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Article: Extensive Metastatic Vascular Calcification in a Patient with Chronic Renal Failure and Tubercular Osteomyelitis as Seen on F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.

Prakash, Sneha / Damle, Nishikant Avinash / Sethi, Prayas / Jana, Manisha

Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India

2023 Volume 38, Issue 1, Page(s) 74–75

Abstract: A 48-year-old male with known tubercular osteomyelitis of the left elbow and chronic renal failure presented with PTH independent hypercalcemia and underwent F-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) to look for ... ...

Abstract	A 48-year-old male with known tubercular osteomyelitis of the left elbow and chronic renal failure presented with PTH independent hypercalcemia and underwent F-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) to look for any underlying malignancy that might be causing his hypercalcemia. The PET/CT did not reveal any malignancy, but extensive metastatic calcification of small- and medium-sized arteries was noted throughout the body with relative sparing of large vessels. Alkaline tissue such as lungs, gastric mucosa, and kidneys that are usually involved in metastatic calcification were also spared. The underlying pathology for this kind of metastatic calcification was most likely chronic granulomatous disease, which was tubercular osteomyelitis in this patient. We present the PET/CT scan images of this unusual case of metastatic vascular calcification.
Language	English
Publishing date	2023-02-24
Publishing country	India
Document type	Journal Article
ZDB-ID	2181722-4
ISSN	0974-0244 ; 0972-3919
ISSN (online)	0974-0244
ISSN	0972-3919
DOI	10.4103/ijnm.ijnm_131_22
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Article ; Online: Mitochondrial toxicity induced by linezolid causing lactic acidosis.

Sharma, Kunal / Keri, Vishakh C / Kumar, Tirlangi Praveen / Sethi, Prayas / Dass, Jasmita / Mishra, Ritesh Kumar

Tropical doctor

2023 Volume 53, Issue 2, Page(s) 315–316

Abstract: Linezolid-induced lactic acidosis is a rare, but life-threatening complication of a commonly used drug. Patients present with persistent lactic acidosis, hypoglycaemia, high central venous oxygen saturation and shock. Linezolid causes mitochondrial ... ...

Abstract	Linezolid-induced lactic acidosis is a rare, but life-threatening complication of a commonly used drug. Patients present with persistent lactic acidosis, hypoglycaemia, high central venous oxygen saturation and shock. Linezolid causes mitochondrial toxicity due to impaired oxidative phosphorylation. This is evidenced by cytoplasmic vacuolations in the myeloid and erythroid precursors of bone marrow smear as illustrated in our case. Discontinuation of the drug, administration of thiamine and haemodialysis reduces lactic acid levels.
MeSH term(s)	Humans ; Linezolid/adverse effects ; Acidosis, Lactic/chemically induced ; Lactic Acid
Chemical Substances	Linezolid (ISQ9I6J12J) ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2023-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	193169-6
ISSN	1758-1133 ; 0049-4755
ISSN (online)	1758-1133
ISSN	0049-4755
DOI	10.1177/00494755231159292
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Article: Plasma Cell Disorders in HIV Infected Patients: A Case Series.

Anuradha, S / Sethi, Prayas

Journal of clinical and diagnostic research : JCDR

2017 Volume 11, Issue 6, Page(s) OR03–OR05

Abstract: People Living with HIV (PLHIV) are at an increased risk of developing malignancies. Plasma cell disorders are also reported with increased incidence in PLHIV compared to the general population. Here, we describe three different plasma cell disorders ... ...

Abstract	People Living with HIV (PLHIV) are at an increased risk of developing malignancies. Plasma cell disorders are also reported with increased incidence in PLHIV compared to the general population. Here, we describe three different plasma cell disorders among PLHIV and highlight their atypical presentations and outcomes in these subjects.
Language	English
Publishing date	2017-06-01
Publishing country	India
Document type	Case Reports
ZDB-ID	2775283-5
ISSN	0973-709X ; 2249-782X
ISSN (online)	0973-709X
ISSN	2249-782X
DOI	10.7860/JCDR/2017/25978.10103
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Article ; Online: Effect of volume of instillate on the diagnostic utility of bronchoalveolar lavage galactomannan in patients with suspected chronic pulmonary aspergillosis-A pilot study.

Ajayababu, Anuj / Singh, Gagandeep / Meena, Ved Prakash / Upadhyay, Ashish Datt / Rana, Bhaskar / Sethi, Prayas / Prakash, Bindu / Singh, Amandeep / Vyas, Surabhi / Sinha, Sanjeev / Xess, Immaculata / Wig, Naveet / Kabra, Sushil Kumar / Ray, Animesh

Mycoses

2024 Volume 67, Issue 1, Page(s) e13695

Abstract: Background: Bronchoalveolar lavage (BAL) galactomannan (GM) is commonly used to diagnose Aspergillus-related lung diseases. However, unlike serum GM, which is measured in undiluted blood, BAL-GM is estimated using variable aliquots and cumulative volume ...

Abstract	Background: Bronchoalveolar lavage (BAL) galactomannan (GM) is commonly used to diagnose Aspergillus-related lung diseases. However, unlike serum GM, which is measured in undiluted blood, BAL-GM is estimated using variable aliquots and cumulative volume of instillates during bronchoscopy. Objective: Since different studies have reported varying diagnostic accuracy and cut-offs for BAL-GM in CPA, we hypothesized that the total volume of instillate and 'order/label' of aliquots significantly affects the BAL-GM values, which was evaluated as part of this study. Patients & methods: We obtained 250 BAL samples from 50 patients (five from each) with suspected chronic pulmonary aspergillosis. BAL fluid was collected after instilling sequential volumes of 40 mL of normal saline each for the first four labels and a fifth label was prepared by mixing 1 mL from each of the previous labels. The GM level of each label was measured by PLATELIA™ ASPERGILLUS Ag enzyme immunoassay. This study measured the discordance, level of agreement, diagnostic characteristics (sensitivity, specificity and AUROC) and best cut-offs for BAL-GM in the different aliquots of lavage fluid. Results: The study population, classified into CPA (28%) and non-CPA (72%) groups, based on ERS/ESCMID criteria (excluding BAL-GM) were not different with respect to clinico-radiological characteristics. The discordance of BAL-GM positivity (using a cut-off of >1) between the serial labels for the same patient ranged between 10% and 22%, while the discordance between classification using BAL-GM positivity (using a cut-off of ≥1) and clinic-radio-microbiological classification ranged between 18% and 30%. The level of agreement for serial labels was at best fair (<0.6 for all except one 'label'). The AUROC for the serial samples ranged between 0.595 and 0.702, with the '40 mL and the 'mix' samples performing the best. The best BAL-GM cut-off also showed significant variation between serial labels of varying dilutions (Range:1.01 - 4.26). Interpretation: This study highlights the variation in BAL-GM measured and the 'positivity' between different 'labels' of aliquots of BAL, with the first aliquot and the mixed sample showing the best performances for diagnosis of CPA. Future studies should attempt to 'standardise' the instilled volume for BAL-GM estimation to standardise the diagnostic yield.
MeSH term(s)	Humans ; Pilot Projects ; Sensitivity and Specificity ; Pulmonary Aspergillosis/diagnosis ; Bronchoalveolar Lavage ; Bronchoalveolar Lavage Fluid/microbiology ; Mannans ; Persistent Infection ; Invasive Pulmonary Aspergillosis/diagnosis ; Invasive Pulmonary Aspergillosis/microbiology ; Galactose/analogs & derivatives
Chemical Substances	galactomannan (11078-30-1) ; Mannans ; Galactose (X2RN3Q8DNE)
Language	English
Publishing date	2024-01-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392487-7
ISSN	1439-0507 ; 0933-7407
ISSN (online)	1439-0507
ISSN	0933-7407
DOI	10.1111/myc.13695
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Article ; Online: Utility of nasal application of lignocaine gel using cotton tip swab versus squirting with slip-tip syringe for transnasal fibreoptic bronchoscopy: a pilot randomised controlled trial.

Ray, Animesh / Biswas, Sagnik / Manjunath, Mouna B / Meena, Ved Prakash / Sethi, Prayas / Sinha, Sanjeev

Postgraduate medical journal

2021 Volume 98, Issue 1163, Page(s) 675–679

Abstract: Background: During flexible fibreoptic bronchoscopy through the nasal route, anaesthesia of the nasal passage is achieved by lignocaine gel application by a slip-tip syringe or with the help of a cotton tip swab. No studies in existing literature have ... ...

Abstract	Background: During flexible fibreoptic bronchoscopy through the nasal route, anaesthesia of the nasal passage is achieved by lignocaine gel application by a slip-tip syringe or with the help of a cotton tip swab. No studies in existing literature have compared the two techniques in terms of efficacy. Methods: 137 consecutive patients undergoing bronchoalveolar lavage (BAL) were recruited over a 2-year period. The patients underwent BAL after nasal anaesthesia-either by slip-tip syringe or by cotton tip swab smeared with 2% lignocaine gel. Patients were monitored for intraprocedural epistaxis, discomfort and improvement in operator visibility of nasal passage. Results: 67 patients were randomised to cotton swab and 70 patients to the gel instillation group. There were no significant differences in terms of epistaxis, 29.9% in the cotton tip swab (95% CI 19.3% to 42.3%) versus 24.3% in the gel instillation group (95% CI 14.8% to 36%) or detection of nasal blocks, 7.5% in the cotton tip swab (95% CI 2.5% to 16.6%) versus 10% in the gel instillation group (95% CI 4.1% to 19.5%) in the two groups, although a significant difference was there in terms of visibility, 73.1% in the cotton tip swab (95% CI 60.9% to 83.2%) versus 42.9% in the gel instillation group (95% CI 31.1% to 55.3%). There was no difference in the mean pain score across the two groups either during the procedure or 1 hour after it. A short systematic review of existing literature on the topic has been provided for comparison. Conclusion: Application of 2% lignocaine gel by slip-tip syringe and cotton tip swab are equivalent in terms of observed and narrated pain experienced by patients, frequency of epistaxis and nasal blocks. Vision was better preserved in the cotton tip swab group.
MeSH term(s)	Bronchoscopy/methods ; Epistaxis ; Humans ; Lidocaine ; Pain/etiology ; Pain/prevention & control ; Pilot Projects ; Syringes
Chemical Substances	Lidocaine (98PI200987)
Language	English
Publishing date	2021-05-26
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	80325-x
ISSN	1469-0756 ; 0032-5473
ISSN (online)	1469-0756
ISSN	0032-5473
DOI	10.1136/postgradmedj-2020-139626
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Article ; Online: 'Locked-in' despite slow treatment: pontine and extrapontine demyelination in hypernatraemic encephalopathy.

Narayan, Ananthu / Arora, Umang / Garg, Prerna / Sethi, Prayas / Kumar, Arvind / Wig, Naveet

Internal medicine journal

2021 Volume 51, Issue 9, Page(s) 1545–1546

MeSH term(s)	Brain Diseases ; Humans ; Magnetic Resonance Imaging ; Myelinolysis, Central Pontine/diagnostic imaging ; Myelinolysis, Central Pontine/etiology
Language	English
Publishing date	2021-09-19
Publishing country	Australia
Document type	Letter
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.15475
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Article ; Online: Decentralizing COVID-19 care-Moving towards a COVID-19-capable healthcare system (CCHS).

Keri, Vishakh C / Brunda, R L / Jorwal, Pankaj / Sethi, Prayas / Wig, Naveet

The International journal of health planning and management

2021 Volume 36, Issue 4, Page(s) 1355–1361

MeSH term(s)	COVID-19/prevention & control ; COVID-19/therapy ; Delivery of Health Care/methods ; Delivery of Health Care/organization & administration ; Humans ; Models, Organizational ; Politics
Language	English
Publishing date	2021-04-07
Publishing country	England
Document type	Letter
ZDB-ID	632786-2
ISSN	1099-1751 ; 0749-6753
ISSN (online)	1099-1751
ISSN	0749-6753
DOI	10.1002/hpm.3158
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Article: Indian medical student perspectives on online mode of education.

Singh, Amandeep / Jadon, Ranveer S / Baitha, Upendra / Sethi, Prayas / Kaur, Harleen / Kumar, Arvind / Ranjan, Piyush / Wig, Naveet

Journal of family medicine and primary care

2022 Volume 11, Issue 7, Page(s) 3915–3922

Abstract: Purpose: The coronavirus pandemic has led to drastic changes in the education system globally. The medical education curriculum has also undergone a significant drift from traditional or physical classes to online classes. The study aims to explore the ... ...

Abstract	Purpose: The coronavirus pandemic has led to drastic changes in the education system globally. The medical education curriculum has also undergone a significant drift from traditional or physical classes to online classes. The study aims to explore the viewpoints of the Indian medical students toward online classes, their ramifications, and suggestions for improvement. Methods: The self-administered online questionnaire using the Google form was developed, validated, and circulated among students of All India Institute of Medical Sciences (AIIMS), New Delhi. The data of the survey were systematically analyzed by descriptive statistics. Results: A total of 223 students filled the Google form. After applying the inclusion and exclusion criteria, 171 students were finalized, and the analysis was done. The data suggested that 49.7% of the participants were facing technical glitches, poor Internet connectivity being the commonest. Eye straining (56.7%) was the major physical health hazard, whereas lack of concentration (53.8%) was the major psychological issue reported by the students. The major advantage of online classes reported was its accessibility (93%) at any time and place, whereas students also reported that the traditional learning method is more interactive and motivating (72.5%). Overall, 72.5% of the students wanted to continue both modes of education after the coronavirus disease (COVID-19) pandemic. Conclusion: As per the analysis of the results, it is concluded that, since both online and offline modes of education have advantages and disadvantages, henceforth, mixed or blended method of learning is the best form of learning medical science.
Language	English
Publishing date	2022-07-22
Publishing country	India
Document type	Journal Article
ZDB-ID	2735275-4
ISSN	2278-7135 ; 2249-4863
ISSN (online)	2278-7135
ISSN	2249-4863
DOI	10.4103/jfmpc.jfmpc_2158_21
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Article: Awareness, Beliefs and Perspectives Regarding Weight Retention and Weight Gain among Postpartum Women in India: A Thematic Analysis of Focus Group Discussions and In-Depth Interviews.

Kaur, Divjyot / Ranjan, Piyush / Kumari, Archana / Malhotra, Anita / Kaloiya, Gauri Shankar / Meena, Ved Prakash / Sethi, Prayas / Vikram, Naval K

Journal of obstetrics and gynaecology of India

2022 Volume 72, Issue 2, Page(s) 168–174

Abstract: Background and aims: The pregnancy weight is usually retained in the form of abdominal fat during the postpartum period. The willingness to lose weight is influenced by knowledge, attitude, beliefs and practices. This study aims to comprehend the ... ...

Abstract	Background and aims: The pregnancy weight is usually retained in the form of abdominal fat during the postpartum period. The willingness to lose weight is influenced by knowledge, attitude, beliefs and practices. This study aims to comprehend the awareness, beliefs and perspectives of postpartum women regarding their perceived factors, barriers and facilitators associated with post-pregnancy weight status. Methods: Overweight and obese postpartum women aged between 20 and 40 years and had delivered an infant in the last 2 years were recruited via convenience and purposive sampling techniques. The final sample comprised 27 participants with a mean age of 29.96 ± 4.50 years. Four focus group discussions and eight in-depth interviews carried out were audio-recorded and transcribed verbatim. Codes, sub-themes and themes were generated using Results: Major themes identified were perceived factors causing postpartum weight retention/weight gain including social and cultural beliefs related to diet and exercise specifically associated with this period, perceived motivators and deterrents of weight loss including eagerness to lose weight and perceived facilitators and barriers to weight loss including intrinsic and extrinsic factors such as time, energy, evidence-based knowledge about diet and physical activity, family support and obligation to family's advice. Conclusion: The unique challenges and barriers associated with postpartum weight loss efforts should be taken into consideration by healthcare professionals and public health policy-makers to design strategies specific to postpartum women. Supplementary information: The online version contains supplementary material available at 10.1007/s13224-022-01644-9.
Language	English
Publishing date	2022-03-17
Publishing country	India
Document type	Journal Article
ZDB-ID	410688-x
ISSN	0971-9202 ; 0022-3190
ISSN	0971-9202 ; 0022-3190
DOI	10.1007/s13224-022-01644-9
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Article: Malarial Antibodies and Endemicity: Does It Affect SARS-CoV-2 Severity and Outcomes?

Sethi, Prayas / Ghosh, Tamoghna / Chowdhury, Souradeep / Bir, Raunak / Verma, Nishant / Pandey, Shivam / Subramanian, Arulselvi / Meena, Ved / Nischal, Neeraj / Bhattacharjee, Sulagna / Aravindan, Ajisha / Anand, Rahul K / Goswami, Devalina / Aggarwal, Richa / Wig, Naveet

Cureus

2023 Volume 15, Issue 10, Page(s) e46871

Abstract: Background India has a disproportionately lower rate of coronavirus disease 2019 (COVID-19) severe disease and lower death rates with respect to other parts of the world. It has been proposed that malaria-endemic countries such as India are relatively ... ...

Abstract	Background India has a disproportionately lower rate of coronavirus disease 2019 (COVID-19) severe disease and lower death rates with respect to other parts of the world. It has been proposed that malaria-endemic countries such as India are relatively protected against severe COVID-19 disease and deaths. Methods This was a cross-sectional, analytical, observational study conducted from August 2020 to July 2021 at a tertiary care COVID-19-designated center in New Delhi, India. It aimed to study the association between antimalarial antibody levels and COVID-19 disease severity and outcomes. Results One hundred forty-six patients were included in the final analysis. The mean (standard deviation {SD}) age of the study population was 44.6 (17.2) years, and there were 85 (58.2%) males. Sixty-five patients had mild disease, 14 patients had moderate disease, and 67 patients had severe disease at the time of enrolment in the study. Forty-six patients expired during the hospital stay. For the antimalarial antibody, there was a statistically significant difference between mild and moderate (p=0.018), mild and severe (p=0.016), and mild and combined moderate and severe diseases (p=0.013). However, there was no difference between the patients who survived and those who did not. Conclusion Antimalarial antibody levels may not be associated with the outcomes of COVID-19 during hospital stay. However, this study has provided some insights into the relationship between the severity and outcomes of COVID-19 and the levels of antimalarial antibodies.
Language	English
Publishing date	2023-10-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.46871
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