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  1. Article ; Online: Avelumab in the Treatment of Advanced Merkel Cell Carcinoma: A Systematic Review.

    Sharma, Ajay N / Shah, Karishma S / Sharma, Aditi A / Yu, Siegrid S

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2024  Volume 50, Issue 5, Page(s) 407–411

    Abstract: Background: Avelumab, a programmed death ligand-1 inhibitor, has shown success in providing durable responses for difficult-to-treat Merkel cell carcinomas (MCCs).: Objective: Evaluate the efficacy and safety of avelumab in the treatment of advanced ... ...

    Abstract Background: Avelumab, a programmed death ligand-1 inhibitor, has shown success in providing durable responses for difficult-to-treat Merkel cell carcinomas (MCCs).
    Objective: Evaluate the efficacy and safety of avelumab in the treatment of advanced MCC.
    Methods: Studies reporting the use of avelumab as a monotherapy or in combination with other agents in the treatment of stage III or IV (advanced) MCC were included. The primary outcomes were overall response rate, overall survival (OS), and treatment-related adverse events.
    Results: A total of 48 studies were included, involving 1,565 patients with advanced MCC. Most patients were male (1,051, 67.3%) with stage IV MCC (517, 97.0%). The overall response rate was 46.1% (partial response-25.4% and complete response-20.7%) after a mean follow-up period of 9.5 months. Kaplan-Meier survival curves for the pooled stage III and IV group demonstrated OS rates of 58% at 1 year, 47% at 2 years, and 28% at 5 years after completion of treatment with avelumab (median OS: 23.1 months). The most common treatment-related adverse events consisted of constitutional (44%), gastrointestinal (19%), and dermatologic (12%) symptoms.
    Conclusion: Avelumab monotherapy and combination therapy have shown success in the overall response rate and survival for patients with advanced MCC.
    MeSH term(s) Carcinoma, Merkel Cell/drug therapy ; Carcinoma, Merkel Cell/pathology ; Humans ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Skin Neoplasms/mortality ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/administration & dosage ; Neoplasm Staging ; Antineoplastic Agents, Immunological/therapeutic use ; Antineoplastic Agents, Immunological/adverse effects ; Treatment Outcome ; Survival Rate
    Chemical Substances avelumab (KXG2PJ551I) ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents, Immunological
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000004107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1212: Show issues Location:
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  2. Article ; Online: Delphi consensus of risk factors for development and progression of finger interphalangeal joint osteoarthritis.

    Shah, Karishma / van Santen, James / Furniss, Dominic

    The Journal of hand surgery, European volume

    2019  Volume 44, Issue 10, Page(s) 1089–1090

    MeSH term(s) Consensus ; Delphi Technique ; Disease Progression ; Female ; Finger Joint/pathology ; Finger Joint/surgery ; Humans ; Male ; Osteoarthritis/pathology ; Osteoarthritis/surgery ; Risk Factors
    Language English
    Publishing date 2019-07-31
    Publishing country England
    Document type Letter
    ZDB-ID 2272801-6
    ISSN 2043-6289 ; 1753-1934
    ISSN (online) 2043-6289
    ISSN 1753-1934
    DOI 10.1177/1753193419865872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Enzyme-linked immunosorbent assay (ELISA): the basics.

    Shah, Karishma / Maghsoudlou, Panagiotis

    British journal of hospital medicine (London, England : 2005)

    2016  Volume 77, Issue 7, Page(s) C98–101

    MeSH term(s) Cross Reactions ; Enzyme-Linked Immunosorbent Assay ; HIV Infections/diagnosis ; Hepatitis B/diagnosis ; Humans ; Malaria/diagnosis ; Point-of-Care Testing ; Pregnancy Tests, Immunologic ; Sensitivity and Specificity
    Language English
    Publishing date 2016-07
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2016.77.7.C98
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Diagnostic accuracy of ultrasound and magnetic resonance imaging in detecting Stener lesions of the thumb: systematic review and meta-analysis.

    Qamhawi, Zahi / Shah, Karishma / Kiernan, Gareth / Furniss, Dominic / Teh, James / Azzopardi, Christine

    The Journal of hand surgery, European volume

    2021  Volume 46, Issue 9, Page(s) 946–953

    Abstract: This study assesses the diagnostic accuracy of ultrasound and magnetic resonance imaging (MRI) in diagnosing Stener lesions of the thumb. MEDLINE, PubMed, Embase and Cochrane CENTRAL were searched for studies using ultrasound or MRI to detect Stener ... ...

    Abstract This study assesses the diagnostic accuracy of ultrasound and magnetic resonance imaging (MRI) in diagnosing Stener lesions of the thumb. MEDLINE, PubMed, Embase and Cochrane CENTRAL were searched for studies using ultrasound or MRI to detect Stener lesions following suspected thumb ulnar collateral ligament injuries. The reference standard was surgical exploration or clinical joint stability. Risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. A random-effects bivariate meta-analysis was used to estimate pooled sensitivity and specificity. Forest plots were generated. Nine ultrasound (315 thumbs) and six MRI (107 thumbs) studies were included in meta-analysis (all high risk of bias). Pooled sensitivity and specificity for ultrasound were 95% and 94%, and for MRI were 93% and 98%. Both ultrasound and MRI demonstrate high diagnostic accuracy in detecting Stener lesions. Ultrasound is an appropriate first-line imaging modality.
    MeSH term(s) Collateral Ligament, Ulnar/injuries ; Hand Injuries ; Humans ; Magnetic Resonance Imaging ; Thumb/diagnostic imaging ; Thumb/injuries ; Ultrasonography
    Language English
    Publishing date 2021-02-17
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2272801-6
    ISSN 2043-6289 ; 1753-1934
    ISSN (online) 2043-6289
    ISSN 1753-1934
    DOI 10.1177/1753193421993015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Letter about a Published Paper: The hand injury caused by cutting avocado in 18 patients.

    Shah, Karishma / Furniss, Dominic / Cogswell, Lucy

    The Journal of hand surgery, European volume

    2018  Volume 43, Issue 8, Page(s) 895–896

    MeSH term(s) Hand Injuries ; Humans ; Persea
    Language English
    Publishing date 2018-09-12
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2272801-6
    ISSN 2043-6289 ; 1753-1934
    ISSN (online) 2043-6289
    ISSN 1753-1934
    DOI 10.1177/1753193418789305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: No evidence of leptin mediating the effect of body mass index on hand pain and its duration in the Chingford 1000 Women Study: original research supplementing the study by Gløersen et al.

    Perera, Romain S / Gulati, Malvika / Shah, Karishma / Hart, Deborah J / Spector, Tim D / Arden, Nigel K / Radojčić, Maja R

    Arthritis & rheumatology (Hoboken, N.J.)

    2022  Volume 74, Issue 8, Page(s) 1452–1454

    MeSH term(s) Body Composition ; Body Mass Index ; Female ; Humans ; Leptin/metabolism ; Pain
    Chemical Substances Leptin
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42132
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    Zs.A 24: Show issues Location:
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  7. Conference proceedings: Surgically Treated Brachial Plexus Tumours: The Oxford University Hospital’s 20-Year Experience

    Shah, Karishma / Moosa, Aliabbas / Dolan, Roisin / Giele, Henk

    2020  , Page(s) IFSSH19–1405

    Event/congress 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT); Berlin; ; International Federation of Societies for Hand Therapy; 2019
    Keywords Medizin, Gesundheit ; brachial plexus tumours ; sarcoma ; neurofibroma ; schwannoma
    Publishing date 2020-02-06
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/19ifssh1252
    Database German Medical Science

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  8. Article ; Online: Cricket related hand injury is associated with increased odds of hand pain and osteoarthritis.

    Shah, Karishma / Furniss, Dominic / Collins, Gary S / Peirce, Nick / Arden, Nigel K / Filbay, Stephanie R

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 16775

    Abstract: Radiographic osteoarthritis (OA) is most prevalent in the hand. The association of hand injury with pain or OA is unclear. The objective was to describe the relationship between hand injury and ipsilateral pain and OA in cricketers. Data from former and ... ...

    Abstract Radiographic osteoarthritis (OA) is most prevalent in the hand. The association of hand injury with pain or OA is unclear. The objective was to describe the relationship between hand injury and ipsilateral pain and OA in cricketers. Data from former and current cricketers aged ≥ 30 years was used. Data included history of cricket-related hand/finger injury leading to > 4 weeks of reduced exercise, hand/finger joint pain on most days of the last month, self-reported history of physician-diagnosed hand/finger OA. Logistic regression assessed the relationship between injury with hand pain (in former cricketers) and with OA (in all cricketers), adjusted for age, seasons played, playing standard. Of 1893 participants (844 former cricketers), 16.9% reported hand pain, 4.3% reported OA. A history of hand injury increased the odds of hand pain (OR (95% CI) 2.2, 1.4 to 3.6). A history of hand injury also had increased odds of hand OA (3.1, 2.1 to 4.7). Cricket-related hand injury was related to an increased odds of hand pain and OA. This highlights the importance of hand injury prevention strategies within cricket. The high prevalence of hand pain is concerning, and further research is needed to determine the impacts of hand pain.
    MeSH term(s) Adult ; Aged ; Athletic Injuries/complications ; Athletic Injuries/physiopathology ; Cricket Sport/injuries ; Female ; Hand Injuries/complications ; Hand Injuries/physiopathology ; Humans ; Male ; Middle Aged ; Osteoarthritis/epidemiology ; Osteoarthritis/etiology ; Osteoarthritis/physiopathology ; Pain/epidemiology ; Pain/etiology ; Pain/physiopathology ; Prevalence ; Self Report
    Language English
    Publishing date 2020-10-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-73586-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Association of ABO blood groups with the severity of coronary artery disease in southern India population: A prospective cross-sectional study.

    Pai M, Umesh / Samanth, Jyothi / Rao, Sudhakar / V, Rekha / A, Megha / P, Ganesh / Shah, Karishma / Kumar, Vaishak / Jose, Josna / Jabeen, Afrah / Lewis, Jean Hancilla / G, Jeena T / Suresh, Ashly / Haque, Nuhmanul

    Indian heart journal

    2023  Volume 75, Issue 4, Page(s) 285–287

    Abstract: This study aimed to find an association between ABO blood groups with presence and severity of Coronary artery disease (CAD) among Indian population. 1500 patients undergoing elective coronary angiogram (CAG) at a tertiary care hospital in Karnataka were ...

    Abstract This study aimed to find an association between ABO blood groups with presence and severity of Coronary artery disease (CAD) among Indian population. 1500 patients undergoing elective coronary angiogram (CAG) at a tertiary care hospital in Karnataka were enrolled in the study. Baseline demographic data and the presence of cardiac comorbidities were documented. Data from baseline echocardiography and angiographic studies were compiled. The incidence of CAD was higher among patients with blood group A. Blood group A also showed a higher incidence of acute coronary syndrome (ACS), left ventricular dysfunction, triple vessel disease, and severe CAD among the patients who underwent CAG.
    MeSH term(s) Humans ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/epidemiology ; ABO Blood-Group System ; Cross-Sectional Studies ; Prospective Studies ; India/epidemiology ; Coronary Angiography ; Severity of Illness Index
    Chemical Substances ABO Blood-Group System
    Language English
    Publishing date 2023-05-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 604366-5
    ISSN 2213-3763 ; 0019-4832
    ISSN (online) 2213-3763
    ISSN 0019-4832
    DOI 10.1016/j.ihj.2023.05.001
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  10. Article ; Online: Correction to: Risk factors for the progression of finger interphalangeal joint osteoarthritis: a systematic review.

    Shah, Karishma / Yang, Xiaotian / Lane, Jennifer C E / Collins, Gary S / Arden, Nigel K / Furniss, Dominic / Filbay, Stephanie R

    Rheumatology international

    2021  Volume 41, Issue 7, Page(s) 1373–1374

    Language English
    Publishing date 2021-06-25
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-021-04823-5
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