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Article ; Online: Ethics of educating teenage patients about skin care in the social media era.

Shah, Rohan R / Vaidya, Darshan / Grant-Kels, Jane M

Journal of the American Academy of Dermatology

2024

Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Letter
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2024.04.038
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Zs.A 1540: Show issues

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Article ; Online: Muir-Torre Syndrome: A Cutaneous Finding Amidst Broader Malignancies.

Shah, Rohan R / Allman, Priscilla / Schwartz, Robert A

American journal of clinical dermatology

2023 Volume 24, Issue 3, Page(s) 375–380

Abstract: Muir-Torre syndrome (MTS) is a rare autosomal dominant genetic condition resulting from microsatellite instability which is caused by mutations in DNA mismatch repair genes. This disorder predisposes individuals to skin tumors and visceral malignancies ... ...

Abstract	Muir-Torre syndrome (MTS) is a rare autosomal dominant genetic condition resulting from microsatellite instability which is caused by mutations in DNA mismatch repair genes. This disorder predisposes individuals to skin tumors and visceral malignancies and may be precipitated in immunocompromised or transplant patients. MTS requires close cancer surveillance for the patient and family because of the tendency to develop aggressive internal malignancies and sebaceous carcinoma. Immunohistochemistry and or genetic testing can confirm the diagnosis of MTS. This review offers an update to the guidelines, diagnosis, and management of MTS while offering a unique perspective on an important but lesser-known syndrome.
MeSH term(s)	Humans ; Muir-Torre Syndrome/diagnosis ; Muir-Torre Syndrome/genetics ; Muir-Torre Syndrome/therapy ; Mutation ; Immunocompromised Host ; Genetic Testing
Language	English
Publishing date	2023-01-25
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	1502476-3
ISSN	1179-1888 ; 1175-0561
ISSN (online)	1179-1888
ISSN	1175-0561
DOI	10.1007/s40257-023-00757-9
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Zs.A 5639: Show issues

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Article ; Online: Birt-Hogg-Dubé syndrome: Another mTOR phenomenon.

Shah, Rohan R / Lambert, William Clark / Schwartz, Robert A

Clinics in dermatology

2022

Abstract: Birt-Hogg-Dubé syndrome is an uncommon autosomal dominant systemic disorder with cutaneous findings notable for fibrofolliculomas or trichodiscomas on the scalp, face, neck, and trunk. These cutaneous signs are associated with bilateral renal cell ... ...

Abstract	Birt-Hogg-Dubé syndrome is an uncommon autosomal dominant systemic disorder with cutaneous findings notable for fibrofolliculomas or trichodiscomas on the scalp, face, neck, and trunk. These cutaneous signs are associated with bilateral renal cell carcinoma, benign renal cysts, pulmonary cysts, and spontaneous pneumothorax. Given its autosomal dominant inheritance pattern, the successful diagnosis of Birt-Hogg-Dubé syndrome (BHDS) may elucidate a diagnosis in family members. BHDS results from a mutation in the FLCN gene encoding the folliculin protein, a transcriptional regulator of the mammalian target of rapamycin signaling pathway. Like tuberous sclerosis, BHDS's clinical features may subside with the use of oral rapamycin for mammalian target of rapamycin inhibition, a theoretical concept meriting exploration. Although its prevalence in the general population has been estimated at 2 cases per million, BHDS has been detected in a few patients from the nearby Portuguese-lineage quarter of the city of Newark, a disproportionate prevalence possibly explained by the founder effect.
Language	English
Publishing date	2022-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1064149-x
ISSN	1879-1131 ; 0738-081X
ISSN (online)	1879-1131
ISSN	0738-081X
DOI	10.1016/j.clindermatol.2022.07.014
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Article ; Online: Occult squamous cell carcinoma within lichenoid dermatitis: three examples of cryptic cancer detection.

Lambert, W Clark / Shah, Rohan R / Lambert, Muriel W / Schwartz, Robert A

Archives of dermatological research

2022 Volume 315, Issue 4, Page(s) 795–798

Abstract: Lichenoid dermatitis can be a perplexing entity encompassing an array of cutaneous disorders. Two hundred forty-three (243) cases of otherwise unclassifiable lichenoid dermatitis were examined histologically employing a special cytokeratin stain. Occult ... ...

Abstract	Lichenoid dermatitis can be a perplexing entity encompassing an array of cutaneous disorders. Two hundred forty-three (243) cases of otherwise unclassifiable lichenoid dermatitis were examined histologically employing a special cytokeratin stain. Occult squamous cell carcinoma was detected in three of the 243 cases, uncovered by special immunohistochemistry staining within histologic specimens of lichenoid dermatitis. We recommend staining for cutaneous cancer becoming a routine practice in evaluating cutaneous lichenoid dermatitis.
MeSH term(s)	Humans ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Lichenoid Eruptions/diagnosis ; Lichenoid Eruptions/pathology ; Skin/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology ; Neurodermatitis
Language	English
Publishing date	2022-10-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-022-02436-x
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Article ; Online: Lichen planus pemphigoides: A unique form of bullous and lichenoid eruptions secondary to nivolumab.

Shah, Rohan R / Bhate, Chinmoy / Hernandez, Amanda / Ho, Chin Hung

Dermatologic therapy

2022 Volume 35, Issue 5, Page(s) e15432

Abstract: The widespread use of PD-1 inhibitors to treat various solid tumors has brought certain challenges for the clinician, including immune-related adverse events (irAEs). Cutaneous toxicities are among the most observed irAEs. Bullous and lichenoid ... ...

Abstract	The widespread use of PD-1 inhibitors to treat various solid tumors has brought certain challenges for the clinician, including immune-related adverse events (irAEs). Cutaneous toxicities are among the most observed irAEs. Bullous and lichenoid dermatoses following PD-1 inhibitor therapy have been described. Here we report a novel case of lichen planus pemphigoides, featuring characteristics of both bullous pemphigoid and lichen planus, in a patient treated with nivolumab for renal cell carcinoma. We subsequently review all three cutaneous conditions which may arise in the context of PD-1 inhibitor therapy.
MeSH term(s)	Carcinoma, Renal Cell/drug therapy ; Female ; Humans ; Immune Checkpoint Inhibitors ; Kidney Neoplasms ; Lichen Planus/chemically induced ; Lichen Planus/diagnosis ; Lichen Planus/drug therapy ; Lichenoid Eruptions/chemically induced ; Lichenoid Eruptions/diagnosis ; Male ; Nivolumab/adverse effects
Chemical Substances	Immune Checkpoint Inhibitors ; Nivolumab (31YO63LBSN)
Language	English
Publishing date	2022-03-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.15432
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Zs.A 5181: Show issues

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Article: Efficacy of Intralesional Vitamin D3 for Treatment of Verruca Vulgaris: A Randomized Control Study.

Noureen, Uzma / Shah, Rohan R / Waqas, Nadia / Sharif, Shawana / Shah, Amar / Rao, Babar K

The Journal of clinical and aesthetic dermatology

2023 Volume 16, Issue 8, Page(s) 47–50

Abstract: Cutaneous warts are benign epithelial lesions caused by human papillomavirus and are common entities, affecting nearly 10 percent of the United States population. While most warts spontaneously resolve, the immunocompromised are susceptible to ... ...

Abstract	Cutaneous warts are benign epithelial lesions caused by human papillomavirus and are common entities, affecting nearly 10 percent of the United States population. While most warts spontaneously resolve, the immunocompromised are susceptible to recalcitrant warts which often require medical treatment. Most current therapies use either physical or chemical destruction for wart removal, but these treatments are associated with adverse effects. Intralesional vitamin D3 has the potential to demonstrate a stronger treatment response due to its ability to stimulate the immune system at the injection site via cell-mediated immunity. We sought to test the efficacy of intralesional vitamin D3 for wart treatment in a sample size of 70 patients over a three-month period. Efficacy was determined as "excellent" if there was greater than a 90-percent reduction in both size and number of lesions, "good" if there was a 60 to 89-percent reduction, and "fair" if there was less than a 60-percent reduction. Treatment efficacy was excellent in 20 (28.6%) patients, good in 29 (41.4%) patients, fair in 18 (25.7%) patients, and poor in three (4.3%) patients. Patients in the younger age group had a higher treatment efficacy compared to other treatment groups. Thus, intralesional vitamin D3 has promising qualities as a treatment for cutaneous warts and should be considered at the clinician's disposal. Vitamin D is an innovative approach for treating warts without the various side effects posed by other commonly used agents. The unique features of this treatment modality including its simplicity, safety, and efficiency make it a promising option for a very common cutaneous condition.
Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2571623-2
ISSN	1941-2789
ISSN	1941-2789
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Article ; Online: Imaging Tools for Noninvasive Hair Assessment.

Rubin, Alexandra / Shah, Rohan R / Khan, Samavia / Haroon, Attiya / Rao, Babar

Cutis

2023 Volume 112, Issue 1, Page(s) E52–E57

Abstract: Trichology tools historically have been limited in their ability to provide noninvasive detailed assessments of the hair and scalp. Recent advances in diagnostic and treatment monitoring technologies have begun to fill this gap. Global photography ... ...

Abstract	Trichology tools historically have been limited in their ability to provide noninvasive detailed assessments of the hair and scalp. Recent advances in diagnostic and treatment monitoring technologies have begun to fill this gap. Global photography previously relied on a film camera and stereotactic imaging equipment but has been simplified by the advent of cameras that use software analysis and provide adjustable outlines to match facial features for the capture of standardized views. Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) both enable in vivo visualization of subcutaneous structures and provide new insight into the dynamic subclinical changes of alopecia. Recent efforts focus on training convolutional neural networks to quantify various hair parameters on OCT scans. When scalp biopsy is necessary, trichoscopy, RCM, and OCT can guide in selecting biopsy sites. Because of the growing clinical applications of these technologies, clinicians should be aware of the advantages and limitations of noninvasive hair-imaging tools.
MeSH term(s)	Humans ; Hair ; Alopecia ; Scalp ; Biopsy ; Photography
Language	English
Publishing date	2023-08-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	391840-3
ISSN	2326-6929 ; 0011-4162 ; 0151-9522
ISSN (online)	2326-6929
ISSN	0011-4162 ; 0151-9522
DOI	10.12788/cutis.0834
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Article: Comparing the Efficacy for Pulse Versus Continuous Dose Terbinafine Therapy in Patients With Onychomycosis.

Saleem, Muhammad Amer / Shah, Rohan R / Sharif, Shawana / Rana, Dip / Waqas, Nadia / Rao, Babar K

Journal of drugs in dermatology : JDD

2023 Volume 22, Issue 10, Page(s) 1017–1020

Abstract: Recently, treatment outcomes in patients with toenail onychomycosis have improved considerably due to more effective oral antifungal medications such as terbinafine and itraconazole. These medications can either be used continuously for several weeks at ... ...

Abstract	Recently, treatment outcomes in patients with toenail onychomycosis have improved considerably due to more effective oral antifungal medications such as terbinafine and itraconazole. These medications can either be used continuously for several weeks at a lower dose or intermittently (pulsed) at a higher dose. Previous literature comparing pulse and continuous therapy has generated mixed results. Our study aims to compare the efficacy, in terms of clinical cure rate, of continuous vs pulse dose terbinafine regimens for toenail onychomycosis. Sixty patients with onychomycosis of Fitzpatrick skin types IV to VI, between 15 and 65 years of age, were divided into a continuous treatment group receiving 250 mg terbinafine once daily for 12 weeks and a pulse treatment group receiving 250 mg twice daily terbinafine for 1 week repeated every 4 weeks for 12 weeks. Each patient was followed up at weeks 4, 8, and 12. Efficacy of the continuous treatment group was significantly greater at 76.67% compared with 26.67% in the pulse treatment group. Thus, we conclude that the clinical cure rate of a continuous dose regimen of terbinafine is a superior treatment option for toenail onychomycosis. However, we also suggest further studies including combinations of multiple agents and hybrid regimen models for the optimal onychomycosis treatment. J Drugs Dermatol. 2023;22(10): doi:10.36849/JDD.7323R1.
MeSH term(s)	Humans ; Terbinafine/therapeutic use ; Onychomycosis/diagnosis ; Onychomycosis/drug therapy ; Naphthalenes/therapeutic use ; Foot Dermatoses/diagnosis ; Foot Dermatoses/drug therapy ; Antifungal Agents ; Itraconazole/adverse effects ; Treatment Outcome
Chemical Substances	Terbinafine (G7RIW8S0XP) ; Naphthalenes ; Antifungal Agents ; Itraconazole (304NUG5GF4)
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
DOI	10.36849/JDD.7323
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Article ; Online: Efficacy of combined spironolactone and topical retinoids in South Asian women with acne.

Tahir, Anam / Khan, Samavia / Shah, Rohan R / Waqas, Nadia / Sharif, Shawana / Rao, Babar

Clinics in dermatology

2023 Volume 42, Issue 1, Page(s) 89–90

MeSH term(s)	Female ; Humans ; Retinoids/therapeutic use ; Spironolactone/therapeutic use ; Acne Vulgaris/drug therapy ; Dermatologic Agents/therapeutic use ; Asian People
Chemical Substances	Retinoids ; Spironolactone (27O7W4T232) ; Dermatologic Agents
Language	English
Publishing date	2023-11-24
Publishing country	United States
Document type	Letter
ZDB-ID	1064149-x
ISSN	1879-1131 ; 0738-081X
ISSN (online)	1879-1131
ISSN	0738-081X
DOI	10.1016/j.clindermatol.2023.11.005
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Article ; Online: Assessment of the Efficacy of Tranexamic Acid Solution 5% in the Treatment of Melasma in Patients of South Asian Descent.

Akhtar, Nazia / Shah, Rohan R / Waqas, Nadia / Jasti, Shravya / Sharif, Shawana / Shah, Amar / Abbasi, Hina H / Rao, Babar

Cutis

2023 Volume 112, Issue 4, Page(s) 187–191.E4

Abstract: Melasma is a common dermatologic condition affecting all skin types. Increasing rates of melasma warrant identification of a reliable topical treatment. In recent years, off-label tranexamic acid (TA) has emerged as a potential treatment of melasma. ... ...

Abstract	Melasma is a common dermatologic condition affecting all skin types. Increasing rates of melasma warrant identification of a reliable topical treatment. In recent years, off-label tranexamic acid (TA) has emerged as a potential treatment of melasma. Although the mechanism of action remains unclear, it is thought that TA inhibits melanin synthesis by blocking the interaction between melanocytes and keratinocytes while reversing the abnormal dermal changes associated with melasma. Our study assessed the efficacy of TA solution 5% for the treatment of melasma in patients with darker skin types.
MeSH term(s)	Humans ; Administration, Oral ; Administration, Topical ; Melanosis/drug therapy ; Tranexamic Acid/therapeutic use ; Treatment Outcome ; South Asian People
Chemical Substances	Tranexamic Acid (6T84R30KC1)
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	391840-3
ISSN	2326-6929 ; 0011-4162 ; 0151-9522
ISSN (online)	2326-6929
ISSN	0011-4162 ; 0151-9522
DOI	10.12788/cutis.0869
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