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  1. Article: Role of midazolam on cancer progression/survival - An updated systematic review.

    Sethi, Ansh / Rezk, Amal / Couban, Rachel / Chowdhury, Tumul

    Indian journal of anaesthesia

    2023  Volume 67, Issue 11, Page(s) 951–961

    Abstract: Background and aims: Cancer is a leading cause of mortality worldwide. Despite advancements in cancer management, cancer progression remains a challenge, requiring the development of novel therapies. Midazolam is a commonly used adjunct to anaesthesia ... ...

    Abstract Background and aims: Cancer is a leading cause of mortality worldwide. Despite advancements in cancer management, cancer progression remains a challenge, requiring the development of novel therapies. Midazolam is a commonly used adjunct to anaesthesia care for various surgeries, including cancer. Recently, there has been a growing interest in exploring the potential role of midazolam as an anticancer agent; however, the exact mechanism of this linkage is yet to be investigated thoroughly.
    Methods: Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline, this systematic review presented aggregated evidence (till November 2022) of the effects of midazolam on cancer progression and survival. All primary research article types where midazolam was administered
    Results: Of 1720 citations, 19 studies were included in this review. All articles were preclinical studies conducted either
    Conclusion: This systematic review highlights that midazolam has the potential to impede cancer progression and decrease cancer cell survival. Extrapolation of these results into human cancer necessitates further investigation.
    Language English
    Publishing date 2023-11-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 412570-8
    ISSN 0019-5049
    ISSN 0019-5049
    DOI 10.4103/ija.ija_731_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The role of heart rate variability in predicting delirium: A systematic review and meta-analysis.

    Amit Patel, Krisha / Sethi, Ansh / Al Azazi, Emad / McClurg, Caitlin / Chowdhury, Tumul

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2024  Volume 124, Page(s) 122–129

    Abstract: Brain and heart interact through multiple ways. Heart rate variability, a non-invasive measurement is studied extensively as a predicting model for various health conditions including subarachnoid hemorrhage, cancer, and diabetes. There is limited ... ...

    Abstract Brain and heart interact through multiple ways. Heart rate variability, a non-invasive measurement is studied extensively as a predicting model for various health conditions including subarachnoid hemorrhage, cancer, and diabetes. There is limited evidence to predict delirium, an acute fluctuating disorder of brain dysfunction, as it poses a significant challenge in the intensive care unit (ICU) and post-operative setting. In this systematic review of 9 articles, heart rate variability indices were used to investigate the occurrence of post-operative and ICU delirium. This systematic review and meta-analysis reveal evidence of a strong predilection between postoperative and intensive care unit delirium and alterations in the heart rate variability, measured by mean differences for standard deviation of NN-intervals. Other heart rate variability indices [root mean squares of successive differences, low-frequency (LF), high-frequency (HF), and LF:HF ratio] showed lack of or very weak association. A non-invasive tool of brain and heart interaction may refine diagnostic predictions for acute brain dysfunctions like delirium in such population and would be an important step in delirium research.
    MeSH term(s) Humans ; Delirium/diagnosis ; Delirium/physiopathology ; Heart Rate/physiology ; Intensive Care Units ; Postoperative Complications/physiopathology ; Postoperative Complications/diagnosis
    Language English
    Publishing date 2024-05-04
    Publishing country Scotland
    Document type Systematic Review ; Journal Article ; Meta-Analysis ; Review
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2024.04.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3999: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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