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  1. Article ; Online: RNA Helicases as Shadow Modulators of Cell Cycle Progression.

    Sergeeva, Olga / Zatsepin, Timofei

    International journal of molecular sciences

    2021  Volume 22, Issue 6

    Abstract: The progress of the cell cycle is directly regulated by modulation of cyclins and cyclin-dependent kinases. However, many proteins that control DNA replication, RNA transcription and the synthesis and degradation of proteins can manage the activity or ... ...

    Abstract The progress of the cell cycle is directly regulated by modulation of cyclins and cyclin-dependent kinases. However, many proteins that control DNA replication, RNA transcription and the synthesis and degradation of proteins can manage the activity or levels of master cell cycle regulators. Among them, RNA helicases are key participants in RNA metabolism involved in the global or specific tuning of cell cycle regulators at the level of transcription and translation. Several RNA helicases have been recently evaluated as promising therapeutic targets, including eIF4A, DDX3 and DDX5. However, targeting RNA helicases can result in side effects due to the influence on the cell cycle. In this review, we discuss direct and indirect participation of RNA helicases in the regulation of the cell cycle in order to draw attention to downstream events that may occur after suppression or inhibition of RNA helicases.
    MeSH term(s) Cell Cycle/genetics ; Cell Division/genetics ; Cyclin-Dependent Kinases/genetics ; DEAD-box RNA Helicases/genetics ; DNA Replication/genetics ; Eukaryotic Initiation Factor-4A/genetics ; Humans ; RNA Helicases/genetics
    Chemical Substances EIF4A1 protein, human ; Cyclin-Dependent Kinases (EC 2.7.11.22) ; Eukaryotic Initiation Factor-4A (EC 2.7.7.-) ; DDX3X protein, human (EC 3.6.1.-) ; Ddx5 protein, human (EC 3.6.1.-) ; DEAD-box RNA Helicases (EC 3.6.4.13) ; RNA Helicases (EC 3.6.4.13)
    Language English
    Publishing date 2021-03-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22062984
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  2. Article ; Online: Histamine against aggression-Facts from fish.

    Sergeeva, Olga A / Haas, Helmut L

    Acta physiologica (Oxford, England)

    2020  Volume 230, Issue 4, Page(s) e13562

    MeSH term(s) Aggression ; Animals ; Histamine ; Prosencephalon ; Receptors, Histamine H3 ; Zebrafish
    Chemical Substances Receptors, Histamine H3 ; Histamine (820484N8I3)
    Language English
    Publishing date 2020-10-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13562
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  3. Article ; Online: Modulation of RNA Splicing by Oligonucleotides: Mechanisms of Action and Therapeutic Implications.

    Sergeeva, Olga V / Shcherbinina, Evgeniya Y / Shomron, Noam / Zatsepin, Timofei S

    Nucleic acid therapeutics

    2022  Volume 32, Issue 3, Page(s) 123–138

    Abstract: Dysregulation of RNA splicing causes many diseases and disorders. Several therapeutic approaches have been developed to correct aberrant alternative splicing events for the treatment of cancers and hereditary diseases, including gene therapy and ... ...

    Abstract Dysregulation of RNA splicing causes many diseases and disorders. Several therapeutic approaches have been developed to correct aberrant alternative splicing events for the treatment of cancers and hereditary diseases, including gene therapy and redirecting splicing, using small molecules or splice switching oligonucleotides (SSO). Significant advances in the chemistry and pharmacology of nucleic acid have led to the development of clinically approved SSO drugs for the treatment of spinal muscular dystrophy and Duchenne muscular dystrophy (DMD). In this review, we discuss the mechanisms of SSO action with emphasis on "less common" approaches to modulate alternative splicing, including bipartite and bifunctional SSO, oligonucleotide decoys for splice factors and SSO-mediated mRNA degradation
    MeSH term(s) Alternative Splicing/genetics ; Humans ; Muscular Dystrophy, Duchenne/drug therapy ; Muscular Dystrophy, Duchenne/genetics ; Oligonucleotides/genetics ; Oligonucleotides/pharmacology ; Oligonucleotides/therapeutic use ; Oligonucleotides, Antisense/genetics ; Oligonucleotides, Antisense/metabolism ; Oligonucleotides, Antisense/therapeutic use ; RNA Splicing/genetics
    Chemical Substances Oligonucleotides ; Oligonucleotides, Antisense
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2639888-6
    ISSN 2159-3345 ; 2159-3337
    ISSN (online) 2159-3345
    ISSN 2159-3337
    DOI 10.1089/nat.2021.0067
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  4. Article: Reactive oxygen species-responsive RNA interference

    Rühle, Jennifer / Klemt, Insa / Abakumova, Tatiana / Sergeeva, Olga / Vetosheva, Polina / Zatsepin, Timofei / Mokhir, Andriy

    Chemical communications. 2022 Mar. 31, v. 58, no. 27

    2022  

    Abstract: Due to oxidative instability, arylboronic acids are not compatible with the solid-phase synthesis of nucleic acids. We solved this problem and, based on these findings, developed siRNA prodrugs activated in the presence of reactive oxygen species (ROS) ... ...

    Abstract Due to oxidative instability, arylboronic acids are not compatible with the solid-phase synthesis of nucleic acids. We solved this problem and, based on these findings, developed siRNA prodrugs activated in the presence of reactive oxygen species (ROS) in vivo. These prodrugs can be used for specific targeting of ROS-rich cancer cells.
    Keywords RNA interference ; oxygen ; reactive oxygen species
    Language English
    Dates of publication 2022-0331
    Size p. 4388-4391.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc00651k
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: GABAergic transmission in hepatic encephalopathy.

    Sergeeva, Olga A

    Archives of biochemistry and biophysics

    2013  Volume 536, Issue 2, Page(s) 122–130

    Abstract: Hepatic encephalopathy (HE)(1) is a neuropsychiatric disorder caused by chronic or acute liver failure. Nearly thirty years ago a hypothesis was formulated explaining the neuropathology of HE by increased GABAergic tone. Recent progress in the GABAA- ... ...

    Abstract Hepatic encephalopathy (HE)(1) is a neuropsychiatric disorder caused by chronic or acute liver failure. Nearly thirty years ago a hypothesis was formulated explaining the neuropathology of HE by increased GABAergic tone. Recent progress in the GABAA-receptor (GABAAR) molecular pharmacology and biochemistry as well as the physiology of GABAergic transmission provided better understanding of GABA's role in health and disease. A detailed analysis of neuronal populations and their GABAergic afferents affected in HE is still missing. The slow progress in understanding the pathology of GABAergic transmission in HE is due to the high complexity of brain circuitries controlled by multiple types of GABAergic interneurons and the large variety of GABAAR, which are differently affected by pathological conditions and not yet fully identified. The mechanisms of action of the GABAAR agonist taurine, allosteric positive modulators (inhibitory neurosteroids, anaesthetics, benzodiazepines and histamine) and inhibitors of the GABAAR (excitatory neurosteroids, Ro15-4513) are discussed with respect to HE pathophysiology. Perspectives for GABAergic drugs in the symptomatic treatment of HE are suggested.
    MeSH term(s) Animals ; Brain/drug effects ; Brain/metabolism ; Brain/physiopathology ; GABA Antagonists/therapeutic use ; Hepatic Encephalopathy/drug therapy ; Hepatic Encephalopathy/genetics ; Hepatic Encephalopathy/metabolism ; Hepatic Encephalopathy/physiopathology ; Humans ; Liver/drug effects ; Liver/metabolism ; Liver/physiopathology ; Receptors, GABA/chemistry ; Receptors, GABA/genetics ; Receptors, GABA/metabolism ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances GABA Antagonists ; Receptors, GABA ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2013-08-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2013.04.005
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  6. Article ; Online: Reactive oxygen species-responsive RNA interference.

    Rühle, Jennifer / Klemt, Insa / Abakumova, Tatiana / Sergeeva, Olga / Vetosheva, Polina / Zatsepin, Timofei / Mokhir, Andriy

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 27, Page(s) 4388–4391

    Abstract: Due to oxidative instability, arylboronic acids are not compatible with the solid-phase synthesis of nucleic acids. We solved this problem and, based on these findings, developed siRNA prodrugs activated in the presence of reactive oxygen species (ROS) ...

    Abstract Due to oxidative instability, arylboronic acids are not compatible with the solid-phase synthesis of nucleic acids. We solved this problem and, based on these findings, developed siRNA prodrugs activated in the presence of reactive oxygen species (ROS)
    MeSH term(s) Oxidation-Reduction ; Prodrugs/pharmacology ; RNA Interference ; RNA, Small Interfering/genetics ; Reactive Oxygen Species/metabolism
    Chemical Substances Prodrugs ; RNA, Small Interfering ; Reactive Oxygen Species
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc00651k
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  7. Article ; Online: NOS1AP Interacts with α-Synuclein and Aggregates in Yeast and Mammalian Cells.

    Matiiv, Anton B / Moskalenko, Svetlana E / Sergeeva, Olga S / Zhouravleva, Galina A / Bondarev, Stanislav A

    International journal of molecular sciences

    2022  Volume 23, Issue 16

    Abstract: ... ...

    Abstract The
    MeSH term(s) Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Neurons/metabolism ; Nitric Oxide Synthase Type I ; Rats ; Saccharomyces cerevisiae/metabolism ; Signal Transduction/physiology ; Synucleinopathies ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; NOS1AP protein, rat ; alpha-Synuclein ; Nitric Oxide Synthase Type I (EC 1.14.13.39) ; Nos1 protein, rat (EC 1.14.13.39)
    Language English
    Publishing date 2022-08-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23169102
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  8. Article ; Online: Terahertz wave rectification in a ferroelectric triglycine sulfate single crystal.

    Bilyk, Vladislav / Grishunin, Kirill / Tinnemans, Paul / Rasing, Theo / Kirilyuk, Andrey / Sergeeva, Olga / Sherstyuk, Natalia / Mishina, Elena / Lavrov, Sergey / Sigov, Alexander

    Optics letters

    2023  Volume 48, Issue 11, Page(s) 2889–2892

    Abstract: The effect of optical rectification (OR) in the terahertz range (THz rectification, TR) is experimentally demonstrated. The effect consists of generating a DC voltage on the faces of a ferroelectric triglycine sulfate (TGS) single crystal under the ... ...

    Abstract The effect of optical rectification (OR) in the terahertz range (THz rectification, TR) is experimentally demonstrated. The effect consists of generating a DC voltage on the faces of a ferroelectric triglycine sulfate (TGS) single crystal under the action of pulsed radiation with a frequency of 1.57 and 1.96 THz and an electric field strength per pulse of 1.3 and 1.5 MV/m, respectively. The FLARE FELIX free-electron laser system (Radboud University, The Netherlands) was used as a THz radiation source. The TR effect makes it possible to directly determine the nonlinear susceptibilities of media (including those under conditions of strong absorption) without any reference or optical channel calibration and also without the need of Fourier transform.
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.479668
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  9. Article ; Online: Noncoding RNA in Liver Regeneration-From Molecular Mechanisms to Clinical Implications.

    Sergeeva, Olga / Sviridov, Evgeny / Zatsepin, Timofei

    Seminars in liver disease

    2019  Volume 40, Issue 1, Page(s) 70–83

    Abstract: The unique ability of the adult liver to regenerate after injury is the basis for efficient surgical resection and liver transplantation and provides solutions for the treatment of liver cancer and acute liver failure. Current success in surgical ... ...

    Abstract The unique ability of the adult liver to regenerate after injury is the basis for efficient surgical resection and liver transplantation and provides solutions for the treatment of liver cancer and acute liver failure. Current success in surgical treatments could be enhanced by directed regulation of liver regeneration. A number of small molecules and growth factors have been tested in mice models to improve liver regeneration. Noncoding ribonucleic acids (ncRNA) are less studied regulators of various cellular processes. Here, the authors carefully review ncRNA involved in liver regeneration and discuss molecular mechanisms and regulatory networks. These ncRNAs modulate the expression of pro- and antiproliferative genes allowing to orchestrate precisely the proliferation of hepatocytes. The authors expect that ncRNA will become new targets in liver regeneration due to recent progress in therapeutic nucleic acids. Among a large number of preclinical studies on ncRNA, only a few entered clinical trials, and further studies are needed to uncover their potential as therapeutic targets.
    MeSH term(s) Animals ; Gene Expression Regulation/genetics ; Humans ; Liver Regeneration/genetics ; Mice ; RNA, Untranslated/genetics
    Chemical Substances RNA, Untranslated
    Language English
    Publishing date 2019-07-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603177-8
    ISSN 1098-8971 ; 0272-8087
    ISSN (online) 1098-8971
    ISSN 0272-8087
    DOI 10.1055/s-0039-1693513
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  10. Article ; Online: [No title information]

    Palkina, Nadezhda / Sergeeva, Olga / Ruksha, Tatiana / Artyukhov, Ivan

    Asian Pacific journal of cancer prevention : APJCP

    2018  Volume 19, Issue 2, Page(s) 503–507

    MeSH term(s) Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Mass Screening/methods ; Melanoma/diagnosis ; Middle Aged ; Physical Examination ; Risk Factors ; Russia ; Siberia ; Skin Neoplasms/diagnosis ; Young Adult
    Language English
    Publishing date 2018-02-26
    Publishing country Thailand
    Document type Journal Article
    ISSN 2476-762X
    ISSN (online) 2476-762X
    DOI 10.22034/APJCP.2018.19.2.503
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