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  1. Article ; Online: Bioassay-Guided Fractionation with Antimalarial and Antimicrobial Activities of

    Samy, Mamdouh Nabil / Mahmoud, Basma Khalaf / Shady, Nourhan Hisham / Abdelmohsen, Usama Ramadan / Ross, Samir Anis

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 23

    Abstract: Bioassay-guided fractionation technique of roots ... ...

    Abstract Bioassay-guided fractionation technique of roots of
    Language English
    Publishing date 2022-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27238382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article ; Online: Evaluation of the anti-infective potential of the seed endophytic fungi of Corchorus olitorius through metabolomics and molecular docking approach.

    Ahmed, Arwa Mortada / Ibrahim, Ayman M / Yahia, Ramadan / Shady, Nourhan Hisham / Mahmoud, Basma Khalaf / Abdelmohsen, Usama Ramadan / Fouad, Mostafa A

    BMC microbiology

    2023  Volume 23, Issue 1, Page(s) 355

    Abstract: Background: Endophytic fungi are very rich sources of natural antibacterial and antifungal compounds. The main aim of this study is to isolate the fungal endophytes from the medicinal plant Corchorus olitorius seeds (F. Malvaceae), followed by ... ...

    Abstract Background: Endophytic fungi are very rich sources of natural antibacterial and antifungal compounds. The main aim of this study is to isolate the fungal endophytes from the medicinal plant Corchorus olitorius seeds (F. Malvaceae), followed by antimicrobial screening against various bacterial and fungal strains.
    Results: Seven endophytic fungal strains belonging to different three genera were isolated, including Penicillium, Fusarium, and Aspergillus. The seven isolated endophytic strains revealed selective noticeable activity against Escherichia coli (ATCC25922) with varied IC
    Conclusion: These results will expand the knowledge of endophytes and provide us with new approaches to face the global antibiotic resistance problem and the future production of undiscovered compounds different from the antibiotics classes.
    MeSH term(s) Corchorus/microbiology ; Molecular Docking Simulation ; Escherichia coli ; Microbial Sensitivity Tests ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/metabolism ; Fungi ; Anti-Bacterial Agents/metabolism ; Aspergillus ; Seeds/microbiology
    Chemical Substances Anti-Infective Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041505-9
    ISSN 1471-2180 ; 1471-2180
    ISSN (online) 1471-2180
    ISSN 1471-2180
    DOI 10.1186/s12866-023-03092-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Wound Healing and Antioxidant Capabilities of

    Shady, Nourhan Hisham / Soltane, Raya / Maher, Sherif A / Saber, Entesar Ali / Elrehany, Mahmoud A / Mostafa, Yaser A / Sayed, Ahmed M / Abdelmohsen, Usama Ramadan

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 11

    Abstract: LC-HRMS-assisted chemical profiling of Zizyphus mauritiana fruit extract (ZFE) led to the dereplication of 28 metabolites. Furthermore, wound healing activity of ZFE in 24 adult male New Zealand Dutch strain albino rabbits was investigated in-vivo ... ...

    Abstract LC-HRMS-assisted chemical profiling of Zizyphus mauritiana fruit extract (ZFE) led to the dereplication of 28 metabolites. Furthermore, wound healing activity of ZFE in 24 adult male New Zealand Dutch strain albino rabbits was investigated in-vivo supported by histopathological investigation. Additionally, the molecular mechanism was studied through different in-vitro investigations as well as, studying both relative gene expression and relative protein expression patterns. Moreover, the antioxidant activity of ZFE extract was examined using two in-vitro assays including hydrogen peroxide and superoxide radical scavenging activities that showed promising antioxidant potential. Topical application of the extract on excision wounds showed a significant increase in the wound healing rate (p < 0.001) in comparison to the untreated and MEBO®-treated groups, enhancing TGF-β1, VEGF, Type I collagen expression, and suppressing inflammatory markers (TNF-α and IL-1β). Moreover, an in silico molecular docking against TNFα, TGFBR1, and IL-1β showed that some of the molecules identified in ZFE can bind to the three wound-healing related protein actives sites. Additionally, PASS computational calculation of antioxidant activity revealed potential activity of three phenolic compounds (Pa score > 0.5). Consequently, ZFE may be a potential alternative medication helping wound healing owing to its antioxidant and anti-inflammatory activities.
    Language English
    Publishing date 2022-05-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11111392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Network Pharmacological Analysis of the Red Sea Sponge

    Abou-Taleb, Heba A / Sayed, Ahmed M / Refaat, Hesham / Alsenani, Faisal / Alaaeldin, Eman / Mokhtar, Fatma A / Abdelmohsen, Usama Ramadan / Shady, Nourhan Hisham

    Marine drugs

    2022  Volume 20, Issue 10

    Abstract: In this study, the LC-HRMS-assisted chemical profiling ... ...

    Abstract In this study, the LC-HRMS-assisted chemical profiling of
    MeSH term(s) Humans ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Caco-2 Cells ; Complex Mixtures ; Indian Ocean ; Liposomes ; Proteoglycans ; Porifera
    Chemical Substances Antineoplastic Agents ; Complex Mixtures ; Liposomes ; Proteoglycans
    Language English
    Publishing date 2022-10-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20100628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Antiulcer Potential of Psidium guajava Seed Extract Supported by Metabolic Profiling and Molecular Docking

    Shady, Nourhan Hisham / Abdullah, Hend Samy / Maher, Sherif A. / Albohy, Amgad / Elrehany, Mahmoud A. / Mokhtar, Fatma Alzahraa / Oraby, Hesham Farouk / Shawky, Ahmed M. / Abdelmohsen, Usama Ramadan

    Antioxidants. 2022 June 23, v. 11, no. 7

    2022  

    Abstract: One of the most severe human health problems is gastric ulceration. The main aim of our study is to explore the gastroprotective effect of the Psidium guajava seeds extract (PGE). Metabolic profiling based on LC-HRMS for the extract led to the ... ...

    Abstract One of the most severe human health problems is gastric ulceration. The main aim of our study is to explore the gastroprotective effect of the Psidium guajava seeds extract (PGE). Metabolic profiling based on LC-HRMS for the extract led to the dereplication of 23 compounds (1–23). We carried out a gastric ulcer model induced by indomethacin in male albino rats in vivo and the extract of PGE was investigated at a dose of 300 mg/kg in comparison to cimetidine (100 mg/kg). Furthermore, the assessment of gastric mucosal lesions and histopathology investigation of gastric tissue was done. It has been proved that Psidium guajava seeds significantly decreased the ulcer index and protected the mucosa from lesions. The antiulcer effect of Psidium guajava seed extract, which has the power of reducing the ensuing inflammatory reactions, can counteract the inflammation induced by indomethacin by the downregulation of relative genes expression (IL-1β, IL-6, and TNF-α). Moreover, PGE significantly downregulated the increased COX-2, TGF-β, and IGF-1 relative genes expression, confirming its beneficial effect in ulcer healing. Moreover, the possible PGE antioxidant potential was determined by in vitro assays using hydrogen peroxide and superoxide radical scavenging and revealed high antioxidant potential. Additionally, on the putatively annotated metabolites, an in silico study was conducted, which emphasized the extract’s antiulcer properties might be attributed to several sterols such as stigmasterol and campesterol. The present study provided evidence of Psidium guajava seeds considered as a potential natural gastroprotective agent.
    Keywords Psidium guajava ; albino ; anti-ulcer activity ; antioxidant activity ; campesterol ; cimetidine ; computer simulation ; histopathology ; human health ; hydrogen peroxide ; indomethacin ; inflammation ; interleukin-6 ; males ; metabolites ; models ; mucosa ; seed extracts ; stigmasterol ; stomach ulcers ; superoxide anion
    Language English
    Dates of publication 2022-0623
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11071230
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Cytotoxic activity of actinomycetes Nocardia sp. and Nocardiopsis sp. associated with marine sponge Amphimedon sp

    Shady, Nourhan Hisham / Tawfike, Ahmed F. / Yahia, Ramadan / Fouad, Mostafa A. / Brachmann, Alexander O. / Piel, Jörn / Abdelmohsen, Usama Ramadan / Kamel, Mohamed Salah

    Natural product research. 2022 June 2, v. 36, no. 11

    2022  

    Abstract: Cancer is a hazard life-threatening disease, which affect huge population worldwide. Marine actinomycetes are considered as promising source for potential chemotherapeutic agents. In our study, we carried out metabolic profiling for Nocardia sp. UR 86 ... ...

    Abstract Cancer is a hazard life-threatening disease, which affect huge population worldwide. Marine actinomycetes are considered as promising source for potential chemotherapeutic agents. In our study, we carried out metabolic profiling for Nocardia sp. UR 86 and Nocardiopsis sp. UR 92 that were cultivated from the Red Sea sponge Amphimedon sp. to investigate their chemical diversity using different media conditions. The crude culture extracts were subjected to high-resolution mass spectrometry (HRMS) analysis. The chemical profiles of the different extracts of Nocardia sp. UR 86 and Nocardiopsis sp. UR 92 revealed their richness in diverse metabolites and consequently twenty compounds (1–20) were annotated. Moreover, the obtained extracts of the differently cultivated Nocardia sp. UR 86 and Nocardiopsis sp. UR 92 were investigated against three cell lines HepG2, MCF-7 and CACO2 and revealed the targeted cytotoxicity of Nocardia sp. and Nocardiopsis sp. metabolites against the three cell lines.
    Keywords Amphimedon ; Nocardia ; Nocardiopsis ; cytotoxicity ; drug therapy ; mass spectrometry ; metabolites ; research ; Red Sea
    Language English
    Dates of publication 2022-0602
    Size p. 2917-2922.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1931865
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Pro-Apoptotic Activity of

    Abdelhafez, Omnia Hesham / Abdel-Rahman, Islam M / Alaaeldin, Eman / Refaat, Hesham / El-Sayed, Refat / Al-Harbi, Sami A / Shawky, Ahmed M / Hegazy, Mohamed-Elamir F / Moustafa, Alaa Y / Shady, Nourhan Hisham

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 11

    Abstract: Cancer is a major disease that threatens human health all over the world. Intervention and prevention in premalignant processes are successful ways to prevent cancer from striking. On the other hand, the marine ecosystem is a treasure storehouse of ... ...

    Abstract Cancer is a major disease that threatens human health all over the world. Intervention and prevention in premalignant processes are successful ways to prevent cancer from striking. On the other hand, the marine ecosystem is a treasure storehouse of promising bioactive metabolites. The use of such marine products can be optimized by selecting a suitable nanocarrier. Therefore,
    Language English
    Publishing date 2023-11-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16111578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: New cytotoxic dammarane type saponins from Ziziphus spina-christi.

    Elmaidomy, Abeer H / El Zawily, Amr / Salem, Aliasger K / Altemani, Faisal H / Algehainy, Naseh A / Altemani, Abdullah H / Rateb, Mostafa E / Abdelmohsen, Usama Ramadan / Shady, Nourhan Hisham

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 20612

    Abstract: Cancer is the world's second-leading cause of death. Drug development efforts frequently focus on medicinal plants since they are a valuable source of anticancer medications. A phytochemical investigation of the edible Ziziphus spina-christi (F. ... ...

    Abstract Cancer is the world's second-leading cause of death. Drug development efforts frequently focus on medicinal plants since they are a valuable source of anticancer medications. A phytochemical investigation of the edible Ziziphus spina-christi (F. Rhamnaceae) leaf extract afforded two new dammarane type saponins identified as christinin E and F (1, 2), along with the known compound christinin A (3). Different cancer cell lines, such as lung cancer (A549), glioblastoma (U87), breast cancer (MDA-MB-231), and colorectal carcinoma (CT-26) cell lines, were used to investigate the extracted compounds' cytotoxic properties. Our findings showed significant effects on all the tested cell lines at varying concentrations (1, 5, 10, and 20 µg/mL). The three compounds exhibited potent activity at low concentrations (< 10 μg/mL), as evidenced by their low IC
    MeSH term(s) Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Ziziphus/chemistry ; Saponins/pharmacology ; Antineoplastic Agents ; Dammaranes
    Chemical Substances Plant Extracts ; Saponins ; Antineoplastic Agents
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-46841-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Phytochemical analysis and anti-infective potential of fungal endophytes isolated from Nigella sativa seeds.

    Shady, Nourhan Hisham / Sobhy, Sara Khalid / Mostafa, Yaser A / Yahia, Ramadan / Glaeser, Stefanie P / Kämpfer, Peter / El-Katatny, Mo'men H / Abdelmohsen, Usama Ramadan

    BMC microbiology

    2023  Volume 23, Issue 1, Page(s) 343

    Abstract: Endophytic fungi, particularly from higher plants have proven to be a rich source of antimicrobial secondary metabolites. The purpose of this study is to examine the antimicrobial potential of three endophytic fungi Aspergillus sp. SA1, Aspergillus sp. ... ...

    Abstract Endophytic fungi, particularly from higher plants have proven to be a rich source of antimicrobial secondary metabolites. The purpose of this study is to examine the antimicrobial potential of three endophytic fungi Aspergillus sp. SA1, Aspergillus sp. SA2, and Aspergillus sp. SA3, cultivated from Nigella sativa seeds against Staphylococcus aureus (ATCC 9144), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Klebsiella pneumoniae (ATCC 13883), MRSA (ATCC 33591), and human pathogen Candida albicans (ATCC 10231). Furthermore, the most active cultivated endophytic fungi were molecularly identified via internal transcribed spacer (ITS) sequencing. HR-ESIMS guided approach has been used successfully in chemical profiling of 26 known bioactive secondary metabolites (1-26), which belongs to different classes of natural compounds such as polyketides, benzenoids, quinones, alcohols, phenols or alkaloids. Finally, in-silico interactions within active site of fungal Cyp51 and bacterial DNA gyrase revealed possibility of being a hit-target for such metabolites as antimicrobials.
    MeSH term(s) Humans ; Endophytes/chemistry ; Nigella sativa ; Microbial Sensitivity Tests ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/chemistry ; Seeds ; Fungi
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2023-11-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041505-9
    ISSN 1471-2180 ; 1471-2180
    ISSN (online) 1471-2180
    ISSN 1471-2180
    DOI 10.1186/s12866-023-03085-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The anti-infective potential of the endophytic fungi associated with

    Hassan, Hind Ashraf / Abdelhafez, Omnia Hesham / Shady, Nourhan Hisham / Yahia, Ramadan / Mohamed, Nada M / Rateb, Mostafa E / Akil, Lina / Khadra, Ibrahim / Glaeser, Stefanie P / Kämpfer, Peter / Abdelmohsen, Usama Ramadan / El-Katatny, Mo'men Hamed

    Natural product research

    2023  Volume 37, Issue 23, Page(s) 4063–4068

    Abstract: Endophytic fungi are known to be a rich source of anti-infective drugs. In our study, ...

    Abstract Endophytic fungi are known to be a rich source of anti-infective drugs. In our study,
    MeSH term(s) Onions ; Phylogeny ; Molecular Docking Simulation ; Anti-Infective Agents/pharmacology ; Fungi ; Candida albicans ; Endophytes
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2167204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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