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Article ; Online: Correlation of fasting lipid profile in non-diabetic CKD patients on conservative management

Deepak Sha K / Pulkit Jindal / Satarla Narendra

National Board of Examinations Journal of Medical Sciences, Vol 1, Iss 8, Pp 497-

2023 Volume 505

Abstract: Background- Chronic kidney disease is emerging as a major chronic disease worldwide. There is surge in incidence of CKD in developing countries that is likely to pose a major problem in both health and economic sector. Ultimately, ESRD occurs due to ... ...

Abstract	Background- Chronic kidney disease is emerging as a major chronic disease worldwide. There is surge in incidence of CKD in developing countries that is likely to pose a major problem in both health and economic sector. Ultimately, ESRD occurs due to progressive and unrelenting loss of nephron function. Aim- This study aims to investigate the potential correlation between fasting lipid profile and carotid intimal thickness in non-diabetic CKD patients who are undergoing conservative management. Discussion- CKD comprises of a spectrum of disease processes which results in metabolic, excretory, and synthetic failure culminating into the buildup of non-protein nitrogenous compounds and presents with numerous clinical features. Conclusion- The findings of this study indicate a significant correlation between fasting lipid profile in CKD patients who are non-diabetic and undergoing conservative management.
Keywords	ckd ; fasting lipid profile ; carotid intimal thickness ; hdl ; ldl ; vldl ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	National Board of Examinations
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Human pan-cancer analysis of the predictive biomarker for the CDKN3.

Chen, Yingjun / Li, Dai / Sha, Kaihui / Zhang, Xuezhong / Liu, Tonggang

European journal of medical research

2024 Volume 29, Issue 1, Page(s) 272

Abstract: Background: Cell cycle protein-dependent kinase inhibitor protein 3 (CDKN3), as a member of the protein kinase family, has been demonstrated to exhibit oncogenic properties in several tumors. However, there are no pan-carcinogenic analyses for CDKN3.: ...

Abstract	Background: Cell cycle protein-dependent kinase inhibitor protein 3 (CDKN3), as a member of the protein kinase family, has been demonstrated to exhibit oncogenic properties in several tumors. However, there are no pan-carcinogenic analyses for CDKN3. Methods: Using bioinformatics tools such as The Cancer Genome Atlas (TCGA) and the UCSC Xena database, a comprehensive pan-cancer analysis of CDKN3 was conducted. The inverstigation encompassed the examination of CDKN3 function actoss 33 different kinds of tumors, as well as the exploration of gene expressions, survival prognosis status, clinical significance, DNA methylation, immune infiltration, and associated signal pathways. Results: CDKN3 was significantly upregulated in most of tumors and correlated with overall survival (OS) of patients. Methylation levels of CDKN3 differed significantly between tumors and normal tissues. In addition, infiltration of CD4 + T cells, cancer-associated fibroblasts, macrophages, and endothelial cells were associated with CDKN3 expression in various tumors. Mechanistically, CDKN3 was associated with P53, PI3K-AKT, cell cycle checkpoints, mitotic spindle checkpoint, and chromosome maintenance. Conclusion: Our pan-cancer analysis conducted in the study provides a comprehensive understanding of the involvement of CDKN3 gene in tumorigenesis. The findings suggest that targeting CDKN3 may potentially lead to novel therapeutic strategies for the treatment of tumors.
MeSH term(s)	Humans ; Neoplasms/genetics ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cyclin-Dependent Kinase Inhibitor Proteins/genetics ; Cyclin-Dependent Kinase Inhibitor Proteins/metabolism ; Prognosis ; Gene Expression Regulation, Neoplastic ; DNA Methylation ; Computational Biology/methods ; Dual-Specificity Phosphatases
Chemical Substances	Biomarkers, Tumor ; CDKN3 protein, human (EC 3.1.3.48) ; Cyclin-Dependent Kinase Inhibitor Proteins ; Dual-Specificity Phosphatases (EC 3.1.3.48)
Language	English
Publishing date	2024-05-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-024-01869-6
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Article ; Online: The "Hand as Foot" teaching method in the structure and function of neurons.

Zhang, Xinyue / Zhang, Minghui / Sha, Kaihui / Song, Lixia

Asian journal of surgery

2023 Volume 46, Issue 8, Page(s) 3267–3268

MeSH term(s)	Humans ; Hand ; Upper Extremity ; Foot ; Lower Extremity ; Neurons
Language	English
Publishing date	2023-03-24
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.03.057
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Article ; Online: Correlation of serum phosphate levels and carotid intimal thickness in CKD patients

Pulkit Jindal / Viswanadha Reddy / Deepak Sha K / Satarla Narendra

National Board of Examinations Journal of Medical Sciences, Vol 1, Iss 9-10, Pp 571-

2023 Volume 582

Abstract: Background- Chronic kidney disease is a significant global health issue characterized by notable morbidity and mortality rates. Among CKD patients, cardiovascular disease stands as the primary cause of death, often accompanied by accelerated ... ...

Abstract	Background- Chronic kidney disease is a significant global health issue characterized by notable morbidity and mortality rates. Among CKD patients, cardiovascular disease stands as the primary cause of death, often accompanied by accelerated atherosclerosis. Hyperphosphatemia, characterized by elevated serum phosphate levels in CKD patients and has been implicated in the progress of vascular calcification and cardiovascular events. Aim: To observe relationship between serum phosphate and carotid intimal thickness in individuals with CKD. Discussion: Existing studies have presented conflicting findings, with some demonstrating a positive correlation while others reporting no significant association. Consequently, a cross-sectional study was conducted on CKD patients representing various stages of renal impairment. Serum phosphate levels were measured, and carotid intimal thickness was assessed using ultrasound imaging. Conclusion: This study demonstrates a significant association between serum phosphate levels and carotid intimal thickness in CKD patients. Elevated serum phosphate levels were found to be correlated with increased carotid intimal thickness, suggesting a potential role of phosphate in the progression of atherosclerosis in CKD.
Keywords	carotid intimal medial thickness ; ckd ; diabetes ; serum phosphate ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	National Board of Examinations
Document type	Article ; Online
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Article: A Case of Allergic Bronchopulmonary Aspergillosis With Failure of Benralizumab and Response to Dupilumab.

Kotetsu, Yasuaki / Ogata, Hiroaki / Sha, Kachi / Moriwaki, Atsushi / Yoshida, Makoto

Cureus

2023 Volume 15, Issue 7, Page(s) e42464

Abstract: We report a case of a 68-year-old woman who was being treated for bronchial asthma and developed allergic bronchopulmonary aspergillosis (ABPA) that was unresponsive to benralizumab therapy but went into remission with dupilumab therapy. The patient ... ...

Abstract	We report a case of a 68-year-old woman who was being treated for bronchial asthma and developed allergic bronchopulmonary aspergillosis (ABPA) that was unresponsive to benralizumab therapy but went into remission with dupilumab therapy. The patient presented with an exacerbation of dry cough and was diagnosed with ABPA based on new diagnostic criteria. Despite the attempted therapeutic intervention, the patient declined to use systemic corticosteroids due to concerns about potential side effects. Subsequently, itraconazole and benralizumab were administered, with temporary relief before relapse. Given the patient's refusal to continue itraconazole and benralizumab, dupilumab was administered as an alternative therapy, which resulted in significant improvement of both symptoms and imaging. Although the use of biological agents for ABPA lacks clear evidence, our results suggest that dupilumab may provide an effective therapeutic strategy.
Language	English
Publishing date	2023-07-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.42464
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Article ; Online: Long-term follow-up of one-stage artificial dermis reconstruction surgery for fingertip defects with exposed phalanx.

Wang, Jingwei / Huang, Zhuqing / Cueva Jumbo, Juan Carlos / Sha, Ke

Hand surgery & rehabilitation

2022 Volume 41, Issue 3, Page(s) 353–361

Abstract: Fingertip injuries are among the most common injuries of the hand. Although numerous treatment methods have been described in detail in the literature, there are a few alternatives that require exploration. We analyzed 24 patients who underwent one-stage ...

Abstract	Fingertip injuries are among the most common injuries of the hand. Although numerous treatment methods have been described in detail in the literature, there are a few alternatives that require exploration. We analyzed 24 patients who underwent one-stage artificial dermis (Pelnac®) reconstruction surgery between 2012 and 2016 to assess the effectiveness of this alternative reconstruction method for extensive fingertip injury with exposed phalanx. There were 16 males and 8 females, with ages ranging from 2 to 75 years. There were 16 type III injuries, 6 type IV, and 2 type II on the Allen classification. Complete epithelialization was achieved by the 4th week in 19 cases and by the 6th week in 5. The wounds of all patients healed completely, without infection. All the injured fingers developed various levels of hooked nail and length shortening except for the 2 type II injuries. There was nail spicule formation in 1 case. There were no cases of cold intolerance, but 2 cases of hypersensitivity and 5 of numbness. Overall 2-point discrimination ceased improving by the 2nd postoperative year. This technique is simple, allows spontaneous healing of the fingertips, and is mostly free from the major complications associated with other treatment methods.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Dermis ; Female ; Finger Injuries/surgery ; Finger Phalanges/surgery ; Fingers/surgery ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Young Adult
Language	English
Publishing date	2022-03-17
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2848776-X
ISSN	2468-1210
ISSN (online)	2468-1210
DOI	10.1016/j.hansur.2022.02.012
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Zs.A 1791: Show issues

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Article ; Online: Assessing the association of leukocyte telomere length with ankylosing spondylitis and rheumatoid arthritis: A bidirectional Mendelian randomization study.

Wei, Donglei / Jiang, Yage / Cheng, Jianwen / Wang, Hui / Sha, Ke / Zhao, Jinmin

Frontiers in immunology

2023 Volume 14, Page(s) 1023991

Abstract: Background: Telomere length shortening can cause senescence and apoptosis in various immune cells, resulting in immune destabilization and ageing of the organism. In this study, we aimed to systematically assess the causal relationship of leukocyte ... ...

Abstract	Background: Telomere length shortening can cause senescence and apoptosis in various immune cells, resulting in immune destabilization and ageing of the organism. In this study, we aimed to systematically assess the causal relationship of leukocyte telomere length (LTL) with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) using a Mendelian randomization study. Methods: LTL (n=472174) was obtained from the UK Biobank genome-wide association study pooled data. AS (n=229640), RA (n=212472) were obtained from FinnGen database. MR-Egger, inverse variance weighting, and weighted median methods were used to estimate the effects of causes. Cochran's Q test, MR Egger intercept test, MR-PRESSO, leave-one-out analysis, and funnel plots were used to look at sensitivity, heterogeneity, and multiple effects. Forward MR analysis considered LTL as the exposure and AS, RA as the outcome. Reverse MR analysis considered AS, RA as the exposure and LTL as the outcome. Results: In the forward MR analysis, inverse variance-weighted and weighted median analysis results indicated that longer LTL might be associated with increased risk of AS (IVW: OR = 1.55, 95% CI: 1.14-2.11, p = 0.006). MR Egger regression analysis showed no pleiotropy between instrumental variables (IVs) (Egger intercept= 0.008, p = 0.294). The leave-one-out analysis showed that each single nucleotide polymorphism (SNP) of AS was robust to each outcome. No significant causal effects were found between AS, RA and LTL in the reverse MR analysis. Conclusion: Longer LTL may be related with an increased risk of developing AS, and these findings provide a foundation for future clinical research on the causal association between LTL and AS.
MeSH term(s)	Humans ; Spondylitis, Ankylosing/genetics ; Spondylitis, Ankylosing/complications ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Arthritis, Rheumatoid/genetics ; Leukocytes ; Telomere/genetics
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1023991
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Article: Coexistence of anomalous muscle, persistent median artery, bifid median nerve causing carpal tunnel syndrome: A case report and literature review.

Qin, Jun / Tan, Xia-Xian / Xue, Ming-Qiang / Wang, Jing-Wei / Zhao, Jin-Min / Sha, Ke

Frontiers in pediatrics

2023 Volume 11, Page(s) 1043442

Abstract: Carpal tunnel syndrome (CTS) is an upper extremity median nerve entrapment disorder that is rare in children and adolescents. Anatomical variations of the wrist, such as anomalous muscles, persistent median artery (PMA), and bifid median nerves (BMN), ... ...

Abstract	Carpal tunnel syndrome (CTS) is an upper extremity median nerve entrapment disorder that is rare in children and adolescents. Anatomical variations of the wrist, such as anomalous muscles, persistent median artery (PMA), and bifid median nerves (BMN), are rare etiology of CTS. Coexistence of all three variants combined with CTS in adolescents has been rarely reported. Case description: A 16-year-old right-hand dominant male presented to our clinic with several years of bilateral thenar muscle atrophy and weakness but no paresthesia or pain in his both hands. Ultrasonography showed that the right median nerve become significantly thinner, and the left median nerve was split into two branches by PMA. Magnetic resonance imaging (MRI) revealed that anomalous muscles in the bilateral wrist extending to the carpal tunnel, causing compression of the median nerve. Considering the possibility of CTS clinically, the patient underwent bilateral open carpal tunnel release without resection of anomalous muscles and PMA. The patient has no discomfort after 2 years. This suggests that anatomical variations of the carpal tunnel may contribute to CTS, which can be confirmed by preoperative ultrasonography and MRI, and the possibility of carpal tunnel anatomical variations should be considered when CTS occurs in adolescents. Open carpal tunnel release is an effective treatment for juvenile CTS without the need to resect abnormal muscle and PMA during the operation.
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1043442
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Article ; Online: Liquid-like Oral Sustained-Release System Based on Acid-Sensitive in situ Hydrogel for Alleviate Gastrointestinal Side Effects of Indobufen.

Tang, Ya / Sun, Peng / Khiing, Adric Hii Ru / Sha, Kang / Qi, Xiaole / Wu, Zhenghong

Journal of pharmaceutical sciences

2023 Volume 112, Issue 12, Page(s) 3141–3153

Abstract: Commonly, most oral non-steroidal anti-inflammatory drugs (NSAIDs) have known gastric adverse reactions due to their long-term and high dose administration. In this study, a novel liquid sustained-release system based on multiple-unit in situ hydrogel ... ...

Abstract	Commonly, most oral non-steroidal anti-inflammatory drugs (NSAIDs) have known gastric adverse reactions due to their long-term and high dose administration. In this study, a novel liquid sustained-release system based on multiple-unit in situ hydrogel beads was designed to address this issue. The system is composed of sodium alginate (SA), gellan gum (GG), zinc oxide (ZnO), and magnesium oxide (MgO). Furthermore, indobufen was loaded into the system to evaluate its gastric mucosal protection effect. This effect can be attributed to the topical antacid, pepsin inhibition, and sustained drug release properties of the system. It was proven that the stored solid gel system could undergo a "solid to liquid" transition after shaking. Once swallowed, the liquid gel could disperse well in the stomach as hydrogel beads. Then, the "liquid to solid" gelation occurred from the exterior to interior of each multiple-unit gel bead, triggered by the release of Zn
MeSH term(s)	Rats ; Animals ; Hydrogels ; Delayed-Action Preparations ; Antacids ; Pepsin A ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects
Chemical Substances	Hydrogels ; Delayed-Action Preparations ; indobufen (6T9949G4LZ) ; Antacids ; Pepsin A (EC 3.4.23.1) ; Anti-Inflammatory Agents, Non-Steroidal
Language	English
Publishing date	2023-07-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	3151-3
ISSN	1520-6017 ; 0022-3549
ISSN (online)	1520-6017
ISSN	0022-3549
DOI	10.1016/j.xphs.2023.07.016
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Article: Androgen deprivation triggers a cytokine signaling switch to induce immune suppression and prostate cancer recurrence.

Sha, Kai / Zhang, Renyaun / Maolake, Aerken / Singh, Shalini / Chatta, Gurkamal / Eng, Kevin H / Nastiuk, Kent L / Krolewski, John J

bioRxiv : the preprint server for biology

2024

Abstract: Androgen deprivation therapy (ADT) is an effective but not curative treatment for advanced and recurrent prostate cancer (PC). We investigated the mechanisms controlling the response to androgen-deprivation by surgical castration in genetically- ... ...

Abstract	Androgen deprivation therapy (ADT) is an effective but not curative treatment for advanced and recurrent prostate cancer (PC). We investigated the mechanisms controlling the response to androgen-deprivation by surgical castration in genetically-engineered mouse models (GEMM) of PC, using high frequency ultrasound imaging to rigorously measure tumor volume. Castration initially causes almost all tumors to shrink in volume, but many tumors subsequently recur within 5-10 weeks. Blockade of tumor necrosis factor (TNF) signaling a few days in advance of castration surgery, using a TNFR2 ligand trap, prevents regression in a PTEN-deficient GEMM. Following tumor regression, a basal stem cell-like population within the tumor increases along with TNF protein levels. Tumor cell lines in culture recapitulate these in vivo observations, suggesting that basal stem cells are the source of TNF. When TNF signaling blockade is administered immediately prior to castration, tumors regress but recurrence is prevented, implying that a late wave of TNF secretion within the tumor, which coincides with the expression of NFkB regulated genes, drives recurrence. The inhibition of signaling downstream of one NFkB-regulated protein, chemokine C-C motif ligand 2 (CCL2), prevents post-castration tumor recurrence, phenocopying post-castration (late) TNF signaling blockade. CCL2 was originally identified as a macrophage chemoattractant and indeed at late times after castration gene sets related to chemotaxis and migration are up-regulated. Importantly, enhanced CCL2 signaling during the tumor recurrence phase coincides with an increase in pro-tumorigenic macrophages and a decrease in CD8 T cells, suggesting that recurrence is driven at least in part by tumor immunosuppression. In summary, we demonstrate that a therapy-induced switch in TNF signaling, a consequence of the increased stem cell-like character of the residual tumor cells surviving ADT, induces an immunosuppressive tumor microenvironment and concomitant tumor recurrence.
Language	English
Publishing date	2024-02-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.12.01.569685
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