Article ; Online: Tlr5
2024 Volume 15, Page(s) 1359534
Abstract: Introduction: Leaky gut has been linked to autoimmune disorders including lupus. We previously reported upregulation of anti-flagellin antibodies in the blood of lupus patients and lupus-prone mice, which led to our hypothesis that a leaky gut drives ... ...
| Abstract | Introduction: Leaky gut has been linked to autoimmune disorders including lupus. We previously reported upregulation of anti-flagellin antibodies in the blood of lupus patients and lupus-prone mice, which led to our hypothesis that a leaky gut drives lupus through bacterial flagellin-mediated activation of toll-like receptor 5 (TLR5). Methods: We created MRL/ Result: Contrary to our hypothesis that the deletion of Conclusion: Global deletion of |
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| MeSH term(s) | Animals ; Female ; Humans ; Mice ; Glomerulonephritis/pathology ; Kidney/pathology ; Mice, Inbred MRL lpr ; Proteinuria ; Toll-Like Receptor 5 |
| Chemical Substances | Toll-Like Receptor 5 ; Tlr5 protein, mouse |
| Language | English |
| Publishing date | 2024-01-30 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2024.1359534 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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