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Article ; Online: Autochthonous Dengue Fever in 2 Patients, Rome, Italy

Serena Vita / Licia Bordi / Giuseppe Sberna / Priscilla Caputi / Daniele Lapa / Angela Corpolongo / Cosmina Mija / Alessandra D’Abramo / Fabrizio Maggi / Francesco Vairo / Eliana Specchiarello / Enrico Girardi / Eleonora Lalle / Emanuele Nicastri

Emerging Infectious Diseases, Vol 30, Iss 1, Pp 183-

2024 Volume 184

Abstract: Since August 2023, outbreaks of dengue virus (DENV) infection have occurred in Italy. We report 2 autochthonous case-patients and their extended follow-up. Despite persistent DENV detected in blood by PCR, results for antigenomic DENV RNA were negative ... ...

Abstract	Since August 2023, outbreaks of dengue virus (DENV) infection have occurred in Italy. We report 2 autochthonous case-patients and their extended follow-up. Despite persistent DENV detected in blood by PCR, results for antigenomic DENV RNA were negative after day 5, suggesting that a 5-day isolation period is adequate to avoid secondary cases.
Keywords	dengue fever ; autochthonous cases ; dengue ; dengue virus ; DENV ; viruses ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Centers for Disease Control and Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pharyngo-tonsillar involvement of Mpox in a cohort of men who have sex with men (MSM)

Carmela Pinnetti / Annalisa Mondi / Valentina Mazzotta / Serena Vita / Fabrizio Carletti / Camilla Aguglia / Alessia Beccacece / Alessandra Vergori / Roberta Gagliardini / Eliana Specchiarello / Tommaso Ascoli Bartoli / Francesco Baldini / Maria Letizia Giancola / Maria Beatrice Valli / Alessandra D'Abramo / Saba Gebremeskel Teklè / Carla Fontana / Anna Rosa Garbuglia / Enrico Girardi /

Fabrizio Maggi / Francesco Vaia / Emanuele Nicastri / Andrea Antinori

Journal of Infection and Public Health, Vol 17, Iss 1, Pp 130-

A serious risk of missing diagnosis

2024 Volume 136

Abstract: During the 2022-outbreak, peculiar clinical presentations of Mpox have been described, some of which can make the diagnosis of the disease extremely challenging. Here we report a case series of fourteen patients with Mpox pharynogotonsillar involvement ( ... ...

Abstract	During the 2022-outbreak, peculiar clinical presentations of Mpox have been described, some of which can make the diagnosis of the disease extremely challenging. Here we report a case series of fourteen patients with Mpox pharynogotonsillar involvement (PTI) seen at National Institute for Infectious Diseases, “Lazzaro Spallanzani”, in Rome, Italy from May to September 2022. All included patients were men who have sex with men (median age 38 years) reporting unprotected sex within three weeks from symptoms onset. Seven out of fourteen patients needed hospitalization due to uncontrolled pain, reduced airspace and difficulty swallowing, of whom five were effectively treated with tecovirimat or cidofovir. The remaining two patients were treated with symptomatic drugs. The typical Mpox muco-cutaneous manifestations were not observed simultaneously with PTI in three patients, two of whom developed the lesions after several days, while one never manifested them. Polymerase Chain Reaction (PCR) for Mpox virus was positive in oropharyngeal swab, saliva and serum. Although PTI occurs in only a small percentage of Mpox cases, its diagnosis is of utmost importance. In fact, this localization, if not identified, could lead to serious complications in the absence of early antiviral treatment and to missed diagnosis with an increased risk of disease transmission.
Keywords	Mpox ; MPXV ; MSM ; Emerging infectious diseases ; Pharyngo-tonsillitis ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Aero-Medical Evacuation during SARS-CoV-2 Pandemic

Domenico Benvenuto / Tommaso Ascoli Bartoli / Ambrogio Curtolo / Claudia Palazzolo / Serena Vita / Andrea Mariano / Laura Scorzolini / Giuseppe Ippolito / Luisa Marchioni / Federico Cerini / Gianpiero D’Offizi / Francesco Vaia / Emanuele Nicastri

Journal of Clinical Medicine, Vol 12, Iss 1, p

Extraordinary Measure or Emerging Treatment Option?

2022 Volume 133

Abstract: Aero-medical evacuation has been considered as a feasible and safe treatment option during COVID pandemic, particularly when the needs of affected patients exceed what local clinics and hospitals are supposed to provide. In this article, we analyzed the ... ...

Abstract	Aero-medical evacuation has been considered as a feasible and safe treatment option during COVID pandemic, particularly when the needs of affected patients exceed what local clinics and hospitals are supposed to provide. In this article, we analyzed the clinical course of 17 patients medically evacuated to the “L. Spallanzani” Institute in Rome, Italy from foreign countries, mainly Africa and Eastern Europe, who had COVID-19 pneumonia with, or without, coinfections such as malaria, HIV, tuberculosis and microbiologically confirmed sepsis syndrome. The aero-medical evacuation of patients with infectious diseases has become one of the greatest medical achievements we have reached during this pandemic; in fact, only two patients with life threatening coinfections have died. Although logistically difficult and cost consuming, medical evacuation should be considered as a treatment option more than a single extraordinary measure, especially among complex cases that require specific technical and human resources.
Keywords	medical evacuation ; COVID-19 ; infectious diseases ; Medicine ; R
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Drug Policies Skyline during COVID-19 Pandemic

Serena Vita / Dora Forliano / Aldo De Luca / Alessia Beccacece / Luisa Marchioni / Emanuele Nicastri / on behalf of the COVID-19 INMI Study Group

Journal of Clinical Medicine, Vol 10, Iss 3117, p

2021 Volume 3117

Abstract: The COVID-19 pandemic has produced an extraordinary care setting where physicians played, and continue to play, a critical role in containing viral spread and treating affected patients. Frontline workers have been receiving day-to-day new information ... ...

Abstract	The COVID-19 pandemic has produced an extraordinary care setting where physicians played, and continue to play, a critical role in containing viral spread and treating affected patients. Frontline workers have been receiving day-to-day new information about therapeutic advances. The purpose of the study is to analyse COVID-19 drug consumption trends in both acute and intensive care settings comparing Defined Daily Doses and the release of scientific clinical data from January to December 2020.
Keywords	DDD ; antivirals ; steroids ; low molecular weight heparin ; hydroxicloroquine ; COVID-19 ; Medicine ; R
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Molecular Identification of New Cases of Human Dirofilariosis ( Dirofilaria repens ) in Italy

Simona Gabrielli / Valentina Mangano / Federica Furzi / Alessandra Oliva / Serena Vita / Roberto Poscia / Paolo Fazii / Josephine Di Paolo / Raffaella Marocco / Claudio Maria Mastroianni / Fabrizio Bruschi / Simonetta Mattiucci

Pathogens, Vol 10, Iss 2, p

2021 Volume 251

Abstract: 1) Dirofilariosis is a vector-borne parasitic disease mainly in domestic and wild carnivores caused by Dirofilaria ( Noctiella ) repens , which is endemic in many countries of the Old World, and D. immitis , which has a worldwide distribution. In recent ...

Abstract	(1) Dirofilariosis is a vector-borne parasitic disease mainly in domestic and wild carnivores caused by Dirofilaria ( Noctiella ) repens , which is endemic in many countries of the Old World, and D. immitis , which has a worldwide distribution. In recent years, an increase in the number of human cases has been reported, suggesting that dirofilariosis is an emergent zoonosis. Here, we describe further cases (N = 8), observed in Central Italy during the years 2018–2019. (2) Molecular diagnosis was performed on: (i) live worms extracted from ocular conjunctiva, cheek, and calf muscle; (ii) histological sections of surgically removed nodules from parenchymal lung, coccyx, and breast. (3) Sequence analysis (650-bp) of the mitochondrial cytochrome oxidase subunit I gene (mtDNA cox 1) showed a match of 100% with the sequences of D. repens previously deposited in GenBank. ELISA test to detect IgG against filarial antigens was performed on four patients’ sera and resulted positive in two patients who showed ocular and subcutaneous dirofilariosis, respectively. Microfilariae have been never detected in the peripheral blood of the patients. (4) The occurrence of N = 8 new cases of human D. repens -infections observed in a two-year period suggests an increased circulation of the parasite in Italy. Therefore, dirofilariosis should be included in differential diagnosis in patients presenting subcutaneous and/or pulmonary nodules. Molecular diagnosis of the etiological agents is fundamental. Specific serological diagnosis needs to be improved in future research work.
Keywords	Dirofilaria repens ; humans ; Italy ; molecular diagnosis ; mtDNA cox 1 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spontaneous ilio-psoas haematomas (IPHs)

Alessandra Vergori / Elisa Pianura / Patrizia Lorenzini / Alessandra D’Abramo / Federica Di Stefano / Susanna Grisetti / Serena Vita / Carmela Pinnetti / Davide Roberto Donno / Maria Cristina Marini / Emanuele Nicastri / Stefania Ianniello / Andrea Antinori

Annals of Medicine, Vol 53, Iss 1, Pp 295-

a warning for COVID-19 inpatients

2021 Volume 301

Abstract: AbstractIntroduction Critically ill patients with COVID-19 are at increased risk of developing a hypercoagulable state due to haemostatic changes directly related to the SARS-CoV-2 infection or to the consequence of the cytokine storm. Anticoagulation is ...

Abstract	AbstractIntroduction Critically ill patients with COVID-19 are at increased risk of developing a hypercoagulable state due to haemostatic changes directly related to the SARS-CoV-2 infection or to the consequence of the cytokine storm. Anticoagulation is now recommended to reduce the thrombotic risk. Ilio-psoas haematoma (IPH) is a potentially lethal condition that can arise during the hospitalization, especially in intensive care units (ICUs) and frequently reported as a complication of anticoagulation treatment.Materials and methods We report a case series of seven subjects with SARS-CoV-2 pneumonia complicated by Ilio-psoas haematomas (IPHs) at our COVID-Hospital in Rome, Italy.Results Over the observation period, 925 subjects with confirmed SARS-CoV-2 infection were admitted to our COVID-hospital. Among them, we found seven spontaneous IPHs with an incidence of 7.6 cases per 1000 hospitalization. All the reported cases had a severe manifestation of COVID-19 pneumonia, with at least one comorbidity and 5/7 were on treatment with low weight molecular heparin for micro or macro pulmonary thrombosis.Conclusions Given the indications to prescribe anticoagulant therapy in COVID-19 and the lack of solid evidences on the optimal dose and duration, it is important to be aware of the iliopsoas haematoma as a potentially serious complication in COVID-19 inpatients.KEY MESSAGECritically ill patients with COVID-19 are at increased risk of hypercoagulability state and anticoagulation therapy is recommended.Ilio-psoas haematoma (IPH) is found to be a complication of anticoagulation regimen especially in severe COVID-19 cases.An incidence of 7.6 cases per 1000 admission of IPHs was reported.Hypoesthesia of the lower limbs, pain triggered by femoral rotation, hypovolaemia and anaemia are the most common symptoms and signs of IPHs that should alert physician.
Keywords	Ilio-psoas haematoma ; heparin ; COVID-19 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Kinetics of viral DNA in body fluids and antibody response in patients with acute Monkeypox virus infection

iScience, Vol 26, Iss 3, Pp 106102- (2023)

2023

Abstract: Summary: We report the follow-up laboratory investigation of three MPXV cases infected in May-June 2022 from diagnosis to disease resolution, monitoring viral shedding in different body fluids and antibody kinetics. Out of 138 non-lesion samples, viral ... ...

Abstract	Summary: We report the follow-up laboratory investigation of three MPXV cases infected in May-June 2022 from diagnosis to disease resolution, monitoring viral shedding in different body fluids and antibody kinetics. Out of 138 non-lesion samples, viral DNA was found in 92.3% saliva, 85.7% semen, 86.2% oropharyngeal swabs, 51.7% plasma, 46.1% stool, and 9.5% urine samples. Viral load quantified by digital PCR widely varied, but tend to be higher in oropharyngeal swabs, saliva, and stool. Replication competent virus was recovered from four out of seventeen samples, including 1 saliva, 1 oropharyngeal swabs, 1 semen, and 1 stool. The analysis of the antibody kinetics revealed that IgM, IgA, and IgG antibodies were detected within two weeks post-symptoms onset for all three patients, with IgG detected early on at day 4-8 and IgM and IgA showing lower titers along the time frame of the study. Antibody levels increased during the second week of illness with IgG reaching high titers.
Keywords	Immunology ; Virology ; Science ; Q
Subject code	630
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Risk Awareness as a Key Determinant of Early Vaccine Uptake in the Mpox Vaccination Campaign in an Italian Region

Giulia Del Duca / Alessandro Tavelli / Ilaria Mastrorosa / Camilla Aguglia / Simone Lanini / Anna Clelia Brita / Roberta Gagliardini / Serena Vita / Alessandra Vergori / Jessica Paulicelli / Giorgia Natalini / Angela D’Urso / Pierluca Piselli / Paola Gallì / Vanessa Mondillo / Claudio Mastroianni / Enrica Tamburrini / Loredana Sarmati / Christof Stingone /

Miriam Lichtner / Emanuele Nicastri / Massimo Farinella / Filippo Leserri / Andrea Siddu / Fabrizio Maggi / Antonella d’Arminio Monforte / Francesco Vairo / Alessandra Barca / Francesco Vaia / Enrico Girardi / Valentina Mazzotta / Andrea Antinori

Vaccines, Vol 11, Iss 12, p

A Cross-Sectional Analysis

2023 Volume 1761

Abstract: Background: we aim to investigate attitudes toward vaccination by analyzing empirical factors associated with vaccine acceptance in the Lazio region mpox vaccination (MpoxVax) campaign in Italy. Methods: all subjects who accessed MpoxVax and signed the ... ...

Abstract	Background: we aim to investigate attitudes toward vaccination by analyzing empirical factors associated with vaccine acceptance in the Lazio region mpox vaccination (MpoxVax) campaign in Italy. Methods: all subjects who accessed MpoxVax and signed the informed consent were prospectively enrolled in the MPOX-VAC Study and were asked to fill out an anonymous survey. Two endpoints were selected: ‘delayed acceptance’ and ‘early acceptance’, defined as access for vaccination >60 and ≤30 days from the vaccination campaign starting (VCS), respectively. Results: over the study period, 1717 individuals underwent vaccination: 129 (7%) > 60 [1588 (92.5%) ≤ 60] and 676 (60%) ≤ 30 days from VCS. A bisexual orientation, a lower education level and a worse perceived physical and mental health were associated with delayed access to vaccination. Being pre-exposure prophylaxis (PrEP) users and, marginally, HIV positive; having a high perceived risk for mpox infection; and reporting high-risk behaviors like the use of recreational drugs/chems, sex under the influence of drugs and/or alcohol and having a higher number of principal sexual partners, were associated with early access to vaccination. Conclusions: according to our data, risk awareness was a major determinant of early MpoxVax acceptance. Conversely, worse perceived health status and a low educational level were critical factors associated with delayed vaccination.
Keywords	mpox infection ; mpox vaccination ; risk awareness ; vaccine acceptance ; vaccine hesitancy ; health-related quality of life ; Medicine ; R
Subject code	300
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Benefits of Steroid Therapy in COVID-19 Patients with Different PaO 2 /FiO 2 Ratio at Admission

Journal of Clinical Medicine, Vol 10, Iss 3236, p

2021 Volume 3236

Abstract: Introduction: The use of steroid therapy in patients within the context of SARS-CoV-2 infection is still a matter of debate. This study aimed to evaluate if potential steroid benefits could be predicted by the ratio of arterial oxygen partial pressure ( ... ...

Abstract	Introduction: The use of steroid therapy in patients within the context of SARS-CoV-2 infection is still a matter of debate. This study aimed to evaluate if potential steroid benefits could be predicted by the ratio of arterial oxygen partial pressure (PaO 2 in mmHg) to fractional inspired oxygen (FiO 2 ) (P/F) in COVID-19 patients at admission. Materials and Methods: Medical records were retrospectively collected from all adult patients admitted because of COVID-19 from 29 January to 31 July 2020. The association of steroid therapy with 28-day all-cause mortality outcome was analysed in a multivariable logistic regression model adjusted for confounding factors. Results: Overall, 511 patients were analysed, of which 39.1% underwent steroid therapy. Steroid treated patients were mostly male, older, and more frequently treated with antiviral drugs and aminoquinolines; the most common comorbidities were hypertension, followed by cardiovascular disease. Overall, 51 patients died within 28-days, and overall 28-days mortality was 19.5% in the cohort of patients exposed to steroids versus 3.9% mortality in unexposed patients ( p < 0.001). Steroid therapy on patients with P/F ratio of 235 mmHg or higher at admission can be considered as detrimental, with an 8% increased probability of death. Conclusions: Steroid therapy is associated with increased 28-day mortality in COVID-19 in patients with mild or no ARDS.
Keywords	steroids ; COVID-19 ; Sars-CoV-2 pneumonia ; ARDS ; Medicine ; R
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Persistent high plasma levels of sCD163 and sCD14 in adult patients with measles virus infection.

Claudia Mascia / Irene Pozzetto / Blerta Kertusha / Raffaella Marocco / Cosmo Del Borgo / Tiziana Tieghi / Serena Vita / Stefano Savinelli / Marco Iannetta / Vincenzo Vullo / Miriam Lichtner / Claudio Maria Mastroianni

PLoS ONE, Vol 13, Iss 5, p e

2018 Volume 0198174

Abstract: BACKGROUND AND AIMS:Measles is an infectious disease that represents a serious public health problem worldwide, being associated with increased susceptibility to secondary infections, especially in the respiratory and gastrointestinal tracts. The aim of ... ...

Abstract	BACKGROUND AND AIMS:Measles is an infectious disease that represents a serious public health problem worldwide, being associated with increased susceptibility to secondary infections, especially in the respiratory and gastrointestinal tracts. The aim of this study was to evaluate sCD163 and sCD14 levels in measles virus (MV) infected patients, as markers of immune activation, in order to better understand their role in the pathogenesis of the disease. TNF-α plasma levels were also evaluated. METHODS:sCD163, sCD14 and TNF-α were measured by ELISA in plasma samples of 27 MV infected patients and 27 healthy donors (HD) included as controls. RESULTS:At the time of hospital admission, sCD163 and sCD14 levels were significantly higher in MV infected patients than in HD, while a decrease in TNF-α levels were found even if without statistical significance. sCD163 and sCD14 levels were significantly decreased after two months from acute infection compared to hospital admission although they remained significantly higher compared to HD. TNF-α levels increased significantly during the follow-up period. Considering clinical parameters, sCD163 levels positively correlated with aspartate aminotransferase, white blood cell count and neutrophils rate, while negatively correlated with the lymphocyte percentage. sCD14 levels positively correlated with the neutrophil and lymphocyte percentages. CONCLUSIONS:These results indicate that, despite the resolution of symptoms, an important macrophage/monocyte activation persists in measles patients, even after two months from infection.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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