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  1. Article ; Online: Noradrenaline released from locus coeruleus axons contracts cerebral capillary pericytes via

    Korte, Nils / James, Greg / You, Haoming / Hirunpattarasilp, Chanawee / Christie, Isabel / Sethi, Huma / Attwell, David

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2023  Volume 43, Issue 7, Page(s) 1142–1152

    Abstract: Noradrenaline (NA) release from locus coeruleus axons generates vascular contractile tone in arteriolar smooth muscle and contractile capillary pericytes. This tone allows neuronal activity to evoke vasodilation that increases local cerebral blood flow ( ... ...

    Abstract Noradrenaline (NA) release from locus coeruleus axons generates vascular contractile tone in arteriolar smooth muscle and contractile capillary pericytes. This tone allows neuronal activity to evoke vasodilation that increases local cerebral blood flow (CBF). Much of the vascular resistance within the brain is located in capillaries and locus coeruleus axons have NA release sites closer to pericytes than to arterioles. In acute brain slices, NA contracted pericytes but did not raise the pericyte cytoplasmic Ca
    MeSH term(s) Pericytes/metabolism ; Locus Coeruleus/metabolism ; Capillaries/physiology ; Norepinephrine/pharmacology ; Norepinephrine/metabolism ; Receptors, Adrenergic, alpha-2/metabolism ; Axons/metabolism
    Chemical Substances Norepinephrine (X4W3ENH1CV) ; Receptors, Adrenergic, alpha-2
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X231152549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Unusual Magnetic Resonance Imaging Features of Scrub Typhus Encephalitis.

    Naik, Shailendra S / Bedadala, Mayurnath R / Sharma, Manik / Sethi, Himanshu

    Neurology India

    2022  Volume 70, Issue 2, Page(s) 760–763

    Abstract: Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi. The diagnosis of scrub typhus relies on the patient's history of exposure, clinical manifestations, and results of serological tests. Our patient had a history of altered ... ...

    Abstract Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi. The diagnosis of scrub typhus relies on the patient's history of exposure, clinical manifestations, and results of serological tests. Our patient had a history of altered sensorium, inability to walk, and macular rashes predominantly distributed over the chest and bilateral upper limbs. Post serological testing, the patient was referred to the radiology department for MRI brain. Radiologically, MRI being a superior modality helps in the evaluation of lesions in depth, helping to simplify the diagnosis of meningitis, scrub typhus encephalitis, and other related conditions. Various findings have been described in scrub typhus encephalitis in MR brain imaging, and our case shows an unusual finding in brain imaging.
    MeSH term(s) Encephalitis/diagnostic imaging ; Fever ; Humans ; Magnetic Resonance Imaging ; Orientia tsutsugamushi ; Scrub Typhus/diagnosis ; Scrub Typhus/diagnostic imaging
    Language English
    Publishing date 2022-05-09
    Publishing country India
    Document type Case Reports
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.344648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Torsion of an appendiceal mucocele.

    Primrose, Sebastian John Ross / Chen, Jason Haomin / Sethi, Harsheet / Webb, Peita

    ANZ journal of surgery

    2022  Volume 92, Issue 12, Page(s) 3364–3365

    Language English
    Publishing date 2022-03-29
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.17671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Capsular bag phimosis.

    Naik, Mayuresh / Sethi, HarinderSingh / Mehta, Anuj

    American journal of ophthalmology case reports

    2020  Volume 20, Page(s) 100999

    Abstract: A 60year old male presented with insidious onset, gradually progressive, painless diminution of vision in the right eye since a year. He was operated for cataract about 7 years ago. However, details of surgery or intraocular lens (IOL) were unavailable. ... ...

    Abstract A 60year old male presented with insidious onset, gradually progressive, painless diminution of vision in the right eye since a year. He was operated for cataract about 7 years ago. However, details of surgery or intraocular lens (IOL) were unavailable. Fellow eye was unremarkable. Examination revealed a visual acuity of FC at 5 mts. Slit-lamp examination revealed a quiet anterior chamber without any cells-flare nor any posterior synechiae. Co-axial retro-illumination revealed an in-the-bag IOL, having both haptics folded on the optic with scarring and contraction of the capsular bag, most apparent in the centre. Fundus examination with indirect ophthamoloscopy was difficult owing to the media haze due to capsular scarring but retina was unremarkable as far as could be seen. A diagnosis of "Capsular Bag Phimosis"1,2,3,4 was made. An ASOCT demonstrated such severe moulding of the IOL that a simple YAG capsulotomy may have increased visual acuity but would have lead to severe image distortion, metamorphopsia and resultant aniseikonia. IOL was explanted alongwith the phimosed capsular bag and a Scleral-fixated IOL was placed to achieve a final BCVA 20/20P Snellen.
    Language English
    Publishing date 2020-12-03
    Publishing country United States
    Document type Journal Article
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2020.100999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Modified bandage-contact-lens used as a guide-marker for performing continuous-curvilinear-capsulorhexis by a first-year-post-graduate-ophthalmology-resident.

    Naik, Mayuresh P / Sethi, HarinderSingh / Kasiviswanathan, Pulkit

    American journal of ophthalmology case reports

    2020  Volume 20, Page(s) 100889

    Abstract: Purpose: To define the use of modified bandage-contact-lens as a guide-marker for performing continuous-curvilinear-capsulorhexis by a first-year-post-graduate-ophthalmology-resident.: Observation: Phacoemulsification has now become the standard ... ...

    Abstract Purpose: To define the use of modified bandage-contact-lens as a guide-marker for performing continuous-curvilinear-capsulorhexis by a first-year-post-graduate-ophthalmology-resident.
    Observation: Phacoemulsification has now become the standard cataract surgery in which anterior capsulorhexis is the first and most crucial step. A perfect capsulorhexis is difficult to learn and even more difficult to master with a steep learning curve when performed free-hand especially by a first-year post-graduate ophthalmology-resident. There is paucity of simple, single-use, easily portable, cost-effective and affordable devices designed especially for performing CCCs in a safe and reproducible way.In our technique, the bandage contact lens (BCL) is trephined using a 6mm corneal trephine. After topical or peribulbar block (as the case may be), the 6mm-guide-marker (trephined BCL) is placed on the cornea. The CCC is then completed using the edge of the contact-lens as a guide for CCC.
    Conclusion: AND IMPORTANCE: CCC with contact-lens-guide-marker is expected to yield better results in carrying out the procedure more accurately being closer to the target in terms of size, circularity and centration as compared to contact-lens-unassisted conventional CCC. This would eventually facilitate better surgical outcomes and we recommend this to be applied as the standard protocol for first-year post-graduate ophthalmology-resident performing the surgery.
    Language English
    Publishing date 2020-08-26
    Publishing country United States
    Document type Case Reports
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2020.100889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hyperoxia evokes pericyte-mediated capillary constriction.

    Hirunpattarasilp, Chanawee / Barkaway, Anna / Davis, Harvey / Pfeiffer, Thomas / Sethi, Huma / Attwell, David

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2022  Volume 42, Issue 11, Page(s) 2032–2047

    Abstract: Oxygen supplementation is regularly prescribed to patients to treat or prevent hypoxia. However, excess oxygenation can lead to reduced cerebral blood flow (CBF) in healthy subjects and worsen the neurological outcome of critically ill patients. Most ... ...

    Abstract Oxygen supplementation is regularly prescribed to patients to treat or prevent hypoxia. However, excess oxygenation can lead to reduced cerebral blood flow (CBF) in healthy subjects and worsen the neurological outcome of critically ill patients. Most studies on the vascular effects of hyperoxia focus on arteries but there is no research on the effects on cerebral capillary pericytes, which are major regulators of CBF. Here, we used bright-field imaging of cerebral capillaries and modeling of CBF to show that hyperoxia (95% superfused O<sub>2</sub>) led to an increase in intracellular calcium level in pericytes and a significant capillary constriction, sufficient to cause an estimated 25% decrease in CBF. Although hyperoxia is reported to cause vascular smooth muscle cell contraction via generation of reactive oxygen species (ROS), endothelin-1 and 20-HETE, we found that increased cytosolic and mitochondrial ROS levels and endothelin release were not involved in the pericyte-mediated capillary constriction. However, a 20-HETE synthesis blocker greatly reduced the hyperoxia-evoked capillary constriction. Our findings establish pericytes as regulators of CBF in hyperoxia and 20-HETE synthesis as an oxygen sensor in CBF regulation. The results also provide a mechanism by which clinically administered oxygen can lead to a worse neurological outcome.
    MeSH term(s) Calcium/metabolism ; Capillaries ; Cerebrovascular Circulation/physiology ; Constriction ; Constriction, Pathologic ; Endothelin-1/metabolism ; Humans ; Hyperoxia/metabolism ; Oxygen/metabolism ; Pericytes/metabolism ; Reactive Oxygen Species/metabolism
    Chemical Substances Endothelin-1 ; Reactive Oxygen Species ; Oxygen (S88TT14065) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-07-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X221111598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1663: Show issues Location:
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  7. Article: Idiopathic Isolated Acquired Steroid Dependent SO Palsy: A Rare Case Report.

    Agarwal, Isha / Naik, Mayuresh / Sethi, HarinderSingh

    Case reports in ophthalmological medicine

    2019  Volume 2019, Page(s) 4812380

    Abstract: 15-year-old boy presented with sudden onset, stable, nonprogressive painless diplopia (greatest in right gaze and inferior field of view) and hyperdeviation of left eye for a year. On ophthalmic examination, the patient had uncrossed diplopia with tilt ... ...

    Abstract 15-year-old boy presented with sudden onset, stable, nonprogressive painless diplopia (greatest in right gaze and inferior field of view) and hyperdeviation of left eye for a year. On ophthalmic examination, the patient had uncrossed diplopia with tilt and separation maximum in dextrodepression. On Park's three step test, left eye hypertropia increased on right gaze and left tilt suggestive of left superior oblique (SO) palsy. On prism bar cover test (PBCT), deviation was more than 25 PD base-down over the left eye for both distance and near in all gazes. MRI head and orbit revealed a normal study while the myasthenia and inflammatory work-up was unremarkable. A provisional diagnosis of "Idiopathic Acquired Left Superior Oblique Palsy" was made and the patient was given trial of oral steroids at 1 mg/kg body weight. At 6 weeks, patient's diplopia resolved and PBCT neutralised at 6PD. Oral steroids were gradually tapered off by 10 mg per week with weekly follow-up. Upon decreasing the dose of prednisolone to 5 mg, intermittent diplopia and 18 PD left hypertropia reappeared. When patient was again restarted on oral steroids at 1 mg/kg body weight, diplopia-hypertropia disappeared at 10 mg OD prednisolone only to reappear at 5 mg OD dosage, leading to the final diagnosis of a "Steroid Dependent Isolated Superior Oblique Palsy". Presently, the patient is maintained on a daily dose of 10 mg oral prednisolone.
    Language English
    Publishing date 2019-01-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2659091-8
    ISSN 2090-6730 ; 2090-6722
    ISSN (online) 2090-6730
    ISSN 2090-6722
    DOI 10.1155/2019/4812380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Syndrome 'X' - Reflection of an 'Endangered Gender'?

    Deb, P / Sethi, H

    Medical journal, Armed Forces India

    2011  Volume 63, Issue 1, Page(s) 95

    Language English
    Publishing date 2011-07-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 196342-9
    ISSN 0377-1237
    ISSN 0377-1237
    DOI 10.1016/S0377-1237(07)80130-4
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  9. Article: The Revaccination of Ty 21a.

    Sethi, H / Keshavamurthy, G

    Medical journal, Armed Forces India

    2011  Volume 61, Issue 1, Page(s) 95

    Language English
    Publishing date 2011-07-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 196342-9
    ISSN 0377-1237
    ISSN 0377-1237
    DOI 10.1016/S0377-1237(05)80143-1
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  10. Article: Needle capsulorhexis in intumescent white cataract using slow injecting viscoelastic device through an anterior chamber maintainer.

    Rahar, S / Sethi, H / Sethi, H / Gupta, V S

    Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH

    2011  Volume 3, Issue 2, Page(s) 214–215

    MeSH term(s) Anterior Chamber ; Capsulorhexis/instrumentation ; Capsulorhexis/methods ; Cataract ; Humans ; Injections, Intraocular/methods ; Needles ; Viscoelastic Substances/administration & dosage
    Chemical Substances Viscoelastic Substances
    Language English
    Publishing date 2011-08-26
    Publishing country Nepal
    Document type Letter
    ZDB-ID 2596436-7
    ISSN 2091-0320 ; 2072-6805
    ISSN (online) 2091-0320
    ISSN 2072-6805
    DOI http://dx.doi.org/10.3126/nepjoph.v3i2.5282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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