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  1. Article ; Online: Destructive disasters, trauma, crush syndrome, and beyond.

    Sever, Mehmet Sükrü / Katı, Yusuf Alper / Özkaya, Ufuk

    Acta orthopaedica et traumatologica turcica

    2024  Volume 57, Issue 6, Page(s) 305–314

    Abstract: Orthopedic injuries, especially fractures of long bones as well as multiple fractures and comminuted fractures, are very common after destructive disasters (e.g., earthquakes, wars, and hurricanes). Another frequent problem is traumatic rhabdomyolysis, ... ...

    Abstract Orthopedic injuries, especially fractures of long bones as well as multiple fractures and comminuted fractures, are very common after destructive disasters (e.g., earthquakes, wars, and hurricanes). Another frequent problem is traumatic rhabdomyolysis, which may result in crush syndrome, the second most frequent cause of death after direct traumatic impact following earthquakes. To improve outcomes, interventions should be initiated even before extrication of the victims, which include maintenance of airway patency and spine stabilization, stopping traumatic bleeding by any means, and initiating fluid resuscitation. On-site amputations have been extensively debated to liberate the victims if the release of trapped limbs is impossible. Early after the rescue, a primary survey and triage are performed, a fluid resuscitation policy is planned, complications are treated, the wounds are decontaminated, and the victim is transported to specialized hospitals. A triage and primary survey are also performed at admission to the hospitals, which are followed by a secondary survey, physical, laboratory, and imaging examinations. Washing and cleaning of the soft-tissue injuries and debridement in open, necrotic wounds are vital. Applications of fasciotomies and amputations are controversial since they are associated with both benefits and serious complications; therefore, clear indications should be defined. Crush syndrome has been described as the presence of systemic manifestations following traumatic rhabdomyolysis, the most important component of which is acute kidney injury that may contribute to fatal hyperkalemia. The overall mortality rate is around 20% in crushed patients, which underlines the importance of prevention. Treatment includes maintaining of fluid electrolyte and acid-base balance, application of dialysis, and also prevention and treatment of complications. The principles and practices in disaster medicine may differ from those applied in routine practice; therefore, organizing repeated training courses may be helpful to provide the most effective healthcare and to save as many lives as possible after mass disasters.
    MeSH term(s) Humans ; Crush Syndrome/therapy ; Crush Syndrome/complications ; Disasters ; Acute Kidney Injury/etiology ; Rhabdomyolysis/diagnosis ; Rhabdomyolysis/etiology ; Rhabdomyolysis/therapy ; Fractures, Bone/complications
    Language English
    Publishing date 2024-03-07
    Publishing country Turkey
    Document type Journal Article
    ISSN 2589-1294
    ISSN (online) 2589-1294
    DOI 10.5152/j.aott.2023.23147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Recommendations for the management of crush victims in mass disasters

    Sever, Mehmet Şükrü

    (Nephrology, dialysis, transplantation ; 27, Suppl. 1)

    2012  

    Author's details workgroup co-chairs: Mehmet Sukru Sever
    Series title Nephrology, dialysis, transplantation ; 27, Suppl. 1
    Collection
    Language English
    Size X, i67 S. : Ill.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017476183
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Facts and myths about altruistic organ donation.

    Sever, Mehmet Sukru / Mueller, Thomas F / Oniscu, Gabriel C / Schena, Paolo / Vanholder, Raymond

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2024  

    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfae039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: The crush syndrome (and lessons learned from the Marmara earthquake)

    Sever, Mehmet Şükrü

    2005  

    Author's details Mehmet Şükrü Sever
    Keywords Crush-Syndrom
    Subject Quetschungs-Syndrom ; Verschüttungs-Syndrom ; Muskelzerfalls-Syndrom ; Myorenales Syndrom ; Tubulovaskuläres Syndrom
    Language English
    Size 292 S. : Ill., Kt., graph. Darst., 24 cm
    Edition 1. ed. (Engl.)
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    Note Literaturverz. S. 271 - 285
    HBZ-ID HT014926066
    ISBN 3-8055-7921-7 ; 978-3-8055-7921-6
    Database Catalogue ZB MED Medicine, Health

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  5. Article: Body Size and Outcomes in Dialysis and Transplant Patients - Does it Matter?

    Sever, Mehmet Sukru

    Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)

    2016  Volume 37, Issue 2-3, Page(s) 49–53

    Abstract: The terminologies of "body size", "body mass index (BMI)", "body weight", "large BMI" and "obesity" are controversial for defining the effects of "adiposity" or "fat excess" on the outcomes of dialysis and transplant patients. However, probably these ... ...

    Abstract The terminologies of "body size", "body mass index (BMI)", "body weight", "large BMI" and "obesity" are controversial for defining the effects of "adiposity" or "fat excess" on the outcomes of dialysis and transplant patients. However, probably these terminologies will be continued to be used in the future as well, because of being older and simpler terminologies. In the general population obesity is a powerful risk factor for cardiovascular morbidity and mortality, while, it conferred a survival advantage to dialysis patients. However, this may be a oversimplification, since obesity may still be a risk factor in non-sarcopenic hemodialysis patients. Obesity is associated with early post-transplant adverse effects (i.e. delayed graft function, graft failure, wound infections, also transplant costs) and unfavorable graft and patient survival. However, thanks to safer immunosuppressive protocols, recently graft and patient survival is similar in obese as those of the non-obese patients. On the other hand, morbid obesity may still be a cause of unfavorable patient and graft survival. Since obese transplant recipients have better life expectancy as compared to wait-listed hemodialysis patients, they should be transplanted as well, while morbidly obese patients should be asked to lose weight before being placed in the waiting lists.
    MeSH term(s) Body Size ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Kidney Transplantation ; Obesity/complications ; Renal Dialysis ; Treatment Outcome
    Language English
    Publishing date 2016-06-24
    Publishing country North Macedonia
    Document type Journal Article ; Review
    ZDB-ID 2743787-5
    ISSN 1857-8985 ; 1857-9345
    ISSN (online) 1857-8985
    ISSN 1857-9345
    DOI 10.1515/prilozi-2016-0016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Acute kidney injury: highlights from the ERA-EDTA Congress in London.

    Sever, Mehmet Sukru

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2016  Volume 31, Issue 2, Page(s) 181–183

    Abstract: The ERA-EDTA 52nd Congress was held in London, 28-31 May 2015. In the scientific programme, overall, during the symposium, there were 18 lectures, 3 minilectures, 15 free communications and 135 poster presentations on acute kidney injury (AKI). Among ... ...

    Abstract The ERA-EDTA 52nd Congress was held in London, 28-31 May 2015. In the scientific programme, overall, during the symposium, there were 18 lectures, 3 minilectures, 15 free communications and 135 poster presentations on acute kidney injury (AKI). Among many excellent reports and presentations, I selected three hot topics on AKI for the readership of Nephrology Dialysis Transplantation.
    MeSH term(s) Acute Kidney Injury/therapy ; Congresses as Topic ; Humans ; London ; Nephrology/methods ; Renal Dialysis
    Language English
    Publishing date 2016-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfv439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Risk factors, pathogenesis, presentation and management of BK virus infection in kidney transplantation.

    Demir, Erol / Turkmen, Aydin / Sever, Mehmet Sukru

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2021  Volume 36, Issue 6, Page(s) 985–987

    Language English
    Publishing date 2021-05-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfz214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Transplantation-steroid-impaired glucose metabolism: a hope for improvement?

    Sever, Mehmet Sukru

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2014  Volume 29, Issue 3, Page(s) 479–482

    MeSH term(s) Blood Glucose ; Carbohydrate Metabolism/drug effects ; Glucose/metabolism ; Humans ; Hyperglycemia/chemically induced ; Hyperglycemia/prevention & control ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation ; Prednisolone/adverse effects ; Prednisolone/therapeutic use
    Chemical Substances Blood Glucose ; Immunosuppressive Agents ; Prednisolone (9PHQ9Y1OLM) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2014-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gft478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Acute Kidney Injury in Active Wars and Other Man-Made Disasters.

    Sever, Mehmet Sukru / Vanholder, Raymond / Lameire, Norbert

    Seminars in nephrology

    2020  Volume 40, Issue 4, Page(s) 341–353

    Abstract: Acute kidney injury (AKI) is frequent during wars and other man-made disasters, and contributes significantly to the overall death toll. War-related AKI may develop as a result of polytrauma, traumatic bleeding and hypovolemia, chemical and airborne ... ...

    Abstract Acute kidney injury (AKI) is frequent during wars and other man-made disasters, and contributes significantly to the overall death toll. War-related AKI may develop as a result of polytrauma, traumatic bleeding and hypovolemia, chemical and airborne toxin exposure, and crush syndrome. Thus, prerenal, intrinsic renal, or postrenal AKI may develop at the battlefield, in field hospitals, or tertiary care centers, resulting not only from traumatic, but also nontraumatic, etiologies. The prognosis usually is unfavorable because of systemic and polytrauma-related complications and suboptimal therapeutic interventions. Measures for decreasing the risk of AKI include making preparations for foreseeable disasters, and early management of polytrauma-related complications, hypovolemia, and other pathogenetic mechanisms. Transporting casualties initially to field hospitals, and afterward to higher-level health care facilities at the earliest convenience, is critical. Other man-made disasters also may cause AKI; however, the number of patients is mostly lower and treatment possibilities are broader than in war. If there is no alternative other than prolonged field care, the medical community must be prepared to offer health care and even perform dialysis in austere conditions, which in that case, is the only option to decrease the death toll resulting from AKI.
    MeSH term(s) Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Crush Syndrome/epidemiology ; Crush Syndrome/therapy ; Disasters ; Humans ; Kidney ; Renal Dialysis
    Language English
    Publishing date 2020-08-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2020.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Posttransplant Tuberculosis.

    Demir, Erol / Sever, Mehmet Sukru

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2017  Volume 15, Issue Suppl 1, Page(s) 10–15

    Abstract: Tuberculosis is a major problem in the posttransplantation period, because of its high incidence and prevalence, difficulty in diagnosis as well as high risk of morbidity and mortality. In solid-organ transplant recipients, the diagnosis of tuberculosis ... ...

    Abstract Tuberculosis is a major problem in the posttransplantation period, because of its high incidence and prevalence, difficulty in diagnosis as well as high risk of morbidity and mortality. In solid-organ transplant recipients, the diagnosis of tuberculosis is complex because it is paucisymptomatic. Tuberculin skin testing results may be negative, and interferon-gamma release assays may be insufficiently sensitive. Furthermore, imaging technique findings are mostly atypical, and sputum smear results can be negative despite the presence of active disease. Therefore, most tuberculosis cases are overlooked, and thus, treatment initiation is often delayed. The treatment of tuberculosis falls under 2 headings: that of active disease and latent disease. The drugs for treating these 2 entities are similar; however, their protocols are completely different. Active disease in the immunocompetent patient is treated mostly by giving isoniazid, rifampicin, pyrazinamide, and ethambutol for 2 months (intensive phase), followed by isoniazid and rifampicin for 4 months (continuation phase). The treatment of immunosuppressed patients is controversial; a similar protocol or longer duration of treatment has been suggested as compared to immunocompetent patients. Because there is a drug interaction between antituberculosis drugs (rifamycins) and immunosuppressants (calcineurin/mammalian target of rapamycin inhibitors and glucocorticoids), the risk of graft rejection increases during the treatment of tuberculosis. For the treatment of latent tuberculosis, in regions with a high prevalence of tuberculosis, universal prophylaxis with isoniazid for 6 months (preferably 9 months) has been recommended. In countries where the risk of tuberculosis is lower, no prophylaxis has been proposed. We propose that the best solution is to individualize therapy for patients at greatest risk of the disease. To conclude, posttransplant tuberculosis is still an important source of comorbidity in transplant recipients because of its high frequency, problems in diagnosis and treatment and association with increased risk of morbidity and mortality.
    MeSH term(s) Antitubercular Agents/adverse effects ; Antitubercular Agents/therapeutic use ; Delayed Diagnosis ; Drug Therapy, Combination ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Organ Transplantation/adverse effects ; Predictive Value of Tests ; Risk Factors ; Treatment Outcome ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/immunology ; Tuberculosis/microbiology
    Chemical Substances Antitubercular Agents ; Immunosuppressive Agents
    Language English
    Publishing date 2017-02
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.mesot2016.L32
    Database MEDical Literature Analysis and Retrieval System OnLINE

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