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  1. AU="Shahabi Rabori, Venus"
  2. AU="Jeronimo, Matthew"
  3. AU="Misra, Maitreyi"
  4. AU="Liu, Xuping"
  5. AU="Corinna Lüneburg"
  6. AU="Clement, Lionel C"
  7. AU="Parkhill, Julian"
  8. AU="Wiita, Arun P"
  9. AU=Lubrano Riccardo
  10. AU=Biggs Andrew
  11. AU="Lian, Kejian"
  12. AU="Almutairi, Abdulrahman"
  13. AU="Cosculluela-Pueyo, Rafaél"
  14. AU="Gehrs, Teresa"
  15. AU="Munir, Atif"
  16. AU="Ou, Ya-Nan"
  17. AU=Brown James E AU=Brown James E
  18. AU="Wang, Zhongmin"
  19. AU="Lemieux, Audrée"
  20. AU="Abdelhameed, Mohamed F"
  21. AU="Schaible, Lonnie M"
  22. AU="Yazie, Taklo Simeneh Yazie"
  23. AU="Jude Orumuah Agbugui"
  24. AU="Kruse, Robert L"
  25. AU="Shyama Nandakumar"
  26. AU="Gelb, M"
  27. AU="Gasparini, L"
  28. AU="Ulvila, J"
  29. AU="Länsimies, Helena"

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  1. Artikel ; Online: Crosstalk of NLRP3 inflammasome and noncoding RNAs in cardiomyopathies.

    Jafari, Negar / Shahabi Rabori, Venus / Zolfi Gol, Ali / Saberiyan, Mohammadreza

    Cell biochemistry and function

    2023  Band 41, Heft 8, Seite(n) 1060–1075

    Abstract: Cardiovascular diseases (CVDs) identified as a serious public health problem. Although there is a lot of evidence that inflammatory processes play a significant role in the progression of CVDs, however, the precise mechanism is not fully understood. ... ...

    Abstract Cardiovascular diseases (CVDs) identified as a serious public health problem. Although there is a lot of evidence that inflammatory processes play a significant role in the progression of CVDs, however, the precise mechanism is not fully understood. Nevertheless, recent studies have focused on inflammation and its related agents. Nucleotide oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3 (NLRP3) is a type of pattern recognition receptor (PRR) that can recognize pathogen-associated molecular patterns and trigger innate immune response. NLRP3 is a component of the NOD-like receptor (NLR) family and have a pivotal role in detecting damage to cardiovascular tissue. It is suggested that activation of NLRP3 inflammasome leads to initiating and propagating the inflammatory response in cardiomyopathy. So, late investigations have highlighted the NLRP3 inflammasome activation in various forms of cardiomyopathy. On the other side, it was shown that noncoding RNAs (ncRNAs), particularly, microRNAs, lncRNAs, and circRNAs possess a regulatory function in the immune system's inflammatory response, implicating their involvement in various inflammatory disorders. In addition, their role in different cardiomyopathies was indicated in recent studies. This review article provides a summary of recent advancements focusing on the function of the NLRP3 inflammasome in common CVDs, especially cardiomyopathy, while also discussing the therapeutic potential of inhibiting the NLRP3 inflammasome regulated by ncRNAs.
    Mesh-Begriff(e) Humans ; Cardiomyopathies/genetics ; Cardiomyopathies/metabolism ; Inflammasomes/metabolism ; Inflammation ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
    Chemische Substanzen Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein
    Sprache Englisch
    Erscheinungsdatum 2023-11-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 283643-9
    ISSN 1099-0844 ; 0263-6484
    ISSN (online) 1099-0844
    ISSN 0263-6484
    DOI 10.1002/cbf.3882
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: LncRNA MALAT1 signaling pathway and clinical applications in overcome on cancers metastasis.

    Mazarei, Madineh / Shahabi Rabori, Venus / Ghasemi, Nazila / Salehi, Mehrnaz / Rayatpisheh, Najmeh / Jahangiri, Negin / Saberiyan, Mohammadreza

    Clinical and experimental medicine

    2023  Band 23, Heft 8, Seite(n) 4457–4472

    Abstract: In spite of its high mortality rate and difficulty in finding a cure, scientific advancements have contributed to a reduction in cancer-related fatalities. Aberrant gene expression during carcinogenesis emphasizes the importance of targeting the ... ...

    Abstract In spite of its high mortality rate and difficulty in finding a cure, scientific advancements have contributed to a reduction in cancer-related fatalities. Aberrant gene expression during carcinogenesis emphasizes the importance of targeting the signaling networks that control gene expression in cancer treatment. Long noncoding RNAs (lncRNAs), which are transcribed RNA molecules that play a role in gene expression regulation, are a recent innovative therapeutic approach for diagnosing and treating malignancies. MALAT1, a well-known lncRNA, functions in gene expression, RNA processing, and epigenetic control. High expression levels of MALAT1 are associated with several human disorders, including metastasis, invasion, autophagy, and proliferation of cancer cells. MALAT1 affects various signaling pathways and microRNAs (miRNAs), and this study aims to outline its functional roles in cancer metastasis and its interactions with cellular signaling pathways. Moreover, MALAT1 and its interactions with signaling pathways can be promising target for cancer treatment.
    Mesh-Begriff(e) Humans ; Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation ; Gene Expression Regulation, Neoplastic ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasms/genetics ; RNA, Long Noncoding/genetics ; Signal Transduction
    Chemische Substanzen MicroRNAs ; RNA, Long Noncoding ; MALAT1 long non-coding RNA, human
    Sprache Englisch
    Erscheinungsdatum 2023-09-11
    Erscheinungsland Italy
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2053018-3
    ISSN 1591-9528 ; 1591-8890
    ISSN (online) 1591-9528
    ISSN 1591-8890
    DOI 10.1007/s10238-023-01179-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5481: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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