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  1. Article ; Online: Functional and Radiological Outcome of Short Same Segment Instrumentation in Thoracolumbar Burst fracture.

    Thapa, Bishnu Babu / Shah, Rajesh Pratap

    Journal of Nepal Health Research Council

    2023  Volume 21, Issue 1, Page(s) 15–18

    Abstract: Background: Thoracolumbar region is important biomechanics transition zone in which rigid thoracic and flexible lumbar spine meet. This area is highly vulnerable to traumatic spinal fracture.Among all spine fracture, compression type is most common and ... ...

    Abstract Background: Thoracolumbar region is important biomechanics transition zone in which rigid thoracic and flexible lumbar spine meet. This area is highly vulnerable to traumatic spinal fracture.Among all spine fracture, compression type is most common and managed conservatively. Thoracolumbar spine fracture can be associated with neurological deficit, spinal instability. The optimal treatment for these injuries is still controversy and subject for research.
    Methods: This retrospective study included 30 patients with single level thoracolumbar fracture.All the patients clinical and radiological parameters were evaluated preoperative, post-operative and 1 year follow up. Clinical parameters were included Visual analogue score, Oswestry disability index. Radiologic measurement were regional kyphotic angle by cobb's method and anterior vertebral body height loss (Mumford' santerior body compression equation method) in X-ray. All the data were analysed in SPSS version 20.
    Results: A total of 30 patients were included in this study,19 were male.The mean age of the patients were 40.8±13.The main cause of injury was fall from height,26 patients. The most common level of fracture vertebra was L1,11 patients.The mean difference of preop and postop kyphosis was 11.70±50 with P<0.05.The mean difference of preop Oswestry disability index and postop Oswestry disability index score was 30.7±7.6 with T score 22(P<0.05).The preop and postop Visual analogue score score also improved ,mean difference was 2.8±1(P<0.05).
    Conclusions: Short segment instrumentation with placement of pedicle screw at fracture vertebra is one option in the treatment of thoracolumbar burst fracture.
    MeSH term(s) Humans ; Male ; Female ; Fractures, Compression/diagnostic imaging ; Fractures, Compression/surgery ; Retrospective Studies ; Nepal ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Hydrogen Peroxide
    Chemical Substances Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2023-09-08
    Publishing country Nepal
    Document type Journal Article
    ZDB-ID 2551251-1
    ISSN 1999-6217 ; 1999-6217
    ISSN (online) 1999-6217
    ISSN 1999-6217
    DOI 10.33314/jnhrc.v21i1.4387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Quantitative and Qualitative Pathogenetic Indices for Review of Data Derived from Homeopathic Pathogenetic Trials.

    Shah, Rajesh

    Homeopathy : the journal of the Faculty of Homeopathy

    2018  Volume 107, Issue 4, Page(s) 274–279

    Abstract: Introduction:  Analysis of data derived from homeopathic pathogenetic trials (HPTs, homeopathic drug provings) has been a challenge. Most parts of the homeopathic pharmacopeia were sourced from Hahnemann's Materia Medica Pura (1825-1833), TF Allen's ... ...

    Abstract Introduction:  Analysis of data derived from homeopathic pathogenetic trials (HPTs, homeopathic drug provings) has been a challenge. Most parts of the homeopathic pharmacopeia were sourced from Hahnemann's Materia Medica Pura (1825-1833), TF Allen's Encyclopedia (1874) and Constantine Hering's Materia Medica (1879-1891), well before randomised controlled trials were in use. As a result, such studies and their outcomes harbour a large risk of inclusion of unreliable symptoms.
    Aims and objective: The main purpose of this article is to introduce Quantitative and Qualitative Pathogenetic Indices to improve the method of analysis of symptoms.
    Materials and methods:  The data from HPTs for human immunodeficiency virus nosode, hepatitis C nosode, capsaicin alkaloids (capsaicin and dihydrocapsaicin) and hydroquinone (HQ) were extracted and analysed in terms of novel Qualitative and Quantitative Pathogenetic Indices. Taken into the consideration were the qualitative aspect of a symptom (i.e. its intensity), and the quantitative aspect by calculating the number of symptoms per volunteer per day. The pathogenetic effects and data evaluation indices were calculated for each HPT. A comparison was made of symptoms of verum versus placebo provers in terms of their quantity and quality.
    Results:  Four HPTs involving 81 volunteers (56 on verum and 25 on placebo) generated 555 symptoms or pathogenetic effects (excluding run-in phase symptoms), of which 448 (81%) were reported by volunteers who were in the verum arm, and 107 (19%) were reported by volunteers on placebo. The overall mean incidence of pathogenetic effects for the four HPTs was thus 8 per verum prover and 4.28 per placebo prover. The corresponding mean Quantitative Pathogenetic Index was 0.23 symptoms per volunteer per day for the verum arm and 0.12 symptoms per volunteer per day for the placebo arm. The overall mean incidence of pathogenetic effects in the run-in phase was less. The overall mean Qualitative Pathogenetic Index (number of symptoms, of a given intensity, per volunteer per day) for the verum arm was 0.09 versus 0.05 for the placebo arm.
    Conclusion:  The symptoms exhibited by volunteers in the verum arm were more numerous and more intense than those in the placebo arm. An innovative and logical method of reporting of symptoms and analysis has been introduced by the use of these pathogenetic indices, which can be used in future as measurement tools for analysis of data from HPTs.
    MeSH term(s) Cysteine/therapeutic use ; Data Collection/methods ; Double-Blind Method ; Drug Combinations ; Homeopathy/methods ; Humans ; Pantothenic Acid/therapeutic use ; Placebos/therapeutic use ; Reference Values ; Severity of Illness Index ; Virulence Factors
    Chemical Substances Drug Combinations ; Placebos ; Virulence Factors ; calcium D-pantothenate, L-cysteine drug combination ; Pantothenic Acid (19F5HK2737) ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2018-08-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2073322-7
    ISSN 1476-4245 ; 1475-4916
    ISSN (online) 1476-4245
    ISSN 1475-4916
    DOI 10.1055/s-0038-1668536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Symptom Similarity versus Disease Similarity: Revisiting the Application of the Law of Similars and Challenging the Symptom-Centric Approach in Homeopathy.

    Shah, Rajesh

    Homeopathy : the journal of the Faculty of Homeopathy

    2018  Volume 107, Issue 3, Page(s) 218–222

    Abstract: The system of homeopathic medicine is based on the Law of Similars. It is often implied by students and practitioners of homeopathy that the fundamental principle suggests that if the substance is capable of producing certain 'symptoms', it can also ... ...

    Abstract The system of homeopathic medicine is based on the Law of Similars. It is often implied by students and practitioners of homeopathy that the fundamental principle suggests that if the substance is capable of producing certain 'symptoms', it can also remove, treat, or 'annihilate' similar symptoms if the same substance is administered in a small dose. Hahnemann clearly highlights the importance of pathogenesis or 'disease-producing power', and not just the symptoms-producing power, as a part of the 'totality of the disease'. The author perceives the need for a rectification in the symptom-centric approach in homeopathy. The pathogenesis of disease includes the mechanisms and the cause, which are more complete than the consideration of mere symptoms. Thus, the fundamental approach needs to be extended beyond the symptoms' similarity to the disease-pathogenesis similarity. Several clinical examples are given based on the imaginary expansion that is constructed on the 'mind' symptoms without the inclusion of the pathogenesis of the medicinal substance, suggesting the limitations and the risks to homeopathy of a purely symptom-centric approach.
    MeSH term(s) Homeopathy/methods ; Humans ; Materia Medica/pharmacology ; Placebo Effect ; Reference Values ; Solvents/chemistry ; Water/chemistry
    Chemical Substances Materia Medica ; Solvents ; Water (059QF0KO0R)
    Language English
    Publishing date 2018-05-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2073322-7
    ISSN 1476-4245 ; 1475-4916
    ISSN (online) 1476-4245
    ISSN 1475-4916
    DOI 10.1055/s-0038-1649499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Interventional Radiology: Blazing New Trails or Playing Catch Up?

    Shah, Rajesh P / Johnson, Matthew

    Journal of vascular and interventional radiology : JVIR

    2022  Volume 33, Issue 7, Page(s) 743–745

    MeSH term(s) Humans ; Radiology, Interventional
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 1137756-2
    ISSN 1535-7732 ; 1051-0443
    ISSN (online) 1535-7732
    ISSN 1051-0443
    DOI 10.1016/j.jvir.2022.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Diagnostic dilemma in hyperechoic breast masses.

    Shah, Rajesh R / Hussain, Maharra S

    Indian journal of cancer

    2022  Volume 59, Issue 3, Page(s) 416–418

    Abstract: Hyperechoic breast lesions are relatively uncommon, constituting only 0.6-6% of all breast masses and 0.6% of all biopsied lesions. The majority of these lesions are benign. There are rare malignancies that can present as hyperechoic masses and careful ... ...

    Abstract Hyperechoic breast lesions are relatively uncommon, constituting only 0.6-6% of all breast masses and 0.6% of all biopsied lesions. The majority of these lesions are benign. There are rare malignancies that can present as hyperechoic masses and careful ultrasonographic assessment must be employed to avoid misdiagnosis.
    MeSH term(s) Female ; Humans ; Aged ; Ultrasonography, Mammary ; Breast/diagnostic imaging ; Breast/pathology ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Diagnostic Errors ; Ovarian Neoplasms
    Language English
    Publishing date 2022-11-22
    Publishing country India
    Document type Case Reports
    ZDB-ID 410194-7
    ISSN 1998-4774 ; 0019-509X
    ISSN (online) 1998-4774
    ISSN 0019-509X
    DOI 10.4103/ijc.IJC_1046_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Phytochemical nature and antimicrobial activity of some medicinal plants

    Shah, Rajesh Kumar

    BIOINFOLET. 2021 Dec., v. 18, no. 4

    2021  

    Abstract: Leaf extractsof three medicinal plants (Azadirachtaindica, Jatropha curcas and Lawsonia inermiss) were analyzed for their phytochemical nature and antimicrobial properties. For this purpose their anti-microbial activity was tested against six micro- ... ...

    Abstract Leaf extractsof three medicinal plants (Azadirachtaindica, Jatropha curcas and Lawsonia inermiss) were analyzed for their phytochemical nature and antimicrobial properties. For this purpose their anti-microbial activity was tested against six micro-organisms employing agar well diffusion method, which gave encouraging results.
    Keywords Jatropha curcas ; agar ; antimicrobial properties ; leaves ; microorganisms ; phytochemicals
    Language English
    Dates of publication 2021-12
    Size p. 463-464.
    Publishing place Dr. Anil M. Mungikar
    Document type Article
    ISSN 0976-4755
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: The Challenge of Non-Reproducibility of Old Homoeopathic Drugs and the Need for their Standardisation and Re-Proving

    Talele, Gitanjali / Shah, Rajesh

    Homœopathic Links

    2023  Volume 36, Issue 03, Page(s) 199–207

    Abstract: Introduction: The system of homoeopathic medicine calls for continued development and upgrading. Many drugs used in homoeopathy have limited information about their original composition and collection method, making their exact reproducibility ... ...

    Abstract Introduction: The system of homoeopathic medicine calls for continued development and upgrading. Many drugs used in homoeopathy have limited information about their original composition and collection method, making their exact reproducibility practically impossible or challenging. To improve the quality, reliability, ethics, legality, purity and science, there is an urgent need to review, revise, revolutionise, re-develop, remove and revamp many drugs in the Materia Medica in the current light of technology and modern medical knowledge.
    Method: A rigorous literature review of homoeopathy Materia Medica, pharmacopeia and manufacturing units was done. Based on the literature review, we have identified some challenges and suggested ways to overcome them.
    Observation and Discussion: The common observation is that most homoeopathy drugs prepared and sold in the market are prepared by simply stepping up the ‘back-potencies.’ Many drugs could be made afresh without depending on the old stocks of back-potencies. Although few pharmacies have started this practice in the UK, Brazil, the United States and India, many pharmacies prefer the back-potency route probably due to the reasons such as difficulty in procuring identical raw materials (e.g. Lachesis, Tarentula Spongia, X-ray), expensive raw materials (e.g. Aurum metallicum Argentum nitricum Platina ) and lack of facility to process the raw material (e.g. Phosphorus Radium bromide Diptherinu m, Carcinosin Well-defined mechanisms are required for drug standardisation, authenticity and quality of source material, standardised potentisation method, quantifiable force parameter, complete tracking record of back potency (traceability).
    Keywords homoeopathy ; drugs ; standardisation ; reproducibility ; sources ; back-potencies
    Language English
    Publishing date 2023-06-22
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1199312-1
    ISSN 1860-3149 ; 1019-2050
    ISSN (online) 1860-3149
    ISSN 1019-2050
    DOI 10.1055/s-0043-1764392
    Database Thieme publisher's database

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  8. Article ; Online: A Clinical Evaluation of a Hepatitis C Nosode in the Treatment of Hepatitis C.

    Shah, Rajesh

    Journal of alternative and complementary medicine (New York, N.Y.)

    2016  Volume 22, Issue 3, Page(s) 197–203

    Abstract: Purpose: Upon identifying the need for an alternative treatment option in the management of hepatitis C to decrease viral load and improve health parameters, the investigator has developed the hepatitis C virus (HCV) nosode.: Methods: An open-label ... ...

    Abstract Purpose: Upon identifying the need for an alternative treatment option in the management of hepatitis C to decrease viral load and improve health parameters, the investigator has developed the hepatitis C virus (HCV) nosode.
    Methods: An open-label observational study in 24 HCV-positive individuals was conducted by using the HCV nosode at 30C and 50C potencies.
    Results: In this clinical trial, the HCV nosode was administered to HCV-positive participants. From week 12 to week 24, the mean viral load decreased; the median viral load decreased by half, from 1,557,567.50 IU/mL to 789,265.50 IU/mL. However, at 24 weeks, the average viral load increased significantly (p = 0.2206) in the participants completing the trial. The study has shown a double population: a large set of responders with marked improvement (week 12 [p = 0.0120] and week 24 [p = 0.0304] and from week 12 to week 24 [p = 0.0028]) and a small set of nonresponders with increasing viral load (week 12 [p = 0.0120] and week 24 [p = 0.0304] and from week 12 to week 24 [p = 0.0028]). Most participants in this study showed improvement in appetite and weight gain. The treatment using the nosode was found to be safe in the tested population.
    Conclusion: The HCV viral load was affected by using ultra-diluted preparation sourced from HCV, as per the Law of Similars, in responders. Further studies of longer duration in patients with uniform baseline characteristics and those that adjust the potency to the individual participant's requirement are recommended.
    MeSH term(s) Adult ; Female ; Hepacivirus/drug effects ; Hepatitis C/drug therapy ; Hepatitis C/virology ; Homeopathy ; Humans ; Male ; Materia Medica/pharmacology ; Materia Medica/therapeutic use ; Viral Load/drug effects
    Chemical Substances Materia Medica
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1237383-7
    ISSN 1557-7708 ; 1075-5535
    ISSN (online) 1557-7708
    ISSN 1075-5535
    DOI 10.1089/acm.2014.0146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Antibacterial activity of bacteriocin producing lactic acid bacteria

    Shah, Rajesh Kumar / Saikia, Apurba

    BIOINFOLET. 2021 Sept., v. 18, no. 3

    2021  

    Abstract: During present study bacteriocin producing Lactic Acid Bacteria (LAB) were isolated from curd. Eight acid producing strains were isolated form the sample. The bacteriocin activity of these strains was screened by agar well diffusion method for which ... ...

    Abstract During present study bacteriocin producing Lactic Acid Bacteria (LAB) were isolated from curd. Eight acid producing strains were isolated form the sample. The bacteriocin activity of these strains was screened by agar well diffusion method for which Escherichia coli and Staphylococcus aureus were used as indicator species. Out of 8 isolates, 2 isolates showed bacteriocin activity against both Gram positive and Gram negative bacteria.
    Keywords Escherichia coli ; Staphylococcus aureus ; agar ; antibacterial properties ; bacteriocins ; indicator species ; lactic acid
    Language English
    Dates of publication 2021-09
    Size p. 345-346.
    Publishing place Dr. Anil M. Mungikar
    Document type Article
    ISSN 0976-4755
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Symptom Similarity versus Disease Similarity: Revisiting the Application of the Law of Similars and Challenging the Symptom-Centric Approach in Homeopathy

    Shah, Rajesh

    Homeopathy

    2018  Volume 107, Issue 03, Page(s) 218–222

    Abstract: The system of homeopathic medicine is based on the Law of Similars. It is often implied by students and practitioners of homeopathy that the fundamental principle suggests that if the substance is capable of producing certain ‘symptoms’, it can also ... ...

    Abstract The system of homeopathic medicine is based on the Law of Similars. It is often implied by students and practitioners of homeopathy that the fundamental principle suggests that if the substance is capable of producing certain ‘symptoms’, it can also remove, treat, or ‘annihilate’ similar symptoms if the same substance is administered in a small dose. Hahnemann clearly highlights the importance of pathogenesis or ‘disease-producing power’, and not just the symptoms-producing power, as a part of the ‘totality of the disease’. The author perceives the need for a rectification in the symptom-centric approach in homeopathy. The pathogenesis of disease includes the mechanisms and the cause, which are more complete than the consideration of mere symptoms. Thus, the fundamental approach needs to be extended beyond the symptoms' similarity to the disease-pathogenesis similarity. Several clinical examples are given based on the imaginary expansion that is constructed on the ‘mind’ symptoms without the inclusion of the pathogenesis of the medicinal substance, suggesting the limitations and the risks to homeopathy of a purely symptom-centric approach.
    Keywords homeopathy ; symptoms ; disease ; pathogenesis ; law of Similars
    Language English
    Publishing date 2018-05-16
    Publisher The Faculty of Homeopathy
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2073322-7
    ISSN 1476-4245 ; 1475-4916
    ISSN (online) 1476-4245
    ISSN 1475-4916
    DOI 10.1055/s-0038-1649499
    Database Thieme publisher's database

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