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  1. AU="Shailendra Gurav"
  2. AU="Hikmet Budak"
  3. AU=Kurd Ramzi
  4. AU=Szefel Jaros?aw
  5. AU="Vaisse, Christian"
  6. AU="Jean-Baptiste Poline"
  7. AU="Halekoh, Ulrich"
  8. AU="H. Fayaz"
  9. AU="Saddam Hussain"
  10. AU="Leary, Steven"
  11. AU="Schuit, Ewoud"
  12. AU=Sun Bingbing
  13. AU=d'Arminio Monforte Antonella
  14. AU="Sylvain Latour"
  15. AU="Velhal, S"
  16. AU="Lutz, Richard A"
  17. AU="Raveesh Kumar"
  18. AU="Andreas von Deimling"
  19. AU="Erik MeersauthorLaboratory of Analytical and Applied Ecochemistry, Faculty of Bioscience Engineering, University of Ghent, Coupure Links 653, 9000 Ghent, Belgium"
  20. AU="Thakkar, Nitya"
  21. AU="Hongtao Tie"
  22. AU="Bhati, Saurabh Kumar"
  23. AU="Choi, Hyunho"
  24. AU="Jayaprakash, Balamuralikrishna"
  25. AU="Lee, Brian H"
  26. AU="May, Susann"
  27. AU="Remondes-Costa, Sónia"
  28. AU="Lauren Sauer"
  29. AU="G Saiz, Paula"
  30. AU="Stoica, George"
  31. AU=Odorizzi Pamela M.
  32. AU=Pollaers Katherine
  33. AU="Stefanova, Veselina"
  34. AU="Geraldine M. O’Connor"
  35. AU="Jim E. Banta"
  36. AU="Marti-Bonmati, Luis"
  37. AU="Doris Kampner"
  38. AU="Luca Soraci"

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  1. Artikel: Rodent models for diabetes.

    Rashmi, Patil / Urmila, Aswar / Likhit, Akotkar / Subhash, Bodhankar / Shailendra, Gurav

    3 Biotech

    2023  Band 13, Heft 3, Seite(n) 80

    Abstract: Diabetes mellitus (DM) is associated with many health complications and is potentially a morbid condition. As prevalence increases at an alarming rate around the world, research into new antidiabetic compounds with different mechanisms is the top ... ...

    Abstract Diabetes mellitus (DM) is associated with many health complications and is potentially a morbid condition. As prevalence increases at an alarming rate around the world, research into new antidiabetic compounds with different mechanisms is the top priority. Therefore, the preclinical experimental induction of DM is imperative for advancing knowledge, understanding pathogenesis, and developing new drugs. Efforts have been made to examine recent literature on the various induction methods of Type I and Type II DM. The review summarizes the different in vivo models of DM induced by chemical, surgical, and genetic (immunological) manipulations and the use of pathogens such as viruses. For good preclinical assessment, the animal model must exhibit face, predictive, and construct validity. Among all reported models, chemically induced DM with streptozotocin was found to be the most preferred model. However, the purpose of the research and the outcomes to be achieved should be taken into account. This review was aimed at bringing together models, benefits, limitations, species, and strains. It will help the researcher to understand the pathophysiology of DM and to choose appropriate animal models.
    Sprache Englisch
    Erscheinungsdatum 2023-02-09
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-023-03488-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Evaluation of in vitro enzyme inhibitory, anti-inflammatory, antioxidant, and antibacterial activities of Oldenlandia corymbosa L. and Oldenlandia umbellata L. whole plant extracts

    Murugesan Divya / Govindarajalu Shanti / Singamoorthy Amalraj / Ehsan Amiri-Ardekani / Shailendra Gurav / Muniappan Ayyanar

    Pharmacological Research - Modern Chinese Medicine, Vol 8, Iss , Pp 100286- (2023)

    2023  

    Abstract: Background: Oldenlandia corymbosa and Oldenlandia umbellata are well-known medicinal plants in various traditional systems of medicine and used to treat bronchitis, asthma, tuberculosis, constipation, and leprosy. We evaluated the phytochemical content, ... ...

    Abstract Background: Oldenlandia corymbosa and Oldenlandia umbellata are well-known medicinal plants in various traditional systems of medicine and used to treat bronchitis, asthma, tuberculosis, constipation, and leprosy. We evaluated the phytochemical content, antioxidant potential, enzyme inhibitory action, anti-inflammatory, and antibacterial activities of the whole plant extracts of O. corymbosa and O. umbellata due to their therapeutic importance. Methods: The phytochemical analysis includes qualitative analysis and quantification of total phenolics, flavonoids, tannins, flavonols, proanthocyanidins, and vitamin E. Enzyme inhibitory assays were studied using α-amylase and α-glucosidase enzymes and anti-inflammatory activity was determined by egg albumin denaturation assay. Antioxidant potential was estimated using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethyl benzothiozoline-6-sulfonic acid) diammonium salt (ABTS), ferric reducing antioxidant power (FRAP), hydroxyl radical, superoxide, nitric oxide, metal chelating, and phosphomolybdenum assays. Minimum inhibitory concentrations of extracts were studied against ten bacterial strains by the microdilution method. Results: The aqueous extract of O.umbellata showed a higher extract yield (5.0%). The highest amount of total phenolics and flavonoids were observed in the ethanolic extract of O.umbellata (77.23±0.46 mg GAE/g) and O.corymbosa (19.01±0.26 mg GAE/g). Ethanolic extract of O.umbellata (IC50 of 31.71±0.32 µg/mL) and aqueous extract of O.corymbosa (30.53±1.83 µg/mL) showed notable α-amylase inhibitory effect and petroleum ether extract of both plants observed good inhibition against α-glucosidase enzyme. Likewise, petroleum ether extract of O.umbellata (IC50 of 57.16±1.88 µg/mL) showed a moderate anti-inflammatory effect. In all extracts, considerable antioxidant potential was recorded specially with aqueous extract in the nitric oxide scavenging assay with an IC50 of 40.72±1.25 µg/mL. Ethanolic extract of O.umbellata and petroleum ether extract ...
    Schlagwörter Antioxidants ; Enzyme inhibition ; Protein denaturation ; Secondary metabolites ; Other systems of medicine ; RZ201-999 ; Therapeutics. Pharmacology ; RM1-950
    Thema/Rubrik (Code) 580
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
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  3. Artikel ; Online: Nutritional Composition, Mineral Profiling, In Vitro Antioxidant, Antibacterial and Enzyme Inhibitory Properties of Selected Indian Guava Cultivars Leaf Extract

    Moses Sam Arul Raj / Singamoorthy Amalraj / Saud Alarifi / Mohan G. Kalaskar / Rupesh Chikhale / Veerasamy Pushparaj Santhi / Shailendra Gurav / Muniappan Ayyanar

    Pharmaceuticals, Vol 16, Iss 12, p

    2023  Band 1636

    Abstract: Psidium guajava L. is a small evergreen tree known for its magnificent medicinal and nutritional value. This study aimed to evaluate the nutritional profile and in vitro pharmacological potentialities of the different leaf extracts of four cultivars of ... ...

    Abstract Psidium guajava L. is a small evergreen tree known for its magnificent medicinal and nutritional value. This study aimed to evaluate the nutritional profile and in vitro pharmacological potentialities of the different leaf extracts of four cultivars of Psidium guajava namely Surka chitti, Allahabad safeda, Karela, and Lucknow-49. The standard procedures of the Association of Official Analytical Chemists (AOAC) were followed to carry out the nutritional analysis and all of the cultivars recorded the presence of elements at a nominal range. The highest presence of phenols (125.77 mg GAE/g) and flavonoids (92.38 mg QE/g) in the methanolic leaf extract of the Karela cultivar was recorded. A wide range of minerals such as sodium, phosphorus, magnesium, zinc, and boron were recorded with a higher percentage in the Karela cultivar of Psidium guajava . In the enzyme inhibitory assays, Allahabad safeda showed potential inhibition with an IC 50 of 113.31 ± 1.07, 98.2 ± 0.66 and 95.73 ± 0.39 μg/mL in α-amylase, α-glucosidase, and tyrosinase inhibition assays, respectively. The strong antioxidant effect was established by Lucknow-49 (IC 50 of 74.43 ± 1.86 μg/mL) and Allahabad safeda (IC 50 of 78.93 ± 0.46 μg/mL) for ABTS and DPPH assays, respectively. The ethyl acetate and methanolic leaf extracts of the Allahabad safeda cultivar showed better inhibition against Pseudomonas aeruginosa with an MIC of 14.84 and 28.69 µg/mL, respectively. A decent mean zone of inhibition was recorded in methanolic leaf extract that ranged from 21–25 mm in diameter against the tested bacterial strains ( Proteus vulgaris , Bacillus subtilis , and P. aeruginosa ). This is the first scientific report on the comparative and comprehensive analysis of indigenous guava cultivars to evidently shortlist the elite cultivars with enriched dietary nutrition and biological activities.
    Schlagwörter antioxidants ; enzyme inhibition ; germplasms ; pharmacology ; proximate analysis ; nutraceuticals ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Thema/Rubrik (Code) 580
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
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  4. Artikel ; Online: Preparation, characterization, and evaluation (in-vitro, ex-vivo, and in-vivo) of naturosomal nanocarriers for enhanced delivery and therapeutic efficacy of hesperetin.

    Shailendra Gurav / Poonam Usapkar / Nilambari Gurav / Sameer Nadaf / Muniappan Ayyanar / Rucheera Verekar / Ritesh Bhole / Chintha Venkataramaiah / Goutam Jena / Rupesh Chikhale

    PLoS ONE, Vol 17, Iss 11, p e

    2022  Band 0274916

    Abstract: The present study intends to formulate, characterize and appraise the phospholipid-based nanovesicular system for enhanced delivery of Hesperetin (HT). The quality by design (QbD) approach was employed to prepare Hesperetin naturosomes (HTN) using the ... ...

    Abstract The present study intends to formulate, characterize and appraise the phospholipid-based nanovesicular system for enhanced delivery of Hesperetin (HT). The quality by design (QbD) approach was employed to prepare Hesperetin naturosomes (HTN) using the solvent evaporation technique and assessed for physicochemical and pharmacological attributes. The FTIR, DSC, and PXRD studies confirmed the successful formation of a vesicular drug-phospholipid complex, while photomicroscopy, SEM, and TEM analysis revealed the morphology of HTN. The functional attributes substantially enhanced the HT's aqueous solubility, drug release, and membrane permeation. The aqueous solubility of HTN was ~10-fold more than that of pure HT. Likewise, the in-vitro dissolution data of HTN showed better competence in releasing the HT (>93%) than the pure HT (~64%) or the physical mixture (~74%). Furthermore, HTN significantly altered HT permeation (>53%) when compared to pure HT (23%) or the physical mixture (28%). The current study showed that naturosomes are a promising way to improve the solubility in water, bioavailability, and therapeutic effectiveness of drugs.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: A plausible involvement of GABAA/benzodiazepine receptor in the anxiolytic-like effect of ethyl acetate fraction and quercetin isolated from Ricinus communis Linn. leaves in mice

    Vaishali Murade / Amit Waghmare / Deepali Pakhare / Sonali Dichayal / Rajesh Patil / Manish Wanjari / Shailendra Gurav / Dinesh Hase

    Phytomedicine Plus, Vol 1, Iss 3, Pp 100041- (2021)

    2021  

    Abstract: Ricinus communis Linn. (Euphorbiaceae) leaves are used in Indian traditional medicine to treat inflammatory and central nervous disorders. The polyphenolic compounds like quercetin (QUR), gallic acid, and rutin display an anxiolytic-like activity. These ... ...

    Abstract Ricinus communis Linn. (Euphorbiaceae) leaves are used in Indian traditional medicine to treat inflammatory and central nervous disorders. The polyphenolic compounds like quercetin (QUR), gallic acid, and rutin display an anxiolytic-like activity. These constituents are also present in Ricinus communis leaves; however there are no scientific investigations conducted to verify the anxiolytic-like effects of ethyl acetate fraction of Ricinus communis (RCLEA) leaves. HPLC technique was used to quantify the polyphenols contained in RCLEA fraction. It revealed the contents (% w/w): gallic acid (0.63), rutin (4.36), QUR (1.62) and Pyrogallol (PYR) (14.07). The present study investigated the anxiolytic-like effects of RCLEA fraction and two major polyphenols in Ricinus communis in experimental models of anxiety compared with a positive control diazepam (DZP) (1 mg/kg, i.p.). In order to investigate the anxiolytic-like effect, doses of RCLEA fraction (25, 50 and 100 mg/kg, i.p), QUR and PYR (1, 5 and 10 mg/kg respectively, i.p.) were administered to mice and subjected to open field test (OFT), elevated plus maze (EPM) or rota-rod test. The results of OFT revealed the significant increase in time spent in central area with treatments of RCLEA fraction (50 and 100 mg/kg, p < 0.05 and p < 0.01 respectively), QUR (10 mg/kg, p < 0.05) and PYR (10 mg/kg, p < 0.05). The reduction in rearings was observed with doses of RCLEA fraction, QUR and PYR. Significant reductions were found in defecation after treatments of RCLEA fraction and QUR and comparable to DZP. The results of OFT were further validated using EPM, showed that RCLEA fraction and QUR treatments (50 and 10 mg/kg, respectively) produced a significant increase in the time spent and entry into the open arms of elevated plus maze, with a profile comparable to that of DZP. No significant changes were observed in the rota-rod test, suggesting that the RCLEA fraction, QUR and PYR did not cause neurotoxicity, sedation and muscle relaxation commonly related to ...
    Schlagwörter Ricinus communis ; Anxiety ; Elevated plus-maze ; Flumazenil ; GABA receptor ; Other systems of medicine ; RZ201-999
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Analgesic and Anti-inflammatory Activities of Trayodashang Guggulu, an Ayurvedic Formulation

    Shivani Gupta / Yadu Nandan Dey / Pushpendra Kannojia / Amit Kumar Halder / Deepti Sharma / Manish M. Wanjari / Shridhar Chougule / Sharad Pawar / Atul Kaushik / Sudesh N. Gaidhani / Shailendra Gurav

    Phytomedicine Plus, Vol 2, Iss 3, Pp 100281- (2022)

    2022  

    Abstract: ABSTRACT: Background: Trayodashang guggulu (TG) is a compound Ayurvedic formulation used in Indian traditional system of medicine for the treatment of various inflammatory conditions like arthritis and associated pain.Purpose:To study the analgesic and ... ...

    Abstract ABSTRACT: Background: Trayodashang guggulu (TG) is a compound Ayurvedic formulation used in Indian traditional system of medicine for the treatment of various inflammatory conditions like arthritis and associated pain.Purpose:To study the analgesic and anti-inflammatory effects of trayodashang guggulu.Methods: Trayodashang guggulu (TG) was standardized as per standard procedures and TLC profile was carried as per Ayurvedic Pharmacopoeia of India and LC-MS analysis was done to identify its bioactive constituents. Trayodashang guggulu was suspended in water and administered orally at 270 and 540 mg/kg dose for evaluating pain and inflammation in rats. Analgesic activity was assessed by Eddy's hot plate, tail immersion and formalin-induced pain models while anti-inflammatory activity was assessed by carrageenan and formalin-induced inflammation models. Further, the mechanism of anti-inflammatory action is predicted through various in silico methods like molecular docking and dynamics studies using AutodockVina and AMBER, respectively.Results: TG was found compliant as per pharmacopoeial standards. TG (270 and 540 mg/kg, orally) did not cause significant reduction in pain in centrally acting pain models i.e. Eddy's hot plate and tail immersion tests as like Pentazocin (10 mg/kg). In formalin-induced pain model, TG (270 and 540 mg/kg, orally) significantly decreased both flinching and licking pain responses in early and late phase while indomethacin (10 mg/kg) only affected late phase flinching and licking. Further, TG showed significant time-dependent reduction in formalin and carrageenan-induced inflammation as compared to vehicle control. Indomethacin (10 mg/kg), standard drug also showed significant reduction in pain and inflammation. LC-MS analysis revealed the presence of 17 phytoconstituents in TG. Further, in silico studies revealed that some of the identified phytochemicals may have inhibitory activity against COX-2 enzyme and the synergistic effects due to multi components may be responsible for the ...
    Schlagwörter Indomethacin ; Inflammatory pain ; Carrageenan ; Formalin ; Arthritis ; Other systems of medicine ; RZ201-999
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-08-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Systemic review

    Shailendra Gurav / Vijay Gulkari / Nandkishore Duragkar / Arun Patil

    Pharmacognosy Reviews, Vol 1, Iss 2, Pp 338-

    Pharmacognosy, phytochemistry, pharmacology and clinical applications of Gymnema sylvestre R Br

    2007  Band 343

    Schlagwörter Therapeutics. Pharmacology ; RM1-950 ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2007-01-01T00:00:00Z
    Verlag Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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