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  1. Article ; Online: Utility of Indocyanine Green for Sentinel Lymph Node Biopsy in Pediatric Sarcoma and Melanoma.

    Campwala, Insiyah / Vignali, Paolo D A / Seynnaeve, Brittani Kn / Davit, Alexander J / Weiss, Kurt / Malek, Marcus M

    Journal of pediatric surgery

    2024  

    Abstract: Background: Indocyanine green (ICG) is a fluorescent dye with increasing use for adult sentinel lymph node biopsy (SLNB). The utility of ICG in pediatric oncology remains understudied. We aim to describe our experience using ICG for SLNB in pediatrics ... ...

    Abstract Background: Indocyanine green (ICG) is a fluorescent dye with increasing use for adult sentinel lymph node biopsy (SLNB). The utility of ICG in pediatric oncology remains understudied. We aim to describe our experience using ICG for SLNB in pediatrics versus standard blue dye.
    Methods: A retrospective review of pediatric patients with melanoma or sarcoma who underwent SLNB with technetium plus ICG or blue dye from 2014 to 2023 at a large academic children's hospital was conducted.
    Results: Twenty-four patients were included; 58.3% were male with median age 13 years (range 4-21 years). The majority had a melanocytic tumor (91.7%) and 8.3% had sarcoma. All patients received technetium with concomitant blue dye (62.5%) or ICG (37.5%). ICG more reliably identified radioactive SLNs, compared to blue dye (mean 100% vs 78.3 ± 8.3%, p = 0.03). There was no significant difference in median operative time (ICG 82 min [68-203] vs blue dye 93 min [78-105], p = 0.84). Seven patients had positive SLNs (29.2%), with recurrence in 2 patients (8.3%) and 1 death (4.2%). There were no adverse events.
    Conclusion: ICG-directed SLNB in children is a safe and effective alternative to blue dye. Use of ICG did not add to operative time, and more often identified sentinel nodes versus blue dye.
    Type of study: Original Research Article, Retrospective Comparative Study.
    Level of evidence: III.
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2024.03.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rare Tumors: Opportunities and challenges from the Children's Oncology Group perspective.

    Schultz, Kris Ann P / Chintagumpala, Murali / Piao, Jin / Chen, Kenneth S / Shah, Rachana / Gartrell, Robyn D / Christison-Lagay, Emily / Pashnakar, Farzana / Berry, Jesse L / O'Neill, Allison F / Vasta, Lauren M / Flynn, Ashley / Mitchell, Sarah G / Seynnaeve, Brittani Kn / Rosenblum, Jeremy / Potter, Samara L / Kamihara, Junne / Rodriguez-Galindo, Carlos / Hawkins, Douglas S /
    Laetsch, Theodore W

    EJC paediatric oncology

    2023  Volume 2

    Abstract: While all childhood cancers are rare, tumors that are particularly infrequent or underrepresented within pediatrics are studied under the umbrella of the Children's Oncology Group Rare Tumor committee, divided into the Retinoblastoma and Infrequent Tumor ...

    Abstract While all childhood cancers are rare, tumors that are particularly infrequent or underrepresented within pediatrics are studied under the umbrella of the Children's Oncology Group Rare Tumor committee, divided into the Retinoblastoma and Infrequent Tumor subcommittees. The Infrequent Tumor subcommittee has traditionally included an emphasis on globally rare tumors such as adrenocortical carcinoma, nasopharyngeal carcinoma, or those tumors that are rare in young children, despite being common in adolescents and young adults, such as colorectal carcinoma, thyroid carcinoma, and melanoma. Pleuropulmonary blastoma, gonadal stromal tumors, pancreatic tumors including pancreatoblastoma, gastrointestinal stromal tumor, nonmelanoma skin cancers, neuroendocrine tumors, and desmoplastic small round cell tumors, as well as other carcinomas are also included under the heading of the Children's Oncology Group Rare Tumor committee. While substantial challenges exist in rare cancers, inclusion and global collaboration remain key priorities to ensure high quality research to advance care.
    Language English
    Publishing date 2023-07-20
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-610X
    ISSN (online) 2772-610X
    DOI 10.1016/j.ejcped.2023.100024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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