epitope, ... ...

    Abstract Antibody-peptide epitope conjugates (APEC) are a new class of modified antibody-drug conjugates that redirect T-cell viral immunity against tumor cells. APECs contain a tumor-specific protease cleavage site linked to a patient-specific viral epitope, resulting in presentation of viral epitopes on cancer cells and subsequent recruitment and killing by CD8+ T cells. Here we developed an experimental pipeline to create patient-specific APECs and identified new preclinical therapies for ovarian carcinoma. Using functional assessment of viral peptide antigen responses to common viruses like cytomegalovirus (CMV) in patients with ovarian cancer, a library of 192 APECs with distinct protease cleavage sequences was created using the anti-epithelial cell adhesion molecule (EpCAM) antibody. Each APEC was tested for in vitro cancer cell killing, and top candidates were screened for killing xenograft tumors grown in zebrafish and mice. These preclinical modeling studies identified EpCAM-MMP7-CMV APEC (EpCAM-MC) as a potential new immunotherapy for ovarian carcinoma. Importantly, EpCAM-MC also demonstrated robust T-cell responses in primary ovarian carcinoma patient ascites samples. This work highlights a robust, customizable platform to rapidly develop patient-specific APECs.
    Significance: This study develops a high-throughput preclinical platform to identify patient-specific antibody-peptide epitope conjugates that target cancer cells and demonstrates the potential of this immunotherapy approach for treating ovarian carcinoma.
    MeSH term(s) Animals ; Antibodies ; CD8-Positive T-Lymphocytes ; Carcinoma, Ovarian Epithelial/drug therapy ; Cytomegalovirus ; Cytomegalovirus Infections ; Epithelial Cell Adhesion Molecule ; Epitopes ; Female ; Humans ; Immunoconjugates/therapeutic use ; Mice ; Ovarian Neoplasms/drug therapy ; Peptide Hydrolases ; Peptides ; Zebrafish
    Chemical Substances Antibodies ; Epithelial Cell Adhesion Molecule ; Epitopes ; Immunoconjugates ; Peptides ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2021-12-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-21-2200
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.135/5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: The E-box binding factors Max/Mnt, MITF, and USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle control genes by phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 signaling.

    Terragni, Jolyon / Nayak, Gauri / Banerjee, Swati / Medrano, Jose-Luis / Graham, Julie R / Brennan, James F / Sepulveda, Sean / Cooper, Geoffrey M

    The Journal of biological chemistry

    2011  Volume 286, Issue 42, Page(s) 36215–36227

    Abstract: Phosphatidylinositol (PI) 3-kinase/Akt signaling plays a critical role in cell proliferation and survival, partly by regulation of FoxO transcription factors. Previous work using global expression profiling indicated that inhibition of PI 3-kinase in ... ...

    Abstract Phosphatidylinositol (PI) 3-kinase/Akt signaling plays a critical role in cell proliferation and survival, partly by regulation of FoxO transcription factors. Previous work using global expression profiling indicated that inhibition of PI 3-kinase in proliferating cells led to induction of genes that promote cell cycle arrest and apoptosis. The upstream regulatory regions of these genes had binding sites not only for FoxO, but also for Myc/Max transcription factors. In the present study, we have addressed the role of Myc family members and related E-box-binding proteins in the regulation of these genes. Chromatin immunoprecipitations and RNA interference indicated that transcription was repressed by Max-Mnt-Sin3a-histone deacetylase complexes in proliferating cells. Inhibition of PI 3-kinase led to a loss of Max/Mnt binding and transcriptional induction by MITF and USF1, as well as FoxO. Both MITF and USF1 were activated by glycogen synthase kinase (GSK) 3, with GSK3 phosphorylation sites on USF1 identified as the previously described activating site threonine 153 as well as serine 186. siRNA against MITF as well as against FoxO3a protected cells from apoptosis following PI 3-kinase inhibition. These results define a novel E-box-regulated network that functions coordinately with FoxO to regulate transcription of apoptotic and cell cycle regulatory genes downstream of PI 3-kinase/Akt/GSK3 signaling.
    MeSH term(s) Apoptosis Regulatory Proteins/biosynthesis ; Apoptosis Regulatory Proteins/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Cell Cycle/physiology ; Cell Line, Tumor ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation/physiology ; Glycogen Synthase Kinase 3/genetics ; Glycogen Synthase Kinase 3/metabolism ; Humans ; Microphthalmia-Associated Transcription Factor/genetics ; Microphthalmia-Associated Transcription Factor/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation/physiology ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Small Interfering/genetics ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Signal Transduction/physiology ; Sin3 Histone Deacetylase and Corepressor Complex ; Transcription, Genetic/physiology ; Upstream Stimulatory Factors/genetics ; Upstream Stimulatory Factors/metabolism
    Chemical Substances Apoptosis Regulatory Proteins ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; Forkhead Transcription Factors ; MAX protein, human ; MITF protein, human ; Microphthalmia-Associated Transcription Factor ; RNA, Small Interfering ; Repressor Proteins ; SIN3A transcription factor ; USF1 protein, human ; Upstream Stimulatory Factors ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 (EC 2.7.11.26) ; Sin3 Histone Deacetylase and Corepressor Complex (EC 3.5.1.98)
    Language English
    Publishing date 2011-08-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M111.246116
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy.

    Millar, David G / Ramjiawan, Rakesh R / Kawaguchi, Kosuke / Gupta, Nisha / Chen, Jiang / Zhang, Songfa / Nojiri, Takashi / Ho, William W / Aoki, Shuichi / Jung, Keehoon / Chen, Ivy / Shi, Feng / Heather, James M / Shigeta, Kohei / Morton, Laura T / Sepulveda, Sean / Wan, Li / Joseph, Ricky / Minogue, Eleanor /
    Khatri, Ashok / Bardia, Aditya / Ellisen, Leif W / Corcoran, Ryan B / Hata, Aaron N / Pai, Sara I / Jain, Rakesh K / Fukumura, Dai / Duda, Dan G / Cobbold, Mark

    Nature biotechnology

    2020  Volume 38, Issue 4, Page(s) 420–425

    Abstract: Several cancer immunotherapy approaches, such as immune checkpoint blockade and adoptive T-cell therapy, boost T-cell activity against the tumor, but these strategies are not effective in the absence of T cells specific for displayed tumor antigens. Here ...

    Abstract Several cancer immunotherapy approaches, such as immune checkpoint blockade and adoptive T-cell therapy, boost T-cell activity against the tumor, but these strategies are not effective in the absence of T cells specific for displayed tumor antigens. Here we outline an immunotherapy in which endogenous T cells specific for a noncancer antigen are retargeted to attack tumors. The approach relies on the use of antibody-peptide epitope conjugates (APECs) to deliver suitable antigens to the tumor surface for presention by HLA-I. To retarget cytomegalovirus (CMV)-specific CD8
    MeSH term(s) Animals ; Antibodies/chemistry ; Antibodies/immunology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/transplantation ; Cell Line, Tumor ; Cytomegalovirus/immunology ; Epitopes, T-Lymphocyte/chemistry ; Epitopes, T-Lymphocyte/immunology ; Histocompatibility Antigens Class I/immunology ; Humans ; Immunoconjugates/chemistry ; Immunoconjugates/immunology ; Immunoconjugates/metabolism ; Immunoconjugates/therapeutic use ; Immunomodulation ; Immunotherapy, Adoptive ; Lymphocyte Activation ; Matrix Metalloproteinases/metabolism ; Mice ; Neoplasms/immunology ; Neoplasms/therapy
    Chemical Substances Antibodies ; Epitopes, T-Lymphocyte ; Histocompatibility Antigens Class I ; Immunoconjugates ; Matrix Metalloproteinases (EC 3.4.24.-)
    Language English
    Publishing date 2020-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/s41587-019-0404-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 137: Show issues
    Zs.MG 43: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Interactions between injury, stress resistance, reproduction, and aging in Drosophila melanogaster.

    Sepulveda, Sean / Shojaeian, Parvin / Rauser, Casandra L / Jafari, Mahtab / Mueller, Laurence D / Rose, Michael R

    Experimental gerontology

    2007  Volume 43, Issue 3, Page(s) 136–145

    Abstract: An important aspect of the aging process in Drosophila melanogaster is the natural loss of antennae, legs, bristles, and parts of wings with age. These injuries lead to a loss of hemolymph, which contains water and nutrients. Stress-resistant lines of D. ...

    Abstract An important aspect of the aging process in Drosophila melanogaster is the natural loss of antennae, legs, bristles, and parts of wings with age. These injuries lead to a loss of hemolymph, which contains water and nutrients. Stress-resistant lines of D. melanogaster are sometimes longer-lived than the populations from which they are derived. One hypothesis tested here is that increased stress-resistance fosters longevity because it allows fruit flies to cope with the loss of hemolymph due to injury to the aging fly. We tested the effects of surgically induced injury on the aging and reproduction of five replicate populations. We then tested the effects of injury on populations that had been selected for different levels of stress resistance and on control populations. Injury affected aging more in males than in females, in part because of a counter-balancing reduction in female reproduction brought about by injury. More specifically, injury reduced female fecundity and male virility. Injury significantly reduced the starvation resistance in some groups of flies, but not in others. These findings undermine any simple interpretation of the interactions between injury, reproduction, and aging based on stress resistance. But they do indicate the existence of significant interactions between these biological processes, interactions that should be resolved in greater mechanistic detail than has been managed here.
    MeSH term(s) Aging/physiology ; Animals ; Drosophila melanogaster/physiology ; Female ; Fertility/physiology ; Hemolymph/physiology ; Male ; Reproduction/physiology ; Sexual Behavior, Animal/physiology ; Stress, Physiological/physiopathology ; Wounds and Injuries/physiopathology
    Language English
    Publishing date 2007-10-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 390992-x
    ISSN 0531-5565
    ISSN 0531-5565
    DOI 10.1016/j.exger.2007.10.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top