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Article ; Online: Anti-rheumatic colchicine phytochemical exhibits potent antiviral activities against avian and seasonal Influenza A viruses (IAVs) via targeting different stages of IAV replication cycle.

Hegazy, Akram / Soltane, Raya / Alasiri, Ahlam / Mostafa, Islam / Metwaly, Ahmed M / Eissa, Ibrahim H / Mahmoud, Sara H / Allayeh, Abdou Kamal / Shama, Noura M Abo / Khalil, Ahmed A / Barre, Ramya S / El-Shazly, Assem Mohamed / Ali, Mohamed A / Martinez-Sobrido, Luis / Mostafa, Ahmed

BMC complementary medicine and therapies

2024 Volume 24, Issue 1, Page(s) 49

Abstract: Background: The continuous evolution of drug-resistant influenza viruses highlights the necessity for repurposing naturally-derived and safe phytochemicals with anti-influenza activity as novel broad-spectrum anti-influenza medications.: Methods: In ... ...

Abstract	Background: The continuous evolution of drug-resistant influenza viruses highlights the necessity for repurposing naturally-derived and safe phytochemicals with anti-influenza activity as novel broad-spectrum anti-influenza medications. Methods: In this study, nitrogenous alkaloids were tested for their viral inhibitory activity against influenza A/H1N1 and A/H5N1 viruses. The cytotoxicity of tested alkaloids on MDCK showed a high safety range (CC Results: Herein, atropine sulphate, pilocarpine hydrochloride and colchicine displayed anti-H5N1 activities with IC Conclusion: This study highlighted the anti-influenza efficacy of biologically active alkaloids including colchicine. Therefore, these alkaloids should be further characterized in vivo (preclinical and clinical studies) to be developed as anti-IAV agents.
MeSH term(s)	Humans ; Colchicine/pharmacology ; Influenza A virus ; Influenza A Virus, H5N1 Subtype ; Pilocarpine ; Influenza A Virus, H1N1 Subtype ; Influenza, Human/drug therapy ; Molecular Docking Simulation ; Seasons ; Phytochemicals/pharmacology ; Atropine ; Antiviral Agents/pharmacology
Chemical Substances	Colchicine (SML2Y3J35T) ; Pilocarpine (01MI4Q9DI3) ; Phytochemicals ; Atropine (7C0697DR9I) ; Antiviral Agents
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-023-04303-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Antiviral activities of plant-derived indole and β-carboline alkaloids against human and avian influenza viruses.

Hegazy, Akram / Mahmoud, Sara H / Elshaier, Yaseen A M M / Shama, Noura M Abo / Nasr, Nasr Fawzy / Ali, M A / El-Shazly, Assem Mohamed / Mostafa, Islam / Mostafa, Ahmed

Scientific reports

2023 Volume 13, Issue 1, Page(s) 1612

Abstract: The persistent evolution of drug-resistant influenza strains represents a global concern. The innovation of new treatment approaches through drug screening strategies and investigating the antiviral potential of bioactive natural-based chemicals may ... ...

Abstract	The persistent evolution of drug-resistant influenza strains represents a global concern. The innovation of new treatment approaches through drug screening strategies and investigating the antiviral potential of bioactive natural-based chemicals may address the issue. Herein, we screened the anti-influenza efficacy of some biologically active indole and β-carboline (βC) indole alkaloids against two different influenza A viruses (IAV) with varied host range ranges; seasonal influenza A/Egypt/NRC098/2019(H1N1) and avian influenza A/chicken/Egypt/N12640A/2016(H5N1). All compounds were first assessed for their half-maximal cytotoxic concentration (CC
MeSH term(s)	Animals ; Humans ; Antiviral Agents/pharmacology ; Strychnine/pharmacology ; Harmaline/pharmacology ; Ligands ; Influenza A virus/physiology ; Alkaloids/pharmacology ; Influenza, Human/drug therapy ; Sulfates/pharmacology ; Virus Replication
Chemical Substances	Antiviral Agents ; Strychnine (H9Y79VD43J) ; Harmaline (CN58I4TOET) ; Ligands ; Alkaloids ; Sulfates
Language	English
Publishing date	2023-01-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-27954-0
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Article ; Online: Iterated Virtual Screening-Assisted Antiviral and Enzyme Inhibition Assays Reveal the Discovery of Novel Promising Anti-SARS-CoV-2 with Dual Activity.

Hamdy, Rania / Fayed, Bahgat / Mostafa, Ahmed / Shama, Noura M Abo / Mahmoud, Sara Hussein / Mehta, Chetan Hasmukh / Nayak, Yogendra / M Soliman, Sameh S

International journal of molecular sciences

2021 Volume 22, Issue 16

Abstract: Unfortunately, COVID-19 is still a threat to humankind and has a dramatic impact on human health, social life, the world economy, and food security. With the limited number of suggested therapies under clinical trials, the discovery of novel therapeutic ... ...

Abstract	Unfortunately, COVID-19 is still a threat to humankind and has a dramatic impact on human health, social life, the world economy, and food security. With the limited number of suggested therapies under clinical trials, the discovery of novel therapeutic agents is essential. Here, a previously identified anti-SARS-CoV-2 compound named
MeSH term(s)	Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/virology ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/metabolism ; Drug Discovery/methods ; Enzyme Assays ; Humans ; Inhibitory Concentration 50 ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protease Inhibitors/pharmacology ; Protease Inhibitors/therapeutic use ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; Serine Endopeptidases/metabolism ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; Protease Inhibitors ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-) ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28)
Language	English
Publishing date	2021-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22169057
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Article ; Online: Prevalence of viral pathogens in a sample of hospitalized Egyptian children with acute lower respiratory tract infections: a two-year prospective study.

Refay, Amira S El / Shehata, Manal A / Sherif, Lobna S / Nady, Hala G El / Kholoussi, Naglaa / Kholoussi, Shams / Baroudy, Nevine R El / Gomma, Mokhtar R / Mahmoud, Sara H / Shama, Noura M Abo / Bagato, Ola / Taweel, Ahmed El / Kandeil, Ahmed / Ali, Mohamed A

Bulletin of the National Research Centre

2022 Volume 46, Issue 1, Page(s) 103

Abstract: Background: Viral pneumonias are a major cause of childhood mortality. Proper management needs early and accurate diagnosis. This study objective is to investigate the viral etiologies of pneumonia in children.: Results: This prospective study ... ...

Abstract	Background: Viral pneumonias are a major cause of childhood mortality. Proper management needs early and accurate diagnosis. This study objective is to investigate the viral etiologies of pneumonia in children. Results: This prospective study enrolled 158 and 101 patients in the first and second year, respectively, and their mean age was 4.72 ± 2.89. Nasopharyngeal swabs were collected and subjected to virus diagnosis by reverse transcription polymerase chain reaction (RT-PCR). Viral etiologies of pneumonia were evidenced in 59.5% of the samples in the first year, all of them were affirmative for influenza A, 2 samples were affirmative for Human coronavirus NL63, and one for Human coronavirus HKU1. In the second year, 87% of patients had a viral illness. The most prevalent agents are human metapneumovirus which was detected in 44 patients (43.6%) followed by human rhinovirus in 35 patients (34.7%) and then parainfluenza-3 viruses in 33 patients (32.7%), while 14 patients had a confirmed diagnosis for both Pan coronavirus and Flu-B virus. Conclusions: Viral infection is prevalent in the childhood period; however, the real magnitude of viral pneumonia in children is underestimated. The reverse transcriptase polymerase chain reaction has to be a vital tool for epidemiological research and is able to clear the gaps in-between clinical pictures and final diagnoses.
Language	English
Publishing date	2022-04-13
Publishing country	Germany
Document type	Journal Article
ISSN	2522-8307
ISSN (online)	2522-8307
DOI	10.1186/s42269-022-00790-4
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Article ; Online: Naturally Available Flavonoid Aglycones as Potential Antiviral Drug Candidates against SARS-CoV-2.

Al-Karmalawy, Ahmed A / Farid, Mai M / Mostafa, Ahmed / Ragheb, Alia Y / H Mahmoud, Sara / Shehata, Mahmoud / Shama, Noura M Abo / GabAllah, Mohamed / Mostafa-Hedeab, Gomaa / Marzouk, Mona M

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 21

Abstract: Flavonoids are important secondary plant metabolites that have been studied for a long time for their therapeutic potential in inflammatory diseases because of their cytokine-modulatory effects. Five flavonoid aglycones were isolated and identified from ... ...

Abstract	Flavonoids are important secondary plant metabolites that have been studied for a long time for their therapeutic potential in inflammatory diseases because of their cytokine-modulatory effects. Five flavonoid aglycones were isolated and identified from the hydrolyzed aqueous methanol extracts of
MeSH term(s)	Animals ; Antiviral Agents/pharmacology ; Brassicaceae/metabolism ; Chlorocebus aethiops ; Chromones/pharmacology ; Coronavirus 3C Proteases/drug effects ; Coronavirus 3C Proteases/metabolism ; Drug Discovery/methods ; Flavones/metabolism ; Flavones/pharmacology ; Flavonoids/pharmacology ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Plant Extracts/pharmacology ; Protease Inhibitors/chemistry ; Quercetin/analogs & derivatives ; Quercetin/pharmacology ; SARS-CoV-2/drug effects ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Vero Cells ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; Chromones ; Flavones ; Flavonoids ; Plant Extracts ; Protease Inhibitors ; pectolinarigenin ; gardenin B (313E89KN5E) ; Quercetin (9IKM0I5T1E) ; taxifolin (9SOB9E3987) ; Coronavirus 3C Proteases (EC 3.4.22.28) ; tangeretin (I4TLA1DLX6) ; hispidulin (N7F61604C2)
Language	English
Publishing date	2021-10-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26216559
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Zs.MO 81: Show issues

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Article ; Online: Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2.

Kandeil, Ahmed / Gomaa, Mokhtar R / El Taweel, Ahmed / Mostafa, Ahmed / Shehata, Mahmoud / Kayed, Ahmed E / Kutkat, Omnia / Moatasim, Yassmin / Mahmoud, Sara H / Kamel, Mina Nabil / Shama, Noura M Abo / El Sayes, Mohamed / El-Shesheny, Rabeh / Yassien, Mahmoud A / Webby, Richard J / Kayali, Ghazi / Ali, Mohamed A

PloS one

2020 Volume 15, Issue 10, Page(s) e0241471

Abstract: Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of the disease in children is much lower than in adults. It is hypothesized that BCG and other childhood vaccinations ... ...

Abstract	Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of the disease in children is much lower than in adults. It is hypothesized that BCG and other childhood vaccinations may provide some protection against SARS-CoV-2 infection through trained or adaptive immune responses. Here, we tested whether BCG, Pneumococcal, Rotavirus, Diphtheria, Tetanus, Pertussis, Hepatitis B, Haemophilus influenzae, Hepatitis B, Meningococcal, Measles, Mumps, and Rubella vaccines provide cross-reactive neutralizing antibodies against SARS-CoV-2 in BALB/c mice. Results indicated that none of these vaccines provided antibodies capable of neutralizing SARS-CoV-2 up to seven weeks post vaccination. We conclude that if such vaccines have any role in COVID-19 immunity, this role is not antibody-mediated.
MeSH term(s)	Adolescent ; Adult ; Aged ; Animals ; Antibodies, Neutralizing/biosynthesis ; Antibodies, Neutralizing/blood ; Antibodies, Viral/biosynthesis ; Antibodies, Viral/blood ; Betacoronavirus/immunology ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Cross Reactions ; Female ; Humans ; Immune Sera/immunology ; Immunogenicity, Vaccine ; Mice ; Mice, Inbred BALB C ; Middle Aged ; Neutralization Tests ; Pandemics/prevention & control ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Vaccination ; Vaccines/immunology ; Vaccines, Inactivated/immunology ; Viral Vaccines/immunology ; Young Adult
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Immune Sera ; Vaccines ; Vaccines, Inactivated ; Viral Vaccines
Keywords	covid19
Language	English
Publishing date	2020-10-28
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0241471
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Article ; Online: Incidence and Seroprevalence of Avian Influenza in a Cohort of Backyard Poultry Growers, Egypt, August 2015-March 2019.

Gomaa, Mokhtar R / El Rifay, Amira S / Abu Zeid, Dina / Elabd, Mona A / Elabd, Eman / Kandeil, Ahmed / Shama, Noura M Abo / Kamel, Mina N / Marouf, Mohamed A / Barakat, Ahmed / Refaey, Samir / Naguib, Amal / McKenzie, Pamela P / Webby, Richard J / Ali, Mohamed A / Kayali, Ghazi

Emerging infectious diseases

2020 Volume 26, Issue 9, Page(s) 2129–2136

Abstract: Currently enzootic avian influenza H5N1, H9N2, and H5N8 viruses were introduced into poultry in Egypt in 2006, 2011, and 2016, respectively. Infections with H5N1 and H9N2 were reported among poultry-exposed humans. We followed 2,402 persons from ... ...

Abstract	Currently enzootic avian influenza H5N1, H9N2, and H5N8 viruses were introduced into poultry in Egypt in 2006, 2011, and 2016, respectively. Infections with H5N1 and H9N2 were reported among poultry-exposed humans. We followed 2,402 persons from households raising backyard poultry from 5 villages in Egypt during August 2015-March 2019. We collected demographic, exposure, and health condition data and annual serum samples from each participant and obtained swab samples from participants reporting influenza-like illness symptoms. We performed serologic and molecular analyses and detected 4 cases of infection with H5N1 and 3 cases with H9N2. We detected very low seroprevalence of H5N1 antibodies and no H5N8 antibodies among the cohort; up to 11% had H9 antibodies. None of the exposure, health status, or demographic variables were related to being seropositive. Our findings indicate that avian influenza remains a public health risk in Eqypt, but infections may go undetected because of their mild or asymptomatic nature.
MeSH term(s)	Animals ; Egypt/epidemiology ; Humans ; Incidence ; Influenza A Virus, H5N1 Subtype ; Influenza A Virus, H9N2 Subtype ; Influenza in Birds/epidemiology ; Influenza, Human/epidemiology ; Poultry ; Seroepidemiologic Studies
Language	English
Publishing date	2020-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2609.200266
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Article ; Online: Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2

Kandeil, Ahmed / Gomaa, Mokhtar R. / El Taweel, Ahmed / Mostafa, Ahmed / Shehata, Mahmoud / Kayed, Ahmed E. / Kutkat, Omnia / Moatasim, Yassmin / Mahmoud, Sara H. / Kamel, Mina Nabil / Shama, Noura M. Abo / El Sayes, Mohamed / El-Shesheny, Rabeh / Yassien, Mahmoud A. / Webby, Richard J. / Kayali, Ghazi / Ali, Mohamed A.

PLOS ONE

2020 Volume 15, Issue 10, Page(s) e0241471

Keywords	General Biochemistry, Genetics and Molecular Biology ; General Agricultural and Biological Sciences ; General Medicine ; covid19
Language	English
Publisher	Public Library of Science (PLoS)
Publishing country	us
Document type	Article ; Online
ISSN	1932-6203
DOI	10.1371/journal.pone.0241471
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2

PLoS One

Abstract	Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of the disease in children is much lower than in adults. It is hypothesized that BCG and other childhood vaccinations may provide some protection against SARS-CoV-2 infection through trained or adaptive immune responses. Here, we tested whether BCG, Pneumococcal, Rotavirus, Diphtheria, Tetanus, Pertussis, Hepatitis B, Haemophilus influenzae, Hepatitis B, Meningococcal, Measles, Mumps, and Rubella vaccines provide cross-reactive neutralizing antibodies against SARS-CoV-2 in BALB/c mice. Results indicated that none of these vaccines provided antibodies capable of neutralizing SARS-CoV-2 up to seven weeks post vaccination. We conclude that if such vaccines have any role in COVID-19 immunity, this role is not antibody-mediated.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #895078
Database	COVID19

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Article ; Online: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Dromedary Camels in Africa and Middle East.

Kandeil, Ahmed / Gomaa, Mokhtar / Nageh, Ahmed / Shehata, Mahmoud M / Kayed, Ahmed E / Sabir, Jamal S M / Abiadh, Awatef / Jrijer, Jamel / Amr, Zuhair / Said, Mounir Abi / Byarugaba, Denis K / Wabwire-Mangen, Fred / Tugume, Titus / Mohamed, Nadira S / Attar, Roba / Hassan, Sabah M / Linjawi, Sabah Abdulaziz / Moatassim, Yassmin / Kutkat, Omnia /

Mahmoud, Sara / Bagato, Ola / Shama, Noura M Abo / El-Shesheny, Rabeh / Mostafa, Ahmed / Perera, Ranawaka Apm / Chu, Daniel Kw / Hassan, Nagla / Elsokary, Basma / Saad, Ahmed / Sobhy, Heba / El Masry, Ihab / McKenzie, Pamela P / Webby, Richard J / Peiris, Malik / Makonnen, Yilma J / Ali, Mohamed A / Kayali, Ghazi

Viruses

2019 Volume 11, Issue 8

Abstract: ...

Abstract	:
MeSH term(s)	Africa/epidemiology ; Animals ; Antibodies, Viral/blood ; Camelus/virology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Coronavirus Infections/veterinary ; Coronavirus Infections/virology ; Disease Reservoirs/virology ; Longitudinal Studies ; Middle East/epidemiology ; Middle East Respiratory Syndrome Coronavirus/classification ; Middle East Respiratory Syndrome Coronavirus/genetics ; Middle East Respiratory Syndrome Coronavirus/immunology ; Phylogeny ; Population Surveillance ; Seroepidemiologic Studies
Chemical Substances	Antibodies, Viral
Keywords	covid19
Language	English
Publishing date	2019-08-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v11080717
Database	MEDical Literature Analysis and Retrieval System OnLINE

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