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Article ; Online: Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey.

Shalaby, Mostafa / ElSheikh, Ahmed M / Hamed, Hosam

2024 Volume 12, Issue 1, Page(s) 48

Abstract: Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice.: Methods: This is a cross-sectional study reported in ... ...

Abstract	Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Burnout, Professional/epidemiology ; COVID-19/epidemiology ; Cross-Sectional Studies ; Pandemics ; SARS-CoV-2 ; Surgeons ; Surveys and Questionnaires ; Middle Aged
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Clinical Study ; Journal Article
ZDB-ID	2705921-2
ISSN	2050-7283 ; 2050-7283
ISSN (online)	2050-7283
ISSN	2050-7283
DOI	10.1186/s40359-023-01517-4
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Article ; Online: Correction: Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey.

Shalaby, Mostafa / ElSheikh, Ahmed M / Hamed, Hosam

BMC psychology

2024 Volume 12, Issue 1, Page(s) 110

Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Published Erratum
ZDB-ID	2705921-2
ISSN	2050-7283 ; 2050-7283
ISSN (online)	2050-7283
ISSN	2050-7283
DOI	10.1186/s40359-024-01577-0
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Article ; Online: Updates on Non-Statin LDL-Lowering Therapy.

Abdulla, Amer / Shalaby, Mostafa / Kumfa, Paul / Raja, Muhammad / Allencherril, Joseph / Sharifeh, Tareq Abu

Current cardiology reports

2024 Volume 26, Issue 4, Page(s) 221–231

Abstract: Purpose of review: There is ample evidence of the benefits and safety of low-density lipoprotein (LDL)-lowering therapies in the prevention of atherosclerotic cardiovascular disease. While statins remain the first-line agent for LDL reduction, several ... ...

Abstract	Purpose of review: There is ample evidence of the benefits and safety of low-density lipoprotein (LDL)-lowering therapies in the prevention of atherosclerotic cardiovascular disease. While statins remain the first-line agent for LDL reduction, several new therapies are now available. This narrative review provides an overview of currently available non-statin LDL-lowering agents, specifically mechanisms of action and data on efficacy and safety. It also discusses recommendations on their use in clinical practice. Recent findings: Ezetimibe, PCSK9 inhibitors, and bempedoic acid have proven safe and efficacious in reducing cardiovascular events in large randomized controlled trials. Inclisiran is a promising agent that suppresses PCSK9 mRNA translation and is currently under investigation in a large clinical outcomes randomized controlled trial assessing its effect on clinical outcomes. Expert consensus advocates for lower LDL targets in higher risk patients and escalation to or a combination of non-statin therapies as needed to achieve these goals.
MeSH term(s)	Humans ; Anticholesteremic Agents/therapeutic use ; Proprotein Convertase 9 ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Ezetimibe/therapeutic use ; Cardiovascular Diseases/drug therapy ; Randomized Controlled Trials as Topic
Chemical Substances	Anticholesteremic Agents ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Ezetimibe (EOR26LQQ24)
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2055373-0
ISSN	1534-3170 ; 1523-3782
ISSN (online)	1534-3170
ISSN	1523-3782
DOI	10.1007/s11886-024-02028-3
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Zs.A 5524: Show issues

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Article ; Online: Temperature-dependent THz properties and emission of organic crystal BNA.

Mansourzadeh, Samira / Vogel, Tim / Shalaby, Mostafa / Saraceno, Clara J

Optics express

2023 Volume 31, Issue 18, Page(s) 29480–29490

Abstract: As high-average power ultrafast lasers become increasingly available for nonlinear conversion, the temperature dependence of the material properties of nonlinear crystals becomes increasingly relevant. Here, we present temperature-dependent THz complex ... ...

Abstract	As high-average power ultrafast lasers become increasingly available for nonlinear conversion, the temperature dependence of the material properties of nonlinear crystals becomes increasingly relevant. Here, we present temperature-dependent THz complex refractive index measurements of the organic crystal BNA over a wide range of temperatures from 300 K down to 80 K for THz frequencies up to 4 THz for the first time. Our measurements show that whereas the temperature-dependent refractive index has only minor deviation from room temperature values, the temperature-dependent absorption coefficient decreases at low temperature (-24% from 300 K to 80 K). We additionally compare these measurements with conversion efficiency and spectra observed during THz generation experiments using the same crystal actively cooled in the same temperature range, using an ultrafast Yb-laser for excitation. Surprisingly, the damage threshold of the material does not improve significantly upon active cooling, pointing to a nonlinear absorption mechanism being responsible for damage. However, we observe a significant increase in THz yield (+23%) at lower temperatures, which is most likely due to the reduced THz absorption. These first findings will be useful for future designs of high-average power pumped organic-crystal based THz-TDS systems.
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.494445
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Article ; Online: Posterior component separation with transversus abdominis muscle release versus mesh-only repair in the treatment of complex ventral-wall hernia: a randomized controlled trial.

Rabie, Mohamed / Abdelnaby, Mahmoud / Morshed, Mosaad / Shalaby, Mostafa

BMC surgery

2022 Volume 22, Issue 1, Page(s) 346

Abstract: Background: Complex ventral hernias (VHs) represent a real challenge to both general and plastic surgeons. This study aims to compare Sublay Mesh-Only Repair to Posterior Component Separation "PCS" with Transversus Abdominis Release "TAR" in the ... ...

Abstract	Background: Complex ventral hernias (VHs) represent a real challenge to both general and plastic surgeons. This study aims to compare Sublay Mesh-Only Repair to Posterior Component Separation "PCS" with Transversus Abdominis Release "TAR" in the treatment of complex ventral-wall hernias (VHs). Methods: This a randomized, controlled, intervention, including two parallel groups: A; Sublay Mesh-Only Repair and Group B; "TAR". Consecutive patients of both genders aged between 18 and 65 years old with complex VHs presented at Mansoura University Hospitals including large-sized abdominal-wall hernia ≥ 10 cm in width, loss of domain ≥ 20%, multiple hernial defects, or recurrent hernias. Immuno-compromised patients, patients with liver impairment, or severe heart failure were considered an exclusion criterion. The primary outcome is the recurrence rate after 12-months following the procedure. Results: Fifty-six patients were recruited in this study. There was no significant difference between both groups regarding recurrence. However, there was significant differences between both groups regarding seroma favoring mesh-only repair. Conclusions: Although TAR may be associated with longer operative times and more blood losses, these were not found to be statistically significant. Postoperative complication, except for seroma, and recurrence rates were comparable in both groups. Trail registration The study was registered on clicaltrials.gov "NCT04516031".
MeSH term(s)	Abdominal Muscles/surgery ; Adolescent ; Adult ; Aged ; Female ; Hernia, Ventral/surgery ; Herniorrhaphy/methods ; Humans ; Male ; Middle Aged ; Seroma ; Surgical Mesh ; Young Adult
Language	English
Publishing date	2022-09-20
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-022-01794-7
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Article ; Online: Efficacy and Safety of Non-Operative Management of Uncomplicated Acute Appendicitis Compared to Appendectomy: An Umbrella Review of Systematic Reviews and Meta-Analyses.

Emile, Sameh Hany / Sakr, Ahmad / Shalaby, Mostafa / Elfeki, Hossam

World journal of surgery

2022 Volume 46, Issue 5, Page(s) 1022–1038

Abstract: Background: Non-operative management (NOM) of uncomplicated acute appendicitis (AA) has been introduced as an alternative to appendectomy. This umbrella review aimed to provide an overview of the efficacy and safety of NOM of uncomplicated AA in the ... ...

Abstract	Background: Non-operative management (NOM) of uncomplicated acute appendicitis (AA) has been introduced as an alternative to appendectomy. This umbrella review aimed to provide an overview of the efficacy and safety of NOM of uncomplicated AA in the published systematic reviews. Methods: This umbrella review has been reported in line with the PRISMA guidelines and umbrella review approach. Systematic reviews with and without meta-analyses on the efficacy of NOM of AA were analyzed. The quality of the reviews was assessed with the AMSTAR 2 tool. The main outcomes measures were the treatment failure and complication rates of NOM and hospital stay as compared to appendectomy. Results: Eighteen systematic reviews were included to this umbrella review. Eight reviews documented higher odds of failure with NOM, whereas two reviews revealed similar odds of failure. Six reviews reported lower odds of complications with NOM, six reported similar odds, and one reported lower odds of complications with surgery. Eight reviews reported similar hospital stay between NOM and appendectomy, one reported longer stay with NOM and another reported shorter stay with NOM. Pooled analyses showed that NOM was associated with higher treatment failure overall, in children-only, adults only, and RCTs-only meta-analyses. NOM was associated with lower complications overall, yet children-only and RCTs-only analyses revealed similar complications to surgery. NOM was associated with shorter stay in the overall and adult-only analysis, but not in the children-only analysis. Conclusions: NOM of AA is associated with higher treatment failure, marginally lower rate of complications and shorter stay than appendectomy.
MeSH term(s)	Acute Disease ; Adult ; Anti-Bacterial Agents/therapeutic use ; Appendectomy/adverse effects ; Appendicitis/drug therapy ; Appendicitis/surgery ; Child ; Humans ; Length of Stay ; Treatment Failure ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-01-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-022-06446-8
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Zs.A 1336: Show issues

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Article ; Online: How to treat rectal prolapse in a male patient with faecal incontinence: Delorme's procedure combined with levatorplasty - a video vignette.

Shalaby, Mostafa / Omar, Waleed / Elfeki, Hossam

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2021 Volume 23, Issue 7, Page(s) 1939

MeSH term(s)	Digestive System Surgical Procedures ; Fecal Incontinence/etiology ; Fecal Incontinence/surgery ; Humans ; Male ; Rectal Prolapse/complications ; Rectal Prolapse/surgery ; Rectum/surgery ; Recurrence
Language	English
Publishing date	2021-04-27
Publishing country	England
Document type	Letter ; Video-Audio Media
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15666
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Zs.A 5799: Show issues

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Article ; Online: Concomitant Mitral Valve Repair vs Replacement During Surgical Ventricular Restoration for Ischemic Cardiomyopathy.

Arafat, Amr A / Alghamdi, Rawan / Alfonso, Juan J / Shalaby, Mostafa A / Alotaibi, Khaled / Pragliola, Claudio

Angiology

2023 Volume 75, Issue 4, Page(s) 331–339

Abstract: There is no consensus regarding mitral valve management during surgical ventricular restoration (SVR) for ischemic cardiomyopathy. We compared the impact of SVR with mitral valve repair (MVr) vs replacement (MVR) on postoperative outcomes and long-term ... ...

Abstract	There is no consensus regarding mitral valve management during surgical ventricular restoration (SVR) for ischemic cardiomyopathy. We compared the impact of SVR with mitral valve repair (MVr) vs replacement (MVR) on postoperative outcomes and long-term survival in ischemic cardiomyopathy and mitral regurgitation patients. This study included 112 patients who underwent SVR from 2009 to 2018 with MVr (n = 75) or MVR (n = 37). Patients who had MVR had higher Euro SCORE II, dyspnea class, a lower ejection fraction, higher pulmonary artery systolic pressure, higher grade of preoperative mitral and tricuspid regurgitation, and higher end-diastolic and end-systolic diameters. Intra-aortic balloon pump was more commonly used in patients with MVR. Hospital mortality occurred in 7 (9.33%) patients in the MVr group vs 3 (8.11%) in the MVR group (P > .99). Freedom from rehospitalization at 1, 5, and 7 years was 87%, 76%, and 70% in the MVr group and 83%, 61%, and 52% in the MVR group (P = .191). Survival at 1, 5, and 7 years was 88%, 78%, and 74% in the MVr group and 88%, 56%, and 56% in the MVR group (P = .027). Adjusted survival did not differ between groups.MVr or MVR are valid options in patients undergoing SVR, with good long-term outcomes.
MeSH term(s)	Humans ; Mitral Valve/surgery ; Heart Valve Prosthesis Implantation/adverse effects ; Treatment Outcome ; Myocardial Ischemia/complications ; Myocardial Ischemia/surgery ; Mitral Valve Insufficiency/surgery ; Cardiomyopathies/surgery
Language	English
Publishing date	2023-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	80040-5
ISSN	1940-1574 ; 0003-3197
ISSN (online)	1940-1574
ISSN	0003-3197
DOI	10.1177/00033197231154353
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Article ; Online: Evaluation of Right-Side Filling Pressure in Patients With Obesity With Heart Failure Using Handheld Ultrasound Score.

Albaeni, Aiham / Sharma, Mohit / Chatila, Khaled F / Shalaby, Mostafa / Ahmad, Masood / Khalife, Wissam I

The American journal of cardiology

2023 Volume 210, Page(s) 44–50

Abstract: The goal of this investigation is to evaluate the accuracy of handheld ultrasound score in assessing right atrial (RA) pressure in patients with obesity with heart failure. We prospectively studied 123 patients with heart failure referred for right-sided ...

Abstract	The goal of this investigation is to evaluate the accuracy of handheld ultrasound score in assessing right atrial (RA) pressure in patients with obesity with heart failure. We prospectively studied 123 patients with heart failure referred for right-sided cardiac catheterization. Handheld ultrasound was performed before catheterization to evaluate volume status by estimating RA pressure using end-expiratory inferior vena cava (IVC) dimension, IVC respiratory collapsibility, and right internal jugular (RIJ) vein respiratory collapsibility. A 3-point simple score was created using multiple logistic regression. The patients were divided into 2 groups based on body mass index. The performance of this score was assessed using the receiver operating characteristics curve in each subgroup and was compared with the performance of the 2-point score (expiratory IVC dimension, IVC respiratory collapsibility). Median age was 58 years (interquartile range 48 to 65), and 37% were women. The 3-point score including RIJ performed better than did the 2-point score in patients with obesity (area under the curve 0.84 [0.74 to 0.95] vs 0.69 [0.58 to 0.81], p = 0.001). The performance of the scores did not differ in patients without obesity (area under the curve 0.85 [0.74 to 0.95] vs 0.82 [0.71 to 0.93], p = 0.49). In patients with obesity, the 3-point score had a specificity of 100% and sensitivity of 21% (11% to 31%) for elevated RA pressure ≥10 mm Hg. In conclusion, a 3-point score including both RIJ and IVC assessment performed better in patients with obesity with heart failure and highlights the importance of comprehensive evaluation in patients with obesity to achieve an accurate, noninvasive assessment of volume status.
MeSH term(s)	Humans ; Female ; Middle Aged ; Male ; Ultrasonography/methods ; Heart Failure/complications ; Heart Failure/diagnostic imaging ; ROC Curve ; Logistic Models ; Vena Cava, Inferior/diagnostic imaging ; Obesity/complications
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.09.102
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Article ; Online: Real-Time High Resolution THz Imaging with a Fiber-Coupled Photo Conductive Antenna and an Uncooled Microbolometer Camera.

Zolliker, Peter / Shalaby, Mostafa / Söllinger, Elisa / Mavrona, Elena / Hack, Erwin

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 11

Abstract: We present a real-time THz imaging method using a commercial fiber-coupled photo conductive antenna as the THz source and an uncooled microbolometer camera for detection. This new combination of state-of-the-art components is very adaptable due to its ... ...

Abstract	We present a real-time THz imaging method using a commercial fiber-coupled photo conductive antenna as the THz source and an uncooled microbolometer camera for detection. This new combination of state-of-the-art components is very adaptable due to its compact and uncooled radiation source, whose fiber coupling allows for a flexible placement. Using a camera with high sensitivity renders real-time imaging possible. As a proof-of-concept, the beam shape of a THz Time Domain Spectrometer was measured. We demonstrate real time imaging at nine frames per second and show its potential for practical applications in transmission geometry covering both material science and security tasks. The results suggest that hidden items, complex structures and the moisture content of (biological) materials can be resolved. We discuss the limits of the current setup, possible improvements and potential (industrial) applications, and we outline the feasibility of imaging in reflection geometry or extending it to multi-spectral imaging using band pass filters.
Language	English
Publishing date	2021-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21113757
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