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  1. Article ; Online: SCAI stage reclassification at 24 h predicts outcome of cardiogenic shock: Insights from the Altshock-2 Registry.

    Serrao, Gregory / Dangas, George

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2023  Volume 101, Issue 3, Page(s) 676

    MeSH term(s) Humans ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/therapy ; Treatment Outcome ; Myocardial Infarction ; Registries ; Hospital Mortality
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.30566
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1226: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Editorial: Current state of the art of human brain white matter: From structural and functional connectivity to neurosurgical applications.

    La Corte, Emanuele / Ordóñez-Rubiano, Edgar G / Paiva, Wellingson Silva / Johnson, Jason Michael / Serrao, Graziano

    Frontiers in neurology

    2022  Volume 13, Page(s) 1068212

    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.1068212
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  3. Article: The Evaluation and Management of Coronary Artery Disease in the Lung Transplant Patient.

    Serrao, Gregory / Vinayak, Manish / Nicolas, Johny / Subramaniam, Varsha / Lai, Ashton C / Laskey, Daniel / Kini, Annapoorna / Seethamraju, Harish / Scheinin, Scott

    Journal of clinical medicine

    2023  Volume 12, Issue 24

    Abstract: Lung transplantation can greatly improve quality of life and extend survival in those with end-stage lung disease. In order to derive the maximal benefit from such a procedure, patients must be carefully selected and be otherwise healthy enough to ... ...

    Abstract Lung transplantation can greatly improve quality of life and extend survival in those with end-stage lung disease. In order to derive the maximal benefit from such a procedure, patients must be carefully selected and be otherwise healthy enough to survive a high-risk surgery and sometimes prolonged immunosuppressive therapy following surgery. Patients therefore must be critically assessed prior to being listed for transplantation with close attention paid towards assessment of cardiovascular health and operative risk. One of the biggest dictators of this is coronary artery disease. In this review article, we discuss the assessment and management of coronary artery disease in the potential lung transplant candidate.
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12247644
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  4. Article ; Online: Incidence, Outcomes, and Opportunity for Left Ventricular Assist Device Weaning for Myocardial Recovery.

    Itagaki, Shinobu / Moss, Noah / Toyoda, Nana / Mancini, Donna / Egorova, Natalia / Serrao, Gregory / Lala, Anuradha / Pinney, Sean P / Boateng, Percy / Adams, David H / Anyanwu, Anelechi C

    JACC. Heart failure

    2024  Volume 12, Issue 5, Page(s) 893–901

    Abstract: Background: Myocardial recovery occurs in patients with advanced heart failure on left ventricular assist device (LVAD) support, but there is the premise that it is rare with uncertain results.: Objectives: The goal of this study was to investigate ... ...

    Abstract Background: Myocardial recovery occurs in patients with advanced heart failure on left ventricular assist device (LVAD) support, but there is the premise that it is rare with uncertain results.
    Objectives: The goal of this study was to investigate the incidence and consequence of LVAD explant after myocardial recovery.
    Methods: Using the United Network for Organ Sharing registry, LVAD implants in the United States between 2005 and 2020 were tracked until death, transplantation, or explant for myocardial recovery. The cohort undergoing explant was followed up for heart failure relapse (defined as relisting followed by delisting due to death, being too ill, or transplantation; or second durable LVAD implant).
    Results: Of 15,728 LVAD implants, 126 patients underwent explant for recovery, which only occurred in 55 (38%) of 145 implanting centers. The crude cumulative incidence was 0.7% at 2 years, whereas the incidence reached 4.7% among designated centers in the selected young nonischemic cohort. Of 126 explanted patients, 76 (60%) were subsequently delisted for sustained recovery. Heart failure relapsing had a relatively higher hazard in the early phase, with a 30-day incidence of 6% (7 of 126) but tapered following with the freedom rate of 72.5% at 4 years.
    Conclusions: In the United States, LVAD explant for myocardial recovery was underutilized, leading to a very low incidence at the national level despite a realistic rate being achieved in designated centers for selected patients. With follow-up extending up to 4 years after explant, more than one-half were successfully removed and stayed off the waitlist, and approximately 70% were free from heart failure relapse events.
    MeSH term(s) Humans ; Heart-Assist Devices ; Heart Failure/epidemiology ; Heart Failure/therapy ; Heart Failure/physiopathology ; Heart Failure/surgery ; Male ; Female ; Middle Aged ; Incidence ; United States/epidemiology ; Device Removal/statistics & numerical data ; Adult ; Recovery of Function ; Registries ; Recurrence ; Aged ; Retrospective Studies
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2023.12.006
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  5. Article ; Online: Craniofacial structures' development in prenatal period: An MRI study.

    Begnoni, G / Serrao, G / Musto, F / Pellegrini, G / Triulzi, F M / Dellavia, C

    Orthodontics & craniofacial research

    2018  Volume 21, Issue 2, Page(s) 96–103

    Abstract: Introduction: The development of skeletal structures (cranial base, upper and lower) and upper airways spaces (oropharyngeal and nasopharyngeal) of the skull has always been an issue of great interest in orthodontics. Foetal MRI images obtained as ... ...

    Abstract Introduction: The development of skeletal structures (cranial base, upper and lower) and upper airways spaces (oropharyngeal and nasopharyngeal) of the skull has always been an issue of great interest in orthodontics. Foetal MRI images obtained as screening exam during pregnancy can help to understand the development of these structures using a sample cephalometric analysis.
    Material and methods: A total of 28 MRI images in sagittal section of foetuses from 20th to 32th weeks of gestation were obtained to dispel doubts about the presence of skeletal malformations. Cephalometric measurements were performed on MRI T2-dependent images acquired with a 1.5 T scanner. The Software Osirix 5 permits to study sagittal and vertical dimensions of the skull analysing linear measurements, angles and areas of the skeletal structures.
    Results: Vertical and sagittal dimension of cranial base, maxilla and mandible grow significantly (P < .01) between the second and third trimester of gestational period as well as nasopharyngeal and oropharyngeal spaces (P < .05). High correlation between the development of anterior cranial base and functional areas devoted to speech and swallow is demonstrated (r: .97).
    Conclusions: The development of craniofacial structures during foetal period seems to show a close correlation between skeletal features and functional spaces with a peak between the second and third trimester of gestation. MRI images result helpful for the clinician to detect with a sample cephalometric analysis anomalies of skeletal and functional structures during prenatal period.
    MeSH term(s) Cephalometry ; Female ; Gestational Age ; Humans ; Hyoid Bone/diagnostic imaging ; Hyoid Bone/embryology ; Magnetic Resonance Imaging ; Male ; Mandible/diagnostic imaging ; Mandible/embryology ; Maxilla/diagnostic imaging ; Maxilla/embryology ; Skull/diagnostic imaging ; Skull/embryology ; Skull Base/diagnostic imaging ; Skull Base/embryology
    Language English
    Publishing date 2018-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2076514-9
    ISSN 1601-6343 ; 1601-6335
    ISSN (online) 1601-6343
    ISSN 1601-6335
    DOI 10.1111/ocr.12222
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5412: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Association between Apical Periodontitis and Chronic Diseases: An Umbrella Review.

    Pinto, Karem Paula / Serrão, Gabriella / Alves Ferreira, Cláudio Malizia / Sassone, Luciana Moura / Fidalgo, Tatiana Kelly da Silva / Silva, Emmanuel J N L

    Iranian endodontic journal

    2022  Volume 18, Issue 3, Page(s) 134–144

    Abstract: Introduction: To assess the methodological quality of systematic reviews (SRs) that evaluated the association between apical periodontitis (AP) and chronic diseases.: Materials and methods: A systematic search was performed in the databases PubMed, ... ...

    Abstract Introduction: To assess the methodological quality of systematic reviews (SRs) that evaluated the association between apical periodontitis (AP) and chronic diseases.
    Materials and methods: A systematic search was performed in the databases PubMed, Virtual Health Library, Scopus, Cochrane Library, Embase, Web of Science and Open Grey. SRs that evaluated the association between any chronic disease and AP, and that had performed a valid risk of bias assessment were included. The AMSTAR-2 tool was used for quality assessment and each included systematic review received a final categorization as having "high", "moderate", "low", or "critically low" quality.
    Results: Nine studies that met the eligibility criteria were included. The diseases investigated were cardiovascular diseases, diabetes mellitus, HIV, osteoporosis, chronic liver disease, blood disorders and autoimmune diseases. The systematic reviews included in this umbrella review showed a 'low' to 'high' quality of evidence.
    Conclusion: There are substantial heterogeneity and several methodological concerns in the included studies. It was observed a positive association between diabetes mellitus and apical periodontitis with limited evidence, no association between HIV and apical periodontitis and a positive association between apical periodontitis and cardiovascular disease, blood disorders, chronic liver disease, osteoporosis and autoimmune diseases with moderate evidence.
    Language English
    Publishing date 2022-07-21
    Publishing country Iran
    Document type Journal Article ; Review
    ZDB-ID 2684659-7
    ISSN 2008-2746 ; 2008-2746
    ISSN (online) 2008-2746
    ISSN 2008-2746
    DOI 10.22037/iej.v18i3.42560
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  7. Article ; Online: Use of Extracorporeal Membrane Oxygenation and Impella as Bridge to Surgery Through Imaging for Cardiogenic Shock.

    Anastasius, Malcolm / Serrao, Greg / Sharma, Samin K / Kini, Annapoorna / Anyanwu, Anelechi / Adams, David / Lerakis, Stamatios

    CASE (Philadelphia, Pa.)

    2022  Volume 6, Issue 5, Page(s) 223–227

    Abstract: Three-dimensional TEE, zoomed volume acquisition, oriented to the surgeon's view of the mitral valve. ...

    Abstract Three-dimensional TEE, zoomed volume acquisition, oriented to the surgeon's view of the mitral valve.
    Language English
    Publishing date 2022-04-13
    Publishing country United States
    Document type Case Reports
    ISSN 2468-6441
    ISSN (online) 2468-6441
    DOI 10.1016/j.case.2022.03.003
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  8. Article ; Online: High-Risk Pulmonary Embolism During Labor:

    Poor, Hooman / Serrao, Gregory / Grapsa, Julia / Chandrashekhar, Y S / Bianco, Angela / Lookstein, Robert A / Fuster, Valentin

    JACC. Case reports

    2022  Volume 6, Page(s) 101650

    Abstract: While in labor, a 37-year-old woman developed acute dyspnea, hypoxemia, and tachycardia. Transthoracic echocardiography demonstrated severe right ventricular dilation and dysfunction, raising the suspicion of acute pulmonary embolism. The patient indeed ... ...

    Abstract While in labor, a 37-year-old woman developed acute dyspnea, hypoxemia, and tachycardia. Transthoracic echocardiography demonstrated severe right ventricular dilation and dysfunction, raising the suspicion of acute pulmonary embolism. The patient indeed had bilateral pulmonary embolism, necessitating percutaneous thrombectomy. Her course was complicated by another saddle pulmonary embolus, heparin-induced thrombocytopenia, and COVID-19 infection. This clinical case illustrates the importance of prompt diagnosis of acute pulmonary embolism in a peripartum female patient, the multidisciplinary approach of management, and how to approach clinical complications such as heparin-induced thrombocytopenia. Furthermore, long-term management in acute pulmonary embolism is presented.
    Language English
    Publishing date 2022-10-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2022.10.001
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  9. Article ; Online: Decavanadate and metformin-decavanadate effects in human melanoma cells.

    De Sousa-Coelho, Ana Luísa / Aureliano, Manuel / Fraqueza, Gil / Serrão, Gisela / Gonçalves, João / Sánchez-Lombardo, Irma / Link, Wolfgang / Ferreira, Bibiana I

    Journal of inorganic biochemistry

    2022  Volume 235, Page(s) 111915

    Abstract: Decavanadate is a polyoxometalate (POMs) that has shown extensive biological activities, including antidiabetic and anticancer activity. Importantly, vanadium-based compounds as well as antidiabetic biguanide drugs, such as metformin, have shown to exert ...

    Abstract Decavanadate is a polyoxometalate (POMs) that has shown extensive biological activities, including antidiabetic and anticancer activity. Importantly, vanadium-based compounds as well as antidiabetic biguanide drugs, such as metformin, have shown to exert therapeutic effects in melanoma. A combination of these agents, the metformin-decavanadate complex, was also recognized for its antidiabetic effects and recently described as a better treatment than the monotherapy with metformin enabling lower dosage in rodent models of diabetes. Herein, we compare the effects of decavanadate and metformin-decavanadate on Ca<sup>2+</sup>-ATPase activity in sarcoplasmic reticulum vesicles from rabbit skeletal muscles and on cell signaling events and viability in human melanoma cells. We show that unlike the decavanadate-mediated non-competitive mechanism, metformin-decavanadate inhibits Ca<sup>2+</sup>-ATPase by a mixed-type competitive-non-competitive inhibition with an IC<sub>50</sub> value about 6 times higher (87 μM) than the previously described for decavanadate (15 μM). We also found that both decavanadate and metformin-decavanadate exert antiproliferative effects on melanoma cells at 10 times lower concentrations than monomeric vanadate. Western blot analysis revealed that both, decavanadate and metformin-decavanadate increased phosphorylation of extracellular signal-regulated kinase (ERK) and serine/threonine protein kinase AKT signaling proteins upon 24 h drug exposure, suggesting that the anti-proliferative activities of these compounds act independent of growth-factor signaling pathways.
    MeSH term(s) Adenosine Triphosphatases ; Animals ; Anions ; Humans ; Hypoglycemic Agents ; Melanoma/drug therapy ; Metformin/pharmacology ; Polyelectrolytes ; Rabbits ; Vanadates/pharmacology
    Chemical Substances Anions ; Hypoglycemic Agents ; Polyelectrolytes ; polyoxometalate ; Vanadates (3WHH0066W5) ; Metformin (9100L32L2N) ; Adenosine Triphosphatases (EC 3.6.1.-)
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 162843-4
    ISSN 1873-3344 ; 0162-0134
    ISSN (online) 1873-3344
    ISSN 0162-0134
    DOI 10.1016/j.jinorgbio.2022.111915
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    Zs.B 1730: Show issues Location:
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  10. Article ; Online: High-Risk Pulmonary Embolism During Labor: JACC Patient Care Pathways.

    Poor, Hooman / Serrao, Gregory / Grapsa, Julia / Chandrashekhar, Y S / Bianco, Angela / Lookstein, Robert A / Fuster, Valentin

    Journal of the American College of Cardiology

    2022  Volume 81, Issue 3, Page(s) 283–291

    Abstract: While in labor, a 37-year-old woman developed acute dyspnea, hypoxemia, and tachycardia. Transthoracic echocardiography demonstrated severe right ventricular dilation and dysfunction, raising the suspicion of acute pulmonary embolism. The patient indeed ... ...

    Abstract While in labor, a 37-year-old woman developed acute dyspnea, hypoxemia, and tachycardia. Transthoracic echocardiography demonstrated severe right ventricular dilation and dysfunction, raising the suspicion of acute pulmonary embolism. The patient indeed had bilateral pulmonary embolism, necessitating percutaneous thrombectomy. Her course was complicated by another saddle pulmonary embolus, heparin-induced thrombocytopenia, and COVID-19 infection. This clinical case illustrates the importance of prompt diagnosis of acute pulmonary embolism in a peripartum female patient, the multidisciplinary approach of management, and how to approach clinical complications such as heparin-induced thrombocytopenia. Furthermore, long-term management in acute pulmonary embolism is presented.
    MeSH term(s) Humans ; Female ; Adult ; Critical Pathways ; COVID-19/complications ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/etiology ; Echocardiography ; Thrombocytopenia ; Acute Disease
    Language English
    Publishing date 2022-10-17
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2022.10.004
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    Zs.MO 196: Show issues

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