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Article ; Online: The use of biological membranes for correction of congenital malformations.

Marchetto, C / Sgrò, A / Gamba, P / Trojan, D / Pagliara, C / Midrio, P

2022 Volume 23, Issue 3, Page(s) 607–614

Abstract: Many congenital malformations often require a multidisciplinary and multistep surgical treatment, including the use of biological membranes. Aims of the study were to describe the use of these membranes for the correction of malformations, their clinical ...

Abstract	Many congenital malformations often require a multidisciplinary and multistep surgical treatment, including the use of biological membranes. Aims of the study were to describe the use of these membranes for the correction of malformations, their clinical performance at follow-up, and patient's tolerance to them. The study included patients treated between 2009 and November 2020 in two referral centers. They were affected by abdominal wall defects (AWD), esophageal atresia/tracheo-esophageal fistula (EA/TEF), diaphragmatic hernia (CDH), spinal defects (SD), and anorectal malformations (ARM). The human origin membranes used during surgery were amniotic membrane, fascia lata, and pericardium provided by the local tissue bank and the porcine-derived membrane available on the market. Thirty-one patients were retrieved. The sample included 10 AWD, 7 EA/TEF, 5 CDH, 4 SD, 2 ARM, and 3 miscellaneous defects. The median age at repair was 139 days (range: 10,5-1494). The median follow-up was 1021 days (range: 485,5-1535). Two patients were lost at follow-up. The defects were successfully repaired and the membranes perfectly tolerated in 28/29 cases. In 1 case of CDH the fascia lata was replaced with a Goretex patch due to recurrence of the defect. This is the largest series on the use of biological membranes in congenital malformations. The variety of tissues allows to choose the best material for each malformation. The excellent tolerance and performance of this first series of patients encourage the use of these membranes to correct different type of malformations at any age.
MeSH term(s)	Animals ; Esophageal Atresia/surgery ; Hernias, Diaphragmatic, Congenital/surgery ; Humans ; Retrospective Studies ; Swine ; Tracheoesophageal Fistula/surgery
Language	English
Publishing date	2022-04-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2170897-6
ISSN	1573-6814 ; 1389-9333
ISSN (online)	1573-6814
ISSN	1389-9333
DOI	10.1007/s10561-022-10003-x
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Zs.A 5972: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Impact of World Tuberculosis Day on digital awareness of tuberculosis: analyses using Google Trends™.

Sgrò, A / Ots, R / Brunetti, E

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

2019 Volume 23, Issue 7, Page(s) 824–829

Abstract: BACKGROUND: ...

Abstract	BACKGROUND:
MeSH term(s)	Developing Countries ; Health Knowledge, Attitudes, Practice ; Health Promotion/trends ; Humans ; Internet ; Tuberculosis, Pulmonary/epidemiology ; Tuberculosis, Pulmonary/prevention & control
Language	English
Publishing date	2019-08-22
Publishing country	France
Document type	Journal Article
ZDB-ID	1385624-8
ISSN	1815-7920 ; 1027-3719
ISSN (online)	1815-7920
ISSN	1027-3719
DOI	10.5588/ijtld.18.0618
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Zs.A 4776: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Epigenome engineering: new technologies for precision medicine.

Sgro, Agustin / Blancafort, Pilar

Nucleic acids research

2020 Volume 48, Issue 22, Page(s) 12453–12482

Abstract: Chromatin adopts different configurations that are regulated by reversible covalent modifications, referred to as epigenetic marks. Epigenetic inhibitors have been approved for clinical use to restore epigenetic aberrations that result in silencing of ... ...

Abstract	Chromatin adopts different configurations that are regulated by reversible covalent modifications, referred to as epigenetic marks. Epigenetic inhibitors have been approved for clinical use to restore epigenetic aberrations that result in silencing of tumor-suppressor genes, oncogene addictions, and enhancement of immune responses. However, these drugs suffer from major limitations, such as a lack of locus selectivity and potential toxicities. Technological advances have opened a new era of precision molecular medicine to reprogram cellular physiology. The locus-specificity of CRISPR/dCas9/12a to manipulate the epigenome is rapidly becoming a highly promising strategy for personalized medicine. This review focuses on new state-of-the-art epigenome editing approaches to modify the epigenome of neoplasms and other disease models towards a more 'normal-like state', having characteristics of normal tissue counterparts. We highlight biomolecular engineering methodologies to assemble, regulate, and deliver multiple epigenetic effectors that maximize the longevity of the therapeutic effect, and we discuss limitations of the platforms such as targeting efficiency and intracellular delivery for future clinical applications.
MeSH term(s)	CRISPR-Cas Systems/genetics ; Chromatin/genetics ; DNA Methylation/genetics ; Epigenome/genetics ; Gene Editing ; Genetic Engineering ; Humans ; Precision Medicine/trends
Chemical Substances	Chromatin
Language	English
Publishing date	2020-11-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkaa1000
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Zs.A 1067: Show issues

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Article ; Online: Improving metronidazole prescription practices in surgical patients: a full cycle audit.

Sgrò, Alessandro / Wu, Diana A / Yalamarthi, Satheesh

Postgraduate medical journal

2021 Volume 97, Issue 1151, Page(s) 605–607

Abstract: Introduction: Metronidazole is commonly prescribed for intra-abdominal infections. Oral metronidazole has high bioavailability (>95%) and intravenous metronidazole should be reserved for patients not suitable for oral preparations.: Methods and ... ...

Abstract	Introduction: Metronidazole is commonly prescribed for intra-abdominal infections. Oral metronidazole has high bioavailability (>95%) and intravenous metronidazole should be reserved for patients not suitable for oral preparations. Methods and materials: This full cycle audit evaluated the type of metronidazole preparation prescribed in adult emergency surgical patients requiring first-line empirical antimicrobial therapy for intra-abdominal infections. The criterion for audit was the proportion of patients who were prescribed intravenous metronidazole when the oral route was available. The first cycle included all consecutive eligible patients between 20 April and 14 May 2020. After an intervention phase educating prescribers about the similar pharmacokinetic properties of oral and intravenous metronidazole, clinical practice was reaudited between 22 June and 16 July 2020. Data were collected by case note and drug chart review. Results: A total of 54 patients were included in the first audit cycle. Of these, 11 (20.4%) were prescribed oral metronidazole and 43 (79.6%) were prescribed intravenous metronidazole. In the majority of cases (35/43, 81.4%), intravenous metronidazole was prescribed in the absence of clear contraindications to the oral preparation. Of the 61 patients included in the reaudit cycle, 23 (37.7%) were prescribed oral metronidazole and 38 (62.3%) were prescribed intravenous metronidazole. The proportion of patients prescribed intravenous metronidazole despite being suitable for oral preparation decreased from 81.4% in the first cycle to 34.2% (13/38) in the reaudit cycle (risk ratio 0.42, 95% CI: 0.26 to 0.67, p<0.0001). Prescribing oral metronidazole when suitable saved up to £10.53/day per patient. Conclusion: This full cycle audit led to a significant improvement in the use of oral metronidazole in suitable patients, as well as a considerable reduction in healthcare costs.
MeSH term(s)	Abdominal Abscess/drug therapy ; Administration, Oral ; Aged ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Drug Utilization/statistics & numerical data ; Female ; Health Care Costs ; Humans ; Inappropriate Prescribing/prevention & control ; Intraabdominal Infections/drug therapy ; Male ; Metronidazole/administration & dosage ; Metronidazole/therapeutic use ; Middle Aged ; Peritonitis/drug therapy ; Prescriptions/statistics & numerical data ; Prospective Studies
Chemical Substances	Anti-Bacterial Agents ; Metronidazole (140QMO216E)
Language	English
Publishing date	2021-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	80325-x
ISSN	1469-0756 ; 0032-5473
ISSN (online)	1469-0756
ISSN	0032-5473
DOI	10.1136/postgradmedj-2021-139940
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Ua VI Zs.340: Show issues

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Article ; Online: The applications of ultrasound, and ultrasonography in dentistry: a scoping review of the literature.

Elbarbary, Mohamed / Sgro, Adam / Khazaei, Saber / Goldberg, Michael / Tenenbaum, Howard C / Azarpazhooh, Amir

Clinical oral investigations

2022 Volume 26, Issue 3, Page(s) 2299–2316

Abstract: Objectives: This scoping review aims to summarize the available literature on the clinical applications of ultrasonography and ultrasound in diagnostic, therapeutic, and interventional dental applications.: Materials and methods: We followed the ... ...

Abstract	Objectives: This scoping review aims to summarize the available literature on the clinical applications of ultrasonography and ultrasound in diagnostic, therapeutic, and interventional dental applications. Materials and methods: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, Extension for Scoping Reviews checklist and conducted a protocol-driven scoping review of randomized controlled trials, cohort studies, cross-sectional studies, case-control studies, and case series that assessed ultrasonography or ultrasound use as a stand-alone diagnostic, therapeutic, and interventional tool in dentistry. We included studies published after 1980, study samples ≥ 10, with diagnostic, concordance, or therapeutic outcomes. We searched Ovid MEDLINE, Embase, and others (up to April 2021) and extracted information regarding study level, patient level, test or treatment level, and outcome level data. Results: Five interventional studies (related to oral medicine, temporomandibular disorders, and dental anesthesia), eight therapeutic studies (related to surgery and orthodontics), and seventy-five diagnostic studies (related to orthodontics, surgery, endodontics, oral medicine, temporomandibular disorders, restorative dentistry, and periodontology) were identified and presented in this review. Conclusion: Ultrasonography has a well-established niche in diagnostic dentistry, while therapeutic and interventional ultrasounds have a smaller, yet present, niche in dentistry. However, further research is needed to report the precise estimates of the diagnostic, therapeutic, and interventional effects. Clinical significance: Dentists are mostly unfamiliar with ultrasonography and ultrasound and their potential uses. This review maps the diagnostic and therapeutic applications of ultrasonography and ultrasound technology in dentistry and highlights the current challenges, gaps of knowledge, and research status of ultrasound technology in this regard.
MeSH term(s)	Cross-Sectional Studies ; Dentistry ; Humans ; Oral Medicine ; Orthodontics ; Ultrasonography
Language	English
Publishing date	2022-01-14
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-021-04340-6
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Zs.A 4788: Show issues

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Article: Congenital Diaphragmatic Hernia: Perinatal Prognostic Factors and Short-Term Outcomes in a Single-Center Series.

Pagliara, Camilla / Zambaiti, Elisa / Brooks, Giulia / Bonadies, Luca / Tognon, Costanza / Salvadori, Sabrina / Sgrò, Alberto / Leon, Francesco Fascetti

Children (Basel, Switzerland)

2023 Volume 10, Issue 2

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10020315
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Article ; Online: Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma.

Sgro, Agustin / Cursons, Joseph / Waryah, Charlene / Woodward, Eleanor A / Foroutan, Momeneh / Lyu, Ruqian / Yeoh, George C T / Leedman, Peter J / Blancafort, Pilar

Clinical epigenetics

2023 Volume 15, Issue 1, Page(s) 73

Abstract: Background: Epigenetic silencing of tumor suppressor genes (TSGs) is a key feature of oncogenesis in hepatocellular carcinoma (HCC). Liver-targeted delivery of CRISPR-activation (CRISPRa) systems makes it possible to exploit chromatin plasticity, by ... ...

Abstract	Background: Epigenetic silencing of tumor suppressor genes (TSGs) is a key feature of oncogenesis in hepatocellular carcinoma (HCC). Liver-targeted delivery of CRISPR-activation (CRISPRa) systems makes it possible to exploit chromatin plasticity, by reprogramming transcriptional dysregulation. Results: Using The Cancer Genome Atlas HCC data, we identify 12 putative TSGs with negative associations between promoter DNA methylation and transcript abundance, with limited genetic alterations. All HCC samples harbor at least one silenced TSG, suggesting that combining a specific panel of genomic targets could maximize efficacy, and potentially improve outcomes as a personalized treatment strategy for HCC patients. Unlike epigenetic modifying drugs lacking locus selectivity, CRISPRa systems enable potent and precise reactivation of at least 4 TSGs tailored to representative HCC lines. Concerted reactivation of HHIP, MT1M, PZP, and TTC36 in Hep3B cells inhibits multiple facets of HCC pathogenesis, such as cell viability, proliferation, and migration. Conclusions: By combining multiple effector domains, we demonstrate the utility of a CRISPRa toolbox of epigenetic effectors and gRNAs for patient-specific treatment of aggressive HCC.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Clustered Regularly Interspaced Short Palindromic Repeats ; DNA Methylation ; Epigenesis, Genetic ; Genes, Tumor Suppressor ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic
Language	English
Publishing date	2023-04-29
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553921-8
ISSN	1868-7083 ; 1868-7075
ISSN (online)	1868-7083
ISSN	1868-7075
DOI	10.1186/s13148-023-01482-0
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Article ; Online: Evaluation of remote digital postoperative wound monitoring in routine surgical practice.

McLean, Kenneth A / Sgrò, Alessandro / Brown, Leo R / Buijs, Louis F / Daines, Luke / Potter, Mark A / Bouamrane, Matt-Mouley / Harrison, Ewen M

NPJ digital medicine

2023 Volume 6, Issue 1, Page(s) 85

Abstract: Remote digital postoperative wound monitoring provides an opportunity to strengthen postoperative community care and minimise the burden of surgical-site infection (SSI). This study aimed to pilot a remote digital postoperative wound monitoring service ... ...

Abstract	Remote digital postoperative wound monitoring provides an opportunity to strengthen postoperative community care and minimise the burden of surgical-site infection (SSI). This study aimed to pilot a remote digital postoperative wound monitoring service and evaluate the readiness for implementation in routine clinical practice. This was a single-arm pilot implementational study of remote digital postoperative wound monitoring across two tertiary care hospitals in the UK (IDEAL stage 2b, clinicaltrials.gov: NCT05069103). Adults undergoing abdominal surgery were recruited and received a smartphone-delivered wound assessment tool for 30-days postoperatively. Patients received 30-day postoperative follow-up, including the Telehealth Usability Questionnaire (TUQ). A thematic mixed-methods approach was used, according to the WHO framework for monitoring and evaluating digital health interventions. 200 patients were enroled, of whom 115 (57.5%) underwent emergency surgical procedures. Overall, the 30-day SSI rate was 16.5% (n = 33/200), with 72.7% (n = 24) diagnosed post-discharge. Usage of the intervention was 83.0% (n = 166/200), with subsequently 74.1% (n = 123/166) TUQ completion. There were no issues reported with feasibility of the technology, with the reliability (3.87, 95% CI: 3.73-4.00) and quality of the interface rated highly (4.18, 95%: 4.06-4.30). Patient acceptance was similarly high with regards to ease of use (4.51, 95% CI: 4.41-4.62), satisfaction (4.27, 95% CI: 4.13-4.41), and usefulness (4.07, 95% CI: 3.92-4.23). Despite the desire for more frequent and personalised interactions, the majority viewed the intervention as providing meaningful benefit over routine postoperative care. Remote digital postoperative wound monitoring successfully demonstrated readiness for implementation with regards to the technology, usability, and healthcare process improvement.
Language	English
Publishing date	2023-05-05
Publishing country	England
Document type	Journal Article
ISSN	2398-6352
ISSN (online)	2398-6352
DOI	10.1038/s41746-023-00824-9
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Article ; Online: Increasing the participation of medical students in surgical research: The Italian case and the role of research collaboratives.

Sgrò, A / Simioni, A / Farina, V / Pasquali, S / Pellino, G / Pata, F

International journal of surgery (London, England)

2018 Volume 60, Page(s) 111–112

Language	English
Publishing date	2018-11-07
Publishing country	England
Document type	Letter
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1016/j.ijsu.2018.11.002
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Zs.A 6502: Show issues

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Article: Laparo-endoscopic combination for the safe extraction of an open safety pin in a 9-month-old child. Case report.

Bisoffi, Silvia / Leon, Francesco Fascetti / Zambaiti, Elisa / Sgrò, Alberto / Antoniello, Luca Maria / Gamba, Piergiorgio

Annals of medicine and surgery (2012)

2021 Volume 69, Page(s) 102716

Abstract: Introduction: and importance: Accidental ingestion of foreign bodies (FBs) is common among infants. In case of sharp FBs, the risk of accidental organ damage with potential life-threatening complications constitutes an absolute indication for removal. ... ...

Abstract	Introduction: and importance: Accidental ingestion of foreign bodies (FBs) is common among infants. In case of sharp FBs, the risk of accidental organ damage with potential life-threatening complications constitutes an absolute indication for removal. We present the case of a child, who, following the ingestion of an open safety pin, was successfully treated exclusively with minimally invasive techniques. Case presentation: A 9-month-old male patient was admitted for hematemesis. An anteroposterior and lateral X-ray of the thorax and abdomen revealed the presence of an open safety pin in the epi-mesogastric region, without a precise localization. Upper and lower gastrointestinal endoscopy, fluoroscopy, and laparoscopy were combined in the same intervention to localize and safely remove the foreign body. The patient was dismissed on a postoperative day 1. Clinical discussion and conclusion: The two main pitfalls of this scenario were the initially uncertain location of the foreign body and the young age of the patient. A combination of different techniques was used to safely locate and remove the foreign body, reducing hospitalization and avoiding repeated radiological exposure. An experienced team in a tertiary paediatric surgical and endoscopic centre increases the chances of success and minimizes invasiveness and the risk of complications.
Language	English
Publishing date	2021-08-13
Publishing country	England
Document type	Case Reports
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2021.102716
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