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Article: Consideraciones éticas de la comunicación diagnóstica en la enfermedad de Alzheimer prodrómica.

Serrano, Cecilia M / Sorokin, Patricia / Taragano, Fernando

Vertex (Buenos Aires, Argentina)

2014 Volume 25, Issue 114, Page(s) 99–101

Abstract: Population aging has increased age-related diseases such as dementia, Alzheimer's disease (AD) being the most common in older adults (50%-60%). It is one of the most feared conditions for its irreversible and incurable, by its chronicity and it consists ... ...

Title translation	Ethical considerations regarding the communication of diagnosis of prodromal Alzheimer's disease.
Abstract	Population aging has increased age-related diseases such as dementia, Alzheimer's disease (AD) being the most common in older adults (50%-60%). It is one of the most feared conditions for its irreversible and incurable, by its chronicity and it consists of a long process of depersonalization. The clinical diagnosis is mainly based on DSM-IV and NINCDS-ADRDA. Definitive diagnosis is post-mortem, as it requires histopathological confirmation. However, there have been new diagnostic criteria based EA biomarkers, which can be done in life, anticipating the course of several years before dementia. Thus, physicians are increasingly exposed to AD patients in early stages, having to face the dilemma of communicating the diagnosis to a patient with cognitive failures and disease awareness, with the implications that generates about him and his family. The objectives of this paper will analyze the ethical problem of communication of clinical diagnosis of AD in prodromal stages (pre-dementia) in our country, based on the analysis of ethical principles (autonomy and non maleficence) involved in decision making.
MeSH term(s)	Alzheimer Disease/diagnosis ; Humans ; Prodromal Symptoms ; Truth Disclosure/ethics
Language	Spanish
Publishing date	2014-03
Publishing country	Argentina
Document type	English Abstract ; Journal Article
ISSN	0327-6139
ISSN	0327-6139
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Article ; Online: Associations Among Loneliness, Purpose in Life and Subjective Cognitive Decline in Ethnoracially Diverse Older Adults Living in the United States.

Pluim, Celina F / Anzai, Juliana A U / Martinez, Jairo E / Munera, Diana / Garza-Naveda, Ana Paola / Vila-Castelar, Clara / Guzmán-Vélez, Edmarie / Ramirez-Gomez, Liliana / Bustin, Julian / Serrano, Cecilia M / Babulal, Ganesh M / Okada de Oliveira, Maira / Quiroz, Yakeel T

Journal of applied gerontology : the official journal of the Southern Gerontological Society

2022 Volume 42, Issue 3, Page(s) 376–386

Abstract: Subjective cognitive decline (SCD), which precedes Mild Cognitive Impairment and dementia, may be affected by purpose in life (PiL) and loneliness in older adults. We investigated associations among PiL, loneliness, and SCD in US Latino ( ...

Abstract	Subjective cognitive decline (SCD), which precedes Mild Cognitive Impairment and dementia, may be affected by purpose in life (PiL) and loneliness in older adults. We investigated associations among PiL, loneliness, and SCD in US Latino (
MeSH term(s)	Aged ; Humans ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/psychology ; Dementia/epidemiology ; Loneliness/psychology ; United States/epidemiology
Language	English
Publishing date	2022-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	155897-3
ISSN	1552-4523 ; 0733-4648
ISSN (online)	1552-4523
ISSN	0733-4648
DOI	10.1177/07334648221139479
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Article ; Online: Assessment of an electronic system for research ethics committees document management: An observational study.

Mariani, Javier / Garau, Laura / Ferrero, Fernando / Vukotich, Claudia / Roitman, Adriel J / Serrano, Cecilia M / Perelis, Leonardo / Domínguez, Adriana G / González Villa Monte, Gabriel

Accountability in research

2021 Volume 30, Issue 1, Page(s) 21–33

Abstract: Since 1 January 2020, the Central Research Ethics Committee of the Health Ministry implemented PRIISA.BA, an in-house developed electronic system for online submission of health research applications to the 63 public and private research ethics ... ...

Abstract	Since 1 January 2020, the Central Research Ethics Committee of the Health Ministry implemented PRIISA.BA, an in-house developed electronic system for online submission of health research applications to the 63 public and private research ethics committees (RECs) of Buenos Aires City, Argentina. This study though to compare the times to first review and the time to approval among applications submitted prior to PRIISA.BA and thereafter, across public RECs. All public RECs of the city were invited to participate. Overall, 453 applications from 10 RECs (242 pre- and 211 post-PRIISA.BA) were available for the analyses. There was a decrease in the time to first review and an increase in the time to approval after PRIISA.BA implementation. The increase in time to approval was transient and limited to the first three months. The results were consistent with analyses limited to non-COVID applications. Our results show an increase in the times to approval after the implementation of an electronic system for online submission of health research applications that, although transient, was significant. These data could be relevant to other RECs implementing this technology since it emphasizes the need of monitoring potential unnecessary delays in reviews during the critical initial period.
MeSH term(s)	Humans ; Ethics Committees, Research ; Biomedical Research ; Filing/methods
Language	English
Publishing date	2021-08-06
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2069334-5
ISSN	1545-5815 ; 0898-9621
ISSN (online)	1545-5815
ISSN	0898-9621
DOI	10.1080/08989621.2021.1960515
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Article: Validation of the Argentine version of the Montreal Cognitive Assessment Test (MOCA): A screening tool for Mild Cognitive Impairment and Mild Dementia in Elderly.

Serrano, Cecilia M / Sorbara, Marcos / Minond, Alexander / Finlay, John B / Arizaga, Raul L / Iturry, Monica / Martinez, Patricia / Heinemann, Gabriela / Gagliardi, Celina / Serra, Andrea / Magliano, Florencia Ces / Yacovino, Darío / Rojas, María Martha Esnaola Y / Ruiz, Adelaida Susana / Graviotto, Héctor Gastón

Dementia & neuropsychologia

2020 Volume 14, Issue 2, Page(s) 145–152

Abstract: The MoCA is a brief useful test to diagnose mild cognitive impairment (MCI) and mild dementia (MD). To date, no Argentine cross-cultural adapted validations of the Spanish version have been reported.: Objective: To validate the MoCA in the elderly and ...

Abstract	The MoCA is a brief useful test to diagnose mild cognitive impairment (MCI) and mild dementia (MD). To date, no Argentine cross-cultural adapted validations of the Spanish version have been reported. Objective: To validate the MoCA in the elderly and study its usefulness in MCI and MD. Methods: This study included 399 individuals over 60 years old evaluated in the Cognitive-Behavioral Department (2017-2018). Patients with<3 years of education, sensory disturbances, psychiatric disorders, or moderate-severe dementia were excluded. The control group comprised cognitively normal subjects. Participants were classified according to neuropsychological assessment and clinical standard criteria into Control, MCI or MD groups. A locally adapted MoCA (MOCA-A) was administered to the patients and controls. Results: Mean educational level was 10.34 years (SD 3.5 years). MoCA-A score differed significantly among groups (p<0.0001). MoCA-A performance correlated with educational level (r: 0.406 p<0.00001). Adopting a cut-off score ≥25 (YI=0.55), the sensitivity for MCI was 84.8% and for MD 100%, with specificity of 69.7%. When adding a single point to the score in patients with ≤12 years of education, the specificity of the test reached 81%. Conclusion: The MoCA-A is an accurate reliable screening test for MCI and MD in Argentina.
Language	English
Publishing date	2020-04-18
Publishing country	Brazil
Document type	Journal Article
ISSN	1980-5764
ISSN	1980-5764
DOI	10.1590/1980-57642020dn14-020007
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Article ; Online: Mild cognitive impairment: risk of dementia according to subtypes.

Serrano, Cecilia M / Dillon, Carol / Leis, Adriana / Taragano, Fernando E / Allegri, Ricardo Francisco

Actas espanolas de psiquiatria

2013 Volume 41, Issue 6, Page(s) 330–339

Abstract: Unlabelled: Mild cognitive impairment (MCI) has 3 clinical subtypes: amnestic (aMCI), multiple domains (mdMCI) and non-amnestic single domain (na-SD-MCI) whose evolutive possibility to dementia has not been profoundly studied.: Objective: This paper ... ...

Abstract	Unlabelled: Mild cognitive impairment (MCI) has 3 clinical subtypes: amnestic (aMCI), multiple domains (mdMCI) and non-amnestic single domain (na-SD-MCI) whose evolutive possibility to dementia has not been profoundly studied. Objective: This paper aims to determine the conversion to dementia of the different subtypes of MCI and determine risk factors associated to conversion to dementia. Methods: A total of 127 patients diagnosed with MCI (age=70.21; SD=13.17) were evaluated with a neuropsychological and neuropsychiatric battery. They were classified into 3 groups: amnestic MCI (n=20), multiple-domain MCI (n=98), non-amnestic MCI (n=9). Seventeen normal subjects (age=74.59; SD=10.63) were included. Results: Of those included, 27.1% developed Alzheimer's type dementia [average time for conversion to Alzheimer's dementia (AD) 11.12 months (SD=0.183)]. None of the controls developed dementia. Thirty-five percent (n=7) of amnestic MCI converted to AD: 20% (n=4) at 6 months and 15% (n=3) at 12 months); 11.1% (n=1) of the non-amnestic single domain MCI converted to AD at 6 months. It was found that 31.6% (n=31) of multiple domain MCI rotated to AD: 15.3% (n=15) at 6 months and 16.3% (n=16) at 12 months. Age (p<0.05, β=1.03) increased the likelihood of rotation to AD. Multi-domain MCI subtype was the most frequent. However, the conversion to dementia in amnestic subtype was the highest, age and retirement being the variables that increased the likelihood of conversion to Dementia.
MeSH term(s)	Aged ; Cognitive Dysfunction/complications ; Dementia/epidemiology ; Dementia/etiology ; Female ; Humans ; Male ; Prospective Studies ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2013-11
Publishing country	Spain
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1480971-0
ISSN	1578-2735 ; 1575-071X ; 1139-9287
ISSN (online)	1578-2735
ISSN	1575-071X ; 1139-9287
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Article ; Online: Impact of Social Isolation on People with Dementia and Their Family Caregivers.

Azevedo, Lílian Viana Dos Santos / Calandri, Ismael Luis / Slachevsky, Andrea / Graviotto, Héctor Gastón / Vieira, Maria Carolina Santos / Andrade, Caíssa Bezerra de / Rossetti, Adriana Peredo / Generoso, Alana Barroso / Carmona, Karoline Carvalho / Pinto, Ludmilla Aparecida Cardoso / Sorbara, Marcos / Pinto, Alejandra / Guajardo, Tania / Olavarria, Loreto / Thumala, Daniela / Crivelli, Lucía / Vivas, Ludmila / Allegri, Ricardo Francisco / Barbosa, Maira Tonidandel /

Serrano, Cecilia M / Miranda-Castillo, Claudia / Caramelli, Paulo

Journal of Alzheimer's disease : JAD

2021 Volume 81, Issue 2, Page(s) 607–617

Abstract: Background: People with dementia and their family caregivers may face a great burden through social isolation due to the COVID-19 pandemic, which can be manifested as various behavioral and clinical symptoms.: Objective: To investigate the impacts of ...

Abstract	Background: People with dementia and their family caregivers may face a great burden through social isolation due to the COVID-19 pandemic, which can be manifested as various behavioral and clinical symptoms. Objective: To investigate the impacts of social isolation due to the COVID-19 pandemic on individuals with dementia and their family caregivers. Methods: Two semi-structured questionnaires were applied via telephone to family caregivers of people diagnosed with dementia in three cities in Argentina, Brazil, and Chile, in order to assess clinical and behavioral changes in people with dementia and in their caregivers. Results: In general, 321 interviews were conducted. A significant decline in memory function has been reported among 53.0%of people with dementia. In addition, 31.2%of individuals with dementia felt sadder and 37.4%had increased anxiety symptoms. These symptoms of anxiety were greater in individuals with mild to moderate dementia, while symptoms of agitation were greater in individuals with severe dementia. Moreover, compulsive-obsessive behavior, hallucinations, increased forgetfulness, altered appetite, and increased difficulty in activities of daily living were reported more frequently among individuals with moderate to severe dementia. Caregivers reported feeling more tired and overwhelmed during this period and these symptoms were also influenced by the severity of dementia. Conclusion: Social isolation during the COVID-19 pandemic triggered a series of negative behavioral repercussions, both for people with dementia and for their family caregivers in these three South American countries.
MeSH term(s)	Activities of Daily Living ; Adult ; Aged ; Aged, 80 and over ; Argentina ; Brazil ; COVID-19/psychology ; Caregivers/psychology ; Chile ; Dementia/psychology ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Physical Distancing ; Social Isolation/psychology ; Surveys and Questionnaires
Language	English
Publishing date	2021-04-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-201580
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Article: Behavioral symptoms related to cognitive impairment.

Dillon, Carol / Serrano, Cecilia M / Castro, Diego / Leguizamón, Patricio Perez / Heisecke, Silvina L / Taragano, Fernando E

Neuropsychiatric disease and treatment

2013 Volume 9, Page(s) 1443–1455

Abstract: Neuropsychiatric symptoms (NPS) are core features of Alzheimer's disease and related dementias. On one hand, behavioral symptoms in patients with mild cognitive impairment (MCI) can indicate an increased risk of progressing to dementia. On the other hand, ...

Abstract	Neuropsychiatric symptoms (NPS) are core features of Alzheimer's disease and related dementias. On one hand, behavioral symptoms in patients with mild cognitive impairment (MCI) can indicate an increased risk of progressing to dementia. On the other hand, mild behavioral impairment (MBI) in patients who usually have normal cognition indicates an increased risk of developing dementia. Whatever the cause, all dementias carry a high rate of NPI. These symptoms can be observed at any stage of the disease, may fluctuate over its course, are a leading cause of stress and overload for caregivers, and increase rates of hospitalization and early institutionalization for patients with dementia. The clinician should be able to promptly recognize NPI through the use of instruments capable of measuring their frequency and severity to support diagnosis, and to help monitor the treatment of behavioral symptoms. The aims of this review are to describe and update the construct 'MBI' and to revise the reported NPS related to prodromal stages of dementia (MCI and MBI) and dementia stages of Alzheimer's disease and frontotemporal lobar degeneration.
Language	English
Publishing date	2013-09-19
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2186503-6
ISSN	1178-2021 ; 1176-6328
ISSN (online)	1178-2021
ISSN	1176-6328
DOI	10.2147/NDT.S47133
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Article: Una encuesta sobre biomarcadores y diagnóstico precoz de la enfermedad de Alzheimer.

Taragano, Fernando E / Castro, Diego M / Serrano, Cecilia M / Heisecke, Silvina L / Pérez Leguizamón, Patricio / Loñ, Leandro / Dillon, Carol

Medicina

2015 Volume 75, Issue 5, Page(s) 282–288

Abstract: Given the potential use of biomarkers in the diagnosis of Alzheimer's disease (AD) in early stages, new ethical and communication dilemmas appear in everyday clinical practice. The aim of this study was to know the opinion of health professionals (HP) ... ...

Title translation	A survey on biomarkers and early diagnosis in Alzheimer's disease.
Abstract	Given the potential use of biomarkers in the diagnosis of Alzheimer's disease (AD) in early stages, new ethical and communication dilemmas appear in everyday clinical practice. The aim of this study was to know the opinion of health professionals (HP) and general public (GP) on the implementation of early diagnostic techniques in AD and the use of biomarkers for this purpose. A survey with multiple choice answers was elaborated in two versions: one for HP and the other for GP. Respondents were invited to participate through a system of mass mailing e-mail; e-mail addresses were collected from CEMIC database. A total of 1503 answers were analyzed: 807 HP and 696 GP. Most respondents, 84.7%, preferred the option of early diagnosis of AD even knowing the lack of curative treatment. Forty five percent of GP and 26.8% of HP replied that there is no ethical dilemma in the use of biomarkers and that no communication or ethical dilemma is generated to physicians when informing the diagnosis of the disease. The HP group showed more divergence in the views than the GP group. These results may indicate a change in the physician-patient relationship, showing the GP group with an active and supportive position towards the use of biomarkers for early diagnosis of AD.
MeSH term(s)	Alzheimer Disease/diagnosis ; Alzheimer Disease/prevention & control ; Bioethical Issues ; Biomarkers ; Early Diagnosis ; Genetic Markers ; Health Personnel/ethics ; Humans ; Physician-Patient Relations/ethics ; Public Opinion ; Surveys and Questionnaires
Chemical Substances	Biomarkers ; Genetic Markers
Language	Spanish
Publishing date	2015
Publishing country	Argentina
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	411586-7
ISSN	1669-9106 ; 0025-7680 ; 0325-951X
ISSN (online)	1669-9106
ISSN	0025-7680 ; 0325-951X
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Article ; Online: Clinical and economic characteristics associated with direct costs of Alzheimer's, frontotemporal and vascular dementia in Argentina.

Rojas, Galeno / Bartoloni, Leonardo / Dillon, Carol / Serrano, Cecilia M / Iturry, Monica / Allegri, Ricardo F

International psychogeriatrics

2011 Volume 23, Issue 4, Page(s) 554–561

Abstract: Background: The economic cost of dementia is high and can be predicted by cognitive and neuropsychiatric profiles. The differential costs of the various subtypes of dementia are unknown in Argentina, and this study therefore aimed to compare these costs. ...

Abstract	Background: The economic cost of dementia is high and can be predicted by cognitive and neuropsychiatric profiles. The differential costs of the various subtypes of dementia are unknown in Argentina, and this study therefore aimed to compare these costs. Methods: Patients with a diagnosis of dementia of Alzheimer-type (DAT), frontotemporal dementia (FTD) and vascular dementia (VaD), and their primary caregivers, were evaluated between 2002 and 2008. Results: 104 patients with dementia (DAT = 44, FTD = 34, VaD = 26) were screened and matched by age and educational level with 29 healthy subjects. Demographic variables showed no significant differences among dementia patients. The annual direct costs were US$4625 for DAT, US$4924 for FTD, and US$5112 for VaD (p > 0.05 between groups). In the post hoc analysis VaD showed higher hospitalization costs than DAT (p < 0.001). VaD exhibited lower medication costs than FTD (p < 0.001). DAT exhibited higher anti-dementia drug costs; FTD had higher psychotropic costs. In the multivariate analysis, depression, activities of daily living, and caregiver burden were correlated with direct costs (r2 = 0.76). Conclusions: The different dementia types have different costs. Overall, costs increased with the presence of behavioral symptoms, depression and functional impairment of activities of daily living.
MeSH term(s)	Activities of Daily Living ; Aged ; Aged, 80 and over ; Alzheimer Disease/complications ; Alzheimer Disease/economics ; Alzheimer Disease/psychology ; Argentina ; Caregivers/economics ; Caregivers/psychology ; Case-Control Studies ; Cost of Illness ; Dementia, Vascular/complications ; Dementia, Vascular/economics ; Dementia, Vascular/psychology ; Depression/economics ; Depression/etiology ; Female ; Frontotemporal Dementia/complications ; Frontotemporal Dementia/economics ; Frontotemporal Dementia/psychology ; Humans ; Male
Language	English
Publishing date	2011-05
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1038825-4
ISSN	1741-203X ; 1041-6102
ISSN (online)	1741-203X
ISSN	1041-6102
DOI	10.1017/S1041610210002012
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Article ; Online: Clinical manifestations of geriatric depression in a memory clinic: toward a proposed subtyping of geriatric depression.

Dillon, Carol / Machnicki, Gerardo / Serrano, Cecilia M / Rojas, Galeno / Vazquez, Gustavo / Allegri, Ricardo F

Journal of affective disorders

2011 Volume 134, Issue 1-3, Page(s) 177–187

Abstract: Background: As the older population increases so does the number of older psychiatric patients. Elderly psychiatric patients manifest certain specific and unique characteristics. Different subtypes of depressive syndromes exist in late-life depression, ... ...

Abstract	Background: As the older population increases so does the number of older psychiatric patients. Elderly psychiatric patients manifest certain specific and unique characteristics. Different subtypes of depressive syndromes exist in late-life depression, and many of these are associated with cognitive impairment. Materials and methods: A total of 109 depressive patients and 30 normal subjects matched by age and educational level were evaluated using a neuropsychiatric interview and an extensive neuropsychological battery. Depressive patients were classified into four different groups by SCAN 2.1 (schedules for clinical assessment in Neuropsychiatry): major depression disorder (n: 34), dysthymia disorder (n: 29), subsyndromal depression (n: 28), and depression due to mild dementia of Alzheimer's type (n: 18). Results: We found significant associations (p<.05) between depressive status and demographic or clinical factors that include marital status (OR: 3.4, CI: 1.2-9.6), level of daily activity (OR: 5.3, CI: 2-14), heart disease (OR: 12.5, CI: 1.6-96.3), and high blood cholesterol levels (p:.032). Neuropsychological differences were observed among the four depressive groups and also between depressive patients and controls. Significant differences were observed in daily life activities and caregivers' burden between depressive patients and normal subjects. Conclusion: Geriatric depression is associated with heart disease, high cholesterol blood levels, marital status, and daily inactivity. Different subtypes of geriatric depression have particular clinical features, such as cognitive profiles, daily life activities, and caregivers' burden, that can help to differentiate among them. Limitations: The cohort referred to a memory clinic with memory complaints is a biased sample, and the results cannot be generalized to other non-memory symptomatic cohorts.
MeSH term(s)	Activities of Daily Living/psychology ; Age of Onset ; Aged ; Alzheimer Disease/epidemiology ; Alzheimer Disease/psychology ; Bias ; Caregivers/psychology ; Cholesterol/blood ; Cognition Disorders/epidemiology ; Dementia/epidemiology ; Dementia/psychology ; Depression/classification ; Depression/psychology ; Depressive Disorder/epidemiology ; Depressive Disorder/psychology ; Depressive Disorder, Major/classification ; Depressive Disorder, Major/psychology ; Female ; Geriatrics ; Humans ; Male ; Memory
Chemical Substances	Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2011-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2011.05.036
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