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Article ; Online: ASO Author Reflections: Can Indocyanine Green Increase the Safety of Bile Duct Dissection and Thus Improve Regional Lymphadenectomy in Re-Do Surgery for Incidental Gallbladder Cancer?

Anselmo, Alessandro / Siragusa, Leandro / Materazzo, Marco / Sforza, Daniele / Bacchiocchi, Giulia / Sensi, Bruno / Tisone, Giuseppe

Annals of surgical oncology

2022 Volume 29, Issue 9, Page(s) 5554

MeSH term(s)	Bile Duct Neoplasms/surgery ; Bile Ducts ; Dissection ; Gallbladder Neoplasms/surgery ; Humans ; Indocyanine Green ; Lymph Node Excision
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2022-06-23
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-022-12045-7
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Article ; Online: Indocyanine Green-Guided Laparoscopic Redo Surgery for Incidental T2a Gallbladder Cancer.

Anselmo, Alessandro / Siragusa, Leandro / Materazzo, Marco / Sforza, Daniele / Bacchiocchi, Giulia / Sensi, Bruno / Tisone, Giuseppe

Annals of surgical oncology

2022 Volume 29, Issue 9, Page(s) 5552–5553

MeSH term(s)	Cholecystectomy, Laparoscopic ; Gallbladder Neoplasms/surgery ; Humans ; Incidental Findings ; Indocyanine Green ; Laparoscopy
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2022-06-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-022-11918-1
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Article ; Online: A Low-Grade Appendiceal Mucinous Neoplasia and Neuroendocrine Appendiceal Collision Tumor: A Case Report and Review of the Literature.

Villa, Massimo / Sforza, Daniele / Siragusa, Leandro / Guida, Andrea Martina / Ciancio Manuelli, Matteo / Pirozzi, Brunella Maria / Pocci, Marco / Palmieri, Giampiero / Grande, Michele

The American journal of case reports

2021 Volume 22, Page(s) e927876

Abstract: BACKGROUND Incidental appendiceal neoplasms account for 1-2% of appendectomies. Mucinous neoplasms and carcinoids are the most frequent lesions, with an incidence of 0.6% and 0.3-0.9%, respectively. Appendiceal collision tumors are extremely rare and ... ...

Abstract	BACKGROUND Incidental appendiceal neoplasms account for 1-2% of appendectomies. Mucinous neoplasms and carcinoids are the most frequent lesions, with an incidence of 0.6% and 0.3-0.9%, respectively. Appendiceal collision tumors are extremely rare and result from the proliferation of 2 different cellular lines. This report describes a young woman with a collision tumor composed of a low-grade appendiceal mucinous neoplasia (LAMN) and an appendiceal neuroendocrine tumor (ANET). CASE REPORT A 31-year-old woman was admitted to our institution presenting with abdominal pain and dysuria. After ultrasound assessment of a dilated appendix with wall thickening and distension by anechogenic material, a diagnosis of acute appendicitis was made. The patient, after a period of antibiotic therapy and observation, underwent an urgent laparoscopic appendectomy due to worsening condition. Surprisingly, the histological exam revealed a Tis LAMN extending from the base of the appendix to the resection margins, and a T3 grade-1 ANET, chromogranin-A and synaptophysin-positive, with a Ki67 less than 1%. On the basis of histological examination and European Neuroendocrine Tumor Network guidelines, in light of the positive LAMN resection margin and ANET mesoappendiceal invasion, after multidisciplinary team discussion, an elective laparoscopic hemicolectomy was indicated. The patient is now in good condition following a regular 5-year follow-up. CONCLUSIONS A collision LAMN and ANET is an exceedingly rare condition. The heterogeneity of clinical presentation and lack of solid evidence seem to recommend a tailored management. Laparoscopy is a safe and useful tool in localized mass excision.
MeSH term(s)	Adult ; Appendectomy ; Appendiceal Neoplasms/diagnosis ; Appendiceal Neoplasms/surgery ; Appendicitis ; Appendix/diagnostic imaging ; Appendix/surgery ; Female ; Humans ; Neuroendocrine Tumors
Language	English
Publishing date	2021-02-23
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.927876
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Article ; Online: Acute Appendicitis During Coronavirus Disease 2019 (COVID-19): Increasing Incidence of Complicate Appendicitis, Severity and Length of Hospitalization.

Pellicciaro, Marco / Vanni, Gianluca / Grande, Simona / Materazzo, Marco / Santori, Francesca / DI Cesare, Tatiana / Manuelli, Matteo Ciancio / Sforza, Daniele / Villa, Massimo / Venditti, Dario / Grande, Michele

In vivo (Athens, Greece)

2022 Volume 36, Issue 3, Page(s) 1325–1332

Abstract: Background/aim: COVID-19 is rapidly spreading, and due to the high morbidity and mortality caused by the pandemic many Governments have introduced social restrictions. Those measures combined with infection-related patient anxiety, led to hiding other ... ...

Abstract	Background/aim: COVID-19 is rapidly spreading, and due to the high morbidity and mortality caused by the pandemic many Governments have introduced social restrictions. Those measures combined with infection-related patient anxiety, led to hiding other diseases. The aim of this study was to evaluate the impact of COVID-19 on numbers and severity of acute appendicitis cases referred during the pandemic. Patients and methods: Between March 2019 and March 2021, all patients who underwent appendectomy in Tor Vergata Hospital, Rome were included. Patients were divided in two groups (COVID-19/pre-COVID-19). Clinical features, intraoperative findings, hospital stay, and histologic examination data were included in the retrospective analysis. Results: Out of 334 admitted patients, 36 (10.7%) had a diagnosis of acute appendicitis (COVID-19 group) vs. 59(11.2%) in the pre-COVID-19 group. The COVID-19 group presented significantly longer hospitalization, incidence of appendicular abscess, perforation, and severity of inflammation at univariate analysis p=0.002, p=0.021, p=0.001, p=0.006, p=0.001, respectively. At multivariate analysis, appendicular abscess (p=0.015) and higher serum levels of C reactive protein (p<0.008) were associated with prolonged hospital stay. Conclusion: This study highlights the correlation between COVID-19 pandemic and the severity of acute appendicitis presentations.
MeSH term(s)	Abscess/complications ; Abscess/surgery ; Acute Disease ; Appendicitis/epidemiology ; Appendicitis/surgery ; COVID-19/epidemiology ; Hospitalization ; Humans ; Incidence ; Laparoscopy ; Pandemics ; Retrospective Studies
Language	English
Publishing date	2022-04-27
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.12833
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Article ; Online: Ileal Neuroendocrine Tumor in a Patient with Sclerosing Mesenteritis: Which Came First?

Pathirannehalage Don, Cristine / Sforza, Daniele / Siragusa, Leandro / Sensi, Bruno / Ciancio Manuelli, Matteo / Telesca, Rossana / Savino, Luca / Ferrazzoli, Valentina / Grande, Simona / Villa, Massimo / Grande, Michele

The American journal of case reports

2021 Volume 22, Page(s) e931372

Abstract: BACKGROUND Jejunoileal neuroendocrine tumors (JI-NETs) are rare tumors that can be associated with mesenteric fibrosis. This case report is of an incidental finding of a JI-NET in a patient who was previously misdiagnosed with sclerosing mesenteritis. ... ...

Abstract	BACKGROUND Jejunoileal neuroendocrine tumors (JI-NETs) are rare tumors that can be associated with mesenteric fibrosis. This case report is of an incidental finding of a JI-NET in a patient who was previously misdiagnosed with sclerosing mesenteritis. CASE REPORT A 42-year-old man was admitted to our institution with diffuse abdominal pain and clinical and radiographic signs of bowel obstruction. He had a previous diagnosis of sclerosing mesenteritis, which had been histologically diagnosed after an exploratory laparoscopy performed in 2009 for recurrent acute abdominal pain. He was also annually monitored through computed tomography scans for an incidentally discovered, gradually enlarging mesenteric mass for which a "wait and watch" management approach was adopted. After a period of fasting and observation, the patient underwent an urgent exploratory laparotomy because of his worsening condition. Intraoperatively, an ileocecal resection was performed, along with excision of the known mesenteric mass. The pathology report revealed an ileal NET with nodal metastases within the mesentery and mesenteric tumor deposits (pT3N1). CONCLUSIONS JI-NETs are rare entities, which are usually encountered as incidental findings or in patients with unspecific abdominal pain. Our case represents a probable delayed diagnosis of JI-NET in the context of sclerosing mesenteritis; therefore, a possible association between these 2 conditions should be investigated.
MeSH term(s)	Adult ; Humans ; Intestinal Neoplasms ; Male ; Mesentery ; Neuroendocrine Tumors/complications ; Neuroendocrine Tumors/diagnosis ; Pancreatic Neoplasms ; Panniculitis, Peritoneal/complications ; Panniculitis, Peritoneal/diagnosis
Language	English
Publishing date	2021-06-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.931372
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Article: A Rare Case of Xanthogranulomatous Pyelonephritis with Spontaneous Renocolic Fistula and IVC Thrombosis.

Sforza, Daniele / Siragusa, Leandro / Ciancio Manuelli, Matteo / De Luca, Linda / Sensi, Bruno / Grande, Simona / Argirò, Renato / Nezzo, Marco / Villa, Massimo / Grande, Michele

Case reports in nephrology

2021 Volume 2021, Page(s) 3604017

Abstract: Xanthogranulomatous pyelonephritis (XGPN) is a rare disorder affecting the kidney which can fistulise to the colon in exceptional cases. We herein report a case of XGPN with renocolic fistula and large vessel thrombosis presenting with sepsis and ... ...

Abstract	Xanthogranulomatous pyelonephritis (XGPN) is a rare disorder affecting the kidney which can fistulise to the colon in exceptional cases. We herein report a case of XGPN with renocolic fistula and large vessel thrombosis presenting with sepsis and pulmonary embolism. Preoperative diagnosis and strategic planning resulted in successful management. A 64-year-old woman presented to the emergency department with abdominal pain and a septic condition, corroborated by venous thromboembolism. Workup diagnosed a left renal abscess with calicocolic fistula. Scintigraphy confirmed a nonfunctioning left kidney. The patient underwent inferior vena cava filter placement and staged surgery. The first, damage control procedure was a loop ileostomy. Ten days later, when the patient's conditions improved, she underwent left nephrectomy and left colectomy with primary anastomosis. Finally, a year later, the ileostomy was closed. At follow-up, the patient was well, with unremarkable renal function. Scrupulous diagnostics, multidisciplinary decision making, and staged intervention have been key to optimal outcome.
Language	English
Publishing date	2021-09-07
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627652-5
ISSN	2090-665X ; 2090-6641
ISSN (online)	2090-665X
ISSN	2090-6641
DOI	10.1155/2021/3604017
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Article ; Online: Native Nephrectomy in Patients With Autosomal Dominant Polycystic Kidney Disease Evaluated for Kidney Transplantation.

Anselmo, Alessandro / Iaria, Giuseppe / Pellicciaro, Marco / Sforza, Daniele / Parente, Alessandro / Campisi, Andrea / Cacciatore, Chiara / Calafiore, Eleonora / Pisani, Gennaro / Tisone, Giuseppe

Transplantation proceedings

2019 Volume 51, Issue 9, Page(s) 2914–2916

Abstract: Native nephrectomy (NN) in patients with autosomal dominant polycystic kidney disease (ADPKD) is indicated in cases of recurrent urinary tract infections and hematuria, neoplastic degeneration, and encumbrance. Timing, indication, and surgical approach ... ...

Abstract	Native nephrectomy (NN) in patients with autosomal dominant polycystic kidney disease (ADPKD) is indicated in cases of recurrent urinary tract infections and hematuria, neoplastic degeneration, and encumbrance. Timing, indication, and surgical approach of NN depends on the symptoms or policy of the center. The aim of our study is to evaluate our experience. In our retrospective study, we included 130 patients with a diagnosis of ADPKD from 530 patients evaluated for renal transplantation from 2011 to 2017. We analyzed the etiologic indication, the timing, and the complications of NN. In our cohort, 53 patients underwent open NN, 85% pre-kidney transplantation (KT), 13% post-KT, and only 1 case simultaneous with KT. In the pre-KT group, indications included: major indication was encumbrance in the. In the post-KT group, the major indication was infection followed by encumbrance, which developed after KT. Complications were: 3 cases of bleeding (1 required relaparotomy, 2 evolved into hematoma and radiological derange); 1 iatrogenic iliac artery injury, which was contextually repaired, and 5 cases of incisional hernia. At 35 ± 7.2 months follow-up, patients' survival was 96%; 1 patient died at the induction of anesthesia and 1 patient from sepsis after double NN and removal of nonfunctional transplanted kidney. NN is not without complications and should be performed when clearly indicated. In our experience, we preferred to perform NN before KT.
MeSH term(s)	Adult ; Aged ; Cohort Studies ; Female ; Humans ; Kidney Transplantation/mortality ; Male ; Middle Aged ; Nephrectomy/mortality ; Polycystic Kidney, Autosomal Dominant/mortality ; Polycystic Kidney, Autosomal Dominant/surgery ; Retrospective Studies
Language	English
Publishing date	2019-11-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2019.08.010
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Article ; Online: Liver abscess caused by foreign body ingestion.

Manzia, Tommaso Maria / Sforza, Daniele / Biancone, Livia / Tisone, Giuseppe

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2013 Volume 45, Issue 8, Page(s) 699

MeSH term(s)	Aged ; Contrast Media ; Drainage ; Foreign Bodies/complications ; Foreign-Body Migration/complications ; Gastric Fistula/diagnostic imaging ; Gastric Fistula/surgery ; Humans ; Liver Abscess/diagnostic imaging ; Liver Abscess/microbiology ; Liver Abscess/surgery ; Male ; Radiology, Interventional/methods ; Tomography, X-Ray Computed/methods ; Treatment Outcome
Chemical Substances	Contrast Media
Language	English
Publishing date	2013-08
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2013.01.019
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Article ; Online: Prostate Cancer Recurrence in Kidney Transplant Recipient 15 Years After Radical Prostatectomy: A Case Report.

Sforza, Daniele / Parente, Alessandro / Pellicciaro, Marco / Morabito, Marika / Iaria, Giuseppe / Anselmo, Alessandro / Lindfors, Elisa Rossi / Corrado, Federica / Cacciatore, Chiara / Del Fabbro, Dario / Ingrosso, Gianluca / Tisone, Giuseppe

Transplantation proceedings

2019 Volume 51, Issue 9, Page(s) 2995–2997

Abstract: Incidence of malignant tumors in kidney transplant recipients is higher than nontransplanted population due to many factors, such as immunosuppression therapy and complex donor-recipient interaction. Genitourinary malignancies have been reported as the ... ...

Abstract	Incidence of malignant tumors in kidney transplant recipients is higher than nontransplanted population due to many factors, such as immunosuppression therapy and complex donor-recipient interaction. Genitourinary malignancies have been reported as the second most common malignancy in kidney transplant recipients. In this regard, prostate cancer is the most common neoplasm. Herein, we describe a rare case of prostate cancer recurrence after 15 years in a patient who underwent kidney transplant after radical prostatectomy.
MeSH term(s)	Aged ; Humans ; Immunocompromised Host ; Immunosuppression/adverse effects ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Male ; Neoplasm Recurrence, Local/immunology ; Prostatectomy ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/immunology
Language	English
Publishing date	2019-10-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2019.04.098
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Article: Long-Term SARS-CoV-2 Infection Associated with Viral Dissemination in Different Body Fluids Including Bile in Two Patients with Acute Cholecystitis.

Scutari, Rossana / Piermatteo, Lorenzo / Ciancio Manuelli, Matteo / Iannetta, Marco / Salpini, Romina / Bertoli, Ada / Alteri, Claudia / Saccomandi, Patrizia / Bellocchi, Maria Concetta / Malagnino, Vincenzo / Teti, Elisabetta / Sforza, Daniele / Siragusa, Leandro / Grande, Michele / Sarmati, Loredana / Svicher, Valentina / Andreoni, Massimo / Ceccherini-Silberstein, Francesca

Life (Basel, Switzerland)

2020 Volume 10, Issue 11

Abstract: Our study aimed to investigate the kinetics of SARS-CoV-2 RNA in bile and in different body fluids of two SARS-CoV-2 positive patients with acute cholecystitis by innovative droplet digital PCR (ddPCR) assays. For each patient, nasopharyngeal- and rectal ...

Abstract	Our study aimed to investigate the kinetics of SARS-CoV-2 RNA in bile and in different body fluids of two SARS-CoV-2 positive patients with acute cholecystitis by innovative droplet digital PCR (ddPCR) assays. For each patient, nasopharyngeal- and rectal swabs, bile, urine, and plasma samples were collected at different time points for SARS-CoV-2 RNA quantification by two ddPCR assays. For both patients, ddPCR revealed persistent and prolonged detection of viral RNA in the nasopharyngeal swab despite triple-negative or single-positive results by qRT-PCR. In Patient 1, SARS-CoV-2 RNA dropped more rapidly in bile and rectal-swab and declined slowly in nasopharyngeal swab and plasma, becoming undetectable in all compartments 97 days after symptoms started. Conversely, in patient 2, SARS-CoV-2 RNA was detected, even if at low copies, in all body samples (with the exception of urine) up to 75 days after the onset of symptoms. This study highlights that SARS-CoV-2 RNA can persist for a prolonged time in respiratory samples and in several biological samples despite negativity to qRT-PCR, supporting SARS-CoV-2's ability to provoke persistent and disseminated infection and therefore to contribute to extra-pulmonary clinical manifestations.
Language	English
Publishing date	2020-11-23
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life10110302
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