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Article ; Online: Phytochemical, Antioxidant, hair growth and wound healing property of Juniperus excelsa, Olea oleaster and Olea europaea

Fatma Said Nasser Al-Owamri / Lamya Saleh Abdullah Al Sibay / Salla Hemadri Reddy / Shaik Althaf Hussain / Venkata Subba Reddy Gangireddygari

Journal of King Saud University: Science, Vol 35, Iss 2, Pp 102446- (2023)

1480

Abstract: To study phytochemical screening, Antioxidant property, and wound healing and hair growth of Olives tree (wild and cultivars) and Juniperus excelsa are the most important natural sources used to treat many diseases around the sultanate of Oman. ... ...

Abstract	To study phytochemical screening, Antioxidant property, and wound healing and hair growth of Olives tree (wild and cultivars) and Juniperus excelsa are the most important natural sources used to treat many diseases around the sultanate of Oman. Preliminary phytochemical analysis and DPPH method of antioxidant assay was carried out invitro. The experimental plant materials were also used to test their effect on hair growth and wound healing on Swiss albino mice(n = 3). Results of phytochemical study showed that tannins, alkaloid, saponin, terpenes, phenolic were found at high concentration (+++), while the rest of the constituents were found at moderate (++) to low concentrations (+). DPPH free radical scavenging potential of water extract of juniperus excelsa was (50 µg/ml = 83.30 %) found to be more effective, at 200 µg/ml concentration be 64.62 % free radical scavenging percentage was noticed. In the wound healing study, it was observed that juniperus extract showed significant result on the recovery of linear wound. Against the hair growth study, it was observed that the wild and cultivar olive water extracts have the best effect on hair growth. From these findings it is clear that these traditional medicinal plant parts can be effectively used for pharmacological preparations.
Keywords	Antioxidant ; Hair growth ; Olives ; Phytochemical screening ; Wound healing ; Phytochemistry ; Science (General) ; Q1-390
Subject code	580
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Alcohol-induced hormonal and metabolic alterations in plasma and erythrocytes-a gender-based study.

Lonappan, Daisy Kunnathuparambil / Kuruvalli, Gouthami / Shaik, Althaf Hussain / Hebbani, Ananda Vardhan / Reddyvari, Hymavathi / Damodara Reddy, Vaddi / Vadamalai, Veeraraghavan

Toxicology mechanisms and methods

2023 Volume 34, Issue 4, Page(s) 350–358

Abstract: Purpose: This study aimed to understand the gender-specific alcohol-induced biochemical changes and TBARS association with the endocrine system.: Methods: Human male and female subjects ranging from 35 ± 10 years old with an 8-10-year drinking ... ...

Abstract	Purpose: This study aimed to understand the gender-specific alcohol-induced biochemical changes and TBARS association with the endocrine system. Methods: Human male and female subjects ranging from 35 ± 10 years old with an 8-10-year drinking history were included in the study. Results: The results demonstrated that testosterone levels were lower in male alcoholics and higher in female alcoholics, as well as higher estrogen and cortisol levels in both genders. In addition, we found lower T3, T4, and thyroid-stimulating hormone (TSH) levels in alcoholics of both sexes. Furthermore, plasma TBARS, protein carbonyls, nitrite, and nitrate levels increased significantly with concomitant decrease in reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in both male and female alcoholics. Furthermore, erythrocyte lysate nitrite and nitrate levels membrane total cholesterol, phospholipid and cholesterol/phospholipid (C/P) ratio with lower total membrane proteins in both genders of alcoholics. SDS-PAGE analysis of erythrocyte membrane proteins revealed increased density of band 3, protein 4.1, 4.2, 4.9 and glycophorins, whereas decreases in spectrin (α and β) were observed in both genders of alcoholics. Besides, alcoholics of both sexes had a lower ability to resist osmotic hemolysis. Plasma TBARS was negatively correlated with testosterone, TSH, T3 and T4 in male alcoholics, moreover, estradiol and cortisol were positively correlated in males and females respectively. Conclusion: Female alcoholics may be more susceptible to osmotic hemolysis due to increased erythrocyte membrane lipid peroxidation with decreased antioxidant status, which results in an altered membrane C/P ratio and membrane protein composition.
MeSH term(s)	Humans ; Male ; Female ; Adult ; Middle Aged ; Thiobarbituric Acid Reactive Substances/metabolism ; Nitrates/metabolism ; Nitrites/metabolism ; Hemolysis ; Hydrocortisone/metabolism ; Antioxidants/metabolism ; Catalase/metabolism ; Erythrocytes/metabolism ; Ethanol ; Oxidative Stress ; Superoxide Dismutase/metabolism ; Glutathione Peroxidase/metabolism ; Lipid Peroxidation ; Phospholipids/metabolism ; Cholesterol/metabolism ; Membrane Proteins/metabolism ; Testosterone/metabolism ; Thyrotropin/metabolism
Chemical Substances	Thiobarbituric Acid Reactive Substances ; Nitrates ; Nitrites ; Hydrocortisone (WI4X0X7BPJ) ; Antioxidants ; Catalase (EC 1.11.1.6) ; Ethanol (3K9958V90M) ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione Peroxidase (EC 1.11.1.9) ; Phospholipids ; Cholesterol (97C5T2UQ7J) ; Membrane Proteins ; Testosterone (3XMK78S47O) ; Thyrotropin (9002-71-5)
Language	English
Publishing date	2023-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2081252-8
ISSN	1537-6524 ; 1537-6516 ; 1051-7235
ISSN (online)	1537-6524
ISSN	1537-6516 ; 1051-7235
DOI	10.1080/15376516.2023.2290071
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Article: Analysis of maslinic acid and gallic acid compounds as xanthine oxidase inhibitors in isoprenaline administered myocardial necrotic rats.

Shaik, Althaf Hussain / Shaik, Shajidha Ruksar / Shaik, Abdul Saheer / Daoud, Ali / Salim, Manoharadas / Kodidhela, Lakshmi Devi

Saudi journal of biological sciences

2021 Volume 28, Issue 4, Page(s) 2575–2580

Abstract: Objective: This research designed to analyze the : Methods: Albino Wistar rats were categorized into four groups with eight rats in each group. A dose of 15 mg/kg of MA and GA were pretreated to each MA and GA groups for seven days. A dose of 85 mg/ ... ...

Abstract	Objective: This research designed to analyze the Methods: Albino Wistar rats were categorized into four groups with eight rats in each group. A dose of 15 mg/kg of MA and GA were pretreated to each MA and GA groups for seven days. A dose of 85 mg/kg of ISO administered to the ISO group along with MA and GA groups except normal group on two consecutive days of pretreatment. All animals sacrificed and the heart tissues were collected for the analysis of XO. The Results: XO enzyme levels were significantly increased in the heart homogenate of ISO administered rats when compared to normal rats. Pretreatment of MA and GA to ISO treated rats significantly brought XO enzyme to the near normal levels which indicate the protective action of MA and GA against myocardial necrosis. The Conclusion: MA and GA compounds manifested the ameliorative effect against ISO administrated myocardial necrosis by inhibiting the free radical generating enzyme XO which is evidenced by both
Language	English
Publishing date	2021-02-10
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2021.01.062
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Article ; Online: Rose Bengal induced formation of thrombosis in rats and an investigation of cardiovascular worries by haematological changes

Liwei Zhang / Qian Xia / Long Yu / Narendra Maddu / Shaik Althaf Hussain / Bangeppagari Manjunatha / Sudhakara Gujjala / Jayasimha Rayalu Daddam / Chinna Padamala Manjuvani / Turki Mayudh Alrubie / Hong Jiang

Journal of King Saud University: Science, Vol 35, Iss 8, Pp 102838- (2023)

2023

Abstract: Background: The present investigation planned to study the cardiovascular worries in Rose Bengal (RB) induced thrombotic rats by analysing biochemical profile of plasma, platelet membrane and cardiac tissue. Methods: Male Wistar rats were categorized ... ...

Abstract	Background: The present investigation planned to study the cardiovascular worries in Rose Bengal (RB) induced thrombotic rats by analysing biochemical profile of plasma, platelet membrane and cardiac tissue. Methods: Male Wistar rats were categorized into two groups. The group I was Control (C) rats and received glucose, whereas group II was Rose Bengal (50 mg/kg) induced thrombotic rats. The animals sacrificed and biological samples collected were analysed for various biochemical parameters. Results: In rats RB induced heart damage/thrombosis showed significantly increased levels of lipid peroxidation (LPO), nitrate and nitrite. In RB administered group the antioxidant activities were lowered significantly i.e., reduced glutathione, glutathione S-transferase, glutathione peroxidase, superoxide dismutase and catalase when compared with control rats. Plasma enzymes SGOT, SGPT were decreased and Na+-K+ ATPase was significantly increased in group II in comparison with group I. There is no significant change in plasma hexokinase enzyme in RB administered rats when compared with control rats. The non-enzymatic and enzymatic antioxidants levels were decreased significantly in experimental groups II to compare with control group I rats. A significant increase in platelet membrane fluidity observed in group II rats when compared with group I rats in DPH and pyrene employed method. A significant raise in LPO of platelet membrane was observed in the experimental rats. Plasma nitrite and nitrate levels were increased in group II when compared to group I. Furthermore, the haematological parameters were also increased in group II when compared to group I rats. Conclusion: This investigation pointed out that the nitric oxide scavenging levels increased and might be protected the oxidative stress and free radicals generated by RB induced cardiac thrombosis in rats.
Keywords	Rose Bengal ; Thrombosis ; Platelet membrane fluidity ; Antioxidants ; Nitric oxide ; Science (General) ; Q1-390
Subject code	630
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article: Eco-Friendly Preparation of Silver Nanoparticles and Their Antiproliferative and Apoptosis-Inducing Ability against Lung Cancer.

Suseela, Vivekananthan / Nirmaladevi, Ramalingam / Pallikondaperumal, Muthukrishnan / Priya, Ramasamy Shanmuga / Shaik, Mohammed Rafi / Shaik, Althaf Hussain / Khan, Mujeeb / Shaik, Baji

Life (Basel, Switzerland)

2022 Volume 12, Issue 12

Abstract: In the present study, the anti-proliferative and apoptotic potential ... ...

Abstract	In the present study, the anti-proliferative and apoptotic potential of
Language	English
Publishing date	2022-12-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12122123
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Article ; Online: Development and Validation for Quantification of Cephapirin and Ceftiofur by Ultraperformance Liquid Chromatography with Triple Quadrupole Mass Spectrometry.

Chittireddy, Hari Naga Prasada Reddy / Kumar, J V Shanmukha / Bhimireddy, Anuradha / Shaik, Mohammed Rafi / Shaik, Althaf Hussain / Alwarthan, Abdulrahman / Shaik, Baji

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 22

Abstract: Cross contamination of β-lactams is one of the highest risks for patients using pharmaceutical products. Penicillin and some non-penicillin β-lactams may cause potentially life-threatening allergic reactions. The trace detection of β-lactam antibiotics ... ...

Abstract	Cross contamination of β-lactams is one of the highest risks for patients using pharmaceutical products. Penicillin and some non-penicillin β-lactams may cause potentially life-threatening allergic reactions. The trace detection of β-lactam antibiotics in cleaning rinse solutions of common reactors and manufacturing aids in pharmaceutical facilities is very crucial. Therefore, the common facilities adopt sophisticated cleaning procedures and develop analytical methods to assess traces of these compounds in rinsed solutions. For this, a highly sensitive and reproducible ultra-performance liquid chromatography with triple quadrupole mass spectrometry (UHPLC-MS/MS) method was developed for the analysis of Cephapirin and Ceftiofur. As per the FDA guidelines described in FDA-2011-D-0104, the contamination of these β-lactam antibiotics must be regulated. The analysis was performed on an XBridge C18 column with 100 mm length, 4.6 mm diameter, and 3.5 µm particle size at an oven temperature of about 40 °C. The mobile phase was composed of 0.15% formic acid in water and acetonitrile as mobile phases A and B, and a flow rate was set to 0.6 mL/min. The method was validated for Cephapirin and Ceftiofur. The quantification precision and accuracy were determined to be the lowest limit of detection 0.15 parts per billion (ppb) and the lowest limit of quantification 0.4 ppb. This method was linear in the range of 0.4 to 1.5 ppb with the determination of coefficient (R2 > 0.99). This sensitive and fast method was fit-for-purpose for detecting and quantifying trace amounts of β-lactam contamination, monitoring cross contamination in facility surface cleaning, and determining the acceptable level of limits for regulatory purposes.
MeSH term(s)	Humans ; Cephapirin ; Tandem Mass Spectrometry/methods ; Anti-Bacterial Agents/analysis ; Reproducibility of Results ; Chromatography, Liquid/methods ; beta-Lactams ; Monobactams ; Penicillins
Chemical Substances	Cephapirin (89B59H32VN) ; ceftiofur (83JL932I1C) ; Anti-Bacterial Agents ; beta-Lactams ; Monobactams ; Penicillins
Language	English
Publishing date	2022-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27227920
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Article ; Online: Green Synthesized Silver Nanoparticles Mitigate Biotic Stress Induced by Meloidogyne incognita in Trachyspermum ammi (L.) by Improving Growth, Biochemical, and Antioxidant Enzyme Activities

Mohammad Danish / Mohammad Altaf / Merajul Islam Robab / Mohammad Shahid / Salim Manoharadas / Shaik Althaf Hussain / Hisamuddin Shaikh

ACS Omega, Vol 6, Iss 17, Pp 11389-

2021 Volume 11403

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
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Article ; Online: An Engineered Multimodular Enzybiotic against Methicillin-Resistant Staphylococcus aureus

Salim Manoharadas / Mohammad Altaf / Abdulwahed Fahad Alrefaei / Naushad Ahmad / Shaik Althaf Hussain / Basel F. Al-Rayes

Life, Vol 11, Iss 1384, p

2021 Volume 1384

Abstract: Development of multidrug antibiotic resistance in bacteria is a predicament encountered worldwide. Researchers are in a constant hunt to develop effective antimicrobial agents to counter these dreadful pathogenic bacteria. Here we describe a chimerically ...

Abstract	Development of multidrug antibiotic resistance in bacteria is a predicament encountered worldwide. Researchers are in a constant hunt to develop effective antimicrobial agents to counter these dreadful pathogenic bacteria. Here we describe a chimerically engineered multimodular enzybiotic to treat a clinical isolate of methicillin-resistant Staphylococcus aureus ( S. aureus ). The cell wall binding domain of phage ϕ11 endolysin was replaced with a truncated and more potent cell wall binding domain from a completely unrelated protein from a different phage. The engineered enzybiotic showed strong activity against clinically relevant methicillin-resistant Staphylococcus aureus . In spite of a multimodular peptidoglycan cleaving catalytic domain, the engineered enzybiotic could not exhibit its activity against a veterinary isolate of S. aureus . Our studies point out that novel antimicrobial proteins can be genetically engineered. Moreover, the cell wall binding domain of the engineered protein is indispensable for a strong binding and stability of the proteins.
Keywords	enzybiotics ; bacteriophage ; MRSA ; antibiotic-resistant bacteria ; Staphylococcus aureus ; Science ; Q
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Studies on Oman elite date palm varieties and preliminary establishment of identity through SSR marker

Hemadri Reddy / Fatma K. AL-Rashdi / Habeeba S. AL-Sulti / Moza Sh. AL-Madhoshi / Shaik Althaf Hussain / Venkata Subba Reddy Gangireddygari

Journal of King Saud University: Science, Vol 34, Iss 8, Pp 102348- (2022)

2022

Abstract: The Date palm (Phoenix dactylifera L.) is perennial, diploid plant found abundantly in the Middle East region. It plays a significant role in traditional as well socioeconomic growth in the Sultanate of Oman. The main focus of the current work is to ... ...

Abstract	The Date palm (Phoenix dactylifera L.) is perennial, diploid plant found abundantly in the Middle East region. It plays a significant role in traditional as well socioeconomic growth in the Sultanate of Oman. The main focus of the current work is to identify different methods of DNA extractions for date palm leaf and further to study the genetic diversity among the seven different cultivar varieties, within the Sultanate of Oman, using SSR marker. Seven cultivars were obtained randomly from different places in Oman namely Khasab, Naghal, Barni, Madloki, Khenezi, Nasho and Fard. Genomic DNA was extracted using Edwards’s method and Maxi kit method (QIAGEN). Fingerprint is established by PCR amplification of DNA samples with five sets of SSR primers to identify the diversity between individual date palm from seven different locations. This study will help the researchers as a tool and the markers for the similarity and differences analysis as well as mapping of date palm in Sultanate of Oman. The findings of the study indicated that five SSR primers tested were able to produce amplicons for date palms from different locations. Percentage of similarity between seven date palm cultivars from different locations was found to be having 74 % significance.
Keywords	Dates ; DNA isolation ; Fingerprinting ; Genetic diversity ; Molecular markers ; Science (General) ; Q1-390
Subject code	571
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Development of saline loaded mask materials, evaluation of the antimicrobial efficacy and survivability of selected bacteria on these mask materials

Julnar Evangelista Pepito / Jayachandran Vavolil Prabhakaran / Dinesh Kada Peela Bheeman / Pankaj Sah / Aldwin Platero Villarias / Shaik Althaf Hussain / Venkata Subba Reddy Gangireddygari / Afraa Said Al Adawi

Journal of King Saud University: Science, Vol 34, Iss 5, Pp 102125- (2022)

2022

Abstract: Objective: Surgical face masks have been recommended by World Health Organization (WHO) during the COVID-19 pandemic. Nowadays wearing masks have become a norm and lifestyle around the globe. The present investigation was carried out to evaluate the ... ...

Abstract	Objective: Surgical face masks have been recommended by World Health Organization (WHO) during the COVID-19 pandemic. Nowadays wearing masks have become a norm and lifestyle around the globe. The present investigation was carried out to evaluate the feasibility of developing masks loaded with analytical grade sodium chloride (NaCl), Iodized salts (IS) and Omani sea salt (OSS) with or without sodium bicarbonate (NaHCO3). Methods: The saline loaded masks were prepared by soaking the middle layer of the mask in 30% (w/v) saline solutions (NaCl, IS, OSS) with or without 10% NaHCO3 for 24 h followed by drying at room temperature. The prepared saline solutions and its combinations were evaluated for antimicrobial efficacy against the bacteria like Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Salmonella typhi, and Staphylococcus aureus, and antifungal activity against the Penicillium spp. and Rhizopus spp. by agar diffusion. Optical microscopy was employed to observe the formation of salt crystal in the mask material. Survivability of S. aureus and P. aeruginosa was tested on the mask material loaded with 30% OSS + 10% NaHCO3 at particular time intervals. Results: The results showed that a combination of 30% OSS + 10% NaHCO3 exhibited promising antimicrobial activity against all the bacteria as well as Rhizopus spp. compared to the 30% IS + 10% NaHCO3. Moreover, the middle layer of the mask loaded with saline solutions of 30% OSS + 10% NaHCO3 or 30% IS + 10% NaHCO3 have antibacterial activity, particularly for oral microbiome. On dehydration, the masks materials showed the presence of a significant amount of salt crystals. Survivability tests showed that both S. aureus and P. aeruginosa were killed within 3 h of contact with the salt crystals on the mask materials. Conclusions: A combination of 30% OSS + 10% NaHCO3 possessed significant antimicrobial activities on the tested microorganisms. Presence of a significant amount of salt crystals on dehydration of the saline loaded masks can be used as an ...
Keywords	Surgical mask ; Omani sea salt ; Sodium bicarbonate ; Antimicrobial activity ; Salt crystals ; Science (General) ; Q1-390
Subject code	630
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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