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Article ; Online: Impact of Cardiac Rehabilitation Programs Post Primary Percutaneous Coronary Intervention on Functional Capacity and Metabolic Profile Through Different Age Groups.

Elsayegh, Ayah Tarek / Karim, Khaled / Shabana, Adel

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension

2023 Volume 30, Issue 2, Page(s) 145–150

Abstract: Introduction: Modern cardiac rehabilitation (CR) is a thorough approach including multiple arms that aim at improving quality of life and functional capacity.: Aim: To study the impact of age on the benefits of cardiac rehabilitation program post- ... ...

Abstract	Introduction: Modern cardiac rehabilitation (CR) is a thorough approach including multiple arms that aim at improving quality of life and functional capacity. Aim: To study the impact of age on the benefits of cardiac rehabilitation program post-successful primary percutaneous coronary intervention (PCI). Methods: This retrospective study includes 250 patients post primary percutaneous coronary intervention (PCI) who underwent a complete 12-week cardiac rehabilitation program. Functional capacity, metabolic profile, and parameters of diastolic function were assessed and compared at baseline and after completing the program. Four age strata were compared in terms of improvement of the various parameters studied. Results: In the whole patient group, the workload achieved in metabolic equivalents (METS) and maximum exercise time significantly increased. Regarding metabolic profile, body mass index (BMI), total cholesterol, low-density lipoprotein (LDL), and Triglycerides significantly decreased. While high-density lipoproteins (HDL) increased but didn't reach significance. Echo data reflecting diastolic dysfunction also improved significantly. We found that the magnitude of improvement in all the earlier-mentioned parameters showed no statistically significant difference among the four age groups studied. Conclusion: Cardiac rehabilitation program post primary percutaneous coronary intervention (PCI) significantly improves functional capacity, metabolic profile, and diastolic function. It is never too old or too young to join the CR program. Different age groups benefit equally from rehabilitation.
MeSH term(s)	Humans ; Cardiac Rehabilitation ; Percutaneous Coronary Intervention ; Retrospective Studies ; Quality of Life ; Metabolome
Language	English
Publishing date	2023-02-09
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	1236337-6
ISSN	1179-1985 ; 1120-9879
ISSN (online)	1179-1985
ISSN	1120-9879
DOI	10.1007/s40292-023-00566-5
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Zs.A 4289: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Corrigendum to 'Consumer preference, growth and profitability of African catfish (

Suzette, Sey E / Nelson, Agbo W / Regina, Edziyie / Philip, Amoah / Mark, Yeboah-Agyepong / Raphael, Nsiah-Gyambibi / Shabana, Abbas

Heliyon

2024 Volume 10, Issue 4, Page(s) e26324

Abstract: This corrects the article DOI: 10.1016/j.heliyon.2021.e06424.]. ...

Abstract	[This corrects the article DOI: 10.1016/j.heliyon.2021.e06424.].
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Published Erratum
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26324
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Article ; Online: Religious and cultural legitimacy of bioethics: lessons from Islamic bioethics.

Shabana, Ayman

Medicine, health care, and philosophy

2013 Volume 16, Issue 4, Page(s) 671–677

Abstract: Islamic religious norms are important for Islamic bioethical deliberations. In Muslim societies religious and cultural norms are sometimes confused but only the former are considered inviolable. I argue that respect for Islamic religious norms is ... ...

Abstract	Islamic religious norms are important for Islamic bioethical deliberations. In Muslim societies religious and cultural norms are sometimes confused but only the former are considered inviolable. I argue that respect for Islamic religious norms is essential for the legitimacy of bioethical standards in the Muslim context. I attribute the legitimating power of these norms, in addition to their purely religious and spiritual underpinnings, to their moral, legal, and communal dimensions. Although diversity within the Islamic ethical tradition defies any reductionist or essentialist reconstruction, legitimacy is secured mainly by approximation of Islamic ethical ideals believed to be inherent in the scriptural texts, rather than by the adoption of particular dogmatic or creedal views. With these characteristics, Islamic (bio) ethics may provide useful insights for comparative ethics and global bioethics.
MeSH term(s)	Bioethics ; Culture ; Humans ; Islam ; Morals ; Religion and Medicine
Language	English
Publishing date	2013-02-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440052-2
ISSN	1572-8633 ; 1386-7423
ISSN (online)	1572-8633
ISSN	1386-7423
DOI	10.1007/s11019-013-9472-6
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Zs.A 5054: Show issues

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Article: Case-report: A rare cause of intestinal obstruction in late pregnancy.

Dholoo, Farzan / Shabana, Amanda / See, Abbas / Hameed, Waseem

International journal of surgery case reports

2020 Volume 80, Page(s) 105391

Abstract: Introduction: Caecal volvulus represents a rare and often life-threatening cause of intestinal obstruction. Diagnosis and management of caecal volvulus remains a clinical challenge, since those presenting with symptoms can have vague nonspecific ... ...

Abstract	Introduction: Caecal volvulus represents a rare and often life-threatening cause of intestinal obstruction. Diagnosis and management of caecal volvulus remains a clinical challenge, since those presenting with symptoms can have vague nonspecific presentations. Symptoms eventually occur, usually secondary to obstruction or ischaemia. This case report will discuss the presentation, investigation and management options available. Presentation: A 31-year-old multigravida, at 38 weeks and 6 days gestation; presented to hospital with a 2-day history of diffuse abdominal pain and distension. Initial examination was unremarkable aside from mild epigastric tenderness. Raised inflammatory markers and concerns for foetal health resulted in an emergency caesarean section. Symptoms however worsened and the patient underwent colonoscopy and computerised tomography (CT) of the abdomen and pelvis with contrast; showing caecal volvulus. The patient was taken to the operating theatres for an emergency right hemicolectomy with formation of end ileostomy. Intra-operatively, areas of necrosis were noted within the caecum suggestive of impending perforation. The patient recovered well post reversal of end ileostomy, with no complications to date. Discussion: Caecal volvulus represents a rare, but potentially fatal cause of intestinal obstruction and ischaemia. High mortality rates are attributed to delayed diagnosis and treatment. Patients may initially present with vague symptoms, which rapidly progress with the development of ischaemia. Multiple management modalities exist. Central to prognosis is early diagnosis. Conclusion: Early diagnosis and intervention are paramount. Imaging via abdominal x-rays and CT are of particular importance. Surgical management is widely reported as the mainstay of treatment. We advise clinicians to remember this rare diagnosis, as a potential cause of abdominal pain and intestinal obstruction; especially in those with predisposing risk factors.
Language	English
Publishing date	2020-12-02
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2020.11.141
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Article: Case-report: A rare cause of an intra-abdominal mass.

Shabana, Amanda / Dholoo, Farzan / Nunn, Rebecca / Hameed, Waseem

International journal of surgery case reports

2020 Volume 67, Page(s) 278–281

Abstract: Introduction: Mesenteric cysts are a rare and often asymptomatic incidental finding on imaging. The diagnosis and management of mesenteric cysts remains a clinical challenge since those presenting with symptoms, often have vague and nonspecific symptoms, ...

Abstract	Introduction: Mesenteric cysts are a rare and often asymptomatic incidental finding on imaging. The diagnosis and management of mesenteric cysts remains a clinical challenge since those presenting with symptoms, often have vague and nonspecific symptoms, owing to variability in cyst location and size. This case report will aim to discuss the presentation, investigation and management options available. Presentation: A 73-year-old female presented with abdominal swelling and a palpable right sided mass. Examination revealed a right sided mass and abdominal distention with vital signs within normal limits. Ultrasound scan (USS) revealed a right-sided 12 cm × 11 cm × 8 cm thin walled cyst. Discussion: Mesenteric cysts are mostly asymptomatic but can cause nonspecific symptoms of abdominal pain, abdominal distension, altered bowel habit, nausea, vomiting and an abdominal mass. Complete surgical excision, either laparoscopically, or through a laparotomy is typically considered first line treatment. If size or location of the cyst precludes complete surgical excision, partial excision with marsupialisation of the opening of the cyst into the abdominal peritoneal cavity is a second option. Conclusion: Mesenteric cysts represent a rare cause of intra-abdominal mass. Owing to low prevalence, literature is limited as is guidance on management. Careful pre-operative planning is essential so as to avoid operative complications. Imaging such as USS is of great importance; however Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) may be of more benefit, owing to the complex anatomical relations within which mesenteric cysts can present. Surgical excision is widely reported as the surgical treatment of choice for symptomatic cysts.
Language	English
Publishing date	2020-02-20
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2020.01.006
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Article ; Online: Relationship between bone turnover markers and oxidative stress in children with type 1 diabetes mellitus.

El Amrousy, Doaa / El-Afify, Dalia / Shabana, Ahmed

Pediatric research

2020 Volume 89, Issue 4, Page(s) 878–881

Abstract: Background: Oxidative stress in children with type 1 DM (T1DM) may negatively affect the bone.: Methods: This study included 40 children with T1DM as the patient group and 40 healthy children of matched age and sex as the control group. Plasma ... ...

Abstract	Background: Oxidative stress in children with type 1 DM (T1DM) may negatively affect the bone. Methods: This study included 40 children with T1DM as the patient group and 40 healthy children of matched age and sex as the control group. Plasma alkaline phosphatase, procollagen type-1 amino-terminal propeptide (P1NP), and urinary deoxypyridinoline (DPD) were measured to assess bone turnover. Glutathione, superoxide dismutase (SOD), and malondialdehyde (MDA) were measured to assess oxidative stress. Results: Patients with T1DM had a significantly lower P1NP level but a significantly higher urinary DPD level compared to the control group. Moreover, there were significantly lower glutathione and SOD levels with significantly higher MDA levels in patients with T1DM. We found a significant positive correlation between P1NP level and both glutathione and SOD levels but a significant negative correlation between P1NP and MDA in patients with T1DM. There was a significant negative correlation between DPD levels and both glutathione and SOD levels and a significant positive correlation between DPD and MDA. Moreover, glutathione was a significant predictor for both P1NP and DPD levels, while MDA was a significant predictor for P1NP levels. Conclusions: There is an association between oxidative stress and bone turnover markers in children with T1DM. Impact: Oxidative stress can negatively affect bone but the exact relationship between oxidative stress and bone turnover in T1DM has not been previously studied in pediatrics. For the best of our knowledge, our study was the first to assess the relationship between oxidative stress and bone turnover in children with T1DM. We revealed that increased oxidative stress in children and adolescents with T1DM may be involved in the impairment of bone turnover process, so treatment strategies toward better glycemic control and decreasing oxidative stress may be beneficial in preventing and treating diabetic bone disease in these children.
MeSH term(s)	Alkaline Phosphatase/blood ; Amino Acids/blood ; Bone Remodeling ; Bone and Bones/metabolism ; Case-Control Studies ; Child ; Diabetes Mellitus, Type 1/blood ; Female ; Glutathione/metabolism ; Humans ; Male ; Malondialdehyde/blood ; Oxidative Stress ; Peptide Fragments/blood ; Procollagen/blood ; Superoxide Dismutase/metabolism
Chemical Substances	Amino Acids ; Peptide Fragments ; Procollagen ; procollagen Type I N-terminal peptide ; Malondialdehyde (4Y8F71G49Q) ; deoxypyridinoline (90032-33-0) ; Superoxide Dismutase (EC 1.15.1.1) ; Alkaline Phosphatase (EC 3.1.3.1) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2020-10-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-020-01197-5
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Zs.A 564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 373: Show issues

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Article ; Online: Inotropic Agents and Vasopressors in the Treatment of Cardiogenic Shock.

Shabana, Amanda / Dholoo, Farzan / Banerjee, Prithwish

Current heart failure reports

2020 Volume 17, Issue 6, Page(s) 438–448

Abstract: Background: Worldwide, cardiogenic shock (CS) is the leading cause of death in patients admitted with an acute myocardial infarction (AMI). CS is characterised by reduced cardiac output secondary to systolic dysfunction which can lead to multi-organ ... ...

Abstract	Background: Worldwide, cardiogenic shock (CS) is the leading cause of death in patients admitted with an acute myocardial infarction (AMI). CS is characterised by reduced cardiac output secondary to systolic dysfunction which can lead to multi-organ failure. The mainstay of medical treatment in CS are inotropes and vasopressors to improve cardiac output. However, current clinical guidelines do not direct clinicians as to which agents to use and in what combinations. This article aims to review the current evidence on the management of CS with a major focus on the use of inotropes and vasopressors. Method: A literature review was conducted analysing published literature from the following databases: PubMed, MedLine, Cochrane Library and Embase, as well as a manual search of articles that were deemed relevant. Relevant articles were identified by using keywords such as "cardiogenic shock". Results: Literature was assessed to review the use of inotropes and vasopressors in CS. Dopamine and adrenaline were associated with increased mortality and arrhythmias. Dobutamine was associated with an improvement in cardiac output, at the determinant of causing arrhythmias. Conversely, noradrenaline was associated with a lower likelihood of arrhythmias and most importantly decreased mortality in CS. Compared to other inotropes, levosimendan appears to have a better safety profile and is associated with decreased mortality in CS, particularly when combined with a vasopressor. Our literature review suggests that treatment combination of the inotrope levosimendan with the vasopressor noradrenaline may be the most effective management option in CS.
MeSH term(s)	Cardiotonic Agents/therapeutic use ; Humans ; Shock, Cardiogenic/drug therapy ; Vasoconstrictor Agents/therapeutic use
Chemical Substances	Cardiotonic Agents ; Vasoconstrictor Agents
Language	English
Publishing date	2020-10-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2151202-4
ISSN	1546-9549 ; 1546-9530
ISSN (online)	1546-9549
ISSN	1546-9530
DOI	10.1007/s11897-020-00493-9
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Zs.A 5936: Show issues

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Article: Patient journey for hypertension and dyslipidemia in Saudi Arabia: highlighting the evidence gaps.

Amir, Ashraf / Alasnag, Mirvat / Al-Raddadi, Rajaa / Al-Bassam, Tawfik / Saeed, Kanwal / Yazıcıoğlu, Mehmet / Shabana, Ayman

Archives of public health = Archives belges de sante publique

2023 Volume 81, Issue 1, Page(s) 122

Abstract: Background: In recent years, Saudi Arabia has witnessed staggering rates of hypertension and dyslipidemia-related cardiovascular (CV) deaths, overburdening the healthcare ecosystem of the country. Appropriate public health interventions can be devised ... ...

Abstract	Background: In recent years, Saudi Arabia has witnessed staggering rates of hypertension and dyslipidemia-related cardiovascular (CV) deaths, overburdening the healthcare ecosystem of the country. Appropriate public health interventions can be devised through quantitative mapping of evidence. Identification of potential data gaps can prioritize future research needs and develop a 'best-fit' framework for patient-centric management of hypertension and dyslipidemia. Methods: This review quantified data gaps in the prevalence and key epidemiological touchpoints of the patient journey including awareness, screening, diagnosis, treatment, adherence, and control in patients with hypertension and dyslipidemia in Saudi Arabia. Studies published in English between January 2010 and December 2021 were identified through a structured search on MEDLINE, Embase, BIOSIS, and PubMed databases. An unstructured search on public and government websites, including Saudi Ministry of Health, without date limits was carried out to fill data gaps. After exclusion of studies based on predefined criteria, a total of 14 studies on hypertension and 12 studies and one anecdotal evidence for dyslipidemia were included in the final analyses. Results: The prevalence of hypertension was reported to be 14.0%-41.8% while that for dyslipidemia was 12.5%-62.0%. The screening rate for hypertension was 100.0% as revealed by the nationwide surveys. Among hypertensive patients, only 27.6%-61.1% patients were aware of their condition, 42.2% patients underwent diagnosis, 27.9%-78.9% patients received antihypertensive treatment, 22.5% patients adhered to treatment medication, while blood pressure (BP) control was achieved in 27.0%-45.0% patients. Likewise, among patients with dyslipidemia, 10.5%-47.3% patients were aware of their condition, 34.6% patients were screened, and 17.8% underwent diagnosis. Although high treatment rates ranging from 40.0%-94.0% were reported, medication adherence recorded was 45.0%-77.4% among the treated patients. The overall low control rates ranged from 28.0%-41.5%. Conclusions: The study findings highlight evidence gaps along key touchpoints of patient journey. Reinforcing the efforts for high-quality evidence-based research at a national level may pave a path for better resource utilization and provide guidance to practice and amend health policies for patients, healthcare practitioners (HCPs), and healthcare policy makers for better patient outcomes in Saudi Arabia.
Language	English
Publishing date	2023-07-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1117688-x
ISSN	2049-3258 ; 0778-7367 ; 0003-9578
ISSN (online)	2049-3258
ISSN	0778-7367 ; 0003-9578
DOI	10.1186/s13690-023-01121-3
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Zs.A 147: Show issues

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Article: Comparing Safety and Efficacy Outcomes of Gastric Bypass and Sleeve Gastrectomy in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Elsaigh, Mohamed / Awan, Bakhtawar / Shabana, Ahmed / Sohail, Azka / Asqalan, Ahmad / Saleh, Omnia / Szul, Justyna / Khalil, Rana / Elgohary, Hatem / Marzouk, Mohamed / Alasmar, Mohamed

Cureus

2024 Volume 16, Issue 1, Page(s) e52796

Abstract: Sleeve Gastrectomy (SG) could be done by the removal of a big portion of the stomach, leading to reduced amounts of food taken as a result of the smaller stomach size. In contrast, Roux-en-Y Gastric Bypass (RYGB) can be done by creating a small stomach ... ...

Abstract	Sleeve Gastrectomy (SG) could be done by the removal of a big portion of the stomach, leading to reduced amounts of food taken as a result of the smaller stomach size. In contrast, Roux-en-Y Gastric Bypass (RYGB) can be done by creating a small stomach pouch and rerouting a part of the small intestine, employing combined mechanisms of restriction and malabsorption to limit food intake and modify nutrient absorption. Our aim is to identify the most effective and safest surgical intervention for individuals with both Type 2 Diabetes Mellitus (T2DM) and obesity, considering both short and long-term outcomes. We will assess participants undergoing either SG or RYGB to determine the optimal surgical approach. We made a thorough search of PubMed, Cochrane Library, Scopus, and Web of Science databases up to November 2023. Our focus was on randomized controlled trials (RCTs) comparing the safety and efficacy of RYGB and SG in T2DM regarding any extractable data. We excluded studies of other designs, such as cohorts, case reports, case series, reviews, in vitro studies, postmortem analyses, and conference abstracts. Utilizing Review Manager 5.4, we performed a meta-analysis, combining risk ratios (RR) with a 95% confidence interval (CI) conducted for binary outcomes, while mean with SD and 95% CI are pooled for the continuous ones. The total number of participants in our study is 4,148 patients. Our analysis indicates superior outcomes in the group undergoing RYGB surgery compared to the SG group (RR = 0.76, 95% (CI) (0.66 to 0.88), P = 0.0002). The pooled data exhibited homogeneity (P = 0.51, I2 = 0%) after employing the leave-one-out method. For the 1-3 year period, six studies involving 332 patients with T2DM yielded non-significant results (RR = 0.83, 95% CI (0.66 to 1.06), P = 0.14) with homogeneity (P = 0.24, I2 = 28%). Conversely, the 5-10 year period, with six studies comprising 728 DM patients, demonstrated significant results (RR = 0.69, 95% CI (0.56 to 0.85), P = 0.14) and homogeneity (P = 0.84, I2 = 0%). In terms of total body weight loss, our findings indicate significantly higher weight loss with RYGB (mean difference (MD) = -6.13, 95% CI (-8.65 to -3.6), P > 0.00001). However, pooled data exhibited considerable heterogeneity (P > 0.00001, I2 = 93%). Subgroup analyses for the 1-3 year period (five studies, 364 DM patients) and 5-10 year period (six studies, 985 DM patients) also revealed significant differences favoring RYGB, with heterogeneity observed in both periods (1-3 years: P > 0.00001, I2 = 95%; 5-10 years: P = 0.001, I2 = 75%). RYGB demonstrated significant long-term improvement in diabetes remission and superior total body weight loss compared to SG. While no notable differences were observed in other efficacy outcomes, safety parameters require further investigation. no significant distinctions were found in any of the safety outcomes: hypertension (HTN), high-density lipoprotein (HDL), hyperlipidemia, fasting blood glucose, vomiting, low-density lipoprotein (LDL), and total cholesterol. Further research is essential to comprehensively assess safety outcomes for both surgical approaches.
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52796
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Article ; Online: Prognostic factors and predictive models in hot gallbladder surgery: A prospective observational study in a high-volume center.

Tebala, Giovanni Domenico / Shabana, Amanda / Patel, Mahul / Samra, Benjamin / Chetwynd, Alan / Nixon, Mickaela / Pradhan, Siddhee / Elhag, Bara'a / Mok, Gabriel / Mighiu, Alexandra / Antunes, Diandra / Slack, Zoe / Cirocchi, Roberto / Bond-Smith, Giles

Annals of hepato-biliary-pancreatic surgery

2024

Abstract: Backgrounds/aims: The standard treatment for acute cholecystitis, biliary pancreatitis and intractable biliary colics ("hot gallbladder") is emergency laparoscopic cholecystectomy (LC). This paper aims to identify the prognostic factors and create ... ...

Abstract	Backgrounds/aims: The standard treatment for acute cholecystitis, biliary pancreatitis and intractable biliary colics ("hot gallbladder") is emergency laparoscopic cholecystectomy (LC). This paper aims to identify the prognostic factors and create statistical models to predict the outcomes of emergency LC for "hot gallbladder." Methods: A prospective observational cohort study was conducted on 466 patients having an emergency LC in 17 months. Primary endpoint was "suboptimal treatment," defined as the use of escape strategies due to the impossibility to complete the LC. Secondary endpoints were postoperative morbidity and length of postoperative stay. Results: About 10% of patients had a "suboptimal treatment" predicted by age and low albumin. Postop morbidity was 17.2%, predicted by age, admission day, and male sex. Postoperative length of stay was correlated to age, low albumin, and delayed surgery. Conclusions: Several predictive prognostic factors were found to be related to poor emergency LC outcomes. These can be useful in the decision-making process and to inform patients of risks and benefits of an emergency vs. delayed LC for hot gallbladder.
Language	English
Publishing date	2024-01-12
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3012179-6
ISSN	2508-5859 ; 2508-5778
ISSN (online)	2508-5859
ISSN	2508-5778
DOI	10.14701/ahbps.23-112
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