Article ; Online: Inflammatory profile analysis reveals differences in cytokine expression between smokers, moist snuff users, and dual users compared to non-tobacco consumers.
2017 Volume 107, Page(s) 43–51
Abstract: Objective and design: The aim of this study is to investigate the inflammatory alterations due to the use of smokeless tobacco and dual use of smokeless tobacco and cigarettes, relative to smoking.: Subjects: Plasma and saliva samples were collected ... ...
| Abstract | Objective and design: The aim of this study is to investigate the inflammatory alterations due to the use of smokeless tobacco and dual use of smokeless tobacco and cigarettes, relative to smoking. Subjects: Plasma and saliva samples were collected from healthy smokers (SMK-100 subjects), moist snuff users (MSC-89 subjects), the dual users (DUSMK-49 subjects), and non-tobacco consumers (NTC-99 subjects) from two cross-sectional studies. Methods: Luminex Human InflammationMAP® 1.0 panel, a multiplex immunoassay. Results: SMK and DUSMK exhibited larger number of alterations in the expression of inflammatory analytes compared to NTC. Eight analytes were significantly elevated (p ≤ .05) within plasma samples of SMK compared to NTC, while one 1 analyte was elevated between the MSC and NTC groups. DUSMK exhibited different levels of 11 analytes, relative to NTC. MSC displayed fewer alterations in inflammatory protein expression compared to smoker groups, and the inflammatory profile of MSC resembles NTC. Five analytes (ICAM-1, VEGF, MMP-9, ferritin and fibrinogen) emerged as potential biomarkers distinguishing tobacco consumers (p < .02). Conclusions: We identified a set of five proteins as potential biomarkers that can inform of inflammation status due to tobacco usage. Our findings contribute a better understanding of how the use of different tobacco products contributes to inflammation. |
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| MeSH term(s) | Adult ; Aged ; Biomarkers/analysis ; Biomarkers/blood ; Cross-Sectional Studies ; Cytokines/analysis ; Cytokines/blood ; Female ; Humans ; Inflammation Mediators/analysis ; Inflammation Mediators/blood ; Intercellular Adhesion Molecule-1/analysis ; Intercellular Adhesion Molecule-1/blood ; Male ; Matrix Metalloproteinase 9/analysis ; Matrix Metalloproteinase 9/blood ; Middle Aged ; Saliva/metabolism ; Smoking ; Tobacco, Smokeless ; Vascular Endothelial Growth Factor A/analysis ; Vascular Endothelial Growth Factor A/blood ; Young Adult | |||||
| Chemical Substances | Biomarkers ; Cytokines ; Inflammation Mediators ; Vascular Endothelial Growth Factor A ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) | |||||
| Language | English | |||||
| Publishing date | 2017-12-06 | |||||
| Publishing country | England | |||||
| Document type | Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 1018055-2 | |||||
| ISSN | 1096-0023 ; 1043-4666 | |||||
| ISSN (online) | 1096-0023 | |||||
| ISSN | 1043-4666 | |||||
| DOI | 10.1016/j.cyto.2017.11.013 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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