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  1. Article: Letter to the Editor: Microbiota in the Respiratory System-A Possible Explanation to Age and Sex Variability in Susceptibility to SARS-CoV-2.

    Shah, Vishal

    Microbiology insights

    2021  Volume 14, Page(s) 1178636120988604

    Abstract: The Human respiratory tract is colonized by a variety of microbes and the microbiota change as we age. In this perspective, literature support is presented for the hypothesis that the respiratory system microbiota could explain the differential age and ... ...

    Abstract The Human respiratory tract is colonized by a variety of microbes and the microbiota change as we age. In this perspective, literature support is presented for the hypothesis that the respiratory system microbiota could explain the differential age and sex breakdown amongst COVID-19 patients. The number of patients in the older and elderly adult group is higher than the other age groups. The perspective presents the possibility that certain genera of bacteria present in the respiratory system microbiota in children and young adults could be directly or through eliciting an immune response from the host, prevent full-fledged infection of SARS-CoV-2. The possibility also exists that the microbiota in older adults and the elderly population have bacteria that make it easier for the virus to cause infection. I call upon the scientific community to investigate the link between human microbiota and SARS-CoV-2 susceptibility to further understand the viral pathogenesis.
    Language English
    Publishing date 2021-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2455264-1
    ISSN 1178-6361
    ISSN 1178-6361
    DOI 10.1177/1178636120988604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Author Reply to Commentary: Endobronchial therapy for typical carcinoid: It's all in the details.

    Shah, Vishal N / Trujillo, Karin P

    JTCVS techniques

    2022  Volume 15, Page(s) 167

    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Editorial
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2022.07.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Royal College of Ophthalmologists' National Ophthalmology Database Study of Cataract Surgery: Report 13, monitoring post-cataract surgery endophthalmitis rates-the rule of X.

    Buchan, John C / Norridge, Charlotte F E / Low, Liying / Shah, Vishal / Donachie, Paul H J

    Eye (London, England)

    2024  Volume 38, Issue 7, Page(s) 1386–1389

    Abstract: Background: Cataract surgical safety has improved over recent decades, with endophthalmitis rates before 2006 typically 0.13-0.15% compared with the most recent UK national estimate of 0.02%. There remains, however, substantial variation in reported ... ...

    Abstract Background: Cataract surgical safety has improved over recent decades, with endophthalmitis rates before 2006 typically 0.13-0.15% compared with the most recent UK national estimate of 0.02%. There remains, however, substantial variation in reported rates from different centres. Due to the low event rate, this disparity may not be noticed and opportunities to improve therefore be missed. We propose a method of monitoring post-cataract endophthalmitis rates that would help centres with higher rates identify this.
    Methods: A statistical tool, available to download or use online, permits comparison of local endophthalmitis rate with the estimated UK rate of 0.02%. Centres are encouraged to maintain a register of endophthalmitis cases, and when the number reaches a threshold (X cases), either in a certain time period or in a fixed number of procedures, then the centre can consider itself as an outlier and trigger local investigations to improve infection control.
    Results: Example outputs are offered, such as for a unit doing 5000 cataracts annually, a value of X is suggested such that the third case of endophthalmitis (X = 3) in a 12-month period would give 85% confidence, the fourth case 90% confidence and the fifth case 95% confidence that the true endophthalmitis rate for that unit was higher than the national average.
    Conclusions: This statistical tool provides a basis for units to set a threshold number of cases of endophthalmitis within a given period that would trigger local processes, thus helping inform local monitoring processes for this rare but potentially catastrophic complication of cataract surgery.
    MeSH term(s) Humans ; Endophthalmitis/epidemiology ; Endophthalmitis/prevention & control ; Endophthalmitis/etiology ; Cataract Extraction/adverse effects ; Cataract Extraction/statistics & numerical data ; United Kingdom/epidemiology ; Databases, Factual ; Ophthalmology/statistics & numerical data ; Postoperative Complications/epidemiology ; Societies, Medical
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-023-02917-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Unmistakable Truncal Dystonia Mistaken as Psychogenic: A Case Report of VAC14-Related Neurodegeneration.

    Bhowmick, Suvorit Subhas / Mahajan, Shreya Kailashchandra / Shah, Vishal / Kashyap, Kriti

    Movement disorders clinical practice

    2023  Volume 10, Issue Suppl 3, Page(s) S15–S20

    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Case Reports
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Successful management of iliofemoral and visceral malperfusion syndrome in acute type A aortic dissection with endovascular revascularization followed by delayed proximal aortic repair.

    Shah, Vishal N / Java, Amit P / Plestis, Konstadinos A

    Journal of cardiac surgery

    2022  

    Abstract: Acute type A aortic dissection with malperfusion syndrome is associated with high mortality. Despite having no consensus-based guidelines, we believe the "endovascular-first" approach should be undertaken. This report describes the successful management ... ...

    Abstract Acute type A aortic dissection with malperfusion syndrome is associated with high mortality. Despite having no consensus-based guidelines, we believe the "endovascular-first" approach should be undertaken. This report describes the successful management of iliofemoral and visceral malperfusion syndrome with endovascular revascularization followed by delayed proximal aortic repair after acute type A aortic dissection.
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.17058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2221: Show issues Location:
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  6. Article ; Online: Abemaciclib: The First FDA-Approved CDK4/6 Inhibitor for the Adjuvant Treatment of HR+ HER2- Early Breast Cancer.

    Raheem, Farah / Ofori, Henry / Simpson, Lacey / Shah, Vishal

    The Annals of pharmacotherapy

    2022  , Page(s) 10600280211073322

    Abstract: Objective: To review the new indication of cyclin-dependent kinase (CDK4/6) inhibitor abemaciclib for the adjuvant treatment of hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-), axillary lymph node (LN) positive ...

    Abstract Objective: To review the new indication of cyclin-dependent kinase (CDK4/6) inhibitor abemaciclib for the adjuvant treatment of hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-), axillary lymph node (LN) positive early breast cancer (EBC) at high risk of recurrence and a Ki-67 ≥20%.
    Data sources: A literature search was performed through PubMed, ClinicalTrials.gov, and Food and Drug Administration (FDA) website (February 1, 2018, to December 23, 2021) to identify relevant information.
    Study selection and data extraction: Human and animal studies related to pharmacology, pharmacokinetics, efficacy, and safety of abemaciclib were identified.
    Data synthesis: Addition of abemaciclib to standard of care endocrine therapy (ET) for patients with high-risk clinicopathologic features and Ki-67 ≥20% demonstrated 30% reduction in the risk of developing invasive disease and distant recurrence. At 15.5 months, abemaciclib + ET demonstrated a significant improvement in invasive disease-free survival (IDFS) vs ET alone (hazard ratio [HR], 0.75; 95% confidence interval [CI], 0.60-0.93,
    Relevance to patient care and clinical practice: This review describes the clinical applicability of adjuvant abemaciclib for patients with HR+, HER2- EBC at high risk for recurrence.
    Conclusion: Adjuvant abemaciclib significantly reduces the risk for early development of invasive disease and distant recurrence in patients with HR+, HER2- node positive EBC. Longer follow-up is needed to determine the impact of adjuvant abemaciclib on late disease recurrence and survival outcomes.
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/10600280211073322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 900: Show issues Location:
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  7. Article: Antibiotic resistance in mucosal bacteria from high Arctic migratory salmonids

    Moniz, Kristy / Walker, Virginia K. / Shah, Vishal

    Environmental microbiology reports. 2022 June, v. 14, no. 3

    2022  

    Abstract: Two related salmonids, Arctic char (Salvelinus alpinus) and lake whitefish (Coregonus clupeaformis) sampled from the high Arctic region of Nunavut, Canada are anadromous fish, migrating annually from the same ice‐covered freshwater waterbodies to spend ... ...

    Abstract Two related salmonids, Arctic char (Salvelinus alpinus) and lake whitefish (Coregonus clupeaformis) sampled from the high Arctic region of Nunavut, Canada are anadromous fish, migrating annually from the same ice‐covered freshwater waterbodies to spend summers in the marine waters of the Arctic Ocean. Microbiota associated with the skin‐associated mucus undergo community change coincident with migration, and irrespective of this turnover, antibiotic resistance was detected in mixed bacterial cultures initiated with mucus samples. Although as expected most bacteria were unculturable, however, 5/7 isolates showed susceptibility to a panel of five common antibiotics. The fish were sampled under severe conditions and at remote locations far from human habitation. Regardless, two isolates, ‘Carnobacterium maltaromaticum sm‐2’ and ‘Arthrobacter citreus sm’, showed multi‐resistance to two or more antibiotics including ampicillin and streptomycin indicating multiple resistance genes. It is unknown if these fish bacteria have ‘natural’ resistance phenotypes or if resistance has been acquired. As result of these observations, we urge long‐term monitoring of drug‐resistant bacteria in the region and caution the assumption of a lack of drug‐resistant organisms even in such extreme environments.
    Keywords Arthrobacter citreus ; Carnobacterium piscicola ; Coregonus clupeaformis ; Salvelinus alpinus ; ampicillin ; anadromous fish ; antibiotic resistance ; freshwater ; human settlements ; migratory behavior ; mucus ; streptomycin ; surface water ; Arctic Ocean ; Arctic region ; Nunavut
    Language English
    Dates of publication 2022-06
    Size p. 385-390.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note JOURNAL ARTICLE
    ISSN 1758-2229
    DOI 10.1111/1758-2229.12975
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Relationship between Substance Use and Socioeconomic Variables in Pennsylvania Adolescents: 2009-2017.

    Shah, Vishal / Watson, Jacob

    Substance use & misuse

    2020  Volume 55, Issue 11, Page(s) 1856–1866

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Adolescent ; Adult ; Humans ; Pennsylvania/epidemiology ; Socioeconomic Factors ; Substance-Related Disorders/epidemiology ; Tobacco Products ; Vaping
    Language English
    Publishing date 2020-05-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1310358-1
    ISSN 1532-2491 ; 1082-6084
    ISSN (online) 1532-2491
    ISSN 1082-6084
    DOI 10.1080/10826084.2020.1771594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Impact of the changes in bacterial outer membrane structure on the anti-bacterial activity of zinc oxide nanoparticles.

    Surwade, Priyanka / Luxton, Todd / Clar, Justin / Xin, Fan / Shah, Vishal

    Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology

    2022  Volume 22, Page(s) 1–8

    Abstract: Metal and metal oxide nanoparticles (NPs) have been increasingly utilized in many industries to harness their documented antibacterial properties. However, the mechanism(s) of action is still debated in the literature. The aim of this study is to ... ...

    Abstract Metal and metal oxide nanoparticles (NPs) have been increasingly utilized in many industries to harness their documented antibacterial properties. However, the mechanism(s) of action is still debated in the literature. The aim of this study is to understand how changes in outer membrane charge of a test bacteria
    Language English
    Publishing date 2022-03-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2017013-0
    ISSN 1572-896X ; 1388-0764
    ISSN (online) 1572-896X
    ISSN 1388-0764
    DOI 10.1007/s11051-020-4767-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Photodynamic therapy with cryotherapy for endobronchial typical carcinoid.

    Shah, Vishal N / Berkheim, David B / Lackner, Rudy P / Trujillo, Karin P

    JTCVS techniques

    2022  Volume 15, Page(s) 161–163

    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2022.04.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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