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Article ; Online: New Technologies to Diagnose and Treat a Multidrug-Resistant Candida auris: A Patent Review.

Rossato, Luana / Simionatto, Simone / Serafini, Mairim Russo / Alves, Izabel Almeida

2022 Volume 187, Issue 5-6, Page(s) 535–546

Abstract: Candida auris is responsible for hospital outbreaks worldwide. Some C. auris isolates may show concomitant resistance to azoles, echinocandins, and polyenes, thereby possibly leaving clinicians with few therapeutic options. In addition, this multi-drug- ... ...

Abstract	Candida auris is responsible for hospital outbreaks worldwide. Some C. auris isolates may show concomitant resistance to azoles, echinocandins, and polyenes, thereby possibly leaving clinicians with few therapeutic options. In addition, this multi-drug-resistant yeast is difficult to identify with conventional methods and has the ability to persist on environmental surfaces causing hospital-acquired infections. The development of new treatment options and tools for identification is critical to control, prevent, and establish an early diagnosis of this emerging pathogen. The aim of this study was to perform a critical patent review to explore and identify the latest advances in therapeutic strategies as well as diagnostic methods for C. auris. A total of 19 patents were identified for a preliminary assessment from the Espacenet database. Three patents were excluded as they were out of focus for this review according to their abstract and/or description. The final selection covered 16 patents, which were surveyed by country, year and classified as treatment or diagnostic methods for C. auris. As noted in the patent reading, in recent years, the interest of academic, government and industry sectors have shown an increasing tendency focused on research and development of new therapeutic molecules and diagnostic methods to combat this emerging pathogen.
MeSH term(s)	Drug Resistance, Multiple, Fungal ; Candida ; Candidiasis/diagnosis ; Candidiasis/drug therapy ; Candidiasis/epidemiology ; Candida auris ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Microbial Sensitivity Tests
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2022-10-04
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	391081-7
ISSN	1573-0832 ; 0369-299X ; 0301-486X ; 0027-5530
ISSN (online)	1573-0832
ISSN	0369-299X ; 0301-486X ; 0027-5530
DOI	10.1007/s11046-022-00669-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Novel Synthesized Tyrosinase Inhibitors: A Systematic Patent Review (2012-Present).

Beltran, Erika / Serafini, Mairim Russo / Alves, Izabel Almeida / Aragón Novoa, Diana Marcela

Current medicinal chemistry

2023 Volume 31, Issue 3, Page(s) 308–335

Abstract: Tyrosine is an enzyme responsible for melanin production. Its abnormal accumulation in different parts of the body is known as hyperpigmentation. Tyrosinase inhibitors have been used as one of the main approaches to treat these kinds of cosmetic and ... ...

Abstract	Tyrosine is an enzyme responsible for melanin production. Its abnormal accumulation in different parts of the body is known as hyperpigmentation. Tyrosinase inhibitors have been used as one of the main approaches to treat these kinds of cosmetic and medical issues. This review aimed to discuss the advances in patents for this class of inhibitors, focusing on synthetic ones, by studying recent patent applications (2012-2022). We performed a screening using the European Patent Office's Espacenet database, from which 15 inventions were selected and fully studied. China has more patent applications, all of them were focused on synthetic methods and the majority declared at least two additional applications as antibrowning agents for fruits and vegetables, biological pesticides, and medicine to treat diseases like Parkinson's or melanoma. The strategies employed by the investigators focused on the examination of previous literature, which oriented on the type of structures that have been found to show good inhibitory activity; the study also examined aspects of their reaction mechanisms and information about the structureactivity relationship. For some groups of inhibitors, such as benzaldehyde and anthraquinone derivatives, the data were meaningful and extensive. In contrast, arginyl and troponoids compounds were difficult to analyze due to the limited research works.
Language	English
Publishing date	2023-02-03
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867330666230203111437
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Zs.A 4432: Show issues

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Article ; Online: New molecules of importance in the prevention and treatment of acne: A systematic patent review (2016-2020).

Calderón-Pardo, Daniela Estefanía / Serafini, Mairim Russo / Alves, Izabel Almeida / Aragón, Diana Marcela

Current medicinal chemistry

2023

Abstract: Background: Acne is a highly prevalent disease that mainly affects the pilosebaceous units associated with sebaceous glands, causing inflammatory skin lesions and affecting the self-esteem, mental health, and quality of life of those who suffer from ... ...

Abstract	Background: Acne is a highly prevalent disease that mainly affects the pilosebaceous units associated with sebaceous glands, causing inflammatory skin lesions and affecting the self-esteem, mental health, and quality of life of those who suffer from this disease. Different treatments exist today to prevent, reduce, and improve symptoms; however, over the years, there have been problems with bacterial resistance and slight effectiveness with prolonged use. Objective: The purpose of this article is based on the review of patents of new products of principal topical administration for the treatment of acne in recent years 2016-2020, to evaluate and analyze novel synthetic molecules and semi-synthetics with potential therapeutic and preventive in the acne treatment. Methods: A systematic review of patents was conducted through the official database of the European Patent Office - Espacenet, where the search focused on the keywords: "acne and bacteria" in the title or abstract. Only patents granted between the years 2016-2020 were included, with products having molecules with a synthetic and semi-synthetic origin, without considering natural, biological products or those used as diagnostic means. Results: A total of 19 patents were selected, most with principally antimicrobial and anti-inflammatory action, where the reduction in the appearance of resistance by C. acnes is verified, and its action is complemented by inhibiting the different pathophysiological mechanisms that lead to the worsening of the disease. Conclusion: Novel approaches in the treatment and prevention of acne, mainly topically, are focused on the reduction of bacterial resistance and irritation compared to current treatments. The use of combined formulations provides better results with additional benefits, improving treatment times and patient adherence.
Language	English
Publishing date	2023-08-17
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867331666230817155906
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Article: Antinociceptive effect of plant-based natural products in chemotherapy-induced peripheral neuropathies: A systematic review.

Santos, Wagner Barbosa Da Rocha / Guimarães, Juliana Oliveira / Pina, Lícia Tairiny Santos / Serafini, Mairim Russo / Guimarães, Adriana Gibara

Frontiers in pharmacology

2022 Volume 13, Page(s) 1001276

Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most prevalent and difficult-to-treat symptoms in cancer patients. For this reason, the explore for unused helpful choices able of filling these impediments is essential. Natural products ... ...

Abstract	Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most prevalent and difficult-to-treat symptoms in cancer patients. For this reason, the explore for unused helpful choices able of filling these impediments is essential. Natural products from plants stand out as a valuable source of therapeutic agents, being options for the treatment of this growing public health problem. Therefore, the objective of this study was to report the effects of natural products from plants and the mechanisms of action involved in the reduction of neuropathy caused by chemotherapy. The search was performed in PubMed, Scopus and Web of Science in March/2021. Two reviewers independently selected the articles and extracted data on characteristics, methods, study results and methodological quality (SYRCLE). Twenty-two studies were selected, describing the potential effect of 22 different phytochemicals in the treatment of CIPN, with emphasis on terpenes, flavonoids and alkaloids. The effect of these compounds was demonstrated in different experimental protocols, with several action targets being proposed, such as modulation of inflammatory mediators and reduction of oxidative stress. The studies demonstrated a predominance of the risk of uncertain bias for randomization, baseline characteristics and concealment of the experimental groups. Our findings suggest a potential antinociceptive effect of natural products from plants on CIPN, probably acting in several places of action, being strategic for the development of new therapeutic options for this multifactorial condition.
Language	English
Publishing date	2022-09-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.1001276
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Article ; Online: Recent Progress in Self-Emulsifying Drug Delivery Systems: A Systematic Patent Review (2011-2020).

Ruiz, Pedro Sebastián Londoño / Serafini, Mairim Russo / Alves, Izabel Almeida / Novoa, Diana Marcela Aragón

Critical reviews in therapeutic drug carrier systems

2022 Volume 39, Issue 2, Page(s) 1–77

Abstract: Self-emulsifying drug delivery systems (SEDDS) are lipid-based isotropic mixtures that enhance the bioavailability of poorly water-soluble drugs and reduce the possible side effects, offering a wide variety of treatments for several pathologies. The aim ... ...

Abstract	Self-emulsifying drug delivery systems (SEDDS) are lipid-based isotropic mixtures that enhance the bioavailability of poorly water-soluble drugs and reduce the possible side effects, offering a wide variety of treatments for several pathologies. The aim of this review is to discuss the state of the art of patents for this drug delivery system by studying recent patent applications (2011 to 2020). We performed a thorough screening using the European Patent Office's Espacenet database, from which 37 inventions were selected and fully studied. China had more patent applications, and the articles published about SEDDS exceeds both in number and technological advance the submitted inventions. Nevertheless, the patents presented herein are innovative to address known issues to traditional SEDDS, including storage and formulation stability, solid formulations, acute gastrointestinal toxicity from surfactants, and drug delivery through alternative routes of administration. This study also revealed that release behavior for SEDDS and associated pharmacokinetics were not completely disclosed by the inventors of the patents and that further studies are required.
MeSH term(s)	Biological Availability ; China ; Drug Delivery Systems ; Emulsions ; Humans ; Surface-Active Agents
Chemical Substances	Emulsions ; Surface-Active Agents
Language	English
Publishing date	2022-03-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2012632-3
ISSN	2162-660X ; 0743-4863
ISSN (online)	2162-660X
ISSN	0743-4863
DOI	10.1615/CritRevTherDrugCarrierSyst.2021038490
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Zs.A 2124: Show issues

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Article ; Online: The management of osteoarthritis symptomatology through nanotechnology: a patent review.

Santos, Mariana Mendonça / Santos, Anamaria Mendonça / Nascimento Júnior, José Adão Carvalho / Andrade, Tatianny De Araujo / Rajkumar, Gomathi / Frank, Luiza Abrahão / Serafini, Mairim Russo

Journal of microencapsulation

2023 Volume 40, Issue 7, Page(s) 475–490

Abstract: Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for ... ...

Abstract	Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for osteoarthritis therapy. This review aimed to evaluate patents that have developed innovations, therapeutic strategies, and alternatives using nanotechnology in osteoarthritis treatment. The results show patents deposited from 2015 to November 2021 in the online databases European Patent Office and World Intellectual Property Organisation. A total of 651 patents were identified for preliminary assessment and 16 were selected for full reading and discussion. The evaluated patents are focused on the intraarticular route, oral route, and topical route for osteoarthritis treatment. The intraarticular route presented a higher patent number, followed by the oral and topical routes, respectively. The development of new technologies allows us to envision a promising and positive future in osteoarthritis treatment.
MeSH term(s)	Humans ; Drug Delivery Systems ; Nanotechnology ; Osteoarthritis/drug therapy
Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	843632-0
ISSN	1464-5246 ; 0265-2048
ISSN (online)	1464-5246
ISSN	0265-2048
DOI	10.1080/02652048.2023.2258955
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Zs.A 2267: Show issues

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Article ; Online: A Descriptive Review of

Pereira, Isabela Fernandes / Santos Oliveira, Ana Maria / Santos, Anamaria Mendonça / de Melo Soares, Denis / Serafini, Mairim Russo / Almeida Alves, Izabel

Recent patents on anti-cancer drug discovery

2023 Volume 19, Issue 2, Page(s) 137–145

Abstract: Background: Cannabis: Objective: The study aimed to conduct a critical patent review to identify and explore the latest advances and therapeutic strategies using : Methods: The research was carried out in the free and online database Espacenet, ... ...

Abstract	Background: Cannabis Objective: The study aimed to conduct a critical patent review to identify and explore the latest advances and therapeutic strategies using Methods: The research was carried out in the free and online database Espacenet, using the descriptors "cancer" and " Results: As observed in the reading of patents, the interest of pharmaceutical industries and researchers and the development of new products to fight cancer have increased in recent years. The main cannabinoids present in the patents are tetrahydrocannabinol, cannabidiol, and hemp. Moreover, the patents were classified and the main applicant countries were the United States followed by Japan, with a higher filing rate in 2019 and, mainly by the industry. Conclusion: In conclusion we can say that, the importance of parliamentary approval in the cultivation and investments that, in addition to bringing innovation to the industrial sector, enriches research in the area, contributing to the creation of new medicines.
MeSH term(s)	Humans ; United States ; Cannabis ; Cannabidiol/therapeutic use ; Patents as Topic ; Cannabinoids/therapeutic use ; Neoplasms/drug therapy
Chemical Substances	Cannabidiol (19GBJ60SN5) ; Cannabinoids
Language	English
Publishing date	2023-02-14
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	2250820-X
ISSN	2212-3970 ; 1574-8928
ISSN (online)	2212-3970
ISSN	1574-8928
DOI	10.2174/1574892818666230213095717
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Article ; Online: Devices for osteoarthritis symptoms treatment: a patent review.

Santos, Mariana Mendonça / Santos, Anamaria Mendonça / Carvalho Nascimento, José Adão / Santana, Cláudio Carvalho / Oliveira, Ana Maria Santos / Cezar, Silvia Vitoria Silva / Santos, Alcimary Bispo / Frank, Luiza Abrahão / Serafini, Mairim Russo

Expert review of medical devices

2024 Volume 21, Issue 1-2, Page(s) 91–107

Abstract: Introduction: Osteoarthritis is a musculoskeletal disease that can lead to the loss and inability of those affected to perform normal daily functions, which leads to a decrease in quality of life. The main symptoms of osteoarthritis are tenderness, ... ...

Abstract	Introduction: Osteoarthritis is a musculoskeletal disease that can lead to the loss and inability of those affected to perform normal daily functions, which leads to a decrease in quality of life. The main symptoms of osteoarthritis are tenderness, joint pain, stiffness, crepitus, limited movement, and local inflammation. Areas covered: The selected patents were deposited from 2010 to April 2022 involving 57 documents that were in line with the study objective in the final selection. The patents were classified in years, country, and applicants. Also, the therapeutic fields that presented the most documents were electrical stimulation, phototherapy, and ultrasound, followed by magnetic, electromagnetic, and thermotherapy. Therefore, the most current therapies used in the documents are already on the market. Expert opinion: Although the OA is cureless, non-surgical treatments are classified as the primary management approach for this disease. The pharmacological and non-pharmacological therapies are employed to reduce its prevalence and ensure the effectiveness of treatments. A strategy for relieving OA symptoms is non-pharmacological treatment, which can be based on exercise and patient education, combined with other alternative therapies. These therapies are used as supplements to the main OA treatments, enhancing the effectiveness of treatment outcomes.
MeSH term(s)	Humans ; Quality of Life ; Osteoarthritis/therapy ; Hyperthermia, Induced ; Inflammation ; Exercise
Language	English
Publishing date	2024-02-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2250857-0
ISSN	1745-2422 ; 1743-4440
ISSN (online)	1745-2422
ISSN	1743-4440
DOI	10.1080/17434440.2023.2298729
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Zs.A 6424: Show issues

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Article ; Online: The use of natural extracts with photoprotective activity: a 2015-2023 patent prospection.

Oliveira, Ana Maria Santos / de Souza Batista, Daniel / de Castro, Tailaine Nascimento / Alves, Izabel Almeida / Souto, Ricardo Bizogne / Mota, Milleno Dantas / Serafini, Mairim Russo / Rajkumar, Gomathi / Cazedey, Edith Cristina Laignier

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

2024

Abstract: Synthetic sunscreen offers protection against excessive exposure to ultraviolet (UV) radiation from the sun, and protects the skin from possible damage. However, they have low efficacy against the formation of reactive oxygen species (ROS), which are ... ...

Abstract	Synthetic sunscreen offers protection against excessive exposure to ultraviolet (UV) radiation from the sun, and protects the skin from possible damage. However, they have low efficacy against the formation of reactive oxygen species (ROS), which are highly reactive molecules that can be generated in the skin when it is exposed to UV radiation, and are known to play a role in oxidative stress, which can contribute to skin aging and damage. Thus, there is an ongoing search for sunscreens that do not have these negative effects. One promising source for these is natural products. Therefore, the current patent review summarizes topical formulations made from natural compounds that have antioxidant properties and can be used as photoprotective or anti-aging agents, either using a single natural extract or a combination of extracts. The review reports basic patent information (applicant country, type of applicant, and year of filing) and gives details about the invention, including its chemical composition, and the in vitro and in vivo tests performed. These patents describe natural products that can be used to protect the skin and validate their efficacy, and safety, in addition to standardizing their formulations. The compositions described illustrate the consistent innovation in the use of natural products to protect against UV damage and photoaging disorders, a promising field which is receiving growing global recognition.
Language	English
Publishing date	2024-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2072584-X
ISSN	1474-9092 ; 1474-905X
ISSN (online)	1474-9092
ISSN	1474-905X
DOI	10.1007/s43630-024-00559-w
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Article: Antitumor Effects of Carvacrol and Thymol: A Systematic Review.

Sampaio, Laeza Alves / Pina, Lícia Tairiny Santos / Serafini, Mairim Russo / Tavares, Débora Dos Santos / Guimarães, Adriana Gibara

Frontiers in pharmacology

2021 Volume 12, Page(s) 702487

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-07-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.702487
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