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  1. Article ; Online: Measurement of antibody levels in patients with COVID-19 over time by immunofluorescence assay

    Betul Borku Uysal / Serap Yavuzer / Mehmet Sami Islamoglu / Mahir Cengiz

    Journal of International Medical Research, Vol

    a longitudinal observational study

    2022  Volume 50

    Abstract: Background During the coronavirus disease 2019 (COVID-19) pandemic, antibody screening is a critical tool to assess anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity. We examined variation in antibody titers associated with age ... ...

    Abstract Background During the coronavirus disease 2019 (COVID-19) pandemic, antibody screening is a critical tool to assess anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity. We examined variation in antibody titers associated with age and sex among patients with confirmed COVID-19. Methods Blood IgG levels were tested in 1081 patients with positive SARS-CoV-2 quantitative reverse transcription polymerase chain reaction (RT-qPCR) tests between 1 September and 31 December 2020. Patients who did not experience reinfection were identified. Serum IgG levels were measured by immunofluorescence assay. Antibody positivity and antibody titers were analyzed according to time since infection, sex, and age. Results The mean (standard deviation) age was 41.2 (14.2) years and 41.2% of patients were women. The lowest antibody positivity rate between the first and ninth month post-infection was detected in the sixth month. The lowest antibody titers among patients aged 20 to 80 years occurred in those aged 30 to 39 years. The IgG titer was positively correlated with age in years (r = 0.125) and decades (r = 0.126). Conclusions Six months after infection, anti-SARS-CoV-2 antibody titers increased. Anti-SARS-CoV-2 antibody titers also increased with age. Immunity and pathogenicity should be investigated in addition to antibody positivity rates and antibody titers.
    Keywords Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: SARS-CoV-2 antibody seroprevalence in healthcare personnel during the pandemic's peak

    Mehmet Sami Islamoglu / Mahir Cengiz / Betul Borku Uysal / Serap Yavuzer

    Medicine Science, Vol 11, Iss 1, Pp 154-

    The experience of single hospital

    2022  Volume 8

    Abstract: Serological severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies determination in healthcare personnels with a increased risk of infection is important for detecting asymptomatic coronavirus disease 2019 (COVID-19) and post-disease ... ...

    Abstract Serological severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies determination in healthcare personnels with a increased risk of infection is important for detecting asymptomatic coronavirus disease 2019 (COVID-19) and post-disease immunity. Purpose of study were to determine the seroprevelance of healthcare personnels with COVID-19 in university hospital. 439 healthcare personnels working at Biruni University Medical Faculty Hospital between March 2020 to January 2021 were included to the study. All participants were divided into groups based on the results of their immunoglobulin G (IgG) antibodies against novel coronavirus in blood test, collecting nasopharyngeal and oropharyngeal swabs reverse transcriptasepolymerase chain reaction (RT-PCR), and thorax computed tomography (CT). Group 1: Antibody positivity and RT- PCR negativity, Group 2: RT-PCR positivity without lung involvement, Group 3: RT-PCR positivity with lung involvement. The RT-PCR positivity was detected as 32.8 % (n=144) in all healthcare personnels, 68.8 % of RT-PCR positive healthcare personnels were symptomatic and 15.3 % of them had lung involvement. The IgG antibody positivity was detected as 41 % (n=180) in all healthcare personnels. The antibody positivity (p=0.353) and titers were similar in the healthcare personnels (p=0.361). Risk of COVID-19 and contagiousness is high in healthcare personnels under pandemic conditions. Additionally the antibody positivity and antibody titer are higher in those who have symptomatic disease compared to those who have asymptomatic. [Med-Science 2022; 11(1.000): 154-8]
    Keywords sars-cov-2 antibody ; healthcare personnel ; seroprevalence,covid-19 ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 360
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Society of TURAZ AKADEMI
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Effect of oral l-Glutamine supplementation on Covid-19 treatment

    Mahir Cengiz / Betul Borku Uysal / Hande Ikitimur / Erkan Ozcan / Mehmet Sami Islamoğlu / Emre Aktepe / Hakan Yavuzer / Serap Yavuzer

    Clinical Nutrition Experimental, Vol 33, Iss , Pp 24-

    2020  Volume 31

    Abstract: Summary: Objectives: The aim of this study is to investigate the effect of oral l-Glutamine supplementation on hospitalization time, need for intensive care unit and Coronavirus Disease-19 (Covid-19) mortality. Methods: The study included 30 Covid-19 ... ...

    Abstract Summary: Objectives: The aim of this study is to investigate the effect of oral l-Glutamine supplementation on hospitalization time, need for intensive care unit and Coronavirus Disease-19 (Covid-19) mortality. Methods: The study included 30 Covid-19 patients using l-Glutamine and 30 Covid-19 patients who did not use l-Glutamine with similar age, gender and clinical status. Diagnostic tests, laboratory examinations, clinical findings and computed thorax tomography imaging of the patients were evaluated. Results: Hospitalization time was 10.4 ± 1.9 days in Covid-19 without L-Glutamine group and 8.9 ± 1.8 days in Covid-19 with L-Glutamine group (p = 0.005). In Covid-19 without the L-Glutamine group, four patients require the ICU though no one in the other group required that (p = 0.038). Only one mortality was observed in Covid-19 without the L-Glutamine group (p = 0.999). Conclusions: Nutritional supplements such as L-Glutamine boost immune system especially by inhibition of inflammatory responses. Our results suggest adding enteral L-glutamine to the normal nutrition in the early period of Covid-19 infection may lead to a shortened hospital stay and lead to less need for ICU. Larger-scale studies are needed to evaluate the effect of adding enteral L-Glutamine to the currently used treatments in the infectious diseases especially like Covid-19.
    Keywords Covid-19 ; SARS Cov-2 ; Pneumonia ; l-Glutamine ; Nutrition ; Nutrition. Foods and food supply ; TX341-641 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The Attitudes of Patients toward the Presence of Students in Internal Medicine Inpatient and Outpatient Practice

    Serap Yavuzer / Mahir Cengiz / Ali Can / Hakan Yavuzer / Serdar Şahin / Mehmet Yürüyen / Emre Sedar Saygılı / Hacı Murat Emül

    İstanbul Medical Journal, Vol 16, Iss 2, Pp 57-

    2015  Volume 61

    Abstract: Objective: The medicine educators increase the clinical skills and professional thinking ability of students by examining patients, showing their attitudes towards them, and attracting their response in the presence of medical students. In this study, we ...

    Abstract Objective: The medicine educators increase the clinical skills and professional thinking ability of students by examining patients, showing their attitudes towards them, and attracting their response in the presence of medical students. In this study, we aimed to investigate the attitudes of patients who applied to internal medicine toward the presence of medical students and the possible factors that may influence such attitudes.Methods: This study was performed between February and December 2013. The patients who were admitted to our four general internal medicine outpatient clinics and one general internal medicine service were included in the study. Their ages ranged from 16 to 88. In this study, we used a questionnaire that was formed by extracting questions that were used in literature.Results: We obtained the data of 723 individuals in the study. The mean age of participants was 40.72±13.91 years (male: 41.95±14.56 years and female: 40.17±13.59 years; p=0.112). Of these patients, 31% were males and 69% were females. Of these patients, 88.4% reported that they “would not be disturbed in the presence of medical students” during the examination and 71.1% allowed “physical examination by a medical student under the supervision of a clinician”. The rates of giving importance for the training of future doctors to the proposals of “the presence of medical students or being examined by the medical students, while being interviewed by the physician” were 89.2% and 97.1%, respectively.Conclusion: Our study is the first in our country that investigated the attitudes of patients towards the presence of medical students in internal medicine practices of examination and treatment of patients. In accordance with the literature, we have detected that the patients who were admitted to the internal medicine clinics are positive and were not in discomfort in the presence of medical students for whom these attitudes may be affected by some conditions
    Keywords Medicine education ; medical student ; clerkship ; patient attitude ; patient behavior ; Medicine ; R
    Subject code 420
    Language English
    Publishing date 2015-06-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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