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Buch ; Online ; E-Book: Toxicology of Nanoparticles: Insights from Drosophila

Agrawal, Namita / Shah, Prasanna

2020

Abstract: This book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial ... ...

Verfasserangabe	edited by Namita Agrawal, Prasanna Shah
Abstract	This book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications. Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.
Schlagwörter	Human physiology ; Nanotechnology ; Biology/Technique ; Pharmacology ; Human Physiology ; Experimental Organisms ; Drosòfila ; Nanopartícules ; Toxicologia
Thema/Rubrik (Code)	615.1901
Sprache	Englisch
Umfang	1 online resource (128 pages)
Ausgabenhinweis	1st ed. 2020.
Verlag	Springer Nature Singapore ; Imprint: Springer
Erscheinungsort	Singapore
Dokumenttyp	Buch ; Online ; E-Book
Bemerkung	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	981-15-5522-2 ; 981-15-5521-4 ; 978-981-15-5522-0 ; 978-981-15-5521-3
DOI	10.1007/978-981-15-5522-0
Datenquelle	ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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Artikel ; Online: Discriminatory alteration of carbohydrate homeostasis by gold nanoparticles ingestion in

Raj, Akanksha / Shah, Prasanna / Singh, Akanksha / Agrawal, Namita

Toxicology and industrial health

2020 Band 36, Heft 10, Seite(n) 769–778

Abstract: With the extensive usage of gold nanoparticles (AuNPs) in various industrial sectors and biomedical applications, evaluation of their possible effects on human health becomes imperative. Therefore, the present study was aimed toward assessing the dose- ... ...

Abstract	With the extensive usage of gold nanoparticles (AuNPs) in various industrial sectors and biomedical applications, evaluation of their possible effects on human health becomes imperative. Therefore, the present study was aimed toward assessing the dose-dependent impact of AuNPs ingestion on metabolic homeostasis using
Mesh-Begriff(e)	Animals ; Carbohydrate Metabolism/drug effects ; Drosophila melanogaster/metabolism ; Eating/physiology ; Gold/adverse effects ; Gold/metabolism ; Homeostasis/drug effects ; Humans ; Larva/metabolism ; Maximum Tolerated Dose ; Metal Nanoparticles/adverse effects ; Models, Animal ; Occupational Diseases/physiopathology ; Occupational Exposure
Chemische Substanzen	Gold (7440-57-5)
Sprache	Englisch
Erscheinungsdatum	2020-08-17
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	56831-4
ISSN	1477-0393 ; 0748-2337
ISSN (online)	1477-0393
ISSN	0748-2337
DOI	10.1177/0748233720947211
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Combating silver nanoparticle-mediated toxicity in Drosophila melanogaster with curcumin.

Singh, Akanksha / Raj, Akanksha / Padmanabhan, Aishwarya / Shah, Prasanna / Agrawal, Namita

Journal of applied toxicology : JAT

2020 Band 41, Heft 8, Seite(n) 1188–1199

Abstract: Nanoscale materials display unique physical and chemical properties that enable their assimilation into a variety of industrial and consumer products. Amongst the widely used nanomaterials, silver nanoparticles (AgNPs) have gained tremendous recognition ... ...

Abstract	Nanoscale materials display unique physical and chemical properties that enable their assimilation into a variety of industrial and consumer products. Amongst the widely used nanomaterials, silver nanoparticles (AgNPs) have gained tremendous recognition for various applications, owing to their extraordinary plasmonic and bactericidal properties. Despite of the extensive usage of AgNPs in various sectors, its impact on human health remains ambiguous. Several studies have established that higher doses of AgNPs are detrimental to organismal health. In order to attain the best from these versatile nanoparticles, a recent advent of green nanotechnology, that is, employment of metal nanoparticles synthesized using plant extracts, has emerged. Here, using Drosophila as a model system, we tested if adding curcumin, a biologically active polyphenolic compound present in turmeric, having multitudes of therapeutic properties, could mitigate AgNP-mediated biotoxicity. We found that co-administration of AgNPs with curcumin in the fly food could alleviate several harmful effects evoked by AgNPs ingestion in Drosophila model. Addition of curcumin superseded reduction in feeding, pupation, eclosion, pigmentation, and fertility caused by AgNPs ingestion. Interestingly, impairment in ovary development observed in flies reared on AgNPs-supplemented food was also partially restored by co-administration of AgNPs with curcumin. Furthermore, substantial alleviation of reactive oxygen species level and cell death was observed in larval tissues upon co-supplementation of AgNPs with curcumin. We therefore propose that curcumin, when administered with AgNPs, can abrogate the toxic manifestations of AgNPs ingestion and hence can be incorporated in various consumer products encompassing it.
Mesh-Begriff(e)	Animals ; Curcumin/pharmacology ; Drosophila melanogaster/drug effects ; Drosophila melanogaster/growth & development ; Female ; Male ; Metal Nanoparticles/toxicity ; Oviposition/drug effects ; Pupa/drug effects ; Pupa/growth & development ; Silver
Chemische Substanzen	Silver (3M4G523W1G) ; Curcumin (IT942ZTH98)
Sprache	Englisch
Erscheinungsdatum	2020-11-04
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604625-3
ISSN	1099-1263 ; 0260-437X
ISSN (online)	1099-1263
ISSN	0260-437X
DOI	10.1002/jat.4103
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: An In Vitro and In Vivo Study of the Efficacy and Toxicity of Plant-Extract-Derived Silver Nanoparticles.

Desai, Anjana S / Singh, Akanksha / Edis, Zehra / Haj Bloukh, Samir / Shah, Prasanna / Pandey, Brajesh / Agrawal, Namita / Bhagat, Neeru

Journal of functional biomaterials

2022 Band 13, Heft 2

Abstract: Silver nanoparticles (AgNPs) display unique plasmonic and antimicrobial properties, enabling them to be helpful in various industrial and consumer products. However, previous studies showed that the commercially acquired silver nanoparticles exhibit ... ...

Abstract	Silver nanoparticles (AgNPs) display unique plasmonic and antimicrobial properties, enabling them to be helpful in various industrial and consumer products. However, previous studies showed that the commercially acquired silver nanoparticles exhibit toxicity even in small doses. Hence, it was imperative to determine suitable synthesis techniques that are the most economical and least toxic to the environment and biological entities. Silver nanoparticles were synthesized using plant extracts and their physico-chemical properties were studied. A time-dependent in vitro study using HEK-293 cells and a dose-dependent in vivo study using a
Sprache	Englisch
Erscheinungsdatum	2022-05-10
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb13020054
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Dose-dependent effect of silver nanoparticles (AgNPs) on fertility and survival of Drosophila: An in-vivo study.

Raj, Akanksha / Shah, Prasanna / Agrawal, Namita

PloS one

2017 Band 12, Heft 5, Seite(n) e0178051

Abstract: Silver nanoparticles (AgNPs) containing consumer products have been proliferating in the market due to its unique antimicrobial property, however, lack of in-depth knowledge about their potential effect on human health in a longer run is of great concern. ...

Abstract	Silver nanoparticles (AgNPs) containing consumer products have been proliferating in the market due to its unique antimicrobial property, however, lack of in-depth knowledge about their potential effect on human health in a longer run is of great concern. Therefore, we investigated dose-dependent in vivo effect of AgNPs using Drosophila as a model system. Drosophila, a genetically tractable organism with distinct developmental stages, short life cycle and significant homology with human serves as an ideal organism to study nanomaterial-mediated toxicity. Our studies suggest that ingestion of AgNPs in Drosophila during adult stage for short and long duration significantly affects egg laying capability along with impaired growth of ovary. Additionally, dietary intake of AgNPs from larval stage has more deleterious effects that result in reduced survival, longevity, ovary size and egg laying capability at a further lower dosage. Interestingly, the trans-generational effect of AgNPs was also observed without feeding progeny with AgNPs, thereby suggesting its impact from previous generation. Our results strongly imply that higher doses of AgNPs and its administration early during development is detrimental to the reproductive health and survival of Drosophila that follows in generations to come without feeding them to AgNPs.
Mesh-Begriff(e)	Animals ; Drosophila melanogaster/drug effects ; Drosophila melanogaster/embryology ; Drosophila melanogaster/growth & development ; Female ; Fertility/drug effects ; Life Cycle Stages/drug effects ; Longevity/drug effects ; Maternal Exposure/adverse effects ; Metal Nanoparticles/adverse effects ; Models, Animal ; Ovary/physiology ; Ovum/drug effects ; Ovum/growth & development ; Reproductive Health ; Silver/adverse effects ; Silver/pharmacology
Chemische Substanzen	Silver (3M4G523W1G)
Sprache	Englisch
Erscheinungsdatum	2017-05-24
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0178051
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Sedentary behavior and altered metabolic activity by AgNPs ingestion in Drosophila melanogaster.

Raj, Akanksha / Shah, Prasanna / Agrawal, Namita

Scientific reports

2017 Band 7, Heft 1, Seite(n) 15617

Abstract: Among several nanoparticles, silver nanoparticles (AgNPs) are extensively used in a wide variety of consumer products due to its unique antimicrobial property. However, dosage effect of AgNPs on behavior and metabolic activity in an in vivo condition is ... ...

Abstract	Among several nanoparticles, silver nanoparticles (AgNPs) are extensively used in a wide variety of consumer products due to its unique antimicrobial property. However, dosage effect of AgNPs on behavior and metabolic activity in an in vivo condition is not well studied. Therefore, to elucidate the impact of AgNPs on behavior and metabolism, systematic and detailed dosages study of AgNPs was performed by rearing Drosophila melanogaster on food without and with AgNPs. We found that dietary intake of AgNPs at early larval stage leads to behavioral abnormalities such as poor crawling and climbing ability of larvae and adults respectively. Interestingly, intake of higher dosage of AgNPs at larval stage significantly altered metabolic activity that includes lipid, carbohydrate and protein levels in adult flies. Further, detailed analysis revealed that AgNPs causes remarkable reduction in the number of lipid droplets (LDs) which are lipid storage organelles in Drosophila. We also observed an increased production of reactive oxygen species (ROS) in AgNPs ingested larval tissues. These results strongly imply that higher dosage of AgNPs ingestion from early larval stage of Drosophila is inimical and thereby draws concern towards the usage of AgNPs in consumer goods.
Mesh-Begriff(e)	Animals ; Drosophila melanogaster/drug effects ; Drosophila melanogaster/physiology ; Metal Nanoparticles/administration & dosage ; Metal Nanoparticles/chemistry ; Reactive Oxygen Species/metabolism ; Sedentary Behavior ; Silver/administration & dosage ; Silver/chemistry
Chemische Substanzen	Reactive Oxygen Species ; Silver (3M4G523W1G)
Sprache	Englisch
Erscheinungsdatum	2017-11-15
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-15645-6
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Air embolism: A rare complication of esophagogastroduodenoscopy!

Jhaveri, Ajay B. / Shah, Sharad C. / Shah, Prasanna S.

Journal of Digestive Endoscopy

2014 Band 05, Heft 03, Seite(n) 114–115

Abstract: Neurological complications of gastrointestinal endoscopy are extremely rare; cerebral air embolism has been described and can be severe and fatal. A high index of suspicion for an air embolism is a must in case of procedural or periprocedural ... ...

Abstract	Neurological complications of gastrointestinal endoscopy are extremely rare; cerebral air embolism has been described and can be severe and fatal. A high index of suspicion for an air embolism is a must in case of procedural or periprocedural cardiopulmonary instability and neurologic symptoms, particularly in patients with recognized risk factors. The diagnosis of an air embolism is often difficult and is complicated by the fact that air may be rapidly absorbed from the circulation. Simple maneuvers to decrease the impact of a potential air embolism include; stopping the procedure, administering high flow 100% oxygen, placing the patient in Trendelenburg and left lateral decubitus position, and discontinuing nitrous oxide. C T Scan and 2 D ECHO are important diagnostic tests.
Schlagwörter	Air embolism ; esophago-gastro-duodenoscopy ; neurological complication
Sprache	Englisch
Erscheinungsdatum	2014-07-01
Verlag	Thieme Medical and Scientific Publishers Private Ltd.
Erscheinungsort	Stuttgart ; New York
Dokumenttyp	Artikel
ZDB-ID	2733732-7
ISSN	0976-5050 ; 0976-5042
ISSN (online)	0976-5050
ISSN	0976-5042
DOI	10.4103/0976-5042.147507
Datenquelle	Thieme Verlag

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Artikel ; Online: Unusual presentation of an uncommon abdominal pathology.

Jain, Paresh / Shah, Prasanna / Bhansali, Mehul

Annals of the Royal College of Surgeons of England

2010 Band 92, Heft 7, Seite(n) W19–21

Abstract: Desmoid tumour is a non-encapsulated locally invasive tumour, originating from fibroblasts, which has ubiquitous distribution in the body. It has a high tendency for local recurrence, causing deformity in the adjacent organ and consequent organ ... ...

Abstract	Desmoid tumour is a non-encapsulated locally invasive tumour, originating from fibroblasts, which has ubiquitous distribution in the body. It has a high tendency for local recurrence, causing deformity in the adjacent organ and consequent organ dysfunction. A case of a 75-year-old man, presenting with high-grade fever, dull aching abdominal pain and weight loss, suspected to be due to malignancy, is reported. Contrast-enhanced computed tomography (CECT) showed a mass in the transverse colon with pericolic collection raising a suspicion of perforation. He underwent a two-stage procedure in the form of defunctioning ileostomy in the initial setting followed by colonic resection and anastomosis 6 weeks later. Histological analysis revealed mesenteric fibromatosis (desmoid tumour). The patient was completely asymptomatic one year after surgery. We report this case, as our patient had none of the predisposing factors. To the best of our knowledge, this is the first case on colonic perforation secondary to desmoid tumour.
Mesh-Begriff(e)	Abdomen, Acute/etiology ; Aged ; Colonic Neoplasms/complications ; Colonic Neoplasms/diagnosis ; Colonic Neoplasms/surgery ; Fibromatosis, Aggressive/complications ; Fibromatosis, Aggressive/diagnosis ; Fibromatosis, Aggressive/surgery ; Humans ; Intestinal Perforation/etiology ; Intestinal Perforation/surgery ; Male ; Tomography, X-Ray Computed
Sprache	Englisch
Erscheinungsdatum	2010-09-07
Erscheinungsland	England
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	80044-2
ISSN	1478-7083 ; 0035-8843
ISSN (online)	1478-7083
ISSN	0035-8843
DOI	10.1308/147870810X12822015504365
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Factors influencing mortality in acute pancreatitis: can we alter them?

Pitchumoni, C S / Patel, Nayan M / Shah, Prasanna

Journal of clinical gastroenterology

2005 Band 39, Heft 9, Seite(n) 798–814

Abstract: Severe acture pancreatitis (SAP), a multisystem disease, is characterized by multiple organ system failure and additionally by local pancreatic complications such as necrosis, abscess, or pseudocyst. The rate of mortality in SAP, which is about 20% of ... ...

Abstract	Severe acture pancreatitis (SAP), a multisystem disease, is characterized by multiple organ system failure and additionally by local pancreatic complications such as necrosis, abscess, or pseudocyst. The rate of mortality in SAP, which is about 20% of all cases of acute pancreatitis (AP), may be as high as 25%, as in infected pancreatic necrosis. The factors that influence mortality in different degrees are various. Etiology for the episode, age, sex, race, ethnicity, genetic makeup, severity on admission, and the extent and nature of pancreatic necrosis (sterile vs. infected) influence the mortality. Other factors include treatment modalities such as administration of prophylactic antibiotics, the mode of feeding (TPN vs. enteral), ERCP with sphincterotomy, and surgery in selected cases. Epidemiological studies indicate that the incidence of AP is increasing along with an increase in obesity, a bad prognostic factor. Many studies have indicated a worse prognosis in idiopathic AP compared to pancreatitis induced by alcoholism or biliary stone. The risk for SAP after ERCP is the subject of extensive study. AP after trauma, organ transplant, or coronary artery bypass surgery is rare but may be serious. Since Ranson reported early prognostic criteria, a number of attempts have been made to simplify or add new clinical or laboratory studies in the early assessment of severity. Obesity, hemoconcentration on admission, presence of pleural effusion, increased fasting blood sugar, as well as creatinine, elevated CRP in serum, and urinary trypsinogen levels are some of the well-documented factors in the literature. The role of appropriate prophylactic antibiotic therapy although still is highly controversial, in properly chosen cases appears to be beneficial and well accepted in clinical practice. Early enteral nutrition has gained much support and jejunal feeding bypassing the pancreatic stimulatory effect of it in the duodenum is desirable in selected cases. The limited role for endoscopic sphincterotomy in patients with demonstrated dilated CBD with impacted stone and evidence of impending cholangitis is well documented. Surgery in AP other than for removal of the gallbladder is often limited to infected pancreatic necrosis, pseudocysts, and pancreatic abscess and in some cases of traumatic pancreatitis with a ruptured duct system. The progress in the understanding of the role of cytokines will over us opportunities to use immunomodulatory therapies to improve the outcome in SAP.
Mesh-Begriff(e)	Antibiotic Prophylaxis ; Cholangiopancreatography, Endoscopic Retrograde ; Early Diagnosis ; Feeding Methods ; Humans ; Immunologic Factors/therapeutic use ; Pancreatectomy ; Pancreatitis, Acute Necrotizing/complications ; Pancreatitis, Acute Necrotizing/diagnosis ; Pancreatitis, Acute Necrotizing/epidemiology ; Pancreatitis, Acute Necrotizing/etiology ; Pancreatitis, Acute Necrotizing/mortality ; Pancreatitis, Acute Necrotizing/therapy ; Risk Factors ; Severity of Illness Index
Chemische Substanzen	Immunologic Factors
Sprache	Englisch
Erscheinungsdatum	2005-10-28
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	448460-5
ISSN	1539-2031 ; 0192-0790
ISSN (online)	1539-2031
ISSN	0192-0790
DOI	10.1097/01.mcg.0000177257.87939.00
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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