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  1. Article ; Online: How Using Probiotics in Poultry Can Fight the Spread of Antibiotic Resistance to Humans?

    Shameeran Ismael / Bland Abdullah / Shaimaa Hasan / Amal Sadiq / Diyan Omer

    Al-Qadisiyah Journal For Agriculture Sciences, Vol 13, Iss 2, Pp 105-

    2023  Volume 109

    Abstract: Globally, there is a severe problem with antibiotic resistance in animals and humans. It may result in diseases that are extremely challenging to treat. In certain situations, conventional antibiotics used to treat an illness may no longer be effective ... ...

    Abstract Globally, there is a severe problem with antibiotic resistance in animals and humans. It may result in diseases that are extremely challenging to treat. In certain situations, conventional antibiotics used to treat an illness may no longer be effective in poultry and an alternative treatment is used. Therefore, using probiotics instead of antibiotic therapy to treat specific health issues in both humans and animals can achieve the desired result, such as preventing infectious zoonotic diseases and enhancing general health. Probiotics are friendly live microorganisms like normal flora, when consumed in a sufficient dose which produces positive effects on the host. This review aimed to prove that using probiotics in poultry instead of antibiotics can fight the spread of pathogenic bacteria such as Salmonella and Campylobacter to humans by ingestion of undercooked poultry meat infected with these bacteria and also increase antibiotic resistance to humans. Finally, concluded that probiotics play a potential role in the spread of antibiotic-resistance genes in our natural environments, we believe it is crucial to implement proper regulation on their use in both livestock and human applications globally.
    Keywords antibiotic resistance ; probiotics ; poultry meat ; infectious diseases ; Agriculture ; S ; Plant culture ; SB1-1110 ; Botany ; QK1-989
    Subject code 630
    Language Arabic
    Publishing date 2023-12-01T00:00:00Z
    Publisher University of Al-Qadisiya
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Dexmedetomidine ameliorates neuropathic pain in streptozotocin (STZ)-induced diabetic rat model

    Somia Ismail / Hanan Farghaly / Mahmoud Abdel- Raheem / Al Shaimaa Hasan

    SVU - International Journal of Medical Sciences, Vol 5, Iss 1, Pp 84-

    2022  Volume 91

    Abstract: Background: Diabetic neuropathy pain (DNP) is one of the most common complications of diabetes mellitus. It is associated with spontaneous pain, hyperalgesia and allodynia and greatly distresses the patients and compromises their quality of life. ... ...

    Abstract Background: Diabetic neuropathy pain (DNP) is one of the most common complications of diabetes mellitus. It is associated with spontaneous pain, hyperalgesia and allodynia and greatly distresses the patients and compromises their quality of life. Dexmedetomidine (DEX) is a selective and potent α2- adrenoceptor agonist which has ananalgesic effect, reducessympathetic nervous tension and decreases release of glutamate. Thus, dexmedetomidine can be used in the treatment of DNP. Objectives: We investigated the effect of dexmedetomidine on blood glucose level and neuropathic pain by using streptozotocin (STZ)-induced diabetic rat model. Materials and Methods: Twenty-four adult male Wistar Albino rats were divided into three groups: vehicle group, streptozotocin group (STZ group) and dexmedetomidine plus streptozotocin group (STZ+DEX group). Results: It was found that rats injected withSTZ only had a decreased pain threshold compared to the vehicle group and this effect was ameliorated by dexmedetomidine administration. Conclusion:The current data suggest that dexmedetomidine can ameliorate hyperalgesia in diabetic neuropathy.
    Keywords diabetic neuropathy pain ; dexmedetomidine ; streptozotocin ; Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher South Valley University, Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Effect of Tramadol Abuse on Male Fertility

    Aya Saadeldin* / Al Shaimaa Hasan / Mohammed Hassan / Gamal A. Alsagheer

    SVU - International Journal of Medical Sciences, Vol 4, Iss 2, Pp 120-

    2021  Volume 127

    Abstract: Background: addiction is still an increasingly social and health issue worldwide, despite all attempts to overcome it. Analgesics are of the most prevalent substances that are abused. In Egypt and the Middle East, tramadol abuse is highly increasing. ... ...

    Abstract Background: addiction is still an increasingly social and health issue worldwide, despite all attempts to overcome it. Analgesics are of the most prevalent substances that are abused. In Egypt and the Middle East, tramadol abuse is highly increasing. This can be correlated to its inexpensive cost, large availability, accessibility and illegal trafficking. Tramadol is a centrally-acting synthetic opioid analgesic that is commonly used to treat different intensities of pain varying from mild to extreme pain conditions. Prolonged administration of tramadol can result in abnormalities of the hypothalamic-pituitary function and decrease in testosterone production. Many experimental studies were done and showed that tramadol affects the level of luteinizing hormone, follicular stimulating hormone, testosterone, estradiol, and prolactin. It also affects sperm quality and motility. We aimed in this review: is to delineate these issues. Conclusion: There is a significant correlation between tramadol abuse and impaired gonadal and male sex hormone and sperm quality parameters.
    Keywords tramadol ; tramadol abuse ; fertility ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher South Valley University, Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Estrogen is required for maintaining the quality of cardiac stem cells.

    Al Shaimaa Hasan / Lan Luo / Satoko Baba / Tao-Sheng Li

    PLoS ONE, Vol 16, Iss 1, p e

    2021  Volume 0245166

    Abstract: Compared to the age-matched men, the incidence of cardiovascular diseases is lower in premenopausal but higher in postmenopausal women, suggesting the cardio-protective role of estrogen in females. Although cardiac stem cells (CSCs) express estrogen ... ...

    Abstract Compared to the age-matched men, the incidence of cardiovascular diseases is lower in premenopausal but higher in postmenopausal women, suggesting the cardio-protective role of estrogen in females. Although cardiac stem cells (CSCs) express estrogen receptors, yet the effects of estrogen on CSCs remain unclear. In this study, we investigated the potential role of estrogen in maintaining the quality of CSCs by in vivo and in vitro experiments. For the in vivo study, estrogen deficiency was induced by ovariectomy in 6-weeks-old C57BL/6 female mice, and then randomly given 17β-estradiol (E2) replacements at a low dose (0.01 mg/60 days) and high dose (0.18 mg/60 days), or vehicle treatment. All mice were killed 2 months after treatments, and heart tissues were collected for ex vivo expansion of CSCs. Compared to age-matched healthy controls, estrogen deficiency slightly decreased the yield of CSCs with significantly lower telomerase activity and more DNA damage. Interestingly, E2 replacements at low and high doses significantly increased the yield of CSCs and reversed the quality impairment of CSCs following estrogen deficiency. For the in vitro study, twice-passaged CSCs from the hearts of adult healthy female mice were cultured with the supplement of 0.01, 0.1, and 1 μM E2 in the medium for 3 days. We found that E2 supplement increased c-kit expression, increased proliferative activity, improved telomerase activity, and reduced DNA damage of CSCs in a dose-dependent manner. Our data suggested the potential role of estrogen in maintaining the quality of CSCs, providing new insight into the cardio-protective effects of estrogen.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Correction

    Al Shaimaa Hasan / Lan Luo / Chen Yan / Tian-Xia Zhang / Yoshishige Urata / Shinji Goto / Safwat A Mangoura / Mahmoud H Abdel-Raheem / Shouhua Zhang / Tao-Sheng Li

    PLoS ONE, Vol 12, Iss 2, p e

    Cardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil Recruitment.

    2017  Volume 0171892

    Abstract: This corrects the article DOI:10.1371/journal.pone.0165255.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0165255.].
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Cardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil Recruitment.

    Al Shaimaa Hasan / Lan Luo / Chen Yan / Tian-Xia Zhang / Yoshishige Urata / Shinji Goto / Safwat A Mangoura / Mahmoud H Abdel-Raheem / Shouhua Zhang / Tao-Sheng Li

    PLoS ONE, Vol 11, Iss 10, p e

    2016  Volume 0165255

    Abstract: Cardiosphere-derived cells (CDCs), one of the promising stem cell sources for myocardial repair, have been tested in clinical trials and resulted in beneficial effects; however, the relevant mechanisms are not fully understood. In this study, we examined ...

    Abstract Cardiosphere-derived cells (CDCs), one of the promising stem cell sources for myocardial repair, have been tested in clinical trials and resulted in beneficial effects; however, the relevant mechanisms are not fully understood. In this study, we examined the hypothesis that CDCs favor heart repair by switching the macrophages from a pro-inflammatory phenotype (M1) into a regulatory anti-inflammatory phenotype (M2). Macrophages from mice were cultured with CDCs-conditioned medium or with fibroblasts-conditioned medium as a control. Immunostaining showed that CDCs-conditioned medium significantly enhanced the expression of CD206 (a marker for M2 macrophages), but decreased the expression of CD86 (a marker for M1 macrophages) 3 days after culture. For animal studies, we used an acute myocardial infarction model of mice. We injected CDCs, fibroblasts, or saline only into the border zone of infarction. Then we collected the heart tissues for histological analysis 5 and 14 days after treatment. Compared with control animals, CDCs treatment significantly decreased M1 macrophages and neutrophils but increased M2 macrophages in the infarcted heart. Furthermore, CDCs-treated mice had reduced infarct size and fewer apoptotic cells compared to the controls. Our data suggest that CDCs facilitate heart repair by modulating M1/M2 macrophage polarization and neutrophil recruitment, which may provide a new insight into the mechanisms of stem cell-based myocardial repair.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Radiation Exposure Decreases the Quantity and Quality of Cardiac Stem Cells in Mice.

    Lan Luo / Yoshishige Urata / Chen Yan / Al Shaimaa Hasan / Shinji Goto / Chang-Ying Guo / Fang-Fang Tou / Yucai Xie / Tao-Sheng Li

    PLoS ONE, Vol 11, Iss 5, p e

    2016  Volume 0152179

    Abstract: Radiation exposure may increase cardiovascular disease risks; however, the precise molecular/cellular mechanisms remain unclear. In the present study, we examined the hypothesis that radiation impairs cardiac stem cells (CSCs), thereby contributing to ... ...

    Abstract Radiation exposure may increase cardiovascular disease risks; however, the precise molecular/cellular mechanisms remain unclear. In the present study, we examined the hypothesis that radiation impairs cardiac stem cells (CSCs), thereby contributing to future cardiovascular disease risks. Adult C57BL/6 mice were exposed to 3 Gy γ-rays, and heart tissues were collected 24 hours later for further experiments. Although c-kit-positive cells were rarely found, radiation exposure significantly induced apoptosis and DNA damage in the cells of the heart. The ex vivo expansion of CSCs from freshly harvested atrial tissues showed a significantly lower production of CSCs in irradiated mice compared with healthy mice. The proliferative activity of CSCs evaluated by Ki-67 expression was not significantly different between the groups. However, compared to the healthy control, CSCs expanded from irradiated mice showed significantly lower telomerase activity, more 53BP1 foci in the nuclei, lower expression of c-kit and higher expression of CD90. Furthermore, CSCs expanded from irradiated mice had significantly poorer potency in the production of insulin-like growth factor-1. Our data suggest that radiation exposure significantly decreases the quantity and quality of CSCs, which may serve as sensitive bio-parameters for predicting future cardiovascular disease risks.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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