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Article: Congenital Diaphragmatic Hernia: Perinatal Prognostic Factors and Short-Term Outcomes in a Single-Center Series.

Pagliara, Camilla / Zambaiti, Elisa / Brooks, Giulia / Bonadies, Luca / Tognon, Costanza / Salvadori, Sabrina / Sgrò, Alberto / Leon, Francesco Fascetti

Children (Basel, Switzerland)

2023 Volume 10, Issue 2

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10020315
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Article: Laparo-endoscopic combination for the safe extraction of an open safety pin in a 9-month-old child. Case report.

Bisoffi, Silvia / Leon, Francesco Fascetti / Zambaiti, Elisa / Sgrò, Alberto / Antoniello, Luca Maria / Gamba, Piergiorgio

Annals of medicine and surgery (2012)

2021 Volume 69, Page(s) 102716

Abstract: Introduction: and importance: Accidental ingestion of foreign bodies (FBs) is common among infants. In case of sharp FBs, the risk of accidental organ damage with potential life-threatening complications constitutes an absolute indication for removal. ... ...

Abstract	Introduction: and importance: Accidental ingestion of foreign bodies (FBs) is common among infants. In case of sharp FBs, the risk of accidental organ damage with potential life-threatening complications constitutes an absolute indication for removal. We present the case of a child, who, following the ingestion of an open safety pin, was successfully treated exclusively with minimally invasive techniques. Case presentation: A 9-month-old male patient was admitted for hematemesis. An anteroposterior and lateral X-ray of the thorax and abdomen revealed the presence of an open safety pin in the epi-mesogastric region, without a precise localization. Upper and lower gastrointestinal endoscopy, fluoroscopy, and laparoscopy were combined in the same intervention to localize and safely remove the foreign body. The patient was dismissed on a postoperative day 1. Clinical discussion and conclusion: The two main pitfalls of this scenario were the initially uncertain location of the foreign body and the young age of the patient. A combination of different techniques was used to safely locate and remove the foreign body, reducing hospitalization and avoiding repeated radiological exposure. An experienced team in a tertiary paediatric surgical and endoscopic centre increases the chances of success and minimizes invasiveness and the risk of complications.
Language	English
Publishing date	2021-08-13
Publishing country	England
Document type	Case Reports
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2021.102716
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Article ; Online: Thoracoscopy versus thoracotomy for congenital lung malformations treatment: A single center experience.

Ganarin, Alba / Sgrò, Alberto / Garcia Magne, Miguel / Volpe, Andrea / Tognon, Costanza / Gamba, Piergiorgio

Pediatric pulmonology

2020 Volume 56, Issue 1, Page(s) 196–202

Abstract: Introduction: Our aim is to compare thoracoscopy to thoracotomy in the treatment of congenital lung malformations (CLM) in children.: Materials and methods: We report a retrospective monocentric cohort study. Patients treated at our Center for CLM ( ... ...

Abstract	Introduction: Our aim is to compare thoracoscopy to thoracotomy in the treatment of congenital lung malformations (CLM) in children. Materials and methods: We report a retrospective monocentric cohort study. Patients treated at our Center for CLM (1991-2020) were divided in two groups: patients treated with video-assisted thoracoscopic surgery (VATS) and open thoracotomy (OT). Characteristics of the two groups were compared through statistical analysis (GraphPad Prism7). A p value less than .05 was considered statistically significant. Results: One hundred six patients were included: 58 in VATS group, 48 in OT group. Prenatal diagnosis was possible in 73.6%. The most frequent surgical procedures were lobectomy (43.4%) and sequestrectomy (22.6%). All VATS patients underwent lung exclusion, mostly by endobronchial blocker (69%). Mean operative time was 146.1 min (±52.04 SD) in VATS and 159.2 (±46.53 SD) in OT (p = .1973). Conversion to OT was necessary in 20.6% of VATS patients, but decreased in the last 5 years (6.2%). There were not any intraoperative complication. Respectively in VATS and OT group, length of stay (LOS) was 4.5 days ± 3.6 SD versus 7.7 ± 3.4 SD (p < .0001), chest tube duration 2.8 days ± 3.4 SD versus 3.7 ± 2.4 SD (p < .0001), antibiotic treatment duration 3.7 days ± 4.7 SD versus 5 ± 2.6 SD (p = .1196). Postoperative complications were described in 22.6%. The commonest histological diagnosis (40.6%) was congenital pulmonary airway malformation. Conclusion: VATS resulted a feasible, effective and safe technique. Operative time and postoperative complications were similar in VATS and OT groups. VATS conversion rate decreased in time. VATS had a statistically significant shorter LOS and chest tube duration.
MeSH term(s)	Child ; Cohort Studies ; Cystic Adenomatoid Malformation of Lung, Congenital/surgery ; Female ; Humans ; Length of Stay ; Lung/surgery ; Lung Diseases/congenital ; Lung Diseases/etiology ; Male ; Pneumonectomy/methods ; Postoperative Complications ; Pregnancy ; Prenatal Diagnosis/adverse effects ; Retrospective Studies ; Thoracic Surgery, Video-Assisted/methods ; Thoracotomy/adverse effects
Language	English
Publishing date	2020-11-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.25138
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Article ; Online: Pediatric endoscopic pilonidal sinus treatment (PEPSiT): report of a multicentric national study on 294 patients.

Esposito, Ciro / Leva, Ernesto / Gamba, Piergiorgio / Sgrò, Alberto / Ferrentino, Umberto / Papparella, Alfonso / Chiarenza, Fabio / Bleve, Cosimo / Mendoza-Sagaon, Mario / Montaruli, Ernesto / Escolino, Maria

Updates in surgery

2023 Volume 75, Issue 6, Page(s) 1625–1631

Abstract: This study aimed to report a multicentric national experience about the outcomes of pediatric endoscopic pilonidal sinus treatment (PEPSiT). The medical records of all pediatric patients, aged up to 18 years, who underwent PEPSiT in the period 2019-2021, ...

Abstract	This study aimed to report a multicentric national experience about the outcomes of pediatric endoscopic pilonidal sinus treatment (PEPSiT). The medical records of all pediatric patients, aged up to 18 years, who underwent PEPSiT in the period 2019-2021, were retrospectively reviewed. Patients' demographics, operative details, and post-operative outcomes were assessed. A total of 294 patients (182 boys), with median age of 14 years (range 10-18), receiving PEPSiT in the study period, were enrolled. Pilonidal sinus disease (PSD) was primary in 258 (87.8%) and recurrent in 36 (12.2%). The median operative time was 36 min (range 11-120). The median VAS pain score was 0.86 (range 0-3) and the median duration of analgesic use was 27 h (range 12-60). The overall success rate was 95.2% (280/294) and the median time to full healing was 23.4 days (range 19-50). Six/294 (2.0%) patients developed Clavien 2 post-operative complications. The recurrence rate was 4.8% (14/294) and all recurrences were re-operated using PEPSiT. Redo-surgery for wound debridement was performed in one (0.3%) patient with late healing. On multivariate analysis, hirsutism and typology of sinus (pits ≥ 2, paramedian and more proximal to the anus) were predictors of PSD recurrence (p = 0.001). To date, this is the largest series of PEPSiT published in the pediatric population. The outcomes reported after a 3 years experience confirm that PEPSiT is a safe, effective, and real minimally invasive procedure to treat adolescents with PSD. It provides patients quick and painless recovery, satisfactory success, and high quality of life.
MeSH term(s)	Male ; Adolescent ; Humans ; Child ; Aged ; Pilonidal Sinus/surgery ; Treatment Outcome ; Retrospective Studies ; Quality of Life ; Neoplasm Recurrence, Local ; Pain, Postoperative/etiology ; Recurrence
Language	English
Publishing date	2023-05-05
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-023-01508-5
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Article ; Online: Outcomes in patients with short bowel syndrome after autologous intestinal reconstruction: Does etiology matter?

Pederiva, Federica / Sgrò, Alberto / Coletta, Riccardo / Khalil, Basem / Morabito, Antonino

Journal of pediatric surgery

2018 Volume 53, Issue 7, Page(s) 1345–1350

Abstract: Background: Short bowel syndrome (SBS) is the most common cause of intestinal failure in children. Many factors have been investigated in an attempt to define which parameters influence most survival and ability to wean off parenteral nutrition (PN). ... ...

Abstract	Background: Short bowel syndrome (SBS) is the most common cause of intestinal failure in children. Many factors have been investigated in an attempt to define which parameters influence most survival and ability to wean off parenteral nutrition (PN). The aim of this study was to investigate if aetiology of SBS affects the outcomes in paediatric patients treated with autologous gastrointestinal reconstructive surgery. Methods: All children with SBS who underwent autologous gastrointestinal reconstructive surgery between 2002 and 2012 were retrospectively reviewed and outcome measures were recorded. Results: Forty-three patients were divided into 4 groups according to aetiology (gastroschisis, volvulus, necrotizing enterocolitis (NEC), intestinal atresia). No significant differences were found among groups regarding survival and median age at surgery. The volvulus group had a lower pre-operative bowel length in comparison with gastroschisis and intestinal atresia and the lowest percentage of patients off PN (30%). Gastroschisis had the lowest rate of preserved ileocaecal valve (10%), while intestinal atresia had the highest (66%). For children who weaned off PN, intestinal atresia had also the longest time to achieve enteral autonomy (14.5months), while NEC had the shortest (3.5months), followed by gastroschisis (8.5months). None of the patients needed transplant. Conclusions: In our experience it does not appear that diagnosis is significantly related to outcome and this is consistent with the conclusions of other reviews. However, it should be noted that in our series patients with volvulus had the worse outcome in terms of weaning off PN when compared with intestinal atresia. Type of study: Retrospective Study. Level of evidence: II.
MeSH term(s)	Child ; Child, Preschool ; Enterocolitis, Necrotizing/complications ; Female ; Gastroschisis/complications ; Humans ; Ileocecal Valve/surgery ; Infant ; Infant, Newborn ; Intestinal Atresia/complications ; Intestinal Volvulus/complications ; Intestines/surgery ; Male ; Parenteral Nutrition ; Retrospective Studies ; Short Bowel Syndrome/etiology ; Short Bowel Syndrome/mortality ; Short Bowel Syndrome/surgery ; Survival Rate ; Treatment Outcome
Language	English
Publishing date	2018-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2018.03.009
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Article ; Online: European reference network for rare inherited congenital anomalies (ERNICA) evidence based guideline on the management of gastroschisis.

Orphanet journal of rare diseases

2024 Volume 19, Issue 1, Page(s) 60

Abstract: Background: The European Reference Network for rare Inherited Congenital Anomalies, ERNICA, guidelines for gastroschisis cover perinatal period to help teams to improve care.: Method: A systematic literature search including 136 publications was ... ...

Abstract	Background: The European Reference Network for rare Inherited Congenital Anomalies, ERNICA, guidelines for gastroschisis cover perinatal period to help teams to improve care. Method: A systematic literature search including 136 publications was conducted. Research findings were assessed following the GRADE methodology. The evidence to decision framework was used to determine the strength and direction of recommendations. Results: The mode or timing of delivery do not impact neonatal mortality, risk of NEC or time on parenteral nutrition (PN). Intra or extra abdominal bowel dilatation predict complex gastroschisis and longer length of hospital stay but not increased perinatal mortality. Outcomes after Bianchi procedure and primary fascia closure under anesthesia are similar. Sutureless closure decreases the rate of surgical site infections and duration of ventilation compared to surgical closure. Silo-staged closure with or without intubation results in similar outcomes. Outcomes of complex gastroschisis (CG) undergoing early or delayed surgical repair are similar. Early enteral feeds starting within 14 days is associated with lower risk of surgical site infection. Recommendations: The panel suggests vaginal birth between 37 and 39 w in cases of uncomplicated gastroschisis. Bianchi's approach is an option in simple gastroschisis. Sutureless closure is suggested when general anesthesia can be avoided, sutured closure. If anesthesia is required. Silo treatment without ventilation and general anesthesia can be considered. In CG with atresia primary intestinal repair can be attempted if the condition of patient and intestine allows. Enteral feeds for simple gastroschisis should start within 14 days.
MeSH term(s)	Infant, Newborn ; Pregnancy ; Female ; Humans ; Gastroschisis/genetics ; Gastroschisis/surgery ; Gastroschisis/complications ; Treatment Outcome ; Retrospective Studies
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2225857-7
ISSN	1750-1172 ; 1750-1172
ISSN (online)	1750-1172
ISSN	1750-1172
DOI	10.1186/s13023-024-03062-8
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Article ; Online: Complex Bench Surgery Does Not Increase the Risk of Vascular Complications after Pediatric Kidney Transplantation.

Ghidini, Filippo / Fascetti Leon, Francesco / De Corti, Federica / Meneghesso, Davide / Longo, Germana / Sgrò, Alberto / Michelon, Stefania / Metrangolo, Salvatore / Meneghini, Luisa / Castagnetti, Marco / Benetti, Elisa / Gamba, Piergiorgio / Dall'Igna, Patrizia

European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie

2022 Volume 33, Issue 2, Page(s) 167–173

Abstract: Introduction: Vascular complications are severe complications of pediatric kidney transplantation (KT). We aimed to investigate whether a complex bench surgery (BS) affects the outcomes.: Methods: All pediatric KT performed at the University ... ...

Abstract	Introduction: Vascular complications are severe complications of pediatric kidney transplantation (KT). We aimed to investigate whether a complex bench surgery (BS) affects the outcomes. Methods: All pediatric KT performed at the University Hospital of Padua from 2015 to 2019 were analyzed, comparing those in which a standard BS was possible to those that necessitated a complex BS. The rates of vascular complications, patients' outcome, and graft survival were compared in the two groups. Results: Eighty KTs were performed in 78 patients with a median age of 11 years (interquartile range [IQR] 4.3-14) and a median body weight of 24 kg (IQR 13-37). Thirty-nine donor kidneys (49%) needed a complex BS due to anomalies of renal veins in 12 (31%) and renal arteries in 16 (41%). The remaining 11 grafts (28%) underwent an elongation of the vein. There was no difference in the rate of primary graft non function ( Conclusion: Complex BS did not compromise survival of the graft and did not put the allograft at risk of vascular complications, such as bleedings or thrombosis.
MeSH term(s)	Child ; Humans ; Kidney Transplantation/adverse effects ; Thrombosis/etiology ; Venous Thrombosis ; Veins ; Graft Survival ; Retrospective Studies ; Kidney
Language	English
Publishing date	2022-07-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1065043-x
ISSN	1439-359X ; 0939-7248 ; 0939-6764 ; 0930-7249
ISSN (online)	1439-359X
ISSN	0939-7248 ; 0939-6764 ; 0930-7249
DOI	10.1055/s-0042-1751046
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Article: Complex Bench Surgery Does Not Increase the Risk of Vascular Complications after Pediatric Kidney Transplantation

European Journal of Pediatric Surgery

2022 Volume 33, Issue 02, Page(s) 167–173

Abstract	Introduction: Vascular complications are severe complications of pediatric kidney transplantation (KT). We aimed to investigate whether a complex bench surgery (BS) affects the outcomes. Methods: All pediatric KT performed at the University Hospital of Padua from 2015 to 2019 were analyzed, comparing those in which a standard BS was possible to those that necessitated a complex BS. The rates of vascular complications, patients' outcome, and graft survival were compared in the two groups. Results: Eighty KTs were performed in 78 patients with a median age of 11 years (interquartile range [IQR] 4.3–14) and a median body weight of 24 kg (IQR 13–37). Thirty-nine donor kidneys (49%) needed a complex BS due to anomalies of renal veins in 12 (31%) and renal arteries in 16 (41%). The remaining 11 grafts (28%) underwent an elongation of the vein. There was no difference in the rate of primary graft non function ( p = 0.97), delayed graft function ( p = 0.72), and overall survival ( p = 0.27). The rates of vascular complications, bleedings, and venous graft thrombosis were similar ( p = 0.51, p = 0.59, p = 0.78, respectively). No arterial thrombosis or stenosis was reported. Conclusion: Complex BS did not compromise survival of the graft and did not put the allograft at risk of vascular complications, such as bleedings or thrombosis.
Keywords	kidney transplantation ; bench surgery ; graft thrombosis ; graft survival ; vascular complications
Language	English
Publishing date	2022-07-19
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1065043-x
ISSN	1439-359X ; 0939-7248 ; 0939-6764 ; 0930-7249
ISSN (online)	1439-359X
ISSN	0939-7248 ; 0939-6764 ; 0930-7249
DOI	10.1055/s-0042-1751046
Database	Thieme publisher's database

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Article: Appendicitis in Children in a Large Italian COVID-19 Pandemic Area.

La Pergola, Enrico / Sgrò, Alberto / Rebosio, Federico / Vavassori, Daniele / Fava, Giorgio / Codrich, Daniela / Montanaro, Beatrice / Leva, Ernesto / Schleef, Jurgen / Cheli, M / Pelizzo, Gloria / Gamba, Piergiorgio / Alberti, Daniele / Betalli, Pietro

Frontiers in pediatrics

2020 Volume 8, Page(s) 600320

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2020-12-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2020.600320
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Article ; Online: Development of a core outcome set for congenital pulmonary airway malformations: study protocol of an international Delphi survey.

Hermelijn, Sergei / Kersten, Casper / Mullassery, Dhanya / Muthialu, Nagarajan / Cobanoglu, Nazan / Gartner, Silvia / Bagolan, Pietro / Mesas Burgos, Carmen / Sgro, Alberto / Heyman, Stijn / Till, Holger / Suominen, Janne / Schurink, Maarten / Desender, Liesbeth / Losty, Paul / Ertresvag, Kjetil / Tiddens, Harm A W M / Wijnen, Rene M H / Schnater, Marco

BMJ open

2021 Volume 11, Issue 4, Page(s) e044544

Abstract: Introduction: A worldwide lack of consensus exists on the optimal management of asymptomatic congenital pulmonary airway malformation (CPAM) even though the incidence is increasing. Either a surgical resection is performed or a wait-and-see policy is ... ...

Abstract	Introduction: A worldwide lack of consensus exists on the optimal management of asymptomatic congenital pulmonary airway malformation (CPAM) even though the incidence is increasing. Either a surgical resection is performed or a wait-and-see policy is employed, depending on the treating physician. Management is largely based on expert opinion and scientific evidence is scarce. Wide variations in outcome measures are seen between studies making comparison difficult thus highlighting the lack of universal consensus in outcome measures as well. We aim to define a core outcome set which will include the most important core outcome parameters for paediatric patients with an asymptomatic CPAM. Methods and analysis: This study will include a critical appraisal of the current literature followed by a three-stage Delphi process with two stakeholder groups. One surgical group including paediatric as well as thoracic surgeons, and a non-surgeon group including paediatric pulmonologists, intensive care and neonatal specialists. All participants will score outcome parameters according to their level of importance and the most important parameters will be determined by consensus. Ethics and dissemination: Electronic informed consent will be obtained from all participants. Ethical approval is not required. After the core outcome set has been defined, we intend to design an international randomised controlled trial: the COllaborative Neonatal NEtwork for the first CPAM Trial, which will be aimed at determining the optimal management of patients with asymptomatic CPAM.
MeSH term(s)	Child ; Consensus ; Delphi Technique ; Humans ; Infant, Newborn ; Outcome Assessment, Health Care ; Research Design ; Research Personnel ; Surveys and Questionnaires
Language	English
Publishing date	2021-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2020-044544
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