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  1. Book: STOP, THAT and one hundred other sleep scales

    Shahid, Azmeh

    2012  

    Author's details Azmeh Shahid ... ed
    Language English
    Size XVII, 421 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017119829
    ISBN 978-1-4419-9892-7 ; 978-1-4939-0775-5 ; 9781441998934 ; 1-4419-9892-6 ; 1-4939-0775-1 ; 1441998934
    Database Catalogue ZB MED Medicine, Health

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  2. Book: Stop, that and one hundred other sleep scales

    Shahid, Azmeh

    2012  

    Author's details Azmeh Shahid ... [et al.], editors
    MeSH term(s) Sleep Wake Disorders/diagnosis ; Surveys and Questionnaires ; Sleep
    Language English
    Size xvii, 421 p. :, ill. ;, 26 cm.
    Publisher Springer
    Publishing place New York
    Document type Book
    ISBN 9781441998927 ; 1441998926 ; 9781441998934 ; 1441998934
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Article ; Online: L-Tryptophan As Treatment for Pediatric Non-Rapid Eye Movement Parasomnia.

    van Zyl, Louis T / Chung, Sharon A / Shahid, Azmeh / Shapiro, Colin M

    Journal of child and adolescent psychopharmacology

    2018  Volume 28, Issue 6, Page(s) 395–401

    Abstract: Objective: Parasomnias are common in childhood but there is no established treatment for parasomnias. The aim of this study was to (1) report on the outcome of using L-tryptophan to manage parasomnias in children and (2) examine sleep architecture and ... ...

    Abstract Objective: Parasomnias are common in childhood but there is no established treatment for parasomnias. The aim of this study was to (1) report on the outcome of using L-tryptophan to manage parasomnias in children and (2) examine sleep architecture and subjective psychological/sleep symptoms in children with parasomnia.
    Method: A retrospective analysis was conducted of charts of children (3-18 years old) who underwent polysomnographic testing and were diagnosed with primary parasomnia. Study patients were either prescribed L-tryptophan (daily dose range: 500-4500 mg, mean dose of 2400 mg) to manage their parasomnias or administered no treatment whereby parents/guardians declined treatment. Questionnaires assessing sleep and psychosocial symptoms were administered at the initial clinical consultation and a follow-up parasomnia outcome questionnaire was administered over the phone to parents/guardians.
    Results: One hundred and sixty-five children (106 boys, 59 girls) received a sleep diagnosis of primary parasomnia. A significantly (p < 0.001) higher proportion (84%) of children taking L-tryptophan experienced improvements in their parasomnia symptoms compared with those (47%) who chose not to use L-tryptophan. Polysomnography revealed that children with parasomnias had an altered sleep architecture based on age-related normative values. Children with a diagnosis of parasomnia were also subjectively more fatigued and endorsed more depressive symptoms.
    Conclusions: This study finds that parasomnias in children are not benign and that treatment with L-tryptophan provides a favorable outcome. Children diagnosed with parasomnia had altered sleep architecture, were more fatigued, and endorsed depressive symptoms. This study supports the need to diagnose and treat parasomnias in children.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Male ; Parasomnias/drug therapy ; Polysomnography ; Retrospective Studies ; Sleep/physiology ; Sleep Stages/physiology ; Surveys and Questionnaires ; Tryptophan/administration & dosage
    Chemical Substances Tryptophan (8DUH1N11BX)
    Language English
    Publishing date 2018-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1055410-5
    ISSN 1557-8992 ; 1044-5463
    ISSN (online) 1557-8992
    ISSN 1044-5463
    DOI 10.1089/cap.2017.0164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Peeking into the minds of troubled adolescents: the utility of polysomnography sleep studies in an inpatient psychiatric unit.

    Shahid, Azmeh / Khairandish, Arash / Gladanac, Bojana / Shapiro, Colin

    Journal of affective disorders

    2012  Volume 139, Issue 1, Page(s) 66–74

    Abstract: Background: Sleep problems are commonly associated with the primary diagnostic criteria for many psychiatric disorders. Evidence suggests sleep disturbances may precede development of psychiatric disorders and the severity of psychopathology reflects ... ...

    Abstract Background: Sleep problems are commonly associated with the primary diagnostic criteria for many psychiatric disorders. Evidence suggests sleep disturbances may precede development of psychiatric disorders and the severity of psychopathology reflects the severity of sleep problems. Polysomnography (PSG) sleep studies in child and adolescent psychiatric populations, a particularly at risk group, has considerable value but has been more elusive requiring further investigation.
    Methods: We performed a retrospective chart review of PSG sleep studies and psychiatrist evaluations of 106 adolescents aged 7-16 admitted to an involuntary adolescent psychiatric inpatient facility.
    Results: Less than 5% of cases had mild/no sleep problems. Hyperarousal hallmarked this population, and severity of sleep disturbances trends with the severity of psychopathology. Inpatients with multiple psychiatric disorders had greater frequencies of insomnia, decreased sleep efficiency, and arousals from SWS (p<0.05). Inpatient's with self-harm behavior more frequently had elevated sleep onset latency (SOL), reduced efficiency, reduced SWS (p<0.05), increased REM, and reduced REM latency compared to inpatients with dysthymia and/or depression.
    Limitations: Lacking an a priori hypothesis, this study was explorative and uncontrolled for factors such as medications. This notwithstanding however, analysis indicates the majority of inpatients were taking cocktails that "should" alleviate sleep symptoms suggesting greater associations may prevail in unmedicated populations.
    Conclusions: This study attests to the potential clinical utility of PSG sleep studies in the management of adolescent psychiatric disorders and contributes to the body of evidence reputing the intimate connection between sleep problems and the development and perpetuation of psychopathology with public health implications.
    MeSH term(s) Adolescent ; Child ; Chronic Disease ; Female ; Hospitalization ; Humans ; Male ; Mental Disorders/complications ; Mental Disorders/psychology ; Polysomnography ; Retrospective Studies ; Sleep Wake Disorders/complications ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/psychology
    Language English
    Publishing date 2012-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2012.01.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Measurements of sleepiness and fatigue.

    Shahid, Azmeh / Shen, Jianhua / Shapiro, Colin M

    Journal of psychosomatic research

    2010  Volume 69, Issue 1, Page(s) 81–89

    Abstract: Sleepiness and fatigue are terms commonly used in clinical practice and research. At times sleepiness and fatigue are used interchangeably; however, each of them has distinct implications for diagnosis and treatment. The objective of this article is to ... ...

    Abstract Sleepiness and fatigue are terms commonly used in clinical practice and research. At times sleepiness and fatigue are used interchangeably; however, each of them has distinct implications for diagnosis and treatment. The objective of this article is to review the psychometric properties of the measurements of sleepiness and fatigue. Although there are objective and subject measures to evaluate sleepiness, only rating scales are available to assess fatigue. Further research should be directed toward exploring the potential mechanisms underlying the measurements of sleepiness and fatigue. Establishing objective assessing instruments to evaluate fatigue and clarifying the relationship between objective and subjective assessments of sleepiness are crucially needed.
    MeSH term(s) Disorders of Excessive Somnolence/diagnosis ; Disorders of Excessive Somnolence/psychology ; Fatigue/diagnosis ; Fatigue/psychology ; Humans ; Psychometrics/statistics & numerical data ; Reproducibility of Results ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/psychology ; Surveys and Questionnaires
    Language English
    Publishing date 2010-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80166-5
    ISSN 1879-1360 ; 0022-3999
    ISSN (online) 1879-1360
    ISSN 0022-3999
    DOI 10.1016/j.jpsychores.2010.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: An approach to long-term sedative-hypnotic use.

    Shahid, Azmeh / Chung, Sharon A / Phillipson, Ron / Shapiro, Colin M

    Nature and science of sleep

    2012  Volume 4, Page(s) 53–61

    Abstract: Insomnia is a common, often chronic medical disorder with significant medical and socioeconomic repercussions. However, unlike other medical conditions, there is intense debate as to whether the long-term treatment of insomnia is clinically appropriate. ... ...

    Abstract Insomnia is a common, often chronic medical disorder with significant medical and socioeconomic repercussions. However, unlike other medical conditions, there is intense debate as to whether the long-term treatment of insomnia is clinically appropriate. The perceived deleterious side effect of sedative-hypnotic medications may result in patients remaining untreated or undertreated. This review proposes that a more subtle approach needs to be taken in the management of patients with chronic insomnia and that long-term use of the newer sedative-hypnotics may be a feasible and effective treatment option when used in conjunction with thorough medical assessment and regular patient follow-up. This review discusses these issues and discusses the pros and cons of long-term sedative-hypnotic use.
    Language English
    Publishing date 2012-04-02
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2587468-8
    ISSN 1179-1608
    ISSN 1179-1608
    DOI 10.2147/NSS.S28362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Toronto Hospital Alertness Test scale: relationship to daytime sleepiness, fatigue, and symptoms of depression and anxiety.

    Shahid, Azmeh / Chung, Sharon A / Maresky, Lance / Danish, Affan / Bingeliene, Arina / Shen, Jianhua / Shapiro, Colin M

    Nature and science of sleep

    2016  Volume 8, Page(s) 41–45

    Abstract: Objective: The Toronto Hospital Alertness Test (THAT) scale was designed to measure alertness, defined as the capacity of the mind to respond appropriately to external and internal stimuli. The present study's aim is to determine normative values of ... ...

    Abstract Objective: The Toronto Hospital Alertness Test (THAT) scale was designed to measure alertness, defined as the capacity of the mind to respond appropriately to external and internal stimuli. The present study's aim is to determine normative values of alertness on the THAT and to explore the relationship among excessive daytime sleepiness, fatigue, depressive symptoms, and alertness.
    Methods: Normative data were collected from 60 healthy males and females. To explore the relationship among alertness, daytime sleepiness, fatigue, depression, and anxiety, data were collected from charts of sleep clinic patients. All study subjects completed measures for fatigue, sleepiness, depressive symptoms, and anxiety.
    Results: The average score on the THAT was 34.9±7.2 (range 22-50) for the control group. The cutoff score for the THAT, indicative of clinically significant reduced alertness, was determined to be ≤20.5 (mean -2 SD). THAT alertness scores were found to be modestly, significantly, and negatively correlated with fatigue levels (r=-0.39, P<0.001), depressive symptoms (r=-0.53, P<0.001), and anxiety symptoms (r=-0.41, P<0.001). No correlations were found between alertness levels and daytime sleepiness. Regression analyses revealed a significant model (F=19.9, P<0.001, adjusted R (2)=0.35) with depressive symptoms (P<0.001) and fatigue (P=0.006) emerging as the only significant predictors of scores on the THAT.
    Conclusion: The findings of this study support that sleepiness is not the same as poor alertness. Depressive symptoms and fatigue, but not sleepiness, were found to have a strong and significant impact on levels of alertness. This is the first study to link poor alertness to depressive symptoms.
    Language English
    Publishing date 2016-01-19
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2587468-8
    ISSN 1179-1608
    ISSN 1179-1608
    DOI 10.2147/NSS.S91928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Zopiclone as positive control in studies examining the residual effects of hypnotic drugs on driving ability.

    Verster, Joris C / Spence, D Warren / Shahid, Azmeh / Pandi-Perumal, Seithikurippu R / Roth, Thomas

    Current drug safety

    2011  Volume 6, Issue 4, Page(s) 209–218

    Abstract: Zopiclone (7.5 mg) is frequently used as a positive control in studies that examine the residual effects of hypnotic drugs on driving ability and related skills. This review summarizes studies examining the effects of zopiclone, and discusses its ... ...

    Abstract Zopiclone (7.5 mg) is frequently used as a positive control in studies that examine the residual effects of hypnotic drugs on driving ability and related skills. This review summarizes studies examining the effects of zopiclone, and discusses its usefulness as a comparator drug for investigations of residual effects of novel sleep medication. A literature review (Pubmed and Embase) was conducted searching for studies that tested zopiclone on driving. Cross references were checked for additional papers. Eight studies utilizing the standardized on-the-road driving test consistently showed that in the morning following bedtime administration zopiclone (7.5 mg) significantly impaired driving performance. A total of 191 healthy volunteers were tested after placebo and zopiclone (7.5 mg). Meta analyses showed no significant differences in driving performance after zopiclone (7.5 mg) between adult and elderly healthy volunteers. The combined effect size (ES) and 95% confidence interval (95%CI) for healthy volunteers was 0.782 (0.620, 0.944). Relative to placebo, an average increment of 3.0 cm in Standard Deviation of Lateral Position (SDLP) was observed when treated with zopiclone (7.5 mg). This deviation was higher than the increment in SDLP reported for drivers with a blood alcohol concentration of 0.05% (+2.4 cm). Results from driving simulators and psychometric tests are consistent with the on-road driving test results. In conclusion, zopiclone (7.5 mg) is a reliable positive control, that consistently shows significant and meaningful impairment on the on-the-road driving test.
    MeSH term(s) Automobile Driving ; Azabicyclo Compounds/adverse effects ; Controlled Clinical Trials as Topic/methods ; Cross-Over Studies ; Humans ; Hypnotics and Sedatives/adverse effects ; Piperazines/adverse effects ; Psychomotor Performance/drug effects ; Psychomotor Performance/physiology
    Chemical Substances Azabicyclo Compounds ; Hypnotics and Sedatives ; Piperazines ; zopiclone (03A5ORL08Q)
    Language English
    Publishing date 2011-11-22
    Publishing country United Arab Emirates
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2250840-5
    ISSN 2212-3911 ; 1574-8863
    ISSN (online) 2212-3911
    ISSN 1574-8863
    DOI 10.2174/157488611798280933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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