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Article ; Online: Tunable ultra-narrow linewidth diode laser for multiple metastable rare gas pumping.

Han, Jinliang / Zhang, Jun / Shan, Xiaonan / Peng, Hangyu / Zhang, Yawei / Qin, Li / Wang, Lijun

2023 Volume 31, Issue 8, Page(s) 13065–13072

Abstract: We present what we believe to be a novel external cavity feedback structure based on a double-layer laser diode array with volume Bragg grating (VBG). Diode laser collimation and external cavity feedback result in a high-power and ultra-narrow linewidth ... ...

Abstract	We present what we believe to be a novel external cavity feedback structure based on a double-layer laser diode array with volume Bragg grating (VBG). Diode laser collimation and external cavity feedback result in a high-power and ultra-narrow linewidth diode laser pumping source with a central wavelength of 811.292 nm, spectral linewidth of 0.052 nm, and output power exceeding 100 W, with external cavity feedback and electro-optical conversion efficiencies exceeding 90% and 46%, respectively. The temperature of VBG is controlled to tune the central wavelength from 811.292 nm to 811.613 nm, covering the Kr* and Ar* absorption spectra. We believe this is the first report of an ultra-narrow linewidth diode laser that can pump two metastable rare gases.
Language	English
Publishing date	2023-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.484481
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Functional Plasmonic Microscope: Characterizing the Metabolic Activity of Single Cells via Sub-nm Membrane Fluctuations.

Khochare, Suraj D / Li, Xiaoliang / Yang, Xu / Shi, Yaping / Feng, Guangxia / Ruchhoeft, Paul / Shih, Wei-Chuan / Shan, Xiaonan

Analytical chemistry

2024 Volume 96, Issue 15, Page(s) 5771–5780

Abstract: Metabolic abnormalities are at the center of many diseases, and the capability to film and quantify the metabolic activities of a single cell is important for understanding the heterogeneities in these abnormalities. In this paper, a functional plasmonic ...

Abstract	Metabolic abnormalities are at the center of many diseases, and the capability to film and quantify the metabolic activities of a single cell is important for understanding the heterogeneities in these abnormalities. In this paper, a functional plasmonic microscope (FPM) is used to image and measure metabolic activities without fluorescent labels at a single-cell level. The FPM can accurately image and quantify the subnanometer membrane fluctuations with a spatial resolution of 0.5 μm in real time. These active cell membrane fluctuations are caused by metabolic activities across the cell membrane. A three-dimensional (3D) morphology of the bottom cell membrane was imaged and reconstructed with FPM to illustrate the capability of the microscope for cell membrane characterization. Then, the subnanometer cell membrane fluctuations of single cells were imaged and quantified with the FPM using HeLa cells. Cell metabolic heterogeneity is analyzed based on membrane fluctuations of each individual cell that is exposed to similar environmental conditions. In addition, we demonstrated that the FPM could be used to evaluate the therapeutic responses of metabolic inhibitors (glycolysis pathway inhibitor STF 31) on a single-cell level. The result showed that the metabolic activities significantly decrease over time, but the nature of this response varies, depicting cell heterogeneity. A low-concentration dose showed a reduced fluctuation frequency with consistent fluctuation amplitudes, while the high-concentration dose showcased a decreasing trend in both cases. These results have demonstrated the capabilities of the functional plasmonic microscope to measure and quantify metabolic activities for drug discovery.
MeSH term(s)	Humans ; HeLa Cells ; Cell Membrane ; Microscopy ; Membranes ; Coloring Agents
Chemical Substances	Coloring Agents
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c04301
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Article: Quantifying Ligand–Protein Binding Kinetics with Self-Assembled Nano-oscillators

Ma, Guangzhong / Shan, Xiaonan / Wang, Shaopeng / Tao, Nongjian

Analytical chemistry. 2019 Oct. 08, v. 91, no. 21

2019

Abstract: Measuring ligand–protein interactions is critical for unveiling molecular-scale biological processes in living systems and for screening drugs. Various detection technologies have been developed, but quantifying the binding kinetics of small molecules to ...

Abstract	Measuring ligand–protein interactions is critical for unveiling molecular-scale biological processes in living systems and for screening drugs. Various detection technologies have been developed, but quantifying the binding kinetics of small molecules to the proteins remains challenging because the sensitivities of the mainstream technologies decrease with the size of the ligand. Here, we report a method to measure and quantify the binding kinetics of both large and small molecules with self-assembled nano-oscillators, each consisting of a nanoparticle tethered to a surface via long polymer molecules. By applying an oscillating electric field normal to the surface, the nanoparticle oscillates, and the oscillation amplitude is proportional to the number of charges on the nano-oscillator. Upon the binding of ligands onto the nano-oscillator, the oscillation amplitude will change. Using a plasmonic imaging approach, the oscillation amplitude is measured with subnanometer precision, allowing us to accurately quantify the binding kinetics of ligands, including small molecules, to their protein receptors. This work demonstrates the capability of nano-oscillators as an useful tool for measuring the binding kinetics of both large and small molecules.
Keywords	drugs ; electric field ; image analysis ; ligands ; nanoparticles ; polymers ; receptors ; screening
Language	English
Dates of publication	2019-1008
Size	p. 14149-14156.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.9b04195
Database	NAL-Catalogue (AGRICOLA)

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Article: Plasmonic Measurement of Electron Transfer between a Single Metal Nanoparticle and an Electrode through a Molecular Layer

Liu, Ruihong / Shan, Xiaonan / Wang, Hui / Tao, Nongjian

Journal of the American Chemical Society. 2019 July 01, v. 141, no. 29

2019

Abstract: We study electron transfer associated with electrocatalytic reduction of hydrogen on single platinum nanoparticles separated from an electrode surface with an alkanethiol monolayer using a plasmonic imaging technique. By varying the monolayer thickness, ... ...

Abstract	We study electron transfer associated with electrocatalytic reduction of hydrogen on single platinum nanoparticles separated from an electrode surface with an alkanethiol monolayer using a plasmonic imaging technique. By varying the monolayer thickness, we show that the reaction rate depends on electron tunneling from the electrode to the nanoparticle. The tunneling decay constant is ∼4.3 nm–1, which is small compared to those in literature for alkanethiols. We attribute it to a reduced tunneling barrier resulting from biasing the electrode potential negatively to the hydrogen reduction regime. In addition to allowing study of electron transfer of single nanoparticles, the work demonstrates an optical method to measure charge transport in molecules electrically wired to two electrodes.
Keywords	catalytic activity ; electrochemistry ; electrodes ; electron transfer ; hydrogen ; image analysis ; nanoparticles ; platinum ; thiols
Language	English
Dates of publication	2019-0701
Size	p. 11694-11699.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.9b05388
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Plasmonic Measurement of Electron Transfer between a Single Metal Nanoparticle and an Electrode through a Molecular Layer.

Liu, Ruihong / Shan, Xiaonan / Wang, Hui / Tao, Nongjian

Journal of the American Chemical Society

2019 Volume 141, Issue 29, Page(s) 11694–11699

Abstract	We study electron transfer associated with electrocatalytic reduction of hydrogen on single platinum nanoparticles separated from an electrode surface with an alkanethiol monolayer using a plasmonic imaging technique. By varying the monolayer thickness, we show that the reaction rate depends on electron tunneling from the electrode to the nanoparticle. The tunneling decay constant is ∼4.3 nm
Language	English
Publishing date	2019-07-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.9b05388
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Quantifying Ligand-Protein Binding Kinetics with Self-Assembled Nano-oscillators.

Ma, Guangzhong / Shan, Xiaonan / Wang, Shaopeng / Tao, Nongjian

Analytical chemistry

2019 Volume 91, Issue 21, Page(s) 14149–14156

Abstract: Measuring ligand-protein interactions is critical for unveiling molecular-scale biological processes in living systems and for screening drugs. Various detection technologies have been developed, but quantifying the binding kinetics of small molecules to ...

Abstract	Measuring ligand-protein interactions is critical for unveiling molecular-scale biological processes in living systems and for screening drugs. Various detection technologies have been developed, but quantifying the binding kinetics of small molecules to the proteins remains challenging because the sensitivities of the mainstream technologies decrease with the size of the ligand. Here, we report a method to measure and quantify the binding kinetics of both large and small molecules with self-assembled nano-oscillators, each consisting of a nanoparticle tethered to a surface via long polymer molecules. By applying an oscillating electric field normal to the surface, the nanoparticle oscillates, and the oscillation amplitude is proportional to the number of charges on the nano-oscillator. Upon the binding of ligands onto the nano-oscillator, the oscillation amplitude will change. Using a plasmonic imaging approach, the oscillation amplitude is measured with subnanometer precision, allowing us to accurately quantify the binding kinetics of ligands, including small molecules, to their protein receptors. This work demonstrates the capability of nano-oscillators as an useful tool for measuring the binding kinetics of both large and small molecules.
MeSH term(s)	Binding Sites ; DNA/chemical synthesis ; DNA/chemistry ; Kinetics ; Ligands ; Nanoparticles/chemistry ; Nanotechnology/instrumentation ; Oscillometry/instrumentation ; Particle Size ; Proteins/chemistry ; Surface Properties
Chemical Substances	Ligands ; Proteins ; DNA (9007-49-2)
Language	English
Publishing date	2019-10-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.9b04195
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Plasmonic Imaging of Oxidation and Reduction of Single Gold Nanoparticles and Their Surface Structural Dynamics.

Garcia, Adaly / Wang, Shaopeng / Tao, Nongjian / Shan, Xiaonan / Wang, Yixian

ACS sensors

2020 Volume 6, Issue 2, Page(s) 502–507

Abstract: Gold nanoparticles (AuNPs) have been widely used in catalytic electrochemistry. Heterogeneity in size, shape, and surface sites leads to variable, particle-specific catalytic activities. Conventional electrochemical methods can only obtain the collective ...

Abstract	Gold nanoparticles (AuNPs) have been widely used in catalytic electrochemistry. Heterogeneity in size, shape, and surface sites leads to variable, particle-specific catalytic activities. Conventional electrochemical methods can only obtain the collective responses from all the catalytic nanoparticles on the electrode surface; the heterogeneity of particle performance will be averaged. Alternatively, plasmonic electrochemical imaging (PECi) is capable of imaging the electrochemical activity at individual nanoparticles. In this work, PECi was used to image the oxidation and reduction of the gold surface at individual AuNPs, and their associated structural alterations were successfully measured. We have studied the electrochemical responses from gold nanocubes, gold nanorods, and gold nanowires with PECi and observed different surface redox activities. We have also demonstrated the capability of monitoring the surface dynamics at individual AuNPs utilizing characteristic PECi derived cyclic voltammograms (CVs).
MeSH term(s)	Electrochemistry ; Gold ; Metal Nanoparticles ; Oxidation-Reduction ; Particle Size
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2020-12-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.0c02055
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Paper Based Milli-Cantilever Sensor for Detecting Hydrocarbon Gases via Smartphone Camera

Qin, Xingcai / Wu, Tao / Zhu, Ying / Shan, Xiaonan / Liu, Chenbin / Tao, Nongjian

Analytical chemistry. 2020 Apr. 30, v. 92, no. 12

2020

Abstract: Hydrocarbon gases, especially toxic ones like benzene and xylene, pose threats to human health and the environment. But existing detection techniques, like bulky GC-MS or portable PID, cannot fulfill people’s requirement of affordable and reliable ... ...

Abstract	Hydrocarbon gases, especially toxic ones like benzene and xylene, pose threats to human health and the environment. But existing detection techniques, like bulky GC-MS or portable PID, cannot fulfill people’s requirement of affordable and reliable hydrocarbons monitoring for the purpose of personal exposure assessment. Here, a simple, low cost, and light hydrocarbon gases sensor using a smartphone camera as a readout was developed based on the paper based milli-cantilever bending induced by polymer swelling. Its sensing cantilever was composed of three layers: functional layer of polyethylene film, adhesive layer of double-side tape, and a substrate of weighing paper. And the dimensions of the milli-fabricated sensing cantilever are 8 mm long, 0.5 mm wide, and 50 μm thick. The sensor response was the displacement of milli-cantilever free end. As proof of concept, its performance to typical hydrocarbons of xylene, hexane, and BTEX was carefully examined. For all of them, the sensor showed good performance of linear response to hydrocarbon concentrations, wide detection range, low detection, and fast response. Taking xylene for example, the sensor showed wide detection range of 15–140 ppm, low detection limit of 15 ppm, and fast response of 30 s. The sensor cross-sensitivity to other hydrocarbons was consistent with polymer swelling theory that the more carbons the hydrocarbon has, the higher the sensor sensitivity. Taking advantage of the rough materials chosen and simple fabrication procedure, the developed sensors also had high stability with time, low cost, and good uniformity. The developed sensor is affordable both physically and financially, has good performance, could meet hydrocarbons monitoring requirements for occupational safety or air pollution in petroleum industry, and would benefit people’s health.
Keywords	air pollution ; analytical chemistry ; benzene ; cameras ; detection limit ; exposure assessment ; hexane ; human health ; industry ; mobile telephones ; occupational health and safety ; paper ; people ; petroleum ; polyethylene film ; polymers ; toxicity ; xylene
Language	English
Dates of publication	2020-0430
Size	p. 8480-8486.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.0c01240
Database	NAL-Catalogue (AGRICOLA)

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Article: Achieving High Spatial Resolution Surface Plasmon Resonance Microscopy with Image Reconstruction

Yu, Hui / Shan Xiaonan / Tao Nongjian / Wang Shaopeng

Analytical chemistry. 2017 Mar. 07, v. 89, no. 5

2017

Abstract: Surface plasmon resonance microscopy (SPRM) is a powerful platform for biomedical imaging and molecular binding kinetics analysis. However, the spatial resolution of SPRM along the plasmon propagation direction (longitudinal) is determined by the ... ...

Abstract	Surface plasmon resonance microscopy (SPRM) is a powerful platform for biomedical imaging and molecular binding kinetics analysis. However, the spatial resolution of SPRM along the plasmon propagation direction (longitudinal) is determined by the decaying length of the plasmonic wave, which can be as large as tens of microns. Different methods have been proposed to improve the spatial resolution, but each at the expense of decreased sensitivity or temporal resolution. Here we present a method to achieve high spatial resolution SPRM based on deconvolution of complex field. The method does not require additional optical setup and improves the spatial resolution in the longitudinal direction. We applied the method to image nanoparticles and achieved close-to-diffraction limit resolution in both longitudinal and transverse directions.
Keywords	image analysis ; microscopy ; nanoparticles ; surface plasmon resonance
Language	English
Dates of publication	2017-0307
Size	p. 2704-2707.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021%2Facs.analchem.6b05049
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A Paper Based Milli-Cantilever Sensor for Detecting Hydrocarbon Gases via Smartphone Camera.

Qin, Xingcai / Wu, Tao / Zhu, Ying / Shan, Xiaonan / Liu, Chenbin / Tao, Nongjian

Analytical chemistry

2020 Volume 92, Issue 12, Page(s) 8480–8486

Abstract	Hydrocarbon gases, especially toxic ones like benzene and xylene, pose threats to human health and the environment. But existing detection techniques, like bulky GC-MS or portable PID, cannot fulfill people's requirement of affordable and reliable hydrocarbons monitoring for the purpose of personal exposure assessment. Here, a simple, low cost, and light hydrocarbon gases sensor using a smartphone camera as a readout was developed based on the paper based milli-cantilever bending induced by polymer swelling. Its sensing cantilever was composed of three layers: functional layer of polyethylene film, adhesive layer of double-side tape, and a substrate of weighing paper. And the dimensions of the milli-fabricated sensing cantilever are 8 mm long, 0.5 mm wide, and 50 μm thick. The sensor response was the displacement of milli-cantilever free end. As proof of concept, its performance to typical hydrocarbons of xylene, hexane, and BTEX was carefully examined. For all of them, the sensor showed good performance of linear response to hydrocarbon concentrations, wide detection range, low detection, and fast response. Taking xylene for example, the sensor showed wide detection range of 15-140 ppm, low detection limit of 15 ppm, and fast response of 30 s. The sensor cross-sensitivity to other hydrocarbons was consistent with polymer swelling theory that the more carbons the hydrocarbon has, the higher the sensor sensitivity. Taking advantage of the rough materials chosen and simple fabrication procedure, the developed sensors also had high stability with time, low cost, and good uniformity. The developed sensor is affordable both physically and financially, has good performance, could meet hydrocarbons monitoring requirements for occupational safety or air pollution in petroleum industry, and would benefit people's health.
Language	English
Publishing date	2020-06-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.0c01240
Database	MEDical Literature Analysis and Retrieval System OnLINE

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