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Article: Missed cervical spine subluxation leading to bilateral facet dislocation with severe deformity requiring 360 fixation.

Talibi, Sayed Samed / Thant, Jonathan Kyaw / Dasic, Davor / Shad, Amjad

2021 Volume 16, Issue 10, Page(s) 3076–3080

Abstract: A 41 year-old male that presented after a fall downstairs and the initial imaging was misinterpreted, missing a subtle abnormality, C5/6 subluxation. The patient presented later with neck pain and further imaging demonstrated bilateral facet dislocation ... ...

Abstract	A 41 year-old male that presented after a fall downstairs and the initial imaging was misinterpreted, missing a subtle abnormality, C5/6 subluxation. The patient presented later with neck pain and further imaging demonstrated bilateral facet dislocation with severe deformity requiring 360 spinal fixation.
Language	English
Publishing date	2021-08-12
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2021.07.036
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Article: Lumbar discal cyst and post-operative discal pseudocyst: a case series.

Jadhav, Neha / Sivakumar, Lawrence / Talibi, Sayed Samed / Momoh, Pearl / Rasul, Fahid / Hussain, Rahim / Shad, Amjad

Journal of surgical case reports

2022 Volume 2022, Issue 5, Page(s) rjac239

Abstract: Four cases of lumbar cyst (2 discal cysts and 2 post-operative discal pseudocysts) who presented predominantly with features of sciatica without any motor, sensory or sphincteric disturbances. The patients were treated conservatively, and the management ... ...

Abstract	Four cases of lumbar cyst (2 discal cysts and 2 post-operative discal pseudocysts) who presented predominantly with features of sciatica without any motor, sensory or sphincteric disturbances. The patients were treated conservatively, and the management was aimed to avert any untoward surgical intervention taking into consideration patient safety and care. Two had previous lumbar decompressive discectomy. During the mean follow-up period of 13 months, there was progressive recovery of symptoms in all our 4 patients. All our patients were successfully managed by conservative approach. An intervertebral disc cyst should be considered in young patients in the differential diagnosis of any extradural intraspinal mass ventral to the thecal sac, notwithstanding its rarity. Alongside, conservative management can be offered as first line of management with appropriate patient selection that is absence of any motor/sensory/sphincteric disturbances. Facetal micro-instability could be one of the aetiologies of this pathology which necessitates further study.
Language	English
Publishing date	2022-05-31
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjac239
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Article ; Online: Utility of Arterial Spin Labeling Magnetic Resonance Imaging in Differentiating Sellar Region Meningiomas from Pituitary Adenomas.

Parikh, Dhruv / Afshari, Fardad T / Sherlala, Khaled / Ahmed, Shahzada / Shad, Amjad

World neurosurgery

2020 Volume 142, Page(s) e407–e412

Abstract: Background: Differentiating sellar region meningiomas from pituitary adenomas on standard magnetic resonance imaging (MRI) sequences can be difficult. Arterial spin labeling (ASL) is a noninvasive technique of magnetic resonance perfusion imaging. The ... ...

Abstract	Background: Differentiating sellar region meningiomas from pituitary adenomas on standard magnetic resonance imaging (MRI) sequences can be difficult. Arterial spin labeling (ASL) is a noninvasive technique of magnetic resonance perfusion imaging. The range of applications of ASL in neurosurgery has increased, and the information provided can be unique and complementary to other MRI sequences. Here we investigate the utility of ASL MRI in differentiating between sellar region meningiomas and pituitary adenomas. Methods: This was a retrospective comparison of quantitative assessments on absolute and normalized tumor blood flow in histologically proven meningiomas versus pituitary adenomas. Results: A total of 15 patients with sellar region lesions were identified, including 9 meningiomas and 6 pituitary adenomas. Mean absolute tumor blood flow and normalized tumor blood flow were significantly higher in meningiomas (131 mL/100 g/min and 2.22) than adenomas (47 mL/100 g/min and 0.92; P < 0.05). Conclusions: ASL MRI is a useful adjunct sequence in differentiating sellar region meningiomas, which exhibit high perfusion, from pituitary adenomas, which exhibit relatively low perfusion.
MeSH term(s)	Adenoma/diagnostic imaging ; Adenoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Diagnosis, Differential ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Meningeal Neoplasms/diagnostic imaging ; Meningeal Neoplasms/pathology ; Meningioma/diagnostic imaging ; Meningioma/pathology ; Middle Aged ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/pathology ; Retrospective Studies ; Spin Labels
Chemical Substances	Spin Labels
Language	English
Publishing date	2020-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2020.07.039
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Article ; Online: Chordomas and chondrosarcomas of the skull base: treatment and outcome analysis in a consecutive case series of 24 patients.

Metcalfe, Christopher / Muzaffar, Jameel / Kulendra, Kevin / Sanghera, Paul / Shaw, Simon / Shad, Amjad / Saravanappa, Natarajan / Paluzzi, Alessandro / Ahmed, Shahzada

World journal of surgical oncology

2021 Volume 19, Issue 1, Page(s) 68

Abstract: Background: We present our 9-year consecutive case series of skull base chordomas and chondrosarcomas from a UK tertiary referral centre, discussing treatments offered and outcomes. This was carried out to improve understanding around current treatment ... ...

Abstract	Background: We present our 9-year consecutive case series of skull base chordomas and chondrosarcomas from a UK tertiary referral centre, discussing treatments offered and outcomes. This was carried out to improve understanding around current treatment and to better inform the management of future patients. Methods: Consecutive case series over a 9-year period (2007-2016). Retrospective data analysis from the electronic skull base multidisciplinary team database and the digital patient records at a UK tertiary referral centre RESULTS: Twenty-four patients were identified (11 chordomas, 13 chondrosarcomas, mean age 52). Nineteen had proton beam therapy (PBT) postoperatively; two had intensity-modulated radiotherapy; two had no further treatment. One patient was lost to follow-up. All chordomas were resected via a transnasal endoscopic approach. Of the 19 patients undergoing resection with PBT, 13 were disease free at latest follow-up, and six patients had local recurrence, of which two died (mean follow up 7.4 years). Of the three patients treated with surgery then IMRT/TomoTherapy, one died 4 years post-treatment, and the other two are alive after 4 and 5 years of follow-up respectively. Of the two patients treated with surgery alone, one was lost to follow-up, and the other is alive after more than 8 years. Chondrosarcoma 5-year survival was 91.6%, and chordoma 4-year survival was 75%. Conclusion: Skull base chordomas and chondrosarcomas can be challenging to resect, and most cases require adjuvant therapy to achieve control. Where complete resection is not possible, it is critical to undertake sufficient resection to permit high-dose radiation.
MeSH term(s)	Chondrosarcoma/surgery ; Chordoma/surgery ; Follow-Up Studies ; Humans ; Middle Aged ; Neoplasm Recurrence, Local/therapy ; Prognosis ; Retrospective Studies ; Skull Base ; Treatment Outcome
Language	English
Publishing date	2021-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/s12957-021-02178-6
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Article ; Online: Use of the novel ANSPACH bone collector for bone autograft in anterior cervical discectomy and cage fusion.

Ekanayake, Jinendra / Shad, Amjad

Acta neurochirurgica

2010 Volume 152, Issue 4, Page(s) 651–653

Abstract: Background: The use of interbody cages with bone autograft following anterior cervical discectomy is well documented. The use of high-speed drills in the drilling of the posterior osteophyte results in the production of bone dust with viable osteophytes. ...

Abstract	Background: The use of interbody cages with bone autograft following anterior cervical discectomy is well documented. The use of high-speed drills in the drilling of the posterior osteophyte results in the production of bone dust with viable osteophytes. We report the use of the ANSPACH bone collector device, which can be connected to standard suction circuitry and used to collect this bone dust. Method/results: A group of six patients undergoing anterior cervical discectomies at one (4) or two levels (2). The bone collector was attached to the suction system. Following collection of the desired bone dust from the devices' collection chambers, it was fitted into the previously sized interbody cages and impacted into the disc spaces. The bone collector is a single-use, disposable device, delivered sterile, designed to connect to standard 6-mm suction tubing. The use of the bone collector provided sufficient bone material for complete filling of the interbody cages in all of the patients. Discussion: The use of autogenous cancellous bone material is the gold standard with regards to bone graft. The collection of bone dust during the use of high-speed drills has a number of applications and could provide a useful source of viable osteogenic material in spinal, cranial and craniofacial procedures. Conclusion: The use of the ANSPACH bone collector incorporated into a standard suction system provides an efficient method of autograft collection, removing the need for an adjunctive procedure with associated donor-site morbidity.
MeSH term(s)	Bone Transplantation/instrumentation ; Cervical Vertebrae/surgery ; Diskectomy/instrumentation ; Disposable Equipment ; Dust ; Equipment Design ; Humans ; Prostheses and Implants ; Spinal Fusion/instrumentation ; Spinal Osteophytosis/surgery ; Suction/instrumentation ; Tissue and Organ Harvesting/instrumentation
Chemical Substances	Dust
Language	English
Publishing date	2010-04
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-009-0513-0
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Article ; Online: Anterior clinoid mucocele--clinical presentation, investigations, and management by endoscopic excision: review of literature.

Kuruvath, Sarin / Ahmed, Shahzada / Johnson, Alan / Shad, Amjad

Journal of neurological surgery. Part A, Central European neurosurgery

2013 Volume 74 Suppl 1, Page(s) e180–4

Abstract: Mucoceles in the anterior clinoid location are exceptionally rare. They present with visual failure and are often misdiagnosed as unilateral optic neuritis. Early recognition with imaging studies and prompt surgical excision is the treatment of choice. ... ...

Abstract	Mucoceles in the anterior clinoid location are exceptionally rare. They present with visual failure and are often misdiagnosed as unilateral optic neuritis. Early recognition with imaging studies and prompt surgical excision is the treatment of choice. Endoscopic surgery achieves this with the least surgical trauma and hospitalization. We report two cases of anterior clinoid mucocele that were treated successfully by endoscopic surgery and also review its management.
MeSH term(s)	Adult ; Cranial Sinuses/surgery ; Endoscopy/methods ; Female ; Headache/etiology ; Humans ; Hyperesthesia/etiology ; Magnetic Resonance Imaging ; Mucocele/pathology ; Mucocele/surgery ; Neurosurgical Procedures/methods ; Optic Nerve Diseases/etiology ; Recovery of Function ; Tomography, X-Ray Computed ; Treatment Outcome
Language	English
Publishing date	2013-12
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	2651663-9
ISSN	2193-6323 ; 2193-6315
ISSN (online)	2193-6323
ISSN	2193-6315
DOI	10.1055/s-0032-1333414
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Article: A rare case of symmetrical four limb gangrene following emergency neurosurgery.

Phan, Pho Nh / Acharya, Vikas / Parikh, Dhruv / Shad, Amjad

International journal of surgery case reports

2015 Volume 16, Page(s) 15–18

Abstract: Introduction: The authors report a case of symmetrical peripheral gangrene (SPG) following emergency neurosurgery.: Presentation of case: A 35-year-old female presented to hospital in Thailand with nausea, headache, and subsequent seizures. She was ... ...

Abstract	Introduction: The authors report a case of symmetrical peripheral gangrene (SPG) following emergency neurosurgery. Presentation of case: A 35-year-old female presented to hospital in Thailand with nausea, headache, and subsequent seizures. She was found to have a large intracranial space-occupying lesion with mass effect. Following emergency surgical debulking and decompression, she suffered from severe sepsis with multiple organ failure, treated with high dose intravenous vasopressors and developed secondary gangrene in all four limbs. She was repatriated to the UK with a baseline GCS of 8 and multiple postoperative medical complications. With initial conservative management, the patient made a prolonged but satisfactory progression to recovery prior to semi-elective debridement and selected digit amputation of the gangrene. Discussion: This is the first reported case of four limb symmetrical peripheral gangrene following an emergency craniotomy. Conclusion: Although rare, SPG is a substantial complication with high mortality and morbidity and therefore should be especially taken into account for emergency intracranial pathologies in neurosurgical patients, particularly if they require emergency surgery.
Language	English
Publishing date	2015-09-18
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2015.09.009
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Article ; Online: The value of prolactin in predicting prolactinοma in hyperprolactinaemic polycystic ovarian syndrome.

Kyritsi, Eleni Magdalini / Dimitriadis, Georgios K / Angelousi, Anna / Mehta, Hiten / Shad, Amjad / Mytilinaiou, Maria / Kaltsas, Gregory / Randeva, Harpal S

European journal of clinical investigation

2018 Volume 48, Issue 7, Page(s) e12961

Abstract: Background: To identify a serum prolactin (PRL) cut-off value indicative of a PRL-producing adenoma in women with polycystic ovarian syndrome (PCOS) and hyperprolactinaemia and characterize such patients.: Materials and methods: In the present ... ...

Abstract	Background: To identify a serum prolactin (PRL) cut-off value indicative of a PRL-producing adenoma in women with polycystic ovarian syndrome (PCOS) and hyperprolactinaemia and characterize such patients. Materials and methods: In the present retrospective case-control study, the medical records of 528 PCOS women were reviewed. Pituitary magnetic resonance imaging (MRI) was performed in PCOS patients with PRL levels ≥94.0 ng/mL and/or symptoms suspicious of a pituitary adenoma (PA). Prolactinoma diagnosis was made in the presence of an MRI-identifiable PA with biochemical and radiological response to dopamine agonists. Receiver operating characteristic (ROC) curve analysis was performed to determine a serum PRL threshold that could identify hyperprolactinaemic PCOS subjects with prolactinomas. Clinical, metabolic and endocrine parameters were also analysed. Results: Among 528 patients with PCOS, 60 (11.4%) had elevated PRL levels. Of 44 (73.3%) patients who had pituitary imaging, 19 had PAs, 18 normal MRI and 7 other abnormalities. Patients harbouring prolactinomas had significantly higher PRL levels compared to patients without adenomas (median PRL 95.4 vs 49.2 ng/mL, P < .0001). A PRL threshold of 85.2 ng/mL could distinguish patients with prolactinomas with 77% sensitivity and 100% specificity [Area Under the curve (AUC) (95%) 0.91(0.8-1.018), P = .0001]. PCOS women with prolactinomas were younger and had lower LH levels compared to women without prolactinomas. Conclusions: In women with PCOS, PRL levels exceeding 85.2 ng/mL are highly suggestive of a prolactinoma warranting pituitary imaging. Pituitary MRI could also be considered in young PCOS patients with milder PRL elevation and low LH levels.
MeSH term(s)	Adult ; Area Under Curve ; Female ; Humans ; Hyperprolactinemia/complications ; Hyperprolactinemia/diagnosis ; Magnetic Resonance Imaging ; Polycystic Ovary Syndrome/complications ; Prolactin/metabolism ; Prolactinoma/complications ; Prolactinoma/diagnosis ; ROC Curve ; Retrospective Studies
Chemical Substances	Prolactin (9002-62-4)
Language	English
Publishing date	2018-06-13
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	186196-7
ISSN	1365-2362 ; 0014-2972 ; 0960-135X
ISSN (online)	1365-2362
ISSN	0014-2972 ; 0960-135X
DOI	10.1111/eci.12961
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Article ; Online: Traumatic bleeding of spinal angiolipoma presenting with subacute paraparesis--a case report and histopathological aspects.

Sankaran, Vijay / Carey, Martyn / Shad, Amjad

British journal of neurosurgery

2010 Volume 24, Issue 6, Page(s) 714–715

Abstract: Spinal angiolipoma is a rare benign tumour. It usually presents as a slowly progressive compressive lesion. Bleeding in this tumour is extremely rare and is spontaneous and acute. This is the first reported case of post-traumatic bleeding from a spinal ... ...

Abstract	Spinal angiolipoma is a rare benign tumour. It usually presents as a slowly progressive compressive lesion. Bleeding in this tumour is extremely rare and is spontaneous and acute. This is the first reported case of post-traumatic bleeding from a spinal angiolipoma, who developed subacute progressive paraparesis. The pathological definition of this rare entity is not well established. Histologically it is distinct from cutaneous angiolipoma.
MeSH term(s)	Aged ; Angiolipoma/complications ; Angiolipoma/surgery ; Hemorrhage/etiology ; Humans ; Laminectomy/methods ; Male ; Paraparesis/etiology ; Paraparesis/surgery ; Spinal Neoplasms/complications ; Spinal Neoplasms/surgery ; Treatment Outcome
Language	English
Publishing date	2010-12
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.3109/02688697.2010.520760
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Article ; Online: Isolated postganglionic Horner syndrome: some lessons learned.

Nambiar, Seena / Blain, Fiona / Agrawal, Pavi / Shad, Amjad / Ahluwalia, Harpreet

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2012 Volume 47, Issue 5, Page(s) e26–7

MeSH term(s)	Cavernous Sinus/pathology ; Female ; Horner Syndrome/diagnosis ; Horner Syndrome/etiology ; Horner Syndrome/physiopathology ; Humans ; Magnetic Resonance Imaging ; Meningeal Neoplasms/complications ; Meningeal Neoplasms/diagnosis ; Meningeal Neoplasms/surgery ; Meningioma/complications ; Meningioma/diagnosis ; Meningioma/surgery ; Middle Aged ; Oculomotor Muscles/innervation ; Sympathetic Fibers, Postganglionic/physiopathology ; Tomography, X-Ray Computed ; Visual Acuity/physiology
Language	English
Publishing date	2012-10
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2012.03.021
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