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  1. Article ; Online: Perforated Amyand hernia with an adenocarcinoma tumour presenting as a groin abscess.

    Gbegli, Emmanuel / Miremadi, Ahmad / Serrao, Eva Mendes / Sadler, Timothy J

    BJR case reports

    2024  Volume 10, Issue 2, Page(s) uaae008

    Abstract: An Amyand hernia is an incarcerated inguinal hernia containing the appendix with or without appendicitis. This is a rare form of inguinal hernia, making up approximately 0.4%-1% of all cases. As with any hernia, this may become strangulated at any time, ... ...

    Abstract An Amyand hernia is an incarcerated inguinal hernia containing the appendix with or without appendicitis. This is a rare form of inguinal hernia, making up approximately 0.4%-1% of all cases. As with any hernia, this may become strangulated at any time, leading to the loss of blood supply and further development of gangrene and complications. Clinically, this can present in a manner indistinguishable from other types of inguinal hernias. In addition, the appendix can be affected by its own set of pathological processes, such as infection, inflammation, and malignancy. Not uncommonly both hernial and appendiceal complications coexist. The clinical diagnosis of an Amyand hernia remains challenging due to its low incidence and indistinct clinical presentation. At present, surgery is usually diagnostic and therapeutic. However, there is a growing number of recent reports showing the invaluable role of imaging on the diagnosis of Amyand hernias and associated complications. The correct and timely recognition of their imaging features including complications can optimize and expedite patient care by guiding diagnosis, treatment, and prognosis. Here, we report for the first time the radiological and pathological findings of a patient with a unique complicated Amyand hernia, which posed a diagnostic challenge for the clinical and radiological teams.
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Case Reports
    ISSN 2055-7159
    ISSN (online) 2055-7159
    DOI 10.1093/bjrcr/uaae008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The different faces of metastatic melanoma in the gastrointestinal tract.

    Serrao, Eva Mendes / Costa, Ana Maria / Ferreira, Sergio / McMorran, Victoria / Cargill, Emma / Hough, Caroline / Shaw, Ashley S / O'Carrigan, Brent / Parkinson, Christine A / Corrie, Pippa G / Sadler, Timothy J

    Insights into imaging

    2022  Volume 13, Issue 1, Page(s) 161

    Abstract: Melanoma is the most aggressive form of skin cancer, with tendency to spread to any organ of the human body, including the gastrointestinal tract (GIT). The diagnosis of metastases to the GIT can be difficult, as they may be clinically silent for ... ...

    Abstract Melanoma is the most aggressive form of skin cancer, with tendency to spread to any organ of the human body, including the gastrointestinal tract (GIT). The diagnosis of metastases to the GIT can be difficult, as they may be clinically silent for somewhile and may occur years after the initial melanoma diagnosis. CT imaging remains the standard modality for staging and surveillance of melanoma patients, and in most cases, it will be the first imaging modality to identify GIT lesions. However, interpretation of CT studies in patients with melanoma can be challenging as lesions may be subtle and random in distribution, as well as sometimes mimicking other conditions. Even so, early diagnosis of GIT metastases is critical to avoid emergency hospitalisations, whilst surgical intervention can be curative in some cases. In this review, we illustrate the various imaging presentations of melanoma metastases within the GIT, discuss the clinical aspects and offer advice on investigation and management. We offer tips intended to aid radiologists in their diagnostic skills and interpretation of melanoma imaging scans.
    Language English
    Publishing date 2022-10-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2543323-4
    ISSN 1869-4101
    ISSN 1869-4101
    DOI 10.1186/s13244-022-01294-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effective treatment with clozapine and valproate for refractory schizophrenia-like psychosis after cerebellar hemorrhage.

    Almeida, Jaime / Serrão, Eva Mendes / Almeida, Andre Traça / Afonso, Joana Gois

    Clinical neuropharmacology

    2011  Volume 34, Issue 3, Page(s) 131–132

    Abstract: Background: The cerebellum has traditionally been regarded as an organ of motor coordination. However, the importance of the cerebellum in psychiatric disorders, behavior, and cognition is increasingly being recognized. There is no consensus concerning ... ...

    Abstract Background: The cerebellum has traditionally been regarded as an organ of motor coordination. However, the importance of the cerebellum in psychiatric disorders, behavior, and cognition is increasingly being recognized. There is no consensus concerning treatment of schizophrenia-like psychosis after cerebellar pathology. Reports describe the use of several antipsychotics, either alone or in combination with antidepressants or lithium. Clozapine is used for the treatment of refractory schizophrenia, but there are no reports of its use in the above-mentioned situation.
    Case presentation: We report the case of a 20-year-old woman who developed a schizophrenia-like psychosis after rupture of arteriovenous malformation at 13 years of age. The psychotic symptoms proved to be resistant to treatment, and several psychopharmacological schemas were tried. The clinical picture only showed consistent improvement with the combined use of clozapine and valproate.
    Conclusions: The relationship between chronic psychosis and cerebellar pathology remains poorly understood. Cases like the present one suggest that clozapine and valproate may be used safely and effectively in refractory schizophrenia-like psychosis associated with cerebellar pathology.
    MeSH term(s) Cerebellum/drug effects ; Cerebellum/pathology ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/diagnosis ; Cerebral Hemorrhage/drug therapy ; Clozapine/administration & dosage ; Drug Therapy, Combination ; Female ; Humans ; Psychotic Disorders/diagnosis ; Psychotic Disorders/drug therapy ; Psychotic Disorders/etiology ; Schizophrenia/diagnosis ; Schizophrenia/drug therapy ; Schizophrenia/etiology ; Treatment Outcome ; Valproic Acid/administration & dosage ; Young Adult
    Chemical Substances Valproic Acid (614OI1Z5WI) ; Clozapine (J60AR2IKIC)
    Language English
    Publishing date 2011-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 199293-4
    ISSN 1537-162X ; 0362-5664
    ISSN (online) 1537-162X
    ISSN 0362-5664
    DOI 10.1097/WNF.0b013e31821f4d91
    Database MEDical Literature Analysis and Retrieval System OnLINE

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