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Book: Risk factors for cerebrovascular disease and stroke

Seshadri, Sudha / Debette, Stéphanie

2016

Author's details	ed. by Sudha Seshadri and Stéphanie Debette
Keywords	Cerebrovascular Disorders / etiology ; Stroke / epidemiology ; Cerebrovascular Disorders / genetics
Language	English
Publisher	Oxford Univ. Press
Publishing place	Oxford u.a.
Publishing country	United States
Document type	Book
Note	Includes bibliographical references
HBZ-ID	HT018956849
ISBN	978-0-19-989584-7 ; 0-19-989584-8
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2016 A 1045	available for loan (reading room)	Lesesaal EG

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Article ; Online: Prevention of Dementia-Thinking Beyond the Age and Amyloid Boxes.

Seshadri, Sudha

JAMA neurology

2019 Volume 77, Issue 2, Page(s) 160–161

MeSH term(s)	Adult ; Amyloid ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Dementia/prevention & control ; Humans
Chemical Substances	Amyloid ; Amyloid beta-Peptides
Language	English
Publishing date	2019-10-31
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2702023-X
ISSN	2168-6157 ; 2168-6149
ISSN (online)	2168-6157
ISSN	2168-6149
DOI	10.1001/jamaneurol.2019.3785
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Article ; Online: Risk Factors, Lifestyle Behaviors, and Vascular Brain Health.

Gottesman, Rebecca F / Seshadri, Sudha

Stroke

2022 Volume 53, Issue 2, Page(s) 394–403

Abstract: Although a relationship between traditional cardiovascular risk factors and stroke has long been recognized, these risk factors likely play a role in other aspects of brain health. Clinical stroke is only the tip of the iceberg of vascular brain injury ... ...

Abstract	Although a relationship between traditional cardiovascular risk factors and stroke has long been recognized, these risk factors likely play a role in other aspects of brain health. Clinical stroke is only the tip of the iceberg of vascular brain injury that includes covert infarcts, white matter hyperintensities, and microbleeds. Furthermore, an individual's risk for not only stroke but poor brain health includes not only these traditional vascular risk factors but also lifestyle and genetic factors. The purpose of this narrative review is to summarize the state of the evidence on traditional and nontraditional vascular risk factors and their contributions to brain health. Additionally, we will review important modifiers that interact with these risk factors to increase, or, in some cases, reduce risk of adverse brain health outcomes, with an emphasis on genes and biomarkers associated with Alzheimer disease. Finally, we will consider the importance of social determinants of health in brain health outcomes.
MeSH term(s)	Alzheimer Disease/epidemiology ; Cerebrovascular Circulation/physiology ; Cerebrovascular Disorders/epidemiology ; Cerebrovascular Disorders/physiopathology ; Health ; Humans ; Life Style ; Risk Factors ; Stroke/epidemiology
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.121.032610
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Article ; Online: Association of Neurotrophic Factors at Midlife With In Vivo Measures of β-Amyloid and Tau Burden 15 Years Later in Dementia-Free Adults.

Weinstein, Galit / Kojis, Daniel J / Ghosh, Saptaparni / Beiser, Alexa S / Seshadri, Sudha

Neurology

2024 Volume 102, Issue 7, Page(s) e209198

Abstract: Background and objectives: Neurotrophic factors (NTFs) play an important role in Alzheimer disease (AD) pathophysiology. Brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) are important NTFs. However, a direct link of ...

Abstract	Background and objectives: Neurotrophic factors (NTFs) play an important role in Alzheimer disease (AD) pathophysiology. Brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) are important NTFs. However, a direct link of BDNF and VEGF circulating levels with in vivo measures of amyloid-β (Aβ) and tau burden remains to be elucidated. We explored the relationship of BDNF and VEGF serum levels with future brain Aβ and tau pathology in a cohort of cognitively healthy, predominantly middle-aged adults and tested for possible effect modifications by sex and menopausal status. Methods: This cross-sectional analysis was conducted using data from the Framingham Heart Study (FHS), a community-based cohort study. The study sample included cognitively healthy participants from the FHS Offspring and Third-generation cohorts. BDNF and VEGF were measured in the third-generation cohort during examination cycles 2 (2005-2008) and 1 (2002-2005), respectively, and in the offspring cohort during examination cycle 7 (1998-2001). Participants underwent Results: The sample included 414 individuals (mean age = 41 ± 9 years; 51% female). Continuous measures of BDNF and VEGF were associated with tau signal in the rhinal region after adjustment for potential confounders (β = -0.15 ± 0.06, Discussion: This study demonstrates a robust association between BDNF and VEGF serum levels with in vivo measures of tau almost 2 decades later. These findings add to mounting evidence from preclinical studies suggesting a role of NTFs as valuable blood biomarkers for AD risk prediction.
MeSH term(s)	Adult ; Middle Aged ; Humans ; Male ; Female ; Vascular Endothelial Growth Factor A ; Brain-Derived Neurotrophic Factor ; tau Proteins/metabolism ; Cohort Studies ; Cross-Sectional Studies ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid/metabolism ; Positron-Emission Tomography ; Cognitive Dysfunction/metabolism
Chemical Substances	Vascular Endothelial Growth Factor A ; Brain-Derived Neurotrophic Factor ; tau Proteins ; Amyloid beta-Peptides ; Amyloid
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000209198
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Article: Editorial: Population Neuroscience of Development and Aging.

Paus, Tomáš / Debette, Stephanie / Seshadri, Sudha

Frontiers in systems neuroscience

2022 Volume 16, Page(s) 897943

Language	English
Publishing date	2022-04-25
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2453005-0
ISSN	1662-5137
ISSN	1662-5137
DOI	10.3389/fnsys.2022.897943
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Article ; Online: Indexes of subclinical atherosclerosis: signposts on the highway to disease.

Seshadri, Sudha

JACC. Cardiovascular imaging

2014 Volume 7, Issue 11, Page(s) 1116–1118

MeSH term(s)	Coronary Artery Disease/epidemiology ; Female ; Humans ; Ischemic Attack, Transient/epidemiology ; Male ; Stroke/epidemiology ; Vascular Calcification/epidemiology
Language	English
Publishing date	2014-11-10
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2491503-8
ISSN	1876-7591 ; 1936-878X
ISSN (online)	1876-7591
ISSN	1936-878X
DOI	10.1016/j.jcmg.2014.09.004
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Article ; Online: Empirical Dietary Inflammatory Pattern Scores Are Not Associated with Worse Cognitive Performance in the Nurses' Health Study.

Melo van Lent, Debora / Samieri, Cécilia / Grodstein, Francine / Seshadri, Sudha

The Journal of nutrition

2022 Volume 152, Issue 11, Page(s) 2526–2533

Abstract: Background: Low-grade chronic inflammation associated with unhealthy diets may lead to cognitive aging.: Objectives: We evaluated whether higher long-term adherence to an empirical dietary inflammatory pattern (EDIP) was associated with lower ... ...

Abstract	Background: Low-grade chronic inflammation associated with unhealthy diets may lead to cognitive aging. Objectives: We evaluated whether higher long-term adherence to an empirical dietary inflammatory pattern (EDIP) was associated with lower cognitive function after age 70 y in the Nurses' Health Study. Methods: A total of 16,058 older (mean ± SD age: 74 ± 2 y) highly educated (≥ bachelor degree) White women completed up to 5 validated 116-item food-frequency questionnaires. An EDIP score, previously derived with the use of reduced rank regression to predict circulating inflammatory markers (i.e., C-reactive protein, TNF-α receptor 2, and IL-6), was computed based on 9 anti-inflammatory and 9 proinflammatory components. A long-term EDIP score was calculated by averaging across 5 exams. The EDIP score was categorized into quintiles, taking the first (anti-inflammatory) quintile as the reference category. Cognitive testing was performed through telephone interviews over 4 follow-up exams (1995-2008). A composite global cognition score, a composite verbal memory score, and the Telephone Interview for Cognitive Status (TICS) were calculated and averaged across the 4 exams (6 y of follow-up). Multivariable linear regressions were used to examine longitudinal relations under study. Results: Higher long-term EDIP scores (i.e., more proinflammatory) were significantly associated with worse performance on global cognitive function (P-trend= 0.018) and TICS (P-trend= 0.004) after adjustment for demographic and lifestyle factors. The associations became nonsignificant after additional adjustments for disease (related) risk factors for dementia. No association was observed between the EDIP score and verbal memory. Conclusions: We observed no relation between long-term EDIP scores and averaged global cognitive function and verbal memory among older women. Our findings suggest no relation between long-term adherence to a proinflammatory diet and cognitive function in a large population of mostly White and generally highly educated older women. Future studies are encouraged to investigate the relation between inflammatory diets and cognitive function in other races/ethnicities and men, and over a longer follow-up period.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Diet/adverse effects ; Inflammation/etiology ; Risk Factors ; Cognition/physiology ; Nurses
Language	English
Publishing date	2022-07-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1093/jn/nxac157
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Article ; Online: Delaying dementia: can antihypertensives prevent Alzheimer dementia?

Seshadri, Sudha

Neurology

2013 Volume 81, Issue 10, Page(s) 860–862

MeSH term(s)	Adrenergic beta-Antagonists/therapeutic use ; Aging/ethnology ; Alzheimer Disease/prevention & control ; Antihypertensive Agents/therapeutic use ; Asian Americans/ethnology ; Cognition Disorders/ethnology ; Cognitive Dysfunction/drug therapy ; Female ; Ginkgo biloba ; Humans ; Hypertension/ethnology ; Male ; Memory/drug effects
Chemical Substances	Adrenergic beta-Antagonists ; Antihypertensive Agents
Language	English
Publishing date	2013-08-02
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0b013e3182a35296
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Article ; Online: A novel neuroimaging signature for ADRD risk stratification in the community.

Satizabal, Claudia L / Beiser, Alexa S / Fletcher, Evan / Seshadri, Sudha / DeCarli, Charles

Alzheimer's & dementia : the journal of the Alzheimer's Association

2023 Volume 20, Issue 3, Page(s) 1881–1893

Abstract: Introduction: Early risk stratification for clinical dementia could lead to preventive therapies. We identified and validated a magnetic resonance imaging (MRI) signature for Alzheimer's disease (AD) and related dementias (ARDR).: Methods: An MRI ... ...

Abstract	Introduction: Early risk stratification for clinical dementia could lead to preventive therapies. We identified and validated a magnetic resonance imaging (MRI) signature for Alzheimer's disease (AD) and related dementias (ARDR). Methods: An MRI ADRD signature was derived from cortical thickness maps in Framingham Heart Study (FHS) participants with AD dementia and matched controls. The signature was related to the risk of ADRD and cognitive function in FHS. Results were replicated in the University of California Davis Alzheimer's Disease Research Center (UCD-ADRC) cohort. Results: Participants in the bottom quartile of the signature had more than three times increased risk for ADRD compared to those in the upper three quartiles (P < 0.001). Greater thickness in the signature was related to better general cognition (P < 0.01) and episodic memory (P = 0.01). Results replicated in UCD-ADRC. Discussion: We identified a robust neuroimaging biomarker for persons at increased risk of ADRD. Other cohorts will further test the validity of this biomarker.
MeSH term(s)	Humans ; Alzheimer Disease/pathology ; Neuroimaging/methods ; Longitudinal Studies ; Biomarkers ; Risk Assessment
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-12-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13600
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Article ; Online: Apathy as a Predictor of Conversion from Mild Cognitive Impairment to Alzheimer's Disease: A Texas Alzheimer's Research and Care Consortium (TARCC) Cohort-Based Analysis.

Salem, Haitham / Suchting, Robert / Gonzales, Mitzi M / Seshadri, Sudha / Teixeira, Antonio L

Journal of Alzheimer's disease : JAD

2023 Volume 92, Issue 1, Page(s) 129–139

Abstract: Background: Apathy is among the neuropsychiatric symptoms frequently observed in people with cognitive impairment. It has been postulated to be a potential predictor of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD).: ... ...

Abstract	Background: Apathy is among the neuropsychiatric symptoms frequently observed in people with cognitive impairment. It has been postulated to be a potential predictor of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Objective: To detect conversion rates from MCI to AD, and to determine the effect of apathy on the progression to AD in patients with MCI enrolled in the Texas Alzheimer's Research and Care Consortium (TARCC) cohort. Methods: Apathy was determined by a positive response to the respective item in the Neuropsychiatric Inventory -Questionnaire (NPI-Q) completed by family members or caregivers. The final dataset included 2,897 observations from 1,092 individuals with MCI at the baseline. Kaplan-Meier survival curves were estimated to provide indices of the probability of conversion to AD over time across all individuals as well as between those with and without apathy. Cox proportional hazards regression measured the hazard associated with apathy and several other predictors of interest. Results: Over a period of 8.21 years, 17.3% of individuals had conversion from MCI to AD (n = 190 of 1,092 total individuals) across observations. The median time-to-conversion across all participants was 6.41 years. Comparing individuals with apathy (n = 158) versus without apathy (n = 934), 36.1% and 14.2% had conversion to AD, respectively. The median time-to-conversion was 3.79 years for individuals with apathy and 6.83 years for individuals without apathy. Cox proportional hazards regression found significant effects of several predictors, including apathy, on time-to-conversion. Age and cognitive performance were found to moderate the relationship between apathy and time-to-conversion. Conclusions: Apathy is associated with progression from MCI to AD, suggesting that it might improve risk prediction and aid targeted intervention delivery.
MeSH term(s)	Humans ; Alzheimer Disease/psychology ; Apathy/physiology ; Texas ; Neuropsychological Tests ; Cognitive Dysfunction/psychology ; Disease Progression
Language	English
Publishing date	2023-01-18
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-220826
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