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Article ; Online: Association between polymorphisms of the DNA repair genes RAD51 and OGG1 and risk of cardiovascular disease.

Alomair, Amar / Alamri, Abdullah / Shaik, Jilani / Aljafari, Salman / Ba Abdullah, Mohammed / Alanazi, Mohammad

2024 Volume 29, Issue 3

Abstract: Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide, and multiple single‑nucleotide polymorphisms of DNA repair genes have been found to be associated with CVD. The aim of the present study was to assess the effects of the ... ...

Abstract	Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide, and multiple single‑nucleotide polymorphisms of DNA repair genes have been found to be associated with CVD. The aim of the present study was to assess the effects of the genetic variants of RAD51 recombinase (RAD51) and 8‑oxoguanine DNA glycosylase (OGG1) on CVD through genotyping and statistical analysis. Regardless of whether there is a significant association or not, the genotyping data on these two polymorphisms are valuable, because there is limited availability of it in certain populations. A total of 240 blood samples were analyzed and genotyped using TaqMan genotyping; 120 were obtained from cases with a history of CVD, and 120 from cases with no history of CVD. A questionnaire was administered to gather information on age, demographics, sex and clinical features, and confirmation was carried out using medical records. The results of the present study confirmed that the polymorphism rs1052133 in OGG1 had no significant association with CVD. On the other hand, the polymorphism rs1801321 in RAD51 exhibited a significant association with CVD. Collectively, the results of the present study revealed that the polymorphism rs1801321 in RAD51 exhibited a significant association with CVD, however a larger sample size to confirm the present findings, may allow for the early identification of CVD and may aid in the decision‑making process concerning treatments for CVD.
MeSH term(s)	Humans ; Cardiovascular Diseases/genetics ; Case-Control Studies ; DNA Glycosylases/genetics ; DNA Repair/genetics ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide ; Rad51 Recombinase/genetics ; Rad51 Recombinase/metabolism
Chemical Substances	DNA Glycosylases (EC 3.2.2.-) ; RAD51 protein, human (EC 2.7.7.-) ; Rad51 Recombinase (EC 2.7.7.-) ; oxoguanine glycosylase 1, human (EC 3.2.2.-)
Language	English
Publishing date	2024-02-09
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2024.13177
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Genetic Variants of HOTAIR Associated with Colorectal Cancer: A Case-Control Study in the Saudi Population.

Alzeer, Haya Saad / Shaik, Jilani P / Reddy Parine, Narasimha / Alanazi, Mohammad / Alamri, Abdullah Al / Bhat, Ramesa Shafi / Daihan, Sooad Al

Genes

2023 Volume 14, Issue 3

Abstract: Genetic polymorphism in long noncoding RNA (lncRNA) HOTAIR is linked with the risk and susceptibility of various cancers in humans. The mechanism involved in the development of CRC is not fully understood but single nucleotide polymorphisms (SNPs) can be ...

Abstract	Genetic polymorphism in long noncoding RNA (lncRNA) HOTAIR is linked with the risk and susceptibility of various cancers in humans. The mechanism involved in the development of CRC is not fully understood but single nucleotide polymorphisms (SNPs) can be used to predict its risk and prognosis. In the present case-control study, we investigated the relationship between HOTAIR (rs12826786, rs920778, and rs1899663) polymorphisms and CRC risk in the Saudi population by genotyping using a TaqMan genotyping assay in 144 CRC cases and 144 age- and sex-matched controls. We found a significant (
MeSH term(s)	Female ; Humans ; Male ; Case-Control Studies ; Colorectal Neoplasms/genetics ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide ; RNA, Long Noncoding/genetics ; Saudi Arabia
Chemical Substances	HOTAIR long untranslated RNA, human ; RNA, Long Noncoding
Language	English
Publishing date	2023-02-26
Publishing country	Switzerland
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14030592
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Article ; Online: Genetic Variants of HOTAIR Associated with Colorectal Cancer: A Case-Control Study in the Saudi Population

Alzeer, Haya Saad / Shaik, Jilani P. / Reddy Parine, Narasimha / Alanazi, Mohammad / Alamri, Abdullah Al / Bhat, Ramesa Shafi / Daihan, Sooad Al

Genes (Basel). 2023 Feb. 26, v. 14, no. 3

2023

Abstract	Genetic polymorphism in long noncoding RNA (lncRNA) HOTAIR is linked with the risk and susceptibility of various cancers in humans. The mechanism involved in the development of CRC is not fully understood but single nucleotide polymorphisms (SNPs) can be used to predict its risk and prognosis. In the present case-control study, we investigated the relationship between HOTAIR (rs12826786, rs920778, and rs1899663) polymorphisms and CRC risk in the Saudi population by genotyping using a TaqMan genotyping assay in 144 CRC cases and 144 age- and sex-matched controls. We found a significant (p < 0.05) association between SNP rs920778 G > A and CRC risk, and a protective role of SNPs rs12826786 (C > T) and rs1899663 (C > A) was noticed. The homozygous mutant “AA” genotype at rs920778 (G > A) showed a significant correlation with the female sex and colon tumor site. The homozygous TT in SNP rs12816786 (C > T) showed a significant protective association in the male and homozygous AA of SNP rs1899663 (C > A) with colon tumor site. These results indicate that HOTAIR can be a powerful biomarker for predicting the risk of colorectal cancer in the Saudi population. The association between HOTAIR gene polymorphisms and the risk of CRC in the Saudi population was reported for the first time here.
Keywords	biomarkers ; case-control studies ; colorectal neoplasms ; females ; genes ; genetic polymorphism ; genotyping ; homozygosity ; males ; mutants ; non-coding RNA ; prognosis ; protective effect ; risk
Language	English
Dates of publication	2023-0226
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14030592
Database	NAL-Catalogue (AGRICOLA)

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Article: Development of Metallo (Calcium/Magnesium) Polyurethane Nanocomposites for Anti-Corrosive Applications.

Alam, Manawwer / Altaf, Mohammad / Ahmed, Mukhtar / Shaik, Mohammed Rafi / Wahab, Rizwan / Shaik, Jilani Purusottapatnam / Samdani, Mohammad Shahzad / Ahmad, Ashfaq

Materials (Basel, Switzerland)

2022 Volume 15, Issue 23

Abstract: Long-term corrosion protection of metals might be provided by nanocomposite coatings having synergistic qualities. In this perspective, rapeseed oil-based polyurethane (ROPU) and nanocomposites with calcium and magnesium ions were designed. The structure ...

Abstract	Long-term corrosion protection of metals might be provided by nanocomposite coatings having synergistic qualities. In this perspective, rapeseed oil-based polyurethane (ROPU) and nanocomposites with calcium and magnesium ions were designed. The structure of these nanocomposites was established through Fourier-transform infrared spectroscopy (FT-IR). The morphological studies were carried out using scanning electron microscopy (SEM) as well as transmission electron microscopy (TEM). Their thermal characteristics were studied using thermogravimetric analysis (TGA). Electrochemical experiments were applied for the assessment of the corrosion inhibition performance of these coatings in 3.5 wt. % NaCl solution for 7 days. After completion of the test, the results revealed a very low i
Language	English
Publishing date	2022-11-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15238374
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Article: Targeted sequencing of crucial cancer causing genes of breast cancer in Saudi patients.

Alanazi, Mohammad / Parine, Narasimha Reddy / Shaik, Jilani Purusottapatnam / Al Naeem, Abdulrahman / Aldhaian, Sooad

Saudi journal of biological sciences

2020 Volume 27, Issue 10, Page(s) 2651–2659

Abstract: Breast cancer is the most common cancer among women worldwide, causing 15% of cancer-related deaths among women. Breast cancer incidence rate is increasing in most countries. In Saudi Arabia, breast cancer constitutes nearly 22% of the newly diagnosed ... ...

Abstract	Breast cancer is the most common cancer among women worldwide, causing 15% of cancer-related deaths among women. Breast cancer incidence rate is increasing in most countries. In Saudi Arabia, breast cancer constitutes nearly 22% of the newly diagnosed cancer cases in women. Breast cancer incidence in the women population of Saudi Arabia is 25.9%, with 18.2% mortality. In this study, targeted sequencing of 164 selected genes was performed on germline and somatic DNA derived from the blood and tissue samples of 50 breast cancer patients using customized panel on Ion torrent platform. This study focused on the identification of genetic variations of different cancer-causing genes, raising the hope for identification of personalized prognosis. After final filtration and validation, we found protein-truncating, non-synonymous missense, and splice site mutations in the known susceptibility genes for breast cancer. We identified a total of 14 point mutations and one deletion in
Language	English
Publishing date	2020-06-06
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2020.05.047
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Article: FTHL17

Alrubie, Turki M / Shaik, Jilani P / Alamri, Abdullah M / Alanazi, Mohammad / Alshareeda, Alaa T / Alqarni, Ayyob / Alawfi, Homoud G / Almaiman, Sarah M / Almutairi, Mikhlid H

Heliyon

2023 Volume 10, Issue 1, Page(s) e23689

Abstract: Background: Colon cancer is a serious public health issue and a major cause of cancer-related mortality worldwide, including Saudi Arabia. Knowledge of genes associated with colon cancer development and progression is essential for identifying new ... ...

Abstract	Background: Colon cancer is a serious public health issue and a major cause of cancer-related mortality worldwide, including Saudi Arabia. Knowledge of genes associated with colon cancer development and progression is essential for identifying new cancer-specific biomarkers to improve the diagnosis of colon cancer. Methods: The expression levels of Results: The analysis of the 15 colon cancer and adjacent normal colon tissue samples revealed that all six genes were expressed in both groups, but their expression levels were significantly higher in the colon cancer group. Furthermore, the mRNA expression levels of the Conclusions: The findings of this study suggest that
Language	English
Publishing date	2023-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e23689
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Article ; Online: Magnetically controlled drug delivery and hyperthermia effects of core-shell Cu@Mn

Mohammad, Faruq / Bwatanglang, Ibrahim Birma / Al-Lohedan, Hamad A / Shaik, Jilani P / Moosavi, Maryam / Dahan, Wasmia Mohammed / Al-Tilasi, Hissah Hamad / Aldhayan, Daifallah M / Chavali, Murthy / Soleiman, Ahmed A

International journal of biological macromolecules

2023 Volume 249, Page(s) 126071

Abstract: Recent increase in the integration of nanotechnology and nanosciences to the biomedical sector fetches the human wellness through the development of sustainable treatment methodologies for cancerous tumors at all stages of their initiation and ... ...

Abstract	Recent increase in the integration of nanotechnology and nanosciences to the biomedical sector fetches the human wellness through the development of sustainable treatment methodologies for cancerous tumors at all stages of their initiation and progression. This involves the development of multifunctional theranostic probes that effectively support for the early cancer diagnosis, avoiding non-target cell toxicity, controlled and customized anticancer drug release etc. Therefore, to advance the field of nanotechnology-based sustainable cancer treatment, we fabricated and tested the efficacy of anticancer drug-loaded magnetic hybrid nanoparticles (NPs) towards in vitro cell culture systems. The developed conjugate of NPs was incorporated with the functions of both controlled drug delivery and heat-releasing ability using Mn
MeSH term(s)	Humans ; Drug Delivery Systems/methods ; Antineoplastic Agents/pharmacokinetics ; Nanoparticles/chemistry ; Fluorouracil/pharmacology ; Hyperthermia, Induced ; Neoplasms
Chemical Substances	Antineoplastic Agents ; manganese oxide (64J2OA7MH3) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2023-07-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.126071
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Article: Two novel SNPs in genes involved in immune response and their association with mandibular residual ridge resorption.

AlSheikh, Hana Al / AlZain, Sahar / Shaik, Jilani P / Bhogoju, Sarayu / Warsy, Arjumand / Reddy Parine, Narasimha

Saudi journal of biological sciences

2020 Volume 27, Issue 3, Page(s) 846–852

Abstract: Residual ridge resorption" (RRR) is a multifactorial condition involving bone resorption of the residual ridge. We investigated 10 single nucleotide polymorphisms (SNPs) in seven genes with the aim of identifying the genetic factors associated with RRR ... ...

Abstract	"Residual ridge resorption" (RRR) is a multifactorial condition involving bone resorption of the residual ridge. We investigated 10 single nucleotide polymorphisms (SNPs) in seven genes with the aim of identifying the genetic factors associated with RRR susceptibility. The study group included 96 RRR patients and 96 controls. Age at first edentulism, duration of edentulism, and bone height were recorded. Saliva was collected from the subjects for DNA extraction. Genotype analysis was performed on the 'SequenomMassARRAYiPLEX'. The genotype and allele frequencies calculated in patients and controls were compared. We found that rs1800896 in the
Language	English
Publishing date	2020-01-17
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2020.01.016
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Article: High-frequency deregulated expression of Wnt signaling pathway members in breast carcinomas.

Khan, Zahid / Arafah, Maha / Shaik, Jilani Purusottapatnam / Mahale, Alka / Alanazi, Mohammad Saud

OncoTargets and therapy

2018 Volume 11, Page(s) 323–335

Abstract: Purpose: Breast carcinoma is the most common malignancy and leading cause of cancer-related deaths in women worldwide including Saudi Arabia. Breast cancer in Saudi women develops at a much early age with median age of onset of 49 years compared to 62 ... ...

Abstract	Purpose: Breast carcinoma is the most common malignancy and leading cause of cancer-related deaths in women worldwide including Saudi Arabia. Breast cancer in Saudi women develops at a much early age with median age of onset of 49 years compared to 62 years observed in patients from USA. Aberrations in wingless and integration site growth factor (Wnt) signaling pathway have been pathologically implicated in development of breast cancers and hence its role was examined in Saudi patients. Materials and methods: We immunohistochemically examined various components of Wnt signaling pathway including β-catenin, tumor suppressor proteins, adenomatous polyposis coli (APC), and Axin, expression of naturally occurring pathway antagonists such as Dickkopf Wnt signaling pathway inhibitor 3 (DKK3), FRP2, and WIF1, as well as Wnt target cyclin D1 and c-Myc to establish if the pathway is constitutively activated in breast cancers arising in Saudi women. Results: Cytoplasmic β-catenin, indicative of activation of the pathway, was observed in 24% of cases. Expression of APC and Axin, which are components of β-catenin destruction complex, was lost in 5% and 10% of tumors, respectively. Additionally, Wnt signaling inhibitors DKK3, FRP2, and Wnt inhibitory factor 1 (WIF1) were not expressed in 8%, 14%, and 5% breast tumors, respectively. Overall, accumulation of cytoplasmic β-catenin and downregulation of other Wnt pathway proteins (APC/Axin/DKK3/FRP2/WIF1) were found in approximately half of the breast cancers (47%) in our cohort. Consistent with this, analysis of Wnt target genes demonstrated moderate-to-strong expression of c-Myc in 58% and cyclin D1 in 50% of breast cancers. Deregulation of Wnt pathway was not associated with age of onset of the disease, tumor grade, and triple-negative status of breast cancers. Conclusions: High level of deregulated expression of Wnt pathway proteins suggests its important role in pathogenesis of breast cancers arising in Saudi women who may benefit from development of therapeutic drugs targeting this pathway.
Language	English
Publishing date	2018-01-11
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495130-4
ISSN	1178-6930
ISSN	1178-6930
DOI	10.2147/OTT.S154395
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Article ; Online: A novel biocompatible formate bridged 1D-Cu(ii) coordination polymer induces apoptosis selectively in human lung adenocarcinoma (A549) cells.

Usman, Mohammad / Khan, Rais Ahmad / Khan, Mohammad Rashid / Abul Farah, Mohammad / BinSharfan, Ibtisam I / Alharbi, Walaa / Shaik, Jilani P / Parine, Narasimha Reddy / Alsalme, Ali / Tabassum, Sartaj

Dalton transactions (Cambridge, England : 2003)

2021 Volume 50, Issue 6, Page(s) 2253–2267

Abstract: Copper compounds are promising candidates for next-generation metal anticancer drugs. Therefore, we synthesized and characterized a formate bridged 1D coordination polymer [Cu(L)(HCOO) ...

Abstract	Copper compounds are promising candidates for next-generation metal anticancer drugs. Therefore, we synthesized and characterized a formate bridged 1D coordination polymer [Cu(L)(HCOO)
MeSH term(s)	Adenocarcinoma of Lung/drug therapy ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Cycle Checkpoints/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Chromones/chemistry ; Chromones/pharmacology ; Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; Copper/chemistry ; Copper/pharmacology ; DNA/chemistry ; DNA Cleavage ; Humans ; Lung Neoplasms/drug therapy ; Matrix Metalloproteinase 2/genetics ; Membrane Potential, Mitochondrial/drug effects ; Transforming Growth Factor beta/genetics
Chemical Substances	Antineoplastic Agents ; Chromones ; Coordination Complexes ; Transforming Growth Factor beta ; Copper (789U1901C5) ; DNA (9007-49-2) ; calf thymus DNA (91080-16-9) ; MMP2 protein, human (EC 3.4.24.24) ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
Language	English
Publishing date	2021-01-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d0dt03782f
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