LIVIVO - Search results -

Search results

Result 1 - 10 of total 10

Search options

Article ; Online: Design and characterization of fibroblast activation protein targeted pan-cancer imaging agent for fluorescence-guided surgery of solid tumors.

Mukkamala, Ramesh / Lindeman, Spencer D / Kragness, Kate A / Shahriar, Imrul / Srinivasarao, Madduri / Low, Philip S

2022 Volume 10, Issue 12, Page(s) 2038–2046

Abstract: Tumor-targeted fluorescent dyes have been shown to significantly improve a surgeon's ability to locate and resect occult malignant lesions, thereby enhancing a patient's chances of long term survival. Although several tumor-targeted fluorescent dyes have ...

Abstract	Tumor-targeted fluorescent dyes have been shown to significantly improve a surgeon's ability to locate and resect occult malignant lesions, thereby enhancing a patient's chances of long term survival. Although several tumor-targeted fluorescent dyes have been developed for imaging specific subsets of human cancers, no tumor-targeted dye has been designed that can image all cancer types. Based on observations that fibroblast activation protein (FAP) is upregulated on cancer-associated fibroblasts (CAFs) that infiltrate essentially all solid tumors, we have undertaken to develop a FAP-targeted fluorescent dye that can image CAFs without accumulating in healthy cells or fibroblasts. We report here that FTL-S-S0456, a novel FAP-targeted near infrared dye that binds FAP with high affinity (∼12 nM) and specificity (>5000-fold over PREP and DPP-IV), concentrates in all seven solid tumor types examined, yielding fluorescence images with high tumor to background ratios that persist for several days. We conclude that FTL-S-S0456 constitutes an excellent ligand-targeted near infrared dye that enables intra-operative imaging of most if not all solid tumors.
MeSH term(s)	Cell Line, Tumor ; Fibroblasts/metabolism ; Fluorescence ; Fluorescent Dyes/metabolism ; Humans ; Neoplasms/diagnostic imaging ; Neoplasms/surgery ; Proteins
Chemical Substances	Fluorescent Dyes ; Proteins
Language	English
Publishing date	2022-03-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d1tb02651h
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Selective reprogramming of regulatory T cells in solid tumors can strongly enhance or inhibit tumor growth.

Alfar, Rami / Napoleon, John V / Shahriar, Imrul / Finnell, Richard / Walchle, Cole / Johnson, Austin / Low, Philip S

Frontiers in immunology

2023 Volume 14, Page(s) 1274199

Abstract: Folate receptor delta (FRδ) has been used as a biomarker for regulatory T cells (Tregs), because its expression is limited to Tregs and ovum. Although FRδ is unable to bind folate, we have used molecular docking software to identify a folate congener ... ...

Abstract	Folate receptor delta (FRδ) has been used as a biomarker for regulatory T cells (Tregs), because its expression is limited to Tregs and ovum. Although FRδ is unable to bind folate, we have used molecular docking software to identify a folate congener that binds FRδ with high affinity and have exploited this FRδ-specific ligand to target attached drugs (imaging agents, immune activators, and immune suppressors) specifically to Tregs in murine tumor xenografts. Analysis of treated tumors demonstrates that targeting of a Toll-like receptor 7 agonist inhibits Treg expression of FOXP3, PD-1, CTLA4, and HELIOS, resulting in 40-80% reduction in tumor growth and repolarization of other tumor-infiltrating immune cells to more inflammatory phenotypes. Targeting of the immunosuppressive drug dexamethasone, in contrast, promotes enhanced tumor growth and shifts the tumor-infiltrating immune cells to more anti-inflammatory phenotypes. Since Tregs comprise <1% of cells in the tumor masses examined, and since the targeted drugs are not internalized by cancer cells, these data demonstrate that Tregs exert a disproportionately large effect on tumor growth. Because the targeted drug did not bind to Tregs or other immune cells in healthy tissues, the data demonstrate that the immunosuppressive properties of Tregs in tumors can be manipulated without causing systemic toxicities associated with global reprogramming of the immune system.
MeSH term(s)	Humans ; Animals ; Mice ; T-Lymphocytes, Regulatory ; Molecular Docking Simulation ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Transcription Factors/metabolism ; Immunosuppressive Agents/metabolism ; Folic Acid/metabolism
Chemical Substances	Transcription Factors ; Immunosuppressive Agents ; Folic Acid (935E97BOY8)
Language	English
Publishing date	2023-10-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1274199
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Design and characterization of fibroblast activation protein targeted pan-cancer imaging agent for fluorescence-guided surgery of solid tumors

Mukkamala, Ramesh / Lindeman, Spencer D. / Kragness, Kate A. / Shahriar, Imrul / Srinivasarao, Madduri / Low, Philip S.

Journal of materials chemistry B. 2022 Mar. 23, v. 10, no. 12

2022

Abstract	Tumor-targeted fluorescent dyes have been shown to significantly improve a surgeon's ability to locate and resect occult malignant lesions, thereby enhancing a patient's chances of long term survival. Although several tumor-targeted fluorescent dyes have been developed for imaging specific subsets of human cancers, no tumor-targeted dye has been designed that can image all cancer types. Based on observations that fibroblast activation protein (FAP) is upregulated on cancer-associated fibroblasts (CAFs) that infiltrate essentially all solid tumors, we have undertaken to develop a FAP-targeted fluorescent dye that can image CAFs without accumulating in healthy cells or fibroblasts. We report here that FTL-S-S0456, a novel FAP-targeted near infrared dye that binds FAP with high affinity (∼12 nM) and specificity (>5000-fold over PREP and DPP-IV), concentrates in all seven solid tumor types examined, yielding fluorescence images with high tumor to background ratios that persist for several days. We conclude that FTL-S-S0456 constitutes an excellent ligand-targeted near infrared dye that enables intra-operative imaging of most if not all solid tumors.
Keywords	chemistry ; fibroblasts ; fluorescence ; fluorescent dyes ; humans ; neoplasms ; patients ; surgery
Language	English
Dates of publication	2022-0323
Size	p. 2038-2046.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d1tb02651h
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Investigation of the impact of nonsynonymous mutations on thyroid peroxidase dimer.

Begum, Mst Noorjahan / Mahtarin, Rumana / Ahmed, Sinthyia / Shahriar, Imrul / Hossain, Shekh Rezwan / Mia, Md Waseque / Qadri, Syed Saleheen / Qadri, Firdausi / Mannoor, Kaiissar / Akhteruzzaman, Sharif

PloS one

2023 Volume 18, Issue 9, Page(s) e0291386

Abstract: Congenital hypothyroidism is one of the most common preventable endocrine disorders associated with thyroid dysgenesis or dyshormonogenesis. Thyroid peroxidase (TPO) gene defect is mainly responsible for dyshormonogenesis; a defect in the thyroid hormone ...

Abstract	Congenital hypothyroidism is one of the most common preventable endocrine disorders associated with thyroid dysgenesis or dyshormonogenesis. Thyroid peroxidase (TPO) gene defect is mainly responsible for dyshormonogenesis; a defect in the thyroid hormone biosynthesis pathway. In Bangladesh, there is limited data regarding the genetic etiology of Congenital Hypothyroidism (CH). The present study investigates the impact of the detected mutations (p.Ala373Ser, and p.Thr725Pro) on the TPO dimer protein. We have performed sequential molecular docking of H2O2 and I- ligands with both monomers of TPO dimer to understand the iodination process in thyroid hormone biosynthesis. Understanding homodimer interactions at the atomic level is a critical challenge to elucidate their biological mechanisms of action. The docking results reveal that mutations in the dimer severely disrupt its catalytic interaction with essential ligands. Molecular dynamics simulation has been performed to validate the docking results, thus realizing the consequence of the mutation in the biological system's mimic. The dynamics results expose that mutations destabilize the TPO dimer protein. Finally, principal component analysis exhibits structural and energy profile discrepancies in wild-type and mutant dimers. The findings of this study highlight that the mutations in TPO protein can critically affect the dimer structure and loss of enzymatic activity is persistent. Other factors also might influence the hormone synthesis pathway, which is under investigation.
MeSH term(s)	Humans ; Iodide Peroxidase/genetics ; Congenital Hypothyroidism/genetics ; Hydrogen Peroxide ; Ligands ; Molecular Docking Simulation ; Mutation
Chemical Substances	Iodide Peroxidase (EC 1.11.1.8) ; Hydrogen Peroxide (BBX060AN9V) ; Ligands
Language	English
Publishing date	2023-09-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0291386
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Design of Neuraminidase-Targeted Imaging and Therapeutic Agents for the Diagnosis and Treatment of Influenza Virus Infections.

Liu, Xin / Luo, Weichuan / Zhang, Boning / Lee, Yong Gu / Shahriar, Imrul / Srinivasarao, Madduri / Low, Philip S

Bioconjugate chemistry

2021 Volume 32, Issue 8, Page(s) 1548–1553

Abstract: The last step in influenza virus replication involves the assembly of viral components on the infected cell's plasma membrane followed by budding of intact virus from the host cell surface. Because viral neuraminidase and hemagglutinin are both inserted ... ...

Abstract	The last step in influenza virus replication involves the assembly of viral components on the infected cell's plasma membrane followed by budding of intact virus from the host cell surface. Because viral neuraminidase and hemagglutinin are both inserted into the host cell's membrane during this process, influenza virus-infected cells are distinguished from uninfected cells by the presence of viral neuraminidase and hemagglutinin on their cell surfaces. In an effort to exploit this difference in cell surface markers for development of diagnostic and therapeutic agents, we have modified an influenza neuraminidase inhibitor, zanamivir, for targeting of attached imaging and therapeutic agents selectively to influenza viruses and virus-infected cells. We have designed here a zanamivir-conjugated rhodamine dye that allows visual monitoring of binding, internalization, and intracellular trafficking of the fluorescence-labeled neuraminidase in virus-infected cells. We also synthesize a zanamivir-
MeSH term(s)	Animals ; Enzyme Inhibitors/analysis ; HEK293 Cells ; Humans ; Influenza A virus/enzymology ; Influenza A virus/isolation & purification ; Influenza, Human/diagnostic imaging ; Mice ; Neuraminidase/analysis ; Neuraminidase/antagonists & inhibitors ; Optical Imaging ; Orthomyxoviridae Infections/diagnostic imaging ; Viral Proteins/analysis ; Viral Proteins/antagonists & inhibitors ; Zanamivir/analysis
Chemical Substances	Enzyme Inhibitors ; Viral Proteins ; Neuraminidase (EC 3.2.1.18) ; Zanamivir (L6O3XI777I)
Language	English
Publishing date	2021-06-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1024041-x
ISSN	1520-4812 ; 1043-1802
ISSN (online)	1520-4812
ISSN	1043-1802
DOI	10.1021/acs.bioconjchem.1c00255
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3400: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cysteine focused covalent inhibitors against the main protease of SARS-CoV-2.

Paul, Archi Sundar / Islam, Rajib / Parves, Md Rimon / Mamun, Abdulla Al / Shahriar, Imrul / Hossain, Md Imran / Hossain, Md Nayeem / Ali, Md Ackas / Halim, Mohammad A

Journal of biomolecular structure & dynamics

2020 Volume 40, Issue 4, Page(s) 1639–1658

Abstract: In viral replication and transcription, the main protease (Mpro) of SARS-CoV-2 plays an important role and appears to be a vital target for drug design. In Mpro, there is a Cys-His catalytic dyad, and ligands that interact with the Cys145 assumed to be ... ...

Abstract	In viral replication and transcription, the main protease (Mpro) of SARS-CoV-2 plays an important role and appears to be a vital target for drug design. In Mpro, there is a Cys-His catalytic dyad, and ligands that interact with the Cys145 assumed to be an effective approach to inhibit the Mpro. In this study, approximately 1400 cysteine-focused ligands were screened to identify the best candidates that can act as potent inhibitors against Mpro. Our results show that the selected ligands strongly interact with the key Cys145 and His41 residues. Covalent docking was performed for the selected candidates containing the acrylonitrile group, which can form a covalent bond with Cys145. All atoms molecular dynamics (MD) simulation was performed on the selected four inhibitors including L1, L2, L3 and L4 to validate the docking interactions. Our results were also compared with a control ligand, α-ketoamide (11r). Principal component analysis on structural and energy data obtained from the MD trajectories shows that L1, L3, L4 and α-ketoamide (11r) have structural similarity with the apo-form of the Mpro. Quantitative structure-activity relationship method was employed for pattern recognition of the best ligands, which discloses that ligands containing acrylonitrile and amide warheads can show better performance. ADMET analysis displays that our selected candidates appear to be safer inhibitors. Our combined studies suggest that the best cysteine focused ligands can help to design an effective lead drug for COVID-19 treatment. Communicated by Ramaswamy H. Sarma.
MeSH term(s)	COVID-19 ; Coronavirus 3C Proteases/antagonists & inhibitors ; Cysteine ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protease Inhibitors/pharmacology ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; Structure-Activity Relationship
Chemical Substances	Protease Inhibitors ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28) ; Cysteine (K848JZ4886)
Keywords	covid19
Language	English
Publishing date	2020-10-13
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2020.1831610
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2093: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Aggregation behavior of cetyldimethylethylammonium bromide under the influence of bovine serum albumin in aqueous/electrolyte solutions at various temperatures and compositions: conductivity and molecular dynamics study.

Ahmed, Md Farid / Molla, Mohammad Robel / Saha, Mousumi / Shahriar, Imrul / Rahman, Mohammad Saidur / Halim, Mohammad A / Rub, Malik Abdul / Hoque, Md Anamul / Asiri, Abdullah M

RSC advances

2019 Volume 9, Issue 12, Page(s) 6556–6567

Abstract: Herein, we have investigated the interaction of bovine serum albumin (BSA), the most abundant globular protein, with a conventional cationic surfactant, cetyldimethylethylammonium bromide (CDMEAB), through a conductivity technique in the absence/presence ...

Abstract	Herein, we have investigated the interaction of bovine serum albumin (BSA), the most abundant globular protein, with a conventional cationic surfactant, cetyldimethylethylammonium bromide (CDMEAB), through a conductivity technique in the absence/presence of electrolyte solutions at various temperatures (298.15-323.15 K). The interaction of the protein with drugs/surfactants and other additives plays a crucial role in the body. Hence, the main concern of the study is to extract the impact of BSA on surfactant molecules and
Language	English
Publishing date	2019-02-25
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra00070d
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Cysteine focused covalent inhibitors against the main protease of SARS-CoV-2

Paul, Archi Sundar / Islam, Rajib / Parves, Md Rimon / Mamun, Abdulla Al / Shahriar, Imrul / Hossain, Md Imran / Hossain, Md Nayeem / Ali, Md Ackas / Halim, Mohammad A

J Biomol Struct Dyn

Abstract	In viral replication and transcription, the main protease (Mpro) of SARS-CoV-2 plays an important role and appears to be a vital target for drug design. In Mpro, there is a Cys-His catalytic dyad, and ligands that interact with the Cys145 assumed to be an effective approach to inhibit the Mpro. In this study, approximately 1400 cysteine-focused ligands were screened to identify the best candidates that can act as potent inhibitors against Mpro. Our results show that the selected ligands strongly interact with the key Cys145 and His41 residues. Covalent docking was performed for the selected candidates containing the acrylonitrile group, which can form a covalent bond with Cys145. All atoms molecular dynamics (MD) simulation was performed on the selected four inhibitors including L1, L2, L3 and L4 to validate the docking interactions. Our results were also compared with a control ligand, α-ketoamide (11r). Principal component analysis on structural and energy data obtained from the MD trajectories shows that L1, L3, L4 and α-ketoamide (11r) have structural similarity with the apo-form of the Mpro. Quantitative structure-activity relationship method was employed for pattern recognition of the best ligands, which discloses that ligands containing acrylonitrile and amide warheads can show better performance. ADMET analysis displays that our selected candidates appear to be safer inhibitors. Our combined studies suggest that the best cysteine focused ligands can help to design an effective lead drug for COVID-19 treatment. Communicated by Ramaswamy H. Sarma.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #851512
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Cysteine focused covalent inhibitors against the main protease of SARS-CoV-2

Paul, Archi Sundar / Islam, Rajib / Parves, Md Rimon / Mamun, Abdulla Al / Shahriar, Imrul / Hossain, Md Imran / Hossain, Md Nayeem / Ali, Md Ackas / Halim, Mohammad A.

Journal of Biomolecular Structure and Dynamics

2020 , Page(s) 1–20

Keywords	Molecular Biology ; Structural Biology ; General Medicine ; covid19
Language	English
Publisher	Informa UK Limited
Publishing country	uk
Document type	Article ; Online
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2020.1831610
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.A 2093: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Mutation Spectrum in TPO Gene of Bangladeshi Patients with Thyroid Dyshormonogenesis and Analysis of the Effects of Different Mutations on the Structural Features and Functions of TPO Protein through

Begum, Mst Noorjahan / Islam, Md Tarikul / Hossain, Shekh Rezwan / Bhuyan, Golam Sarower / Halim, Mohammad A / Shahriar, Imrul / Sarker, Suprovath Kumar / Haque, Shahinur / Konika, Tasnia Kawsar / Islam, Md Sazzadul / Rahat, Asifuzzaman / Qadri, Syeda Kashfi / Sultana, Rosy / Begum, Suraiya / Sultana, Sadia / Saha, Narayan / Hasan, Mizanul / Hasanat, M A / Banu, Hurjahan /

Shekhar, Hossain Uddin / Chowdhury, Emran Kabir / Sajib, Abu A / Islam, Abul B M M K / Qadri, Syed Saleheen / Qadri, Firdausi / Akhteruzzaman, Sharif / Mannoor, Kaiissar

BioMed research international

2019 Volume 2019, Page(s) 9218903

Abstract: Although thyroid dyshormonogenesis (TDH) accounts for 10-20% of congenital hypothyroidism (CH), the molecular etiology of TDH is unknown in Bangladesh. Thyroid peroxidase (TPO) is most frequently associated with TDH and the present study investigated the ...

Abstract	Although thyroid dyshormonogenesis (TDH) accounts for 10-20% of congenital hypothyroidism (CH), the molecular etiology of TDH is unknown in Bangladesh. Thyroid peroxidase (TPO) is most frequently associated with TDH and the present study investigated the spectrum of TPO mutations in Bangladeshi patients and analyzed the effects of mutations on TPO protein structure through
MeSH term(s)	Adolescent ; Amino Acid Substitution/genetics ; Autoantigens/chemistry ; Autoantigens/genetics ; Bangladesh/epidemiology ; Child ; Child, Preschool ; Computer Simulation ; Congenital Hypothyroidism/epidemiology ; Congenital Hypothyroidism/genetics ; Congenital Hypothyroidism/pathology ; Female ; Genotype ; Humans ; Iodide Peroxidase/chemistry ; Iodide Peroxidase/genetics ; Iron-Binding Proteins/chemistry ; Iron-Binding Proteins/genetics ; Male ; Models, Molecular ; Molecular Docking Simulation ; Mutation/genetics ; Phenotype ; Structure-Activity Relationship ; Thyroid Gland/metabolism ; Thyroid Gland/pathology
Chemical Substances	Autoantigens ; Iron-Binding Proteins ; TPO protein, human (EC 1.11.1.7) ; Iodide Peroxidase (EC 1.11.1.8)
Language	English
Publishing date	2019-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2019/9218903
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito