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Article: Molecular Radiobiology in Non-Small Cell Lung Cancer: Prognostic and Predictive Response Factors.

Peinado-Serrano, Javier / Carnero, Amancio

2022 Volume 14, Issue 9

Abstract: Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, generating huge economic and social impacts that have not slowed in recent years. Oncological treatment for this neoplasm usually includes surgery, chemotherapy, ... ...

Abstract	Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, generating huge economic and social impacts that have not slowed in recent years. Oncological treatment for this neoplasm usually includes surgery, chemotherapy, treatments on molecular targets and ionizing radiation. The prognosis in terms of overall survival (OS) and the different therapeutic responses between patients can be explained, to a large extent, by the existence of widely heterogeneous molecular profiles. The identification of prognostic and predictive gene signatures of response to cancer treatment, could help in making therapeutic decisions in patients affected by NSCLC. Given the published scientific evidence, we believe that the search for prognostic and/or predictive gene signatures of response to radiotherapy treatment can significantly help clinical decision-making. These signatures may condition the fractions, the total dose to be administered and/or the combination of systemic treatments in conjunction with radiation. The ultimate goal is to achieve better clinical results, minimizing the adverse effects associated with current cancer therapies.
Language	English
Publishing date	2022-04-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14092202
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Bayesian taut splines for estimating the number of modes

Chacón, José E. / Serrano, Javier Fernández

2023

Abstract: The number of modes in a probability density function is representative of the model's complexity and can also be viewed as the number of existing subpopulations. Despite its relevance, little research has been devoted to its estimation. Focusing on the ... ...

Abstract	The number of modes in a probability density function is representative of the model's complexity and can also be viewed as the number of existing subpopulations. Despite its relevance, little research has been devoted to its estimation. Focusing on the univariate setting, we propose a novel approach targeting prediction accuracy inspired by some overlooked aspects of the problem. We argue for the need for structure in the solutions, the subjective and uncertain nature of modes, and the convenience of a holistic view blending global and local density properties. Our method builds upon a combination of flexible kernel estimators and parsimonious compositional splines. Feature exploration, model selection and mode testing are implemented in the Bayesian inference paradigm, providing soft solutions and allowing to incorporate expert judgement in the process. The usefulness of our proposal is illustrated through a case study in sports analytics, showcasing multiple companion visualisation tools. A thorough simulation study demonstrates that traditional modality-driven approaches paradoxically struggle to provide accurate results. In this context, our method emerges as a top-tier alternative offering innovative solutions for analysts. Comment: 28 pages, 15 figures (manuscript) + 11 pages, 10 figures (supplementary material)
Keywords	Statistics - Methodology ; Computer Science - Machine Learning ; Mathematics - Statistics Theory ; Statistics - Machine Learning ; 62G05 (Primary) 62G07 ; 62F15 ; 62C10 ; 62C86 (Secondary)
Subject code	006
Publishing date	2023-07-11
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Editorial: Family and school-based interventions to increase adolescents' leisure-time physical activity.

Tilga, Henri / Koka, Andre / Sevil-Serrano, Javier

Frontiers in psychology

2023 Volume 14, Page(s) 1208687

Language	English
Publishing date	2023-06-13
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1208687
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Article ; Online: Clinical characteristics associated with elevated levels of lipoprotein(a) in patients with vascular risk.

Rubio-Serrano, Javier / Gullón Ojesto, Alejandra / Suárez Fernández, Carmen

Advances in laboratory medicine

2023 Volume 4, Issue 4, Page(s) 396–401

Abstract: Objectives: Lipoprotein(a) (Lp(a)) is increasingly used in the evaluation of patients with vascular risk due to its association with cardiovascular events. The purpose of this study was to identify the clinical characteristics of patients with elevated ... ...

Abstract	Objectives: Lipoprotein(a) (Lp(a)) is increasingly used in the evaluation of patients with vascular risk due to its association with cardiovascular events. The purpose of this study was to identify the clinical characteristics of patients with elevated levels of Lp(a) attended in an outpatient vascular risk unit. Methods: An observational, retrospective study was conducted to assess the clinical characteristics of patients with elevated levels of Lp(a) (≥50 mg/dL), as compared to patients with normal values (<50 mg/dL). The sample was composed of 878 patients identified as having a high vascular risk due to a diagnosis of vascular disease, attended in a vascular risk unit between 2021 and 2022. Results: The highest levels of Lp(a) were independently associated with a higher probability of having a history of peripheral arterial disease (p=0.024), polygenic familial hypercholesterolemia (PH, p=0.030) and combined familial hypercholesterolemia (CFH, p=0.015); and using PCSK9 inhibitor treatment (p=0.029) and combination therapy with statins and ezetimibe (p=0.018). In contrast, there were no significant differences in relation to familial history of early cardiovascular disease (p=0.143) or personal history of cardiovascular disease (p=0.063), which contrasts with other series. Conclusions: Elevated levels of Lp(a) were associated with a history of peripheral arterial disease, diagnosis of FHP and CFH, and need for more intense lipid-lowering treatments.
Language	English
Publishing date	2023-12-01
Publishing country	Germany
Document type	Journal Article
ISSN	2628-491X
ISSN (online)	2628-491X
DOI	10.1515/almed-2023-0150
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Article ; Online: [No title information]

Rubio-Serrano, Javier / Gullón Ojesto, Alejandra / Suárez Fernández, Carmen

Advances in laboratory medicine

2023 Volume 4, Issue 4, Page(s) 402–407

Title translation	Características clínicas asociadas a niveles elevados de lipoproteína(a) en pacientes atendidos por riesgo vascular.
Language	Spanish
Publishing date	2023-10-23
Publishing country	Germany
Document type	Journal Article
ISSN	2628-491X
ISSN (online)	2628-491X
DOI	10.1515/almed-2023-0090
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Article ; Online: Boreal winter stratospheric climatology in EC-EARTH: CMIP6 version

Palmeiro, Froila M / García Serrano, Javier / Rodrigo, Mario / Abalos, Marta / Christiansen, Bo / Yang, Shuting

Clim Dyn. 2023 Feb., v. 60, no. 3-4 p.883-898

2023

Abstract: The performance of the European Consortium Earth-system model (EC-EARTH) in the boreal winter stratosphere is comprehensively assessed for the first time, in particular its version 3.3 that contributes to CMIP6. A 100-year long simulation with prescribed ...

Abstract	The performance of the European Consortium Earth-system model (EC-EARTH) in the boreal winter stratosphere is comprehensively assessed for the first time, in particular its version 3.3 that contributes to CMIP6. A 100-year long simulation with prescribed climatological boundary conditions and fixed radiative forcing, representative of present-day climate, is used to evaluate the simulation of the climatological stratospheric circulation and to identify model biases. Results show that EC-EARTH has a large issue with the vertical distribution of stratospheric temperature from the tropics to mid-latitudes, seemingly linked to radiative processes of ozone, leading to a biased warm middle-upper stratosphere. Associated with this model bias, EC-EARTH simulates a stronger polar vortex at upper-stratospheric levels while the Brewer-Dobson circulation at middle/lower levels is weaker than reanalysis. The amplitude of the climatological planetary waves is overall underestimated, but the magnitude of the background wave injection from the troposphere into the stratosphere is overestimated, related to a weaker polar vortex at lower-stratospheric levels and, thus, a less effective wave filtering. This bias in the westerly flow could have a contribution from parameterized waves. The overestimation of background wave driving is maximum in early-winter, and may explain the overestimated frequency of sudden stratospheric warmings at this time, as compared to reanalysis. The spatial distribution of wave injection climatology has revealed a distinctive role of the climatological planetary waves: while large-scale waves (wavenumbers 1–2) dominate the eddy heat flux over the North Pacific, small-scale waves (wavenumbers 3–4) are responsible for the doubled-lobe structure of the eddy heat flux over Eurasia. EC-EARTH properly simulates this climatological feature, although overestimates its amplitude over central Eurasia.
Keywords	climate ; climatology ; heat transfer ; latitude ; models ; ozone ; spatial distribution ; stratosphere ; temperature ; troposphere ; winter ; Eurasia
Language	English
Dates of publication	2023-02
Size	p. 883-898.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1471747-5
ISSN	1432-0894 ; 0930-7575
ISSN (online)	1432-0894
ISSN	0930-7575
DOI	10.1007/s00382-022-06368-0
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Multiple combustion modes switching to realize full-load efficient energy conversion of n-butanol/diesel dual direct injection (DI2) engine

Cai, Yikang / Jia, Ming / Li, Yaopeng / Cao, Jingjie / Garcia, Antonio / Monsalve-Serrano, Javier

Energy Conversion and Management. 2023 Feb., v. 278 p.116722-

2023

Abstract: The dual direct injection (DI²) engine system involves the in-cylinder co-direct injections of two fuels with the potential to address the operation limitations of traditional dual-fuel engines at part load conditions. However, for the DI² engine, its ... ...

Abstract	The dual direct injection (DI²) engine system involves the in-cylinder co-direct injections of two fuels with the potential to address the operation limitations of traditional dual-fuel engines at part load conditions. However, for the DI² engine, its optimal fueling strategies and combustion modes under different load conditions are still unknown. By selecting n-butanol and diesel as the test fuels, this study devotes to identifying the optimal combustion schemes of the DI² engine at different loads using three-dimensional engine simulation combined with an improved genetic algorithm, and further revealing its optimal fuel stratification and auto-ignition characteristics. The results showed that for low load, the optimal DI² strategy is to pre-inject a low proportion of diesel (near 20%) into the cylinder early in the compression stroke and then introduce n-butanol into this diesel atmosphere. On the contrary, the fuel injection sequence is reversed at mid load, in which n-butanol is first injected into the combustion chamber to form a partially premixed n-butanol/air mixture, followed by a late diesel injection at −50 to −20 °CA after top dead center (TDC). As for the high-load operation, n-butanol is still preferred to be partially premixed, but the diesel injection event is delayed until after TDC. The main factors driving the ignition under low load are the fuel reactivity and temperature, while at mid load the ignition is primarily initiated by fuel reactivity, however, the effect of temperature is highlighted under high load.
Keywords	administrative management ; algorithms ; butanol ; combustion ; energy conversion ; fuels ; temperature ; Dual direct injection (DI2) ; Multi-load optimization ; Multiple combustion modes ; Ignition control
Language	English
Dates of publication	2023-02
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2000891-0
ISSN	0196-8904
ISSN	0196-8904
DOI	10.1016/j.enconman.2023.116722
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Article ; Online: Is there a common pattern of dental specialties in the world? Orthodontics, the constant element.

Garcia-Espona, Ignacio / Garcia-Espona, Cristina / Alarcón, José Antonio / Garcia-Espona, Eugenia / Fernández-Serrano, Javier

BMC oral health

2024 Volume 24, Issue 1, Page(s) 49

Abstract: Background: There is a lack of studies comparing the status of dental specialties worldwide. Therefore, this study aimed to analyze the differences and similarities between the number and types of dental specialties in 31 countries, including every ... ...

Abstract	Background: There is a lack of studies comparing the status of dental specialties worldwide. Therefore, this study aimed to analyze the differences and similarities between the number and types of dental specialties in 31 countries, including every continent, in the world. Materials and methods: Available official documents and webpages from regulatory bodies, official colleges and councils, and dental institutions were collected from 31 countries and analyzed to obtain reliable data on dental specialties. Differences were analyzed using the Lorentz curve and Gini test. Additionally, a cluster analysis was performed to obtain groups of countries with similar patterns in the number and types of dental specialties. Results: A total of 32 different specialties were officially recognized among all the analyzed countries. Orthodontics and oral surgery (100% and 93.1%, respectively) were the two most frequently officially recognized dental specialties worldwide. The total global degree of inequality in the 31 analyzed countries was 42.4%. The Anglo-Saxon countries showed the greatest similarity, approximately 15-fold higher than the European countries. Cluster analysis differentiated six main groups of countries according to the number and types of dental specialties. European countries formed one of the two largest clusters, and the other cluster was of Anglo-Saxon, Asian, African, and several Eastern European countries with a high number of specialties. Conclusions: Officially recognized dental specialties in the different continents and countries show an asymmetric organization. The number, names, and skills of officially recognized dental specialties exhibited significant differences, showing inequalities in their organization. The Anglo-Saxon pattern of dental specialties showed greater equality than the European pattern. Orthodontics was the only constant element among the different patterns.
MeSH term(s)	Cluster Analysis ; Dental Care ; Surgery, Oral ; Specialization
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-023-03713-5
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Article ; Online: Differences in the Ratios of General and Dental Specialists in Europe.

Fernández-Serrano, Javier / García-Espona, Eugenia / Alarcón, José Antonio / García-Espona, Cristina / García-Espona, Ignacio

International dental journal

2024 Volume 74, Issue 3, Page(s) 519–525

Abstract: Background: The European Economic Area (EEA) is composed of member states with a multitude of different regions. This study aimed to analyse the ratios of general dentists and dental specialists to the total population and the proportion of dental ... ...

Abstract	Background: The European Economic Area (EEA) is composed of member states with a multitude of different regions. This study aimed to analyse the ratios of general dentists and dental specialists to the total population and the proportion of dental specialists to general dentists in 24 European countries and to explore specific intranational differences within 2 countries: France and Germany. Methods: Available official documents and webpages from the United Kingdom and 23 of the 30 countries comprising the EEA were analysed. Data were expressed as absolute values, ratios of general dentists and dental specialists in the total of population, and percentages of dental specialists/dentists. The Mann-Whitney U test was used to clarify the main ratios that distinguish France from Germany, and cluster analysis was employed to determine similar areas. Results: Significant differences were found between countries, with Ireland and Austria having the lowest ratio of dentists and Romania and Greece having the highest. The Czech Republic, the Netherlands, France, and Denmark had the lowest ratios of dental specialists to the total population. Lithuania, Sweden, and Germany had the highest number of dental specialists. Orthodontists were the most numerous specialists (5.0% of dentists), followed by oral surgeons (2.7%). In France, differences between departments were pronounced and associated with the presence of dental schools and per capita income. In Germany, only the correlation between per capita income and the density of oral surgeons was significant. Conclusions: Diverse ratios of general dentists and dental specialists to the total population and the proportion of dental specialists to general dentists were discovered within the examined countries, and their maximum values were 2.5, 5.7, and 4.1 times the minimum values, respectively. Differences were even found within the same country, as was the case in France and, to a lesser extent, in Germany.
MeSH term(s)	Europe ; Humans ; Specialties, Dental/statistics & numerical data ; Dentists/statistics & numerical data ; Dentists/supply & distribution ; General Practice, Dental/statistics & numerical data ; France ; Germany
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	218262-2
ISSN	1875-595X ; 0020-6539
ISSN (online)	1875-595X
ISSN	0020-6539
DOI	10.1016/j.identj.2023.12.004
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Article ; Online: European inequalities and similarities in officially recognized dental specialties.

García-Espona, Ignacio / García-Espona, Eugenia / Alarcón, José Antonio / Fernández-Serrano, Javier

BMC oral health

2023 Volume 23, Issue 1, Page(s) 280

Abstract: Background: Although the European Economic Space usually acts in a united and organized way, several main differences are found regarding the type and number of dental specialties all around this group of member states. The aim of the study is to ... ...

Abstract	Background: Although the European Economic Space usually acts in a united and organized way, several main differences are found regarding the type and number of dental specialties all around this group of member states. The aim of the study is to analyse the inequalities and similarities existing between 21 European countries, highlighting the number and types of recognized dental specialties. Methods: Available official documents and webpages from 20 out of the 30 countries of which the European Economic Space is comprised plus the United Kingdom (UK), were analysed to obtain reliable data referred to dental specialties. Differences were tested with the Lorentz curve and Gini test. Additionally, a Cluster analysis was performed to obtain groups of countries with a similar pattern in the number and type of dental specialties. Results: Up to a total of 15 different specialties are officially recognized in all the analysed countries. Orthodontics (90%) and Oral Surgery (81%) are the two most frequently recognized specialties. The total global degree of inequality of the analysed countries was 40.2%. Cluster analysis differentiated three different main groups of countries according to the number and type of dental specialties. Conclusions: The situation of dental specialties in the area of the EES plus the UK exhibits an unequal organization. Cluster analysis showed 3 main clusters of countries with a similar pattern of dental specialties.
MeSH term(s)	Humans ; Europe ; United Kingdom ; Orthodontics ; Surgery, Oral ; Dental Care ; Specialties, Dental
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-023-02987-z
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