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  1. Article ; Online: EVERY SHERIFF NEEDS A DEPUTY: TARGETING NON-PARENCHYMAL CELLS TO TREAT HEPATIC FIBROSIS.

    McGettigan, Brett / Shah, Vijay

    Journal of hepatology

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2024.04.015
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Acute Kidney Injury among Neonates with Perinatal Asphyxia in a Tertiary Care Centre.

    Giri, Arun / Yadav, Sunil Kumar / Shah, Vijay Kumar

    JNMA; journal of the Nepal Medical Association

    2024  Volume 62, Issue 269, Page(s) 13–16

    Abstract: Introduction: Perinatal asphyxia is a very common cause of morbidity and mortality in both term and preterm neonates and ranks the second most important cause of neonatal death. The incidence and importance of acute kidney injury in the neonatal period ... ...

    Abstract Introduction: Perinatal asphyxia is a very common cause of morbidity and mortality in both term and preterm neonates and ranks the second most important cause of neonatal death. The incidence and importance of acute kidney injury in the neonatal period are becoming increasingly apparent. Early diagnosis and timely management of acute kidney injury is very important in these newborns to avoid other long-term adverse events. This study aimed to find out the prevalence of acute kidney injury among neonates with perinatal asphyxia in a tertiary care centre.
    Methods: A descriptive cross-sectional study was conducted at the neonatal intensive care unit and nursery in a tertiary care hospital of Eastern Nepal from 1 November 2021 to 31 October 2022 after obtaining ethical approval from the Institutional Review Committee. A convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval.
    Results: Among 97 neonates, the prevalence of acute kidney injury was seen among 60 (61.86%) (50.25-69.75, 95% Confidence Interval) neonates. Out of which 42 (70%) were males and 18 (30%) were female.
    Conclusions: The prevalence of acute kidney injury among neonates with perinatal asphyxia was found to be higher than other studies done in a similar setting.
    Keywords: acute kidney injury; neonates; prevalence.
    MeSH term(s) Male ; Pregnancy ; Humans ; Infant, Newborn ; Female ; Tertiary Care Centers ; Asphyxia ; Cross-Sectional Studies ; Asphyxia Neonatorum/epidemiology ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology
    Language English
    Publishing date 2024-01-02
    Publishing country Nepal
    Document type Journal Article
    ZDB-ID 2209910-4
    ISSN 1815-672X ; 0028-2715
    ISSN (online) 1815-672X
    ISSN 0028-2715
    DOI 10.31729/jnma.8402
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  3. Article ; Online: Review article: current and emerging therapies for acute alcohol-associated hepatitis.

    Rattan, Puru / Shah, Vijay H

    Alimentary pharmacology & therapeutics

    2022  Volume 56, Issue 1, Page(s) 28–40

    Abstract: Background: Alcohol-associated hepatitis is an acute manifestation of alcohol-associated liver disease (ALD) and is associated with 30%-40% mortality at 28 days. Abstinence and corticosteroids are the mainstays of treatment, but the latter only improves ...

    Abstract Background: Alcohol-associated hepatitis is an acute manifestation of alcohol-associated liver disease (ALD) and is associated with 30%-40% mortality at 28 days. Abstinence and corticosteroids are the mainstays of treatment, but the latter only improves short-term mortality, so new and improved therapies remain an unmet need.
    Aims: The aim was to review the pathophysiology of alcohol-associated hepatitis and how various targets can be used by current and emerging therapies as treatment.
    Methods: A thorough literature review was conducted on acute alcohol-associated hepatitis, current therapies and therapies under investigation.
    Results: With the increasing prevalence of alcohol use disorder and ALD, the burden of alcohol-associated hepatitis is also expected to rise. The current understanding of alcohol-associated hepatitis pathophysiology has led to clinical trials of several therapies involving IL-1 antagonism, modification of the gut microbiome and liver regeneration.
    Conclusions: Corticosteroid therapy for alcohol-associated hepatitis is restricted in its applicability and has limited efficacy. Developing multidisciplinary, patient-centred care models based on digital health technologies, in combination with continued discovery of novel therapies using multiomics data and computational biology techniques will be necessary to tackle the increasing burden of alcohol-associated hepatitis.
    MeSH term(s) Alcohol Drinking ; Alcoholism ; Hepatitis, Alcoholic/complications ; Humans ; Liver Diseases, Alcoholic/complications ; Liver Transplantation
    Language English
    Publishing date 2022-05-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.16969
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: A NET gain in our understanding of acute liver failure.

    Hilscher, Moira B / Shah, Vijay H

    Hepatology (Baltimore, Md.)

    2022  Volume 75, Issue 3, Page(s) 511–513

    MeSH term(s) Humans ; Liver Failure, Acute/etiology
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.32278
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    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Alcohol Use Disorder and Alcohol-Associated Liver Disease.

    Ramkissoon, Resham / Shah, Vijay H

    Alcohol research : current reviews

    2022  Volume 42, Issue 1, Page(s) 13

    Abstract: This article is part of a Festschrift commemorating the 50th anniversary of the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Established in 1970, first as part of the National Institute of Mental Health and later as an independent ... ...

    Abstract This article is part of a Festschrift commemorating the 50th anniversary of the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Established in 1970, first as part of the National Institute of Mental Health and later as an independent institute of the National Institutes of Health, NIAAA today is the world's largest funding agency for alcohol research. In addition to its own intramural research program, NIAAA supports the entire spectrum of innovative basic, translational, and clinical research to advance the diagnosis, prevention, and treatment of alcohol use disorder and alcohol-related problems. To celebrate the anniversary, NIAAA hosted a 2-day symposium, "Alcohol Across the Lifespan: 50 Years of Evidence-Based Diagnosis, Prevention, and Treatment Research," devoted to key topics within the field of alcohol research. This article is based on Dr. Shah's presentation at the event. NIAAA Director George F. Koob, Ph.D., serves as editor of the Festschrift.
    MeSH term(s) United States ; Humans ; Alcoholism/complications ; Alcoholism/diagnosis ; Alcohol Drinking ; National Institute on Alcohol Abuse and Alcoholism (U.S.) ; Liver Diseases, Alcoholic ; National Institutes of Health (U.S.) ; Alcohol-Related Disorders
    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2677485-9
    ISSN 2169-4796 ; 1930-0573 ; 2168-3492 ; 0090-838X
    ISSN (online) 2169-4796 ; 1930-0573
    ISSN 2168-3492 ; 0090-838X
    DOI 10.35946/arcr.v42.1.13
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    Zs.B 2180: Show issues Location:
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  6. Article ; Online: Angiocrine Signaling in Sinusoidal Health and Disease.

    Cooper, Shawna A / Kostallari, Enis / Shah, Vijay H

    Seminars in liver disease

    2023  Volume 43, Issue 3, Page(s) 245–257

    Abstract: Liver sinusoidal endothelial cells (LSECs) are key players in maintaining hepatic homeostasis. They also play crucial roles during liver injury by communicating with liver cell types as well as immune cells and promoting portal hypertension, fibrosis, ... ...

    Abstract Liver sinusoidal endothelial cells (LSECs) are key players in maintaining hepatic homeostasis. They also play crucial roles during liver injury by communicating with liver cell types as well as immune cells and promoting portal hypertension, fibrosis, and inflammation. Cutting-edge technology, such as single cell and spatial transcriptomics, have revealed the existence of distinct LSEC subpopulations with a clear zonation in the liver. The signals released by LSECs are commonly called "angiocrine signaling." In this review, we summarize the role of angiocrine signaling in health and disease, including zonation in healthy liver, regeneration, fibrosis, portal hypertension, nonalcoholic fatty liver disease, alcohol-associated liver disease, aging, drug-induced liver injury, and ischemia/reperfusion, as well as potential therapeutic advances. In conclusion, sinusoidal endotheliopathy is recognized in liver disease and promising preclinical studies are paving the path toward LSEC-specific pharmacotherapies.
    MeSH term(s) Humans ; Endothelial Cells/metabolism ; Liver/pathology ; Non-alcoholic Fatty Liver Disease/metabolism ; Hypertension, Portal/metabolism ; Fibrosis ; Liver Cirrhosis/metabolism
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 603177-8
    ISSN 1098-8971 ; 0272-8087
    ISSN (online) 1098-8971
    ISSN 0272-8087
    DOI 10.1055/a-2128-5907
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    Zs.A 1752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Acute on Chronic Liver Failure in Patients with Alcohol-Associated Hepatitis: A Review.

    Kezer, Camille A / Simonetto, Douglas A / Shah, Vijay H

    Clinics in liver disease

    2023  Volume 27, Issue 3, Page(s) 659–670

    Abstract: Acute on chronic liver failure (ACLF) is a unique disease process associated with significant short-term mortality wherein patients with either chronic liver disease or cirrhosis suffer rapid decompensation in hepatic function accompanied by extrahepatic ...

    Abstract Acute on chronic liver failure (ACLF) is a unique disease process associated with significant short-term mortality wherein patients with either chronic liver disease or cirrhosis suffer rapid decompensation in hepatic function accompanied by extrahepatic organ failures. Alcohol-associated hepatitis (AH) is a common precipitant of ACLF and has been shown to uniquely affect the pathophysiology of systemic and hepatic immune responses in patients with ACLF. Treatment of AH-associated ACLF includes supportive measures as well as treatment directed at AH; however, AH-directed therapies unfortunately remain limited and are of suboptimal efficacy.
    MeSH term(s) Humans ; Acute-On-Chronic Liver Failure/etiology ; Acute-On-Chronic Liver Failure/therapy ; Hepatitis, Alcoholic/complications ; Liver Cirrhosis
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1472315-3
    ISSN 1557-8224 ; 1089-3261
    ISSN (online) 1557-8224
    ISSN 1089-3261
    DOI 10.1016/j.cld.2023.03.009
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  8. Article ; Online: Thematic reviews: The future of hepatology.

    Malhi, Harmeet / Shah, Vijay / Gores, Gregory J

    Hepatology (Baltimore, Md.)

    2023  Volume 78, Issue 2, Page(s) 388

    MeSH term(s) Gastroenterology ; Forecasting
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000409
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    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Emerging targets for therapy in ALD: Lessons from NASH.

    Singal, Ashwani K / Shah, Vijay H / Malhi, Harmeet

    Hepatology (Baltimore, Md.)

    2023  

    Abstract: Alcohol-associated liver disease due to harmful alcohol use and NAFLD associated with metabolic syndrome are the 2 most common liver diseases worldwide. Control of respective risk factors is the cornerstone in the long-term management of these diseases. ... ...

    Abstract Alcohol-associated liver disease due to harmful alcohol use and NAFLD associated with metabolic syndrome are the 2 most common liver diseases worldwide. Control of respective risk factors is the cornerstone in the long-term management of these diseases. Furthermore, there are no effective therapies. Both diseases are characterized by metabolic derangements; thus, the focus of this review was to broaden our understanding of metabolic targets investigated in NAFLD, and how these can be applied to alcohol-associated liver disease. Conserved pathogenic pathways such as dysregulated lipid metabolism, cell death pathways including apoptosis and activation of innate immune cells, and stellate cells mediate both alcohol and NAFLDs, resulting in histological abnormalities of steatosis, inflammation, fibrosis, and cirrhosis. However, pathways such as gut microbiome changes, glucose metabolism and insulin resistance, inflammatory signaling, and microRNA abnormalities are distinct in these 2 diseases. In this review article, we describe conserved and distinct pathogenic pathways highlighting therapeutic targets that may be of potential in both diseases and those that are unique to each disease.
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Deep learning-based detection of hepatobiliary disorders in ophthalmic imaging.

    Ahn, Joseph C / Shah, Vijay H

    The Lancet. Digital health

    2021  Volume 3, Issue 2, Page(s) e68–e69

    MeSH term(s) Deep Learning ; Diagnostic Imaging ; Digestive System Diseases ; Eye ; Humans ; Prospective Studies
    Language English
    Publishing date 2021-01-28
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2589-7500
    ISSN (online) 2589-7500
    DOI 10.1016/S2589-7500(20)30319-8
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