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  1. Article ; Online: Well differentiated thyroid cancer: are we over treating our patients?

    Nixon, I J / Shah, J P

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2013  Volume 40, Issue 2, Page(s) 129–132

    MeSH term(s) Carcinoma/therapy ; Carcinoma, Papillary/therapy ; Disease-Free Survival ; Humans ; Iodine Radioisotopes/therapeutic use ; Neoplasms, Multiple Primary/therapy ; Thyroid Cancer, Papillary ; Thyroid Neoplasms/therapy ; Thyroidectomy ; Treatment Outcome
    Chemical Substances Iodine Radioisotopes
    Language English
    Publishing date 2013-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2013.12.003
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  2. Article ; Online: Parathyroid carcinoma.

    Givi, B / Shah, J P

    Clinical oncology (Royal College of Radiologists (Great Britain))

    2010  Volume 22, Issue 6, Page(s) 498–507

    Abstract: Parathyroid carcinoma is a rare endocrine malignancy. The reported incidence is from 0.5 to 5% of primary hyperparathyroidism cases in various series. The cause is unknown, but clinical correlations with different genetic syndromes exist. Mutations in ... ...

    Abstract Parathyroid carcinoma is a rare endocrine malignancy. The reported incidence is from 0.5 to 5% of primary hyperparathyroidism cases in various series. The cause is unknown, but clinical correlations with different genetic syndromes exist. Mutations in the HPRT2 gene seem to play a significant role in the pathogenesis of this disease. Men and women are equally affected, usually in the fourth or fifth decade of life. Most patients will present with signs and symptoms of hypercalcaemia. Cases of non-functioning carcinoma are exceedingly rare. Surgical resection is the most effective method of treatment and palliation. A significant proportion of patients will experience recurrence, and will need further surgical and, eventually, medical management of hypercalcaemia. The disease is progressive but slow growing. Most patients will require multiple operations to resect recurrent disease. The main cause of morbidity and mortality is the sequela of uncontrolled chronic hypercalcaemia rather than tumour burden. The current paper will review the epidemiology, pathogenesis, clinical presentation and diagnostic work-up of this disease. Surgical management in different scenarios is reviewed in detail, followed by other types of treatment and management of incurable disease.
    MeSH term(s) Diagnosis, Differential ; Female ; Humans ; Hypercalcemia/etiology ; Hypoxanthine Phosphoribosyltransferase/genetics ; Male ; Middle Aged ; Neoplasm Recurrence, Local/surgery ; Parathyroid Neoplasms/complications ; Parathyroid Neoplasms/diagnosis ; Parathyroid Neoplasms/genetics ; Parathyroid Neoplasms/therapy ; Prognosis
    Chemical Substances Hypoxanthine Phosphoribosyltransferase (EC 2.4.2.8)
    Language English
    Publishing date 2010-05-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1036844-9
    ISSN 1433-2981 ; 0936-6555
    ISSN (online) 1433-2981
    ISSN 0936-6555
    DOI 10.1016/j.clon.2010.04.007
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    Zs.A 2774: Show issues Location:
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  3. Article ; Online: Thyroid cancer: surgery for the primary tumor.

    Nixon, I J / Ganly, I / Shah, J P

    Oral oncology

    2013  Volume 49, Issue 7, Page(s) 654–658

    Abstract: Surgery is the mainstay of therapy for most patients who present with thyroid cancer. The surgeon must select an appropriate procedure based upon pre operative factors such as tumor histology, extent of primary disease, the presence of regional or ... ...

    Abstract Surgery is the mainstay of therapy for most patients who present with thyroid cancer. The surgeon must select an appropriate procedure based upon pre operative factors such as tumor histology, extent of primary disease, the presence of regional or distant metastases, associated disease in the contralateral thyroid lobe and the potential for post operative adjuvant therapy. Preservation of the vital structures in the central neck, including the recurrent and superior laryngeal nerves and the parathyroid glands is critical as is the maintenance of absolute hemostasis. In this review article we describe the management of Well Differentiated Thyroid Cancer (WDTC) presenting as a solitary nodule, WDTC in a background of multinodular disease and the management of WDTC presenting as advanced local disease. We go onto discuss the impact that regional and distant metastases have on the choice of surgical approach. The focus of this article is WDTC, however the principles of management of the primary in medullary and anaplastic carcinoma are also discussed.
    MeSH term(s) Cell Differentiation ; Humans ; Thyroid Neoplasms/classification ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery
    Language English
    Publishing date 2013-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2013.03.439
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    Zs.A 456: Show issues Location:
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  4. Article: Craniofacial surgery for malignant tumors of the paranasal sinuses.

    Shah, J P

    Otolaryngologia polska = The Polish otolaryngology

    2000  Volume 54, Issue 1, Page(s) 13–15

    MeSH term(s) Humans ; Paranasal Sinus Neoplasms/pathology ; Paranasal Sinus Neoplasms/surgery ; Surgical Procedures, Operative/methods
    Language English
    Publishing date 2000
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 417458-6
    ISSN 2300-8423 ; 0030-6657
    ISSN (online) 2300-8423
    ISSN 0030-6657
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  5. Article ; Online: SU-E-I-02: Size-Dependent Computed Tomography Histogram Analysis: Towards Breast Tissue Segmentation.

    Mann, S D / Shah, J P / Tornai, M P

    Medical physics

    2012  Volume 39, Issue 6Part4, Page(s) 3625

    Abstract: Purpose: To examine the effects of object size on scatter-corrected CT histograms to be used in threshold-based tissue segmentation.: Methods: A polyethylene cone filled with various concentrations of water and methanol mixtures, simulating glandular ...

    Abstract Purpose: To examine the effects of object size on scatter-corrected CT histograms to be used in threshold-based tissue segmentation.
    Methods: A polyethylene cone filled with various concentrations of water and methanol mixtures, simulating glandular and adipose tissues, were imaged with our quasi-monochromatic dedicated breast CT, and scatter corrected using beam-stop array measurements. Images were reconstructed using iterative OSC, and individual coronal slices along the central axis of the cone were analyzed, with radii ranging from 3.25-6.25cm. Histograms from each slice were fit with two Gaussians (fluid filling and cone material) using nonlinear least squares methods, and the corresponding standard deviation and peak centroid of each filled material were evaluated as a function of object radius. Identical methods were applied to dedicated breast CT images of four patients for clinical comparison.
    Results: Analysis of phantoms and breast data indicates low correlation between the standard deviation and object diameter. The centroids of the Gaussian peaks demonstrate an inverse linear relationship with increasing object size, independent of object material. The clinical datasets show a similar linear relationship between centroids and breast radius.
    Conclusions: Data indicate that using a linear combination of Gaussian distribution functions to segment breast tissue in scatter corrected, quasi-monochromatic cone beam dedicated breast CT is possible. An object size-independent variation of attenuation values may allow for consistent restraints on initial fit parameters, resulting in improved confidence using Gaussian curve fitting. Appropriate scaling of the size-dependent volume slices, or independent slice analysis, is necessary to minimize binning variability for accurate tissue segmentation using Gaussian curve fitting. This work is supported by National Institutes of Health (R01-CA096821) and NIH Training Grant (T32-EB007185). MPT is the inventor of this hybrid breast imaging technology, and is named as an inventor on the patent for this technology assigned to Duke (US Pat. #7,609,808). If this technology becomes commercially successful, MPT and Duke could benefit financially.
    Language English
    Publishing date 2012-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1118/1.4734716
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    Zs.A 1210: Show issues Location:
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  6. Article: Surgery of the anterior skull base for malignant tumors.

    Shah, J P

    Acta oto-rhino-laryngologica Belgica

    1999  Volume 53, Issue 3, Page(s) 191–194

    Abstract: Craniofacial resection is one of the surgical approaches for treatment of malignant tumours near or involving the anterior skull base. The indications, preoperative evaluation, surgical procedure, reconstruction, complications and prognostic factors are ... ...

    Abstract Craniofacial resection is one of the surgical approaches for treatment of malignant tumours near or involving the anterior skull base. The indications, preoperative evaluation, surgical procedure, reconstruction, complications and prognostic factors are discussed.
    MeSH term(s) Facial Bones/surgery ; Humans ; Reconstructive Surgical Procedures ; Skull Base/surgery ; Skull Base Neoplasms/surgery
    Language English
    Publishing date 1999
    Publishing country Belgium
    Document type Journal Article
    ZDB-ID 80021-1
    ISSN 0001-6497
    ISSN 0001-6497
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  7. Article: Dimensions of "Functional Status" in trials or wasting.

    Shah, J P

    The Journal of nutrition

    1999  Volume 129, Issue 1S Suppl, Page(s) 279S–281S

    MeSH term(s) Activities of Daily Living ; Clinical Trials as Topic ; Energy Metabolism/physiology ; Health Status ; Humans ; Oxygen Consumption/physiology ; Physical Exertion/physiology ; Wasting Syndrome/physiopathology ; Wasting Syndrome/therapy
    Language English
    Publishing date 1999-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
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  8. Article: Hayes Martin lecture. The making of a specialty.

    Shah, J P

    American journal of surgery

    1998  Volume 176, Issue 5, Page(s) 398–403

    MeSH term(s) General Surgery/education ; General Surgery/history ; Head and Neck Neoplasms/surgery ; History, 20th Century ; Humans ; Medical Oncology/education ; Medical Oncology/history ; Societies, Medical/history
    Language English
    Publishing date 1998-11
    Publishing country United States
    Document type Historical Article ; Lecture
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/s0002-9610(98)00247-5
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  9. Article ; Online: Comparison of surgery or radiotherapy on complications and quality of life in patients with the stage IB and IIA uterine cervical cancer (Gynecol Oncol Oct 2009; 115(1):41-45).

    Garg, G / Shah, J P / Toy, E P

    Gynecologic oncology

    2010  Volume 116, Issue 3, Page(s) 587; author reply 587–8

    MeSH term(s) Female ; Humans ; Neoplasm Staging ; Quality of Life ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/radiotherapy ; Uterine Cervical Neoplasms/surgery
    Language English
    Publishing date 2010-03
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 801461-9
    ISSN 1095-6859 ; 0090-8258
    ISSN (online) 1095-6859
    ISSN 0090-8258
    DOI 10.1016/j.ygyno.2009.10.057
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  10. Article: Frontiers in head and neck oncology. Introduction.

    Shah, J P

    Seminars in surgical oncology

    1995  Volume 11, Issue 3, Page(s) 181–182

    MeSH term(s) Combined Modality Therapy ; Head and Neck Neoplasms/radiotherapy ; Head and Neck Neoplasms/surgery ; Humans ; Radiotherapy, Adjuvant
    Language English
    Publishing date 1995-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632539-7
    ISSN 1098-2388 ; 8756-0437
    ISSN (online) 1098-2388
    ISSN 8756-0437
    DOI 10.1002/ssu.2980110302
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