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Article ; Online: Therapeutic prime/pull vaccination of HSV-2-infected guinea pigs with the ribonucleotide reductase 2 (RR2) protein and CXCL11 chemokine boosts antiviral local tissue-resident and effector memory CD4

Quadiri, Afshana / Prakash, Swayam / Dhanushkodi, Nisha Rajeswari / Singer, Mahmoud / Zayou, Latifa / Shaik, Amin Mohammed / Sun, Miyo / Suzer, Berfin / Lau, Lauren Su Lin / Chilukurri, Amruth / Vahed, Hawa / Schaefer, Hubert / BenMohamed, Lbachir

Journal of virology

2024 Volume 98, Issue 5, Page(s) e0159623

Abstract: Following acute herpes simplex virus type 2 (HSV-2) infection, the virus undergoes an asymptomatic latent infection of sensory neurons of dorsal root ganglia (DRG). Chemical and physical stress cause intermittent virus reactivation from latently infected ...

Abstract	Following acute herpes simplex virus type 2 (HSV-2) infection, the virus undergoes an asymptomatic latent infection of sensory neurons of dorsal root ganglia (DRG). Chemical and physical stress cause intermittent virus reactivation from latently infected DRG and recurrent virus shedding in the genital mucosal epithelium causing genital herpes in symptomatic patients. While T cells appear to play a role in controlling virus reactivation from DRG and reducing the severity of recurrent genital herpes, the mechanisms for recruiting these T cells into DRG and the vaginal mucosa (VM) remain to be fully elucidated. The present study investigates the effect of CXCL9, CXCL10, and CXCL11 T-cell-attracting chemokines on the frequency and function of DRG- and VM-resident CD4
MeSH term(s)	Animals ; Herpes Genitalis/immunology ; Herpes Genitalis/prevention & control ; Guinea Pigs ; Herpesvirus 2, Human/immunology ; CD8-Positive T-Lymphocytes/immunology ; Female ; Chemokine CXCL11/immunology ; Chemokine CXCL11/metabolism ; CD4-Positive T-Lymphocytes/immunology ; Ganglia, Spinal/immunology ; Ganglia, Spinal/virology ; Ribonucleotide Reductases/metabolism ; Vagina/virology ; Vagina/immunology ; Vaccination ; Disease Models, Animal ; Memory T Cells/immunology
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01596-23
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Article ; Online: Antiviral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models.

Dhanushkodi, Nisha Rajeswari / Prakash, Swayam / Quadiri, Afshana / Zayou, Latifa / Srivastava, Ruchi / Shaik, Amin Mohammed / Suzer, Berfin / Ibraim, Izabela Coimbra / Landucci, Gary / Tifrea, Delia F / Singer, Mahmoud / Jamal, Leila / Edwards, Robert A / Vahed, Hawa / Brown, Lawrence / BenMohamed, Lbachir

Journal of immunology (Baltimore, Md. : 1950)

2024 Volume 212, Issue 4, Page(s) 576–585

Abstract: SARS-CoV-2 variants of concern (VOCs) continue to evolve and reemerge with chronic inflammatory long COVID sequelae, necessitating the development of anti-inflammatory therapeutic molecules. Therapeutic effects of the receptor for advanced glycation end ... ...

Abstract	SARS-CoV-2 variants of concern (VOCs) continue to evolve and reemerge with chronic inflammatory long COVID sequelae, necessitating the development of anti-inflammatory therapeutic molecules. Therapeutic effects of the receptor for advanced glycation end products (RAGE) were reported in many inflammatory diseases. However, a therapeutic effect of RAGE in COVID-19 has not been reported. In the present study, we investigated whether and how the RAGE-Ig fusion protein would have an antiviral and anti-inflammatory therapeutic effect in the COVID-19 system. The protective therapeutic effect of RAGE-Ig was determined in vivo in K18-hACE2 transgenic mice and Syrian golden hamsters infected with six VOCs of SARS-CoV-2. The underlying antiviral mechanism of RAGE-Ig was determined in vitro in SARS-CoV-2-infected human lung epithelial cells (BEAS-2B). Following treatment of K18-hACE2 mice and hamsters infected with various SARS-CoV-2 VOCs with RAGE-Ig, we demonstrated (1) significant dose-dependent protection (i.e., greater survival, less weight loss, lower virus replication in the lungs); (2) a reduction of inflammatory macrophages (F4/80+/Ly6C+) and neutrophils (CD11b+/Ly6G+) infiltrating the infected lungs; (3) a RAGE-Ig dose-dependent increase in the expression of type I IFNs (IFN-α and IFN-β) and type III IFN (IFNλ2) and a decrease in the inflammatory cytokines (IL-6 and IL-8) in SARS-CoV-2-infected human lung epithelial cells; and (4) a dose-dependent decrease in the expression of CD64 (FcgR1) on monocytes and lung epithelial cells from symptomatic COVID-19 patients. Our preclinical findings revealed type I and III IFN-mediated antiviral and anti-inflammatory therapeutic effects of RAGE-Ig protein against COVID-19 caused by multiple SARS-CoV-2 VOCs.
MeSH term(s)	Cricetinae ; Humans ; Mice ; Animals ; SARS-CoV-2 ; Mesocricetus ; COVID-19 ; Receptor for Advanced Glycation End Products/genetics ; Post-Acute COVID-19 Syndrome ; Mice, Transgenic ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Disease Models, Animal ; Lung ; gamma-Globulins ; Melphalan
Chemical Substances	Receptor for Advanced Glycation End Products ; K-18 conjugate ; Antiviral Agents ; gamma-Globulins ; Melphalan (Q41OR9510P)
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2300392
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Article: Therapeutic Prime/Pull Vaccination of HSV-2 Infected Guinea Pigs with the Ribonucleotide Reductase 2 (RR2) Protein and CXCL11 Chemokine Boosts Antiviral Local Tissue-Resident and Effector Memory CD4

Quadiri, Afshana / Prakash, Swayam / Dhanushkodi, Nisha Rajeswari / Singer, Mahmoud / Zayou, Latifa / Shaik, Amin Mohammed / Sun, Miyo / Suzer, Berfin / Lau, Lauren / Chilukurri, Amruth / Vahed, Hawa / Schaefer, Hubert / BenMohamed, Lbachir

bioRxiv : the preprint server for biology

2023

Abstract: Following acute herpes simplex virus type 2 (HSV-2) infection, the virus undergoes latency in sensory neurons of the dorsal root ganglia (DRG). Intermittent virus reactivation from latency and shedding in the vaginal mucosa (VM) causes recurrent genital ... ...

Abstract	Following acute herpes simplex virus type 2 (HSV-2) infection, the virus undergoes latency in sensory neurons of the dorsal root ganglia (DRG). Intermittent virus reactivation from latency and shedding in the vaginal mucosa (VM) causes recurrent genital herpes. While T-cells appear to play a role in controlling virus reactivation and reducing the severity of recurrent genital herpes, the mechanisms for recruiting these T-cells into DRG and VM tissues remain to be fully elucidated. The present study investigates the effect of CXCL9, CXCL10, and CXCL11 T-cell-attracting chemokines on the frequency and function of DRG- and VM-resident CD4
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.08.552454
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Article ; Online: Cross-protection induced by highly conserved human B, CD4

Prakash, Swayam / Dhanushkodi, Nisha R / Zayou, Latifa / Ibraim, Izabela Coimbra / Quadiri, Afshana / Coulon, Pierre Gregoire / Tifrea, Delia F / Suzer, Berfin / Shaik, Amin Mohammed / Chilukuri, Amruth / Edwards, Robert A / Singer, Mahmoud / Vahed, Hawa / Nesburn, Anthony B / Kuppermann, Baruch D / Ulmer, Jeffrey B / Gil, Daniel / Jones, Trevor M / BenMohamed, Lbachir

Frontiers in immunology

2024 Volume 15, Page(s) 1328905

Abstract: Background: The coronavirus disease 2019 (COVID-19) pandemic has created one of the largest global health crises in almost a century. Although the current rate of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections has decreased ... ...

Abstract	Background: The coronavirus disease 2019 (COVID-19) pandemic has created one of the largest global health crises in almost a century. Although the current rate of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections has decreased significantly, the long-term outlook of COVID-19 remains a serious cause of morbidity and mortality worldwide, with the mortality rate still substantially surpassing even that recorded for influenza viruses. The continued emergence of SARS-CoV-2 variants of concern (VOCs), including multiple heavily mutated Omicron sub-variants, has prolonged the COVID-19 pandemic and underscores the urgent need for a next-generation vaccine that will protect from multiple SARS-CoV-2 VOCs. Methods: We designed a multi-epitope-based coronavirus vaccine that incorporated B, CD4 Results: The pan-variant SARS-CoV-2 vaccine (i) is safe , (ii) induces high frequencies of lung-resident functional CD8 Conclusion: A multi-epitope pan-variant SARS-CoV-2 vaccine bearing conserved human B- and T- cell epitopes from structural and non-structural SARS-CoV-2 antigens induced cross-protective immunity that facilitated virus clearance, and reduced morbidity, COVID-19-related lung pathology, and death caused by multiple SARS-CoV-2 VOCs.
MeSH term(s)	Animals ; Humans ; Mice ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Epitopes, T-Lymphocyte/genetics ; Pandemics ; SARS-CoV-2/genetics ; Cross Protection
Chemical Substances	COVID-19 Vaccines ; Epitopes, T-Lymphocyte
Language	English
Publishing date	2024-01-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1328905
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Article ; Online: A multi-epitope/CXCL11 prime/pull coronavirus mucosal vaccine boosts the frequency and the function of lung-resident memory CD4

Zayou, Latifa / Prakash, Swayam / Dhanushkodi, Nisha Rajeswari / Quadiri, Afshana / Ibraim, Izabela Coimbra / Singer, Mahmoud / Salem, Amirah / Shaik, Amin Mohammed / Suzer, Berfin / Chilukuri, Amruth / Tran, Jennifer / Nguyen, Pauline Chau / Sun, Miyo / Hormi-Carver, Kathy K / Belmouden, Ahmed / Vahed, Hawa / Gil, Daniel / Ulmer, Jeffrey B / BenMohamed, Lbachir

Journal of virology

2023 Volume 97, Issue 12, Page(s) e0109623

Abstract: Importance: Although the current rate of SARS-CoV-2 infections has decreased significantly, COVID-19 still ranks very high as a cause of death worldwide. As of October 2023, the weekly mortality rate is still at 600 deaths in the United States alone, ... ...

Abstract	Importance: Although the current rate of SARS-CoV-2 infections has decreased significantly, COVID-19 still ranks very high as a cause of death worldwide. As of October 2023, the weekly mortality rate is still at 600 deaths in the United States alone, which surpasses even the worst mortality rates recorded for influenza. Thus, the long-term outlook of COVID-19 is still a serious concern outlining the need for the next-generation vaccine. This study found that a prime/pull coronavirus vaccine strategy increased the frequency of functional SARS-CoV-2-specific CD4
MeSH term(s)	Animals ; Humans ; Mice ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Chemokine CXCL11/immunology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Epitopes ; Lung/immunology ; Lung/virology ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus ; Disease Models, Animal
Chemical Substances	Chemokine CXCL11 ; COVID-19 Vaccines ; CXCL11 protein, human ; Epitopes ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01096-23
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa.

Journal of immunology (Baltimore, Md. : 1950)

2023 Volume 211, Issue 1, Page(s) 118–129

Abstract: Four major mucosal-associated chemokines, CCL25, CCL28, CXCL14, and CXCL17, play an important role in protecting mucosal surfaces from infectious pathogens. However, their role in protection against genital herpes remains to be fully explored. The CCL28 ... ...

Abstract	Four major mucosal-associated chemokines, CCL25, CCL28, CXCL14, and CXCL17, play an important role in protecting mucosal surfaces from infectious pathogens. However, their role in protection against genital herpes remains to be fully explored. The CCL28 is a chemoattractant for the CCR10 receptor-expressing immune cells and is produced homeostatically in the human vaginal mucosa (VM). In this study, we investigated the role of the CCL28/CCR10 chemokine axis in mobilizing protective antiviral B and T cell subsets into the VM site of herpes infection. We report a significant increase in the frequencies of HSV-specific memory CCR10+CD44+CD8+ T cells, expressing high levels of CCR10, in herpes-infected asymptomatic (ASYMP) women compared with symptomatic women. Similarly, a significant increase in the CCL28 chemokine (a ligand of CCR10), was detected in the VM of herpes-infected ASYMP C57BL/6 mice, associated with the mobilization of high frequencies of HSV-specific effector memory CCR10+CD44+CD62L-CD8+ TEM cells and memory CCR10+B220+CD27+ B cells in the VM of HSV-infected ASYMP mice. Inversely, compared with wild-type C57BL/6 mice, the CCL28 knockout (CCL28-/-) mice (1) appeared to be more susceptible to intravaginal infection and reinfection with HSV type 2, and (2) exhibited a significant decrease in the frequencies of HSV-specific effector memory CCR10+CD44+CD62L-CD8+ TEM cells and of memory CD27+B220+ B cells in the infected VM. These findings suggest a critical role of the CCL28/CCR10 chemokine axis in the mobilization of antiviral memory B and T cells within the VM to protect against genital herpes infection and disease.
MeSH term(s)	Humans ; Female ; Mice ; Animals ; Herpes Genitalis ; Antiviral Agents/metabolism ; Mice, Inbred C57BL ; CD8-Positive T-Lymphocytes ; Herpesvirus 2, Human ; Mucous Membrane ; Antiviral Restriction Factors ; Receptors, CCR10/metabolism ; Chemokines, CC/metabolism ; Hyaluronan Receptors/metabolism
Chemical Substances	Antiviral Agents ; Antiviral Restriction Factors ; CCR10 protein, human ; Receptors, CCR10 ; CCL28 protein, human ; Chemokines, CC ; CD44 protein, human ; Hyaluronan Receptors
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2300093
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Article ; Online: A Multi-Epitope/CXCL11 Prime/Pull Coronavirus Mucosal Vaccine Boosts the Frequency and the Function of Lung-Resident CD4+ and CD8+ Memory T Cells and Protects Against COVID-19-like Symptoms and Death Caused by SARS-CoV-2 infection

Zayou, Latifa / Prakash, Swayam / Dhanushkodi, Nisha R / Quadiri, Afshana / Ibraim, Izabela Coimbra / Singer, Mahmoud / Salem, Amirah / Shaik, Amin Mohammed / Suzer, Berfin / Chilukuri, Amruth / Tran, Jennifer / Nguyen, Pauline Chau / Sun, Miyo / Hormi-Carver, Kathy K / Belmouden, Ahmed / Vahed, Hawa / Ulmer, Jeffrey B / BENMOHAMED, LBACHIR

bioRxiv

Abstract: The pandemic of the coronavirus disease 2019 (COVID-19) has created the largest global health crisis in almost a century. Following exposure to SARS-CoV-2, the virus particles replicate in the lungs, induce a cytokine storm and potentially cause life- ... ...

Abstract	The pandemic of the coronavirus disease 2019 (COVID-19) has created the largest global health crisis in almost a century. Following exposure to SARS-CoV-2, the virus particles replicate in the lungs, induce a cytokine storm and potentially cause life-threatening inflammatory disease. Low frequencies of function SARS-CoV-2-specific CD4+ and CD8+ T cells in the lungs of COVID-19 patients were associated with severe cases of COVID-19. The apparent low level of T cell-attracting CXCL9, CXCL10, and CXCL11 chemokines in infected lungs may not be sufficient enough to assure the sequestration and/or homing of CD4+ and CD8+ T cells from the circulation into infected lungs. We hypothesize that a Coronavirus vaccine strategy that boosts the frequencies of functional SARS-CoV-2-specific CD4+ and CD8+ T cells in the lungs would lead to better protection against SARS-CoV-2 infection, COVID19-like symptoms, and death. In the present study, we designed and pre-clinically tested the safety, immunogenicity, and protective efficacy of a novel multi-epitope//CXCL11 prime/pull mucosal Coronavirus vaccine. This prime/pull vaccine strategy consists of intranasal delivery of a lung-tropic adeno-associated virus type 9 (AAV-9) vector that incorporates highly conserved human B, CD4+ CD8+ cell epitopes of SARS-CoV-2 (prime) and pulling the primed B and T cells into the lungs using the T cell attracting chemokine, CXCL-11 (pull). We demonstrated that immunization of HLA-DR0101/HLA-A0201/hACE2 triple transgenic mice with this multi-epitope//CXCL11 prime/pull Coronavirus mucosal vaccine: (i) Increased the frequencies of CD4+ and CD8+ TEM, TCM, and TRM cells in the lungs; and (ii) reduced COVID19-like symptoms, lowered virus replication, and prevented deaths following challenge with SARS-CoV-2. These findings discuss the importance of bolstering the number and function of lung-resident memory CD4+ and CD8+ T cells for better protection against SARS-CoV-2 infection, COVID-19-like symptoms, and death.
Keywords	covid19
Language	English
Publishing date	2023-05-26
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2023.05.23.542024
Database	COVID19

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Article ; Online: Anti-Viral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein Against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models

Dhanushkodi, Nisha / Prakash, Swayam / Quadiri, Afshana / Zayou, Latifa / Srivastava, Ruchi / Shaik, Amin Mohammed / Suzer, Berfin / Ibraim, Izabela Coimbra / Landucci, Gary / Tifrea, Delia F / Singer, Mahmoud / Jamal, Leila / Edwards, Robert A / Vahed, Hawa / Brown, Lawrence / BENMOHAMED, LBACHIR

bioRxiv

Abstract: Significance: SARS-CoV-2 Variants of Concern (VOCs) continue to evolve and re-emerge with chronic inflammatory long-COVID sequelae necessitating the development of anti-inflammatory therapeutic molecules. Therapeutic effects of the Receptor for Advanced ... ...

Abstract	Significance: SARS-CoV-2 Variants of Concern (VOCs) continue to evolve and re-emerge with chronic inflammatory long-COVID sequelae necessitating the development of anti-inflammatory therapeutic molecules. Therapeutic effects of the Receptor for Advanced Glycation End products (RAGE) were reported in many inflammatory diseases. However, a therapeutic effect of the RAGE in COVID-19 has not been reported. In the present study, we investigated whether and how the RAGE-Ig fusion protein would have an anti-viral and anti-inflammatory therapeutic effect in the COVID-19 system. Methods: The protective therapeutic effect of RAGE-Ig was determined in vitro in K18-hACE2 transgenic mice and Syrian golden hamsters infected with six various VOCs of SARS-CoV-2. The underlying anti-viral mechanism of RAGE-Ig was determined in vitro in SARS-CoV-2-infected human lung epithelial cells (BEAS-2B). Results: Following treatment of K18-hACE2 mice and hamsters infected with various SARS-CoV-2 VOCs with RAGE-Ig, we demonstrated: (i) significant dose-dependent protection (i.e. greater survival, less weight loss, lower virus replication in the lungs); (ii) a reduction of inflammatory macrophages (F4/80+/Ly6C+) and neutrophils (CD11b+/Ly6G+) infiltrating the infected lungs; (iii) a RAGE-Ig dose-dependent increase in the expression of type I interferons (IFN-alpha;, and IFN-beta) and type III interferon (IFN lambda2) and a decrease in the inflammatory cytokines (IL-6 and IL-8) in SARS-CoV-2-infected human lung epithelial cells; and (iv) a dose-dependent decrease in the expression of CD64 (FcgR1) on monocytes and lung epithelial cells from symptomatic COVID-19 patients. Conclusion: Our pre-clinical findings revealed type I and III interferons-mediated anti-viral and anti-inflammatory therapeutic effects of RAGE-Ig protein against COVID-19 caused by multiple SARS-CoV-2 VOCs.
Keywords	covid19
Language	English
Publishing date	2023-06-08
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2023.06.07.544133
Database	COVID19

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Article ; Online: Therapeutic prime/pull vaccination of HSV-2-infected guinea pigs with the ribonucleotide reductase 2 (RR2) protein and CXCL11 chemokine boosts antiviral local tissue-resident and effector memory CD4

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Article ; Online: Antiviral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models.

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Article: Therapeutic Prime/Pull Vaccination of HSV-2 Infected Guinea Pigs with the Ribonucleotide Reductase 2 (RR2) Protein and CXCL11 Chemokine Boosts Antiviral Local Tissue-Resident and Effector Memory CD4

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Article ; Online: Cross-protection induced by highly conserved human B, CD4

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Article ; Online: A multi-epitope/CXCL11 prime/pull coronavirus mucosal vaccine boosts the frequency and the function of lung-resident memory CD4

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Article ; Online: Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa.

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Article ; Online: A Multi-Epitope/CXCL11 Prime/Pull Coronavirus Mucosal Vaccine Boosts the Frequency and the Function of Lung-Resident CD4+ and CD8+ Memory T Cells and Protects Against COVID-19-like Symptoms and Death Caused by SARS-CoV-2 infection

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Article ; Online: Anti-Viral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein Against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models

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