Article ; Online: Dynamic changes in lung water density and volume following supine body positioning.
Magnetic resonance in medicine
2024 Volume 91, Issue 6, Page(s) 2612–2620
Abstract: Purpose: Measure the changes in relative lung water density (rLWD), lung volume, and total lung water content as a function of time after supine body positioning.: Methods: An efficient ultrashort-TE pulse sequence with a yarnball k-space trajectory ... ...
| Abstract | Purpose: Measure the changes in relative lung water density (rLWD), lung volume, and total lung water content as a function of time after supine body positioning. Methods: An efficient ultrashort-TE pulse sequence with a yarnball k-space trajectory was used to measure water density-weighted lung images for 25 min following supine body positioning (free breathing, 74-s acquisitions, 3D images at functional residual capacity, 18 time points) in 9 healthy volunteers. Global and regional (10 chest-to-back positions) rLWD, lung volume, and total lung water volume were measured in all subjects at all time points. Volume changes were validated with a nitrogen washout study in 3 participants. Results: Global rLWD increased significantly (p = 0.001) from 31.8 ± 5.5% to 34.8 ± 6.8%, while lung volumes decreased significantly (p < 0.001) from 2390 ± 620 mL to 2130 ± 630 mL over the same 25-min interval. Total lung water volume decreased slightly from 730 ± 125 mL to 706 ± 126 mL (p = 0.028). There was a significant chest-to-back gradient in rLWD (20.7 ± 4.6% to 39.9 ± 6.1%) at all time points with absolute increases of 1.8 ± 1.2% at the chest and 5.4 ± 1.9% at the back. Nitrogen washout studies yielded a similar reduction in lung volume (12.5 ± 0.9%) and time course following supine positioning. Conclusion: Lung volumes during tidal breathing decrease significantly over tens of minutes following supine body positioning, with corresponding increases in lung water density (9.2 ± 4.4% relative increase). The total volume of lung water is slightly reduced over this interval (3.3 ± 4.0% relative change). Evaluation of rLWD should take time after supine positioning, and more generally, all sources of lung volume changes should be taken into consideration to avoid significant bias. |
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| MeSH term(s) | Humans ; Patient Positioning ; Lung/diagnostic imaging ; Lung Volume Measurements ; Respiration ; Nitrogen ; Supine Position |
| Chemical Substances | Nitrogen (N762921K75) |
| Language | English |
| Publishing date | 2024-01-21 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 605774-3 |
| ISSN | 1522-2594 ; 0740-3194 |
| ISSN (online) | 1522-2594 |
| ISSN | 0740-3194 |
| DOI | 10.1002/mrm.30017 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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