Article ; Online: Comparative frequency of specified adverse events following Vero cell culture-derived Japanese encephalitis and Vi capsular polysaccharide typhoid vaccines in U.S. military personnel, July 2011-August 2019.
2023 Volume 41, Issue 9, Page(s) 1537–1540
Abstract: Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC; Ixiaro) was approved in the United States in 2009. The previous JE vaccine, an inactivated mouse brain-derived vaccine, had been associated with rare, but serious, allergic and ... ...
Abstract | Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC; Ixiaro) was approved in the United States in 2009. The previous JE vaccine, an inactivated mouse brain-derived vaccine, had been associated with rare, but serious, allergic and neurologic adverse events (AE). Studies and AE surveillance have supported JE-VC's safety, but one evaluation among military personnel found elevated hypersensitivity and neurologic AE rates. However, co-administration of multiple vaccines to some personnel might have affected results. We retrospectively compared rates of hypersensitivity and neurologic AEs within 28 days following vaccination of military personnel with JE-VC or parenteral Vi capsular polysaccharide typhoid vaccine administered without other vaccines from July 1, 2011, through August 31, 2019. Rates of most events were similar between the vaccines. Only delayed hypersensitivity reactions occurred more frequently following JE-VC (rate ratio: 4.2, 95 % CI 1.2-15.3; p = 0.03), but rates were low for both vaccines. These results support JE-VC's safety. |
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MeSH term(s) | Animals ; Chlorocebus aethiops ; Mice ; United States ; Humans ; Encephalitis, Japanese/prevention & control ; Typhoid-Paratyphoid Vaccines ; Military Personnel ; Retrospective Studies ; Japanese Encephalitis Vaccines ; Vero Cells ; Hypersensitivity ; Vaccines, Inactivated ; Polysaccharides ; Cell Culture Techniques |
Chemical Substances | Typhoid-Paratyphoid Vaccines ; Japanese Encephalitis Vaccines ; Vaccines, Inactivated ; Polysaccharides |
Language | English |
Publishing date | 2023-01-30 |
Publishing country | Netherlands |
Document type | Journal Article |
ZDB-ID | 605674-x |
ISSN | 1873-2518 ; 0264-410X |
ISSN (online) | 1873-2518 |
ISSN | 0264-410X |
DOI | 10.1016/j.vaccine.2023.01.061 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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