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Artikel ; Online: Development of Mosquito-Borne Infectious Disease Prevention Strategies Based on Genetic or Bacterial Manipulation of the Mosquito (Diptera: Culicidae) Host: Introduction.

Severson, David W

2021 Band 58, Heft 5, Seite(n) 1973

Mesh-Begriff(e)	Animals ; Animals, Genetically Modified ; Bacterial Physiological Phenomena ; Culicidae ; Mosquito Vectors ; Vector Borne Diseases/prevention & control
Sprache	Englisch
Erscheinungsdatum	2021-07-20
Erscheinungsland	England
Dokumenttyp	Introductory Journal Article
ZDB-ID	410635-0
ISSN	1938-2928 ; 0022-2585
ISSN (online)	1938-2928
ISSN	0022-2585
DOI	10.1093/jme/tjab092
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Quantitative Trait Locus Determining the Time of Blood Feeding in Culex pipiens (Diptera: Culicidae).

Hickner, Paul V / Mori, Akio / Rund, Samuel S C / Severson, David W

Journal of medical entomology

2022 Band 59, Heft 5, Seite(n) 1500–1506

Abstract: Mosquitoes and other blood feeding arthropods are vectors of pathogens causing serious human diseases, such as Plasmodium spp. (malaria), Wuchereria bancrofti (lymphatic filariasis), Borrelia burgdorferi (Lyme disease), and viruses causing dengue, Zika, ... ...

Abstract	Mosquitoes and other blood feeding arthropods are vectors of pathogens causing serious human diseases, such as Plasmodium spp. (malaria), Wuchereria bancrofti (lymphatic filariasis), Borrelia burgdorferi (Lyme disease), and viruses causing dengue, Zika, West Nile, chikungunya, and yellow fever. Among the most effective strategies for the prevention of vector-borne diseases are those aimed at reducing human-vector interactions, such as insecticide applications and insecticide-treated bed nets (ITNs). In some areas where ITNs are widely used, behavioral adaptations have resulted in mosquitoes shifting their time of blood feeding to earlier or later in the night when the bed nets are not being employed. Little is known about the genetic basis of these behavioral shifts. We conducted quantitative trait locus (QTL) analysis using two strains of Culex pipiens sensu lato with contrasting blood feeding behaviors, wherein the lab adapted Shasta strain blood feeds at any time of the day or night, while the newly established Trinidad strain feeds only at night. We identified a single locus on chromosome 2 associated with the observed variation in feeding times. None of the core clock genes period, timeless, clock, cycle, PAR-domain protein 1, vrille, discs overgrown, cryptochrome 1, or cryptochrome 2 were located within the QTL region. We then monitored locomotor behavior to determine if they differed in their flight activity. The highly nocturnal Trinidad strain showed little daytime activity while the day-feeding Shasta strain was active during the day, suggesting blood feeding behavior and flight activity are physiologically linked.
Mesh-Begriff(e)	Animals ; Cryptochromes/genetics ; Culex/physiology ; Culicidae/genetics ; Feeding Behavior ; Humans ; Mosquito Vectors/genetics ; Quantitative Trait Loci ; Zika Virus/genetics ; Zika Virus Infection
Chemische Substanzen	Cryptochromes
Sprache	Englisch
Erscheinungsdatum	2022-08-17
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	410635-0
ISSN	1938-2928 ; 0022-2585
ISSN (online)	1938-2928
ISSN	0022-2585
DOI	10.1093/jme/tjac118
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: QTL determining the time of blood feeding in Culex pipiens (Diptera: Culicidae)

Hickner, Paul V. / Mori, Akio / Rund , Samuel S.C. / Severson , David W.

Journal of medical entomology. 2022 , v. 59, no. 5

2022

Abstract	Mosquitoes and other blood feeding arthropods are vectors of pathogens causing serious human diseases, such as Plasmodium spp. (malaria), Wuchereria bancrofti (lymphatic filariasis), Borrelia burgdorferi (Lyme disease), and viruses causing dengue, Zika, West Nile, chikungunya, and yellow fever. Among the most effective strategies for the prevention of vector-borne diseases are those aimed at reducing human-vector interactions, such as insecticide applications and insecticide-treated bed nets (ITNs). In some areas where ITNs are widely used, behavioral adaptations have resulted in mosquitoes shifting their time of blood feeding to earlier or later in the night when the bed nets are not being employed. Little is known about the genetic basis of these behavioral shifts. We conducted QTL analysis using two strains of Culex pipiens (L.) sensu lato with contrasting blood feeding behaviors, wherein the lab adapted Shasta strain blood feeds at any time of the day or night, while the newly established Trinidad strain feeds only at night. We identified a single locus on chromosome 2 associated with the observed variation in feeding times. None of the core clock genes period, timeless, clock, cycle, PAR-domain protein 1, vrille, discs overgrown, cryptochrome 1, or cryptochrome 2 were located within the QTL region. We then monitored locomotor behavior to determine if they differed in their flight activity. The highly nocturnal Trinidad strain showed little daytime activity while the day-feeding Shasta strain was active during the day, suggesting blood feeding behavior and flight activity are physiologically linked.
Schlagwörter	Bancroftian filariasis ; Borrelia burgdorferi ; Culex pipiens ; Lyme disease ; Plasmodium ; Wuchereria bancrofti ; blood ; cryptochromes ; dengue ; flight ; humans ; insecticide application ; insecticides ; loci ; malaria ; medical entomology ; yellow fever ; Trinidad and Tobago
Sprache	Englisch
Erscheinungsverlauf	2022-09
Umfang	p. 1500-1506.
Erscheinungsort	Entomological Society of America
Dokumenttyp	Artikel
ZDB-ID	410635-0
ISSN	0022-2585
ISSN	0022-2585
DOI	10.1093/jme/tjac118
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Genome-Wide Transcriptome Profiling Reveals Genes Associated with Meiotic Drive System of <i>Aedes aegypti</i>

Shin, Dongyoung / Behura, Susanta K / Severson, David W

Insects. 2019 Jan. 10, v. 10, no. 1

2019

Abstract: Aedes aegypti is an important mosquito vector of several arboviruses, including dengue, yellow fever, Zika, and Chikungunya, which cause significant human morbidity and mortality globally. In certain populations of this mosquito, a native meiotic drive ... ...

Abstract	Aedes aegypti is an important mosquito vector of several arboviruses, including dengue, yellow fever, Zika, and Chikungunya, which cause significant human morbidity and mortality globally. In certain populations of this mosquito, a native meiotic drive system causes abnormal spermatogenesis that results in highly male-biased progenies from some matings. Although the basic genetics and cytogenetics of the drive mechanism were elucidated, very little is known on a transcriptome level about how the meiotic drive phenotype is expressed in individual males. To address this question, we conducted a whole-genome microarray expression study of testes from a meiotic-drive-carrying strain (T37) in comparison with testes from a non-drive-carrying strain (RED). Based on bioinformatics analyses of the microarray data, we identified 209 genes associated with the meiotic drive phenotype that were significantly differentially expressed between the two strains. K-means cluster analysis revealed nine clusters, in which genes upregulated in T37 testes were assigned to five clusters and genes downregulated in T37 testes were assigned to four clusters. Our data further revealed that genes related to protein translation, phosphorylation, and binding, as well as to G-protein-coupled receptor (GPCR) and peptidase activities, are differentially upregulated in testes from males with the meiotic drive genotype. Based on pathway analysis of these differentially expressed genes, it was observed that the glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway may play a role in the meiotic drive system. Overall, this investigation enhances our understanding of whole-genome gene expression associated with the meiotic drive system in Ae. aegypti.
Schlagwörter	Aedes aegypti ; G-protein coupled receptors ; arboviruses ; bioinformatics ; biosynthesis ; cluster analysis ; dengue ; enzyme activity ; gene expression ; gene expression regulation ; genes ; genotype ; human diseases ; insect vectors ; males ; meiotic drive ; microarray technology ; morbidity ; mortality ; phenotype ; phosphorylation ; spermatogenesis ; testes ; transcriptome ; transcriptomics ; translation (genetics) ; yellow fever
Sprache	Englisch
Erscheinungsverlauf	2019-0110
Erscheinungsort	Multidisciplinary Digital Publishing Institute
Dokumenttyp	Artikel
ISSN	2075-4450
DOI	10.3390/insects10010025
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Genome-Wide Transcriptome Profiling Reveals Genes Associated with Meiotic Drive System of

Shin, Dongyoung / Behura, Susanta K / Severson, David W

Insects

2019 Band 10, Heft 1

Abstract: ... Aedes ... ...

Abstract	Aedes aegypti
Sprache	Englisch
Erscheinungsdatum	2019-01-10
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects10010025
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: DNA Barcoding Analysis of Trinidad

Ali, Renee / Lezcano, Raul Diosany / Jayaraman, Jayaraj / Mohammed, Azad / Carrington, Christine V F / Daniel, Brent / Lovin, Diane D / Cunningham, Joanne M / Severson, David W / Ramsubhag, Adesh

Vector borne and zoonotic diseases (Larchmont, N.Y.)

2024 Band 24, Heft 4, Seite(n) 237–244

Abstract: Background: ...

Abstract	Background:
Mesh-Begriff(e)	Animals ; Female ; Culicidae ; DNA Barcoding, Taxonomic/veterinary ; Mosquito Vectors/genetics ; Mosquito Vectors/anatomy & histology ; Phylogeny ; Trinidad and Tobago
Sprache	Englisch
Erscheinungsdatum	2024-02-02
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2047199-3
ISSN	1557-7759 ; 1530-3667
ISSN (online)	1557-7759
ISSN	1530-3667
DOI	10.1089/vbz.2023.0031
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Genome Investigations of Vector Competence in Aedes aegypti to Inform Novel Arbovirus Disease Control Approaches.

Severson, David W / Behura, Susanta K

Insects

2016 Band 7, Heft 4

Abstract: Dengue (DENV), yellow fever, chikungunya, and Zika virus transmission to humans by a mosquito host is confounded by both intrinsic and extrinsic variables. Besides virulence factors of the individual arboviruses, likelihood of virus transmission is ... ...

Abstract	Dengue (DENV), yellow fever, chikungunya, and Zika virus transmission to humans by a mosquito host is confounded by both intrinsic and extrinsic variables. Besides virulence factors of the individual arboviruses, likelihood of virus transmission is subject to variability in the genome of the primary mosquito vector,
Sprache	Englisch
Erscheinungsdatum	2016-10-30
Erscheinungsland	Switzerland
Dokumenttyp	Review ; Journal Article
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects7040058
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Motif mismatches in microsatellites: insights from genome-wide investigation among 20 insect species.

Behura, Susanta K / Severson, David W

DNA research : an international journal for rapid publication of reports on genes and genomes

2015 Band 22, Heft 1, Seite(n) 29–38

Abstract: We present a detailed genome-wide comparative study of motif mismatches of microsatellites among 20 insect species representing five taxonomic orders. The results show that varying proportions (∼15-46%) of microsatellites identified in these species are ... ...

Abstract	We present a detailed genome-wide comparative study of motif mismatches of microsatellites among 20 insect species representing five taxonomic orders. The results show that varying proportions (∼15-46%) of microsatellites identified in these species are imperfect in motif structure, and that they also vary in chromosomal distribution within genomes. It was observed that the genomic abundance of imperfect repeats is significantly associated with the length and number of motif mismatches of microsatellites. Furthermore, microsatellites with a higher number of mismatches tend to have lower abundance in the genome, suggesting that sequence heterogeneity of repeat motifs is a key determinant of genomic abundance of microsatellites. This relationship seems to be a general feature of microsatellites even in unrelated species such as yeast, roundworm, mouse and human. We provide a mechanistic explanation of the evolutionary link between motif heterogeneity and genomic abundance of microsatellites by examining the patterns of motif mismatches and allele sequences of single-nucleotide polymorphisms identified within microsatellite loci. Using Drosophila Reference Genetic Panel data, we further show that pattern of allelic variation modulates motif heterogeneity of microsatellites, and provide estimates of allele age of specific imperfect microsatellites found within protein-coding genes.
Mesh-Begriff(e)	Animals ; Chromosomes, Insect/genetics ; Genome-Wide Association Study ; Humans ; Insect Proteins/genetics ; Insecta/genetics ; Mice ; Microsatellite Repeats
Chemische Substanzen	Insect Proteins
Sprache	Englisch
Erscheinungsdatum	2015-02
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1212508-8
ISSN	1756-1663 ; 1340-2838
ISSN (online)	1756-1663
ISSN	1340-2838
DOI	10.1093/dnares/dsu036
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Bidirectional promoters of insects: genome-wide comparison, evolutionary implication and influence on gene expression.

Behura, Susanta K / Severson, David W

Journal of molecular biology

2015 Band 427, Heft 2, Seite(n) 521–536

Abstract: Bidirectional promoters are widespread in insect genomes. By analyzing 23 insect genomes we show that the frequency of bidirectional gene pairs varies according to genome compactness and density of genes among the species. The density of bidirectional ... ...

Abstract	Bidirectional promoters are widespread in insect genomes. By analyzing 23 insect genomes we show that the frequency of bidirectional gene pairs varies according to genome compactness and density of genes among the species. The density of bidirectional genes expected based on number of genes per megabase of genome explains the observed density suggesting that bidirectional pairing of genes may be due to random event. We identified specific transcription factor binding motifs that are enriched in bidirectional promoters across insect species. Furthermore, we observed that bidirectional promoters may act as transcriptional hotspots in insect genomes where protein coding genes tend to aggregate in significantly biased (p < 0.001) manner compared to unidirectional promoters. Natural selection seems to have an association with the extent of bidirectionality of genes among the species. The rate of non-synonymous-to-synonymous changes (dN/dS) shows a second-order polynomial distribution with bidirectionality between species indicating that bidirectionality is dependent upon evolutionary pressure acting on the genomes. Analysis of genome-wide microarray expression data of multiple insect species suggested that bidirectionality has a similar association with transcriptome variation across species. Furthermore, bidirectional promoters show significant association with correlated expression of the divergent gene pairs depending upon their motif composition. Analysis of gene ontology showed that bidirectional genes tend to have a common association with functions related to "binding" (including ion binding, nucleotide binding and protein binding) across genomes. Such functional constraint of bidirectional genes may explain their widespread persistence in genome of diverse insect species.
Mesh-Begriff(e)	Animals ; Evolution, Molecular ; Gene Expression ; Gene Order ; Genetic Association Studies/methods ; Genome, Insect ; Insecta/classification ; Insecta/genetics ; Promoter Regions, Genetic ; Protein Binding ; Species Specificity
Sprache	Englisch
Erscheinungsdatum	2015-01-30
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80229-3
ISSN	1089-8638 ; 0022-2836
ISSN (online)	1089-8638
ISSN	0022-2836
DOI	10.1016/j.jmb.2014.11.008
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Mating Competitiveness of Transgenic Aedes aegypti (Diptera: Culicidae) Males Against Wild-Type Males Reared Under Simulated Field Conditions.

Kang, David S / Cunningham, Joanne M / Lovin, Diane D / Chadee, Dave D / Severson, David W

Journal of medical entomology

2020 Band 57, Heft 6, Seite(n) 1775–1781

Abstract: Efforts directed at genetic modification of mosquitoes for population control or replacement are highly dependent on the initial mating success of transgenic male mosquitoes following their release into natural populations. Adult mosquito phenotypes are ... ...

Abstract	Efforts directed at genetic modification of mosquitoes for population control or replacement are highly dependent on the initial mating success of transgenic male mosquitoes following their release into natural populations. Adult mosquito phenotypes are influenced by the environmental conditions experienced as larvae. Semifield studies conducted to date have not taken that under consideration when testing male mating fitness, and have compared mating success of males reared under identical environmental conditions. We performed pairwise mating challenges between males from a genetically modified laboratory strain (BF2) versus males from a recent Trinidad field isolate of Aedes aegypti (L.), a major vector of multiple arboviruses. We utilized larval density and nutrition to simulate environmental stress experienced by the Trinidad males and females. Our results indicated that environmental stress during larval development negatively influenced the competitiveness and reproductive success of males from the Trinidad population when paired with optimum reared BF2 males. Small (0.027 m3) and large (0.216 m3) trials were conducted wherein stressed or optimum Trinidad males competed with optimum BF2 males for mating with stressed Trinidad females. When competing with stress reared Trinidad males, optimum reared BF2 males were predominant in matings with stress reared Trinidad females, and large proportions of these females mated with males of both strains. When competing with optimum reared Trinidad males, no difference in mating success was observed between them and BF2 males, and frequencies of multiple matings were low. Our results indicate that future mating competition studies should incorporate appropriate environmental conditions when designing mating fitness trials of genetically modified males.
Mesh-Begriff(e)	Aedes/physiology ; Animals ; Animals, Genetically Modified/physiology ; Competitive Behavior ; Male ; Sexual Behavior, Animal ; Trinidad and Tobago
Sprache	Englisch
Erscheinungsdatum	2020-06-18
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	410635-0
ISSN	1938-2928 ; 0022-2585
ISSN (online)	1938-2928
ISSN	0022-2585
DOI	10.1093/jme/tjaa111
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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