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Article ; Online: Scalp capillarectasia as a trichoscopic sign of COVID-19-associated telogen effluvium.

Saber, Mina / Mardani, Elahe / Shahmoradi, Zabihollah

2023 Volume 22, Issue 8, Page(s) 2372–2373

MeSH term(s)	Humans ; Scalp/diagnostic imaging ; COVID-19 ; Alopecia Areata
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Letter
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.15717
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Article ; Online: Effectiveness of oral tofacitinib treatment on patients with moderate-to-severe alopecia areata in Iran.

Asilian, Ali / Mohammadian, Parisa / Shahmoradi, Zabihollah

Journal of cosmetic dermatology

2023 Volume 23, Issue 3, Page(s) 886–890

Abstract: Introduction: Alopecia areata is an inflammatory hair loss and a common autoimmune disease. Conducting treatment studies on alopecia areata is difficult due to unpredictable periods and even spontaneous recovery from the disease. In this study, the ... ...

Abstract	Introduction: Alopecia areata is an inflammatory hair loss and a common autoimmune disease. Conducting treatment studies on alopecia areata is difficult due to unpredictable periods and even spontaneous recovery from the disease. In this study, the effectiveness of tofacitinib in treating alopecia areata was investigated. Materials and methods: The severity of the disease was evaluated using the Alopecia Severity Tool (SALT), and based on the medical history and patient's documents and photos, the score before and after the treatment was obtained. The patients were prescribed tofacitinib tablets at a dose of 5 mg twice a day for at least 6 months and were followed for a minimum of 18 months. Results: No side effect was observed in 97.9% of the patients. After 6 months, except for three patients who did not need any maintenance dose, others needed an average daily intake of 7 mg of tofacitinib. After 18 months, the hair loss decreased by 6.45 times compared to the beginning and by 0.5 times compared to the end of 6 months (p < 0.05). In addition, it was found that body hair loss decreased 4 times compared to the beginning and 0.6 times compared to the end of 6 months (p < 0.05). The reduction of nail involvement after 18 months and 6 months was 1.2 times and 0.6, respectively, (p < 0.05). Conclusion: Treatment of alopecia areata with tofacitinib is recommended due to its effectiveness in reducing hair loss on the head, body, and nail involvement with few reversible side effects.
MeSH term(s)	Humans ; Alopecia Areata/drug therapy ; Iran ; Pyrroles/adverse effects ; Alopecia/drug therapy ; Alopecia/chemically induced ; Piperidines ; Pyrimidines
Chemical Substances	tofacitinib (87LA6FU830) ; Pyrroles ; Piperidines ; Pyrimidines
Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.16049
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Article ; Online: Tranexamic acid microinjections versus tranexamic acid mesoneedling in the treatment of facial melasma: A randomized assessor-blind split-face controlled trial.

Poostiyan, Nazila / Alizadeh, Maryam / Shahmoradi, Zabihollah / Fatemi Naeini, Farahnaz

Journal of cosmetic dermatology

2023 Volume 22, Issue 4, Page(s) 1238–1244

Abstract: Background: Melasma is a hyperpigmentary disorder causing cosmetic disfigurement. We aimed to compare the efficacy and safety of tranexamic acid (TXA) microinjections with TXA mesoneedling for facial melasma.: Methods: This randomized assessor-blind ... ...

Abstract	Background: Melasma is a hyperpigmentary disorder causing cosmetic disfigurement. We aimed to compare the efficacy and safety of tranexamic acid (TXA) microinjections with TXA mesoneedling for facial melasma. Methods: This randomized assessor-blind split-face controlled trial included patients with symmetric facial melasma. One side of the face received TXA (100 mg/ml) mesoneedling and the other side intradermal TXA microinjections. The interventions were repeated three times with 4-week intervals (weeks 0, 4, and 8). The primary outcome was improvement in modified Melasma Area and Severity Index (mMASI) 4 weeks after the final treatment session. Secondary outcomes were complications and patient satisfaction with the treatments evaluated by a visual analog scale (VAS). Results: All 27 patients included in the study were female (mean age: 44.22 ± 8.39 years). Both groups were comparable in terms of mMASI scores before and after treatment (standardized mean difference [SMD] = 0.32, 95% confidence interval [CI] -0.22; 0.85, p = 0.248 and SMD = -0.13, 95% CI -0.66; 0.40, p = 0.633, respectively). The mMASI score change from baseline was not different (SMD = -0.39, 95% CI -0.93; 0.15, p = 0.157). However, patient satisfaction was significantly higher with TXA mesoneedling (SMD = 0.77, 95% CI 0.21; 1.32, p = 0.007). Post-inflammatory hyperpigmentation occurred in one patient in the TXA mesoneedling group. Erythema, scaling, and edema were significantly higher with TXA mesoneedling (p < 0.001). Conclusions: TXA mesoneedling was comparable with TXA microinjection in the treatment of facial melasma, while patient satisfaction was significantly higher with TXA mesoneedling; however, the high frequency of complications occurring with this treatment should be taken into account.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Male ; Tranexamic Acid ; Microinjections ; Treatment Outcome ; Melanosis/drug therapy ; Hyperpigmentation
Chemical Substances	Tranexamic Acid (6T84R30KC1)
Language	English
Publishing date	2023-01-06
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.15580
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Article: A Comparative Study on the Usefulness of Fractional CO

Mokhtari, Fatemeh / Safavi, Zahra / Faghihi, Gita / Asilian, Ali / Shahmoradi, Zabihollah

Advanced biomedical research

2023 Volume 12, Page(s) 90

Abstract: Background: Acne is a dermatologic condition with a high burden in terms of psychosocial consequences as a result of scars remaining on the skin. Its effects are severe in adolescence and finding treatments with short therapy courses, superior results, ... ...

Abstract	Background: Acne is a dermatologic condition with a high burden in terms of psychosocial consequences as a result of scars remaining on the skin. Its effects are severe in adolescence and finding treatments with short therapy courses, superior results, and fewer adverse effects are of high importance. Materials and methods: We included 30 individuals with acne vulgaris scars in Al-Zahra academic training hospital from June 2018 to Jan 2019. Each individual received both fractional CO Results: Based on subjective satisfaction (p < 0.05) and physicians' assessment (p < 0.01), fractional CO Conclusion: Laser therapies are common in the treatment of scars and each modality has special advantages and disadvantages. Choosing among them should be based on various criteria. Fractional CO
Language	English
Publishing date	2023-04-25
Publishing country	India
Document type	Journal Article
ZDB-ID	2672524-1
ISSN	2277-9175
ISSN	2277-9175
DOI	10.4103/abr.abr_330_21
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Article: Pregnancy-triggered pemphigus vulgaris with favorable fetal outcomes: A case report.

Mohaghegh, Fatemeh / Shahmoradi, Zabihollah / Alizadeh, Maryam

Clinical case reports

2022 Volume 10, Issue 4, Page(s) e05734

Abstract: Pemphigus vulgaris is an autoimmune bullous dermatosis which if occurred during pregnancy may result in neonatal complications. In this study we report a 41 years old woman with pemphigus vulgaris that triggered by pregnancy in first trimester of ... ...

Abstract	Pemphigus vulgaris is an autoimmune bullous dermatosis which if occurred during pregnancy may result in neonatal complications. In this study we report a 41 years old woman with pemphigus vulgaris that triggered by pregnancy in first trimester of pregnancy followed by the premature birth of a healthy neonate.
Language	English
Publishing date	2022-04-15
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.5734
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Article ; Online: Adrenocorticotropic hormone (ACTH) level and adrenal deficiency in patients with mucocutaneous pemphigus.

Salehi, Mohammadreza / Shahmoradi, Zabihollah / Razavi, Seyed Mohammad / Lali, Iraj / Faghihian, Elham

Hormone molecular biology and clinical investigation

2022

Abstract: Objectives: This study aimed to evaluate the level of adrenocorticotropic hormone (ACTH) and adrenal insufficiency in patients with mucocutaneous pemphigus lesions who use oral corticosteroids.: Methods: This descriptive-analytical study was ... ...

Abstract	Objectives: This study aimed to evaluate the level of adrenocorticotropic hormone (ACTH) and adrenal insufficiency in patients with mucocutaneous pemphigus lesions who use oral corticosteroids. Methods: This descriptive-analytical study was performed on 54 patients (48.44 ± 12.74 years) with mucocutaneous pemphigus in 2019. Those patients taken corticosteroids in different doses and way. At first, collected patients information including age, sex, type of pemphigus, duration of use, patient dosage, duration of corticosteroid administration, and method of administration were collected daily. Adrenal gland function was measured by evaluating ACTH levels. Data were analyzed by using Pearson correlation coefficient and t-test. Results: Our study showed that 37 cases (68.5%) had normal ACTH average hormone level (7.3-63.3 mL/pg), 11 cases (20.4%) were lower levels (<7.2 mL/pg), and 6 cases (11.1%) were higher levels (63.3 > mL/pg). Wo observed no significant relationship between ACTH and duration of corticosteroids usage (p=0.207). Conclusions: Taking a maintenance dose of between 12.5 and 25 mg daily does not usually lead to adrenal insufficiency. The present study showed that the lower the daily dose of corticosteroids, the lower the likelihood of adrenal insufficiency.
Language	English
Publishing date	2022-05-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2536635-X
ISSN	1868-1891 ; 1868-1883
ISSN (online)	1868-1891
ISSN	1868-1883
DOI	10.1515/hmbci-2021-0097
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Article ; Online: Toxoplasmosis and symptoms severity in patients with COVID-19 in referral centers in Northern Iran

Geraili, Ali / Badirzadeh, Alireza / Sadeghi, Maryam / Mousavi, Seyed Mahmoud / Mousavi, Parisa / Shahmoradi, Zabihollah / Hosseini, Sayed-Mohsen / Hejazi, Seyed Hossein / Rafiei-Sefiddashti, Raheleh

J Parasit Dis. 2023 Mar., v. 47, no. 1 p.185-191

2023

Abstract: Toxoplasmosis has been categorized as one of the long-lasting protozoan parasitic infections. It affects almost one-third of the world’s population. In recent years, several documented studies have elucidated that infected individuals have a remarkably ... ...

Abstract	Toxoplasmosis has been categorized as one of the long-lasting protozoan parasitic infections. It affects almost one-third of the world’s population. In recent years, several documented studies have elucidated that infected individuals have a remarkably higher incidence of distinct health problems and show various adverse effects. In the PCR-positive COVID-19 patients in Gonbad-e-Kavus, Kalaleh, and Minoodasht counties in the northern part of Iran from June 2021 to December 2021, we sought to investigate any potential relationships between the severity of COVID-19 symptoms and acute and latent toxoplasmosis caused by Toxoplasma gondii (T. gondii). Whole blood samples of 161 COVID-19 patients with positive PCR. The samples were centrifuged to separate serum and screened for two important antibodies against T. gondii (IgM and IgG) by using ELISA kits for human anti-T. gondii IgM and IgG. Anti-T. gondii IgM and IgG antibodies were detected in 8/161 (5.0%) and 42/161 (26.1%) COVID-19 patients, respectively. No significant relationships were found between Toxoplasma IgM and IgG results with clinical signs, age, sex, contact with animals, comorbidities, and also the mortality rate of people with COVID-19. These findings showed that acute and latent toxoplasmosis infections are common among patients with COVID-19; however, no significant associations were found between toxoplasma infections and the symptoms of COVID-19. Therefore, toxoplasmosis is not considered a risk factor for COVID-19.
Keywords	COVID-19 infection ; Protozoa ; Toxoplasma gondii ; blood serum ; humans ; mortality ; people ; risk factors ; toxoplasmosis ; Iran
Language	English
Dates of publication	2023-03
Size	p. 185-191.
Publishing place	Springer India
Document type	Article ; Online
ZDB-ID	2548456-4
ISSN	0975-0703 ; 0971-7196
ISSN (online)	0975-0703
ISSN	0971-7196
DOI	10.1007/s12639-022-01556-5
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Efficacy of topical gabapentin in women with primary macular amyloidosis: A side-by-side triple-blinded randomized clinical trial.

Abtahi-Naeini, Bahareh / Hemati, Elahe / Faghihi, Gita / Shahmoradi, Zabihollah / Paknazar, Fatemeh / Rastegarnasab, Fereshte / Varshosaz, Jaleh / Hadian, Mahdi / Akbari, Mojtaba / Sabzghabaee, Ali Mohammad

Journal of cosmetic dermatology

2024 Volume 23, Issue 5, Page(s) 1677–1684

Abstract: Background: Primary cutaneous macular amyloidosis (PCMA) is a chronic pruritic cutaneous disease characterized by heterogeneous extracellular deposition of amyloid protein in the skin.: Aims: This study aimed to evaluate the efficacy of topical 6% ... ...

Abstract	Background: Primary cutaneous macular amyloidosis (PCMA) is a chronic pruritic cutaneous disease characterized by heterogeneous extracellular deposition of amyloid protein in the skin. Aims: This study aimed to evaluate the efficacy of topical 6% gabapentin cream for the treatment of patients with PCMA. Materials and methods: In this triple-blind clinical trial, a total of 34 patients, who were diagnosed with PCMA, treated using two different strategies of topical gabapentin as the active group and vehicle cream as the control group. Results: Pruritus score reduction in both groups was statistically significant compared with the baseline value (p < 0.001). There was a significant pigmentation score reduction in intervention group compared with control group after 1 month of the study (p < 0.001). The differences of pigmentation score changes between the groups were not significant at month 2 (p = 0.52) and month 3 (p = 0.22). Conclusions: The results of this study suggest that topical gabapentin cream may be effective as a topical agent in the treatment of pruritus associated with PCMA without any significant adverse effects. It is recommended to perform similar studies with a larger sample size and longer duration in both sexes.
MeSH term(s)	Humans ; Gabapentin/administration & dosage ; Female ; Middle Aged ; Pruritus/drug therapy ; Pruritus/etiology ; Treatment Outcome ; Amyloidosis/drug therapy ; Amyloidosis/complications ; Adult ; Skin Diseases, Genetic/drug therapy ; Aged ; Skin Cream/administration & dosage ; Administration, Cutaneous ; Double-Blind Method ; Amyloidosis, Familial
Chemical Substances	Gabapentin (6CW7F3G59X)
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.16180
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Article: Clinical and Epidemiological Features of Patients with Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Iran: Different Points of Children from Adults.

Abtahi-Naeini, Bahareh / Dehghan, Mohammad-Sadegh / Paknazar, Fatemeh / Shahmoradi, Zabihollah / Faghihi, Gita / Sabzghabaee, Ali Mohammad / Akbari, Mojtaba / Hadian, Mahdi / Momen, Tooba

International journal of pediatrics

2022 Volume 2022, Page(s) 8163588

Abstract: Background: Different epidemiologic aspects of drug-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in children are scarce.: Aim: To compare the clinical and epidemiological features of patients with drug-induced SJS and ... ...

Abstract	Background: Different epidemiologic aspects of drug-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in children are scarce. Aim: To compare the clinical and epidemiological features of patients with drug-induced SJS and TEN in children and adults. Method: This retrospective study was conducted at two academic referral centers (Isfahan, Iran) over 5 years. SJS and TEN were clinically diagnosed and confirmed by skin biopsy as needed. Results: One hundred one patients (31 children and 70 adults) with a female to male ratio of 1.1 : 1 was identified in the present study. SJS was more commonly diagnosed in both pediatric and adult patients. The most frequent reason for drug administration identified was the infection (45.2%) and seizure (45.2%) in children and infection (34.3%) and psychiatry disorder (27.1%) in adults ( Conclusions: The present study showed several differences between the pediatric and adult patients with SJS and TEN, including the reason for drug administration, culprit drugs, length of hospital stay, presence of fever, and final diagnosis of disease.
Language	English
Publishing date	2022-02-08
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2495026-9
ISSN	1687-9759 ; 1687-9740
ISSN (online)	1687-9759
ISSN	1687-9740
DOI	10.1155/2022/8163588
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Article: Gulucatime versus Glucantime: A Serious Warning on Counterfeit Medicines.

Abtahi-Naeini, Bahareh / Shahmoradi, Zabihollah / Niknami, Elmira / Saffaei, Ali

Journal of research in pharmacy practice

2019 Volume 8, Issue 4, Page(s) 228–229

Language	English
Publishing date	2019-12-27
Publishing country	India
Document type	Journal Article
ZDB-ID	2734861-1
ISSN	2279-042X ; 2319-9644
ISSN (online)	2279-042X
ISSN	2319-9644
DOI	10.4103/jrpp.JRPP_19_84
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