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Article ; Online: Silk Fibroin-Based Biomaterials for Tissue Engineering Applications

Guangfei Li / Shan Sun

Molecules, Vol 27, Iss 2757, p

2022 Volume 2757

Abstract: Tissue engineering (TE) involves the combination of cells with scaffolding materials and appropriate growth factors in order to regenerate or replace damaged and degenerated tissues and organs. The scaffold materials serve as templates for tissue ... ...

Abstract	Tissue engineering (TE) involves the combination of cells with scaffolding materials and appropriate growth factors in order to regenerate or replace damaged and degenerated tissues and organs. The scaffold materials serve as templates for tissue formation and play a vital role in TE. Among scaffold materials, silk fibroin (SF), a naturally occurring protein, has attracted great attention in TE applications due to its excellent mechanical properties, biodegradability, biocompatibility, and bio-absorbability. SF is usually dissolved in an aqueous solution and can be easily reconstituted into different forms, including films, mats, hydrogels, and sponges, through various fabrication techniques, including spin coating, electrospinning, freeze drying, and supercritical CO 2 -assisted drying. Furthermore, to facilitate the fabrication of more complex SF-based scaffolds, high-precision techniques such as micro-patterning and bio-printing have been explored in recent years. These processes contribute to the diversity of surface area, mean pore size, porosity, and mechanical properties of different silk fibroin scaffolds and can be used in various TE applications to provide appropriate morphological and mechanical properties. This review introduces the physicochemical and mechanical properties of SF and looks into a range of SF-based scaffolds that have recently been developed. The typical applications of SF-based scaffolds for TE of bone, cartilage, teeth and mandible tissue, cartilage, skeletal muscle, and vascular tissue are highlighted and discussed followed by a discussion of issues to be addressed in future studies.
Keywords	tissue engineering ; silk fibroin ; biomaterial ; Organic chemistry ; QD241-441
Subject code	620
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pilot fatigue survey: A study of the mutual influence among fatigue factors in the "work" dimension.

Jun-Ya, Sun / Rui-Shan, Sun

Frontiers in public health

2023 Volume 11, Page(s) 1014503

Abstract: Background: Fatigue risk management for pilots has received increasing attention. The existing fatigue management systems have detailed descriptions of the factors and the mutual influences among the factors that affect the dimension of "sleep", which ... ...

Abstract	Background: Fatigue risk management for pilots has received increasing attention. The existing fatigue management systems have detailed descriptions of the factors and the mutual influences among the factors that affect the dimension of "sleep", which is one of the most important causes of fatigue. However, the analysis of the influencing factors of the "work" dimension of fatigue causes has not been very detailed or accurate, especially the exploration of the mutual influence among many fatigue-influencing factors in the "work" dimension. Objective: The purpose of this study was to explore the mutual influence among fatigue-influencing factors related to the "work" dimension in the analysis of pilot fatigue causes. Methods: This study designed a questionnaire on the dimension of "work" in the causes of pilot fatigue and collected a total of 270 feedback data points from international flight pilots. Based on the questionnaires and data, descriptive statistical analysis, exploratory factor analysis and confirmatory factor analysis were performed to explore the influencing factors and their mutual influences on the "work" dimension of pilot fatigue. Results: There is a strong, mutual influence relationship among the fatigue causes of long-haul flight pilots - working status, working conditions and working schedules - in the dimension of "work". The workload only has a strong correlation with the working schedule, and the interaction relationships with the working status or working conditions are weak. Conclusion: This study analyses the mutual influence among the influencing factors of the "work" dimension of pilot fatigue, and we expect to provide empirical data for pilot fatigue risk management and to help improve fatigue risk management systems.
MeSH term(s)	Humans ; Sleep Deprivation/complications ; Pilots ; Work Schedule Tolerance ; Sleep ; Fatigue/etiology
Language	English
Publishing date	2023-02-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1014503
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Influence Mechanism of High-Tech Industrial Agglomeration on Green Innovation Performance

Jiaoping Yang / Shujun Wang / Shan Sun / Jianhua Zhu

Sustainability, Vol 14, Iss 3187, p

Evidence from China

2022 Volume 3187

Abstract: This paper uses panel data from 30 provinces and cities in China between 2008 and 2017. It calculates the green innovation performance of each province and city based on the super-efficiency SBM model of unexpected output and measures the high-tech ... ...

Abstract	This paper uses panel data from 30 provinces and cities in China between 2008 and 2017. It calculates the green innovation performance of each province and city based on the super-efficiency SBM model of unexpected output and measures the high-tech industrial agglomeration degree of each province and city by using the location entropy method. The influence of high-tech industrial agglomeration on green innovation is also empirically tested. It is found that the agglomeration level of high-tech industry and green innovation performance in Eastern China are much higher than those in Central and Western regions. There is a significant positive relationship between high-tech industrial agglomeration and green innovation performance. Human capital has a mediating effect in the positive impact of high-tech industry agglomeration on green innovation performance. The moderating effect of environmental regulation is markedly established. The higher the level of environmental regulation, the stronger the mediating effect of human capital. Based on the above conclusions, this paper puts forward relevant policy suggestions for promoting the organic combination of green and innovation-driven development and for promoting green transformation in China.
Keywords	high-tech industry agglomeration ; green innovation performance ; human capital ; environmental regulation ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	650
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Emerging role of the itaconate-mediated rescue of cellular metabolic stress

Der-Shan Sun / Hsin-Hou Chang

Tzu-Chi Medical Journal, Vol 34, Iss 2, Pp 134-

2022 Volume 138

Abstract: Metabolic regulations play vital roles on maintaining the homeostasis of our body. Evidence have suggested that ATF3 and nuclear factor erythroid 2–related factor 2 (NRF2) are critical for maintaining cell function, metabolism, and inflammation/anti- ... ...

Abstract	Metabolic regulations play vital roles on maintaining the homeostasis of our body. Evidence have suggested that ATF3 and nuclear factor erythroid 2–related factor 2 (NRF2) are critical for maintaining cell function, metabolism, and inflammation/anti-inflammation regulations when cells are under stress, while the upstream regulators in the stressed cells remain elusive. Recent findings have shown that tricarboxylic acid cycle metabolites such as itaconate and succinate are not just mitochondrial metabolites, but rather important signaling mediators, involving in the regulations of metabolism, immune modulation. Itaconate exerts anti-inflammatory role through regulating ATF3 and NRF2 pathways under stressed conditions. In addition, itaconate inhibits succinate dehydrogenase, succinate oxidation and thus blocking succinate-mediated inflammatory processes. These findings suggest itaconate-ATF3 and itaconate-NRF2 axes are well-coordinated machineries that facilitate the rescue against cellular stress. Here, we review these fascinating discoveries, a research field may help the development of more effective therapeutic approach to manage stress-induced inflammation, tissue damage, and metabolic disorder.
Keywords	atf3 ; inflammasome ; itaconate ; mitochondrial stress ; nuclear factor erythroid 2–related factor 2 ; Medicine ; R
Subject code	570
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of Tree Species and Soil Enzyme Activities on Soil Nutrients in Dryland Plantations

Yage Li / Chun Han / Shan Sun / Changming Zhao

Forests, Vol 12, Iss 1153, p

2021 Volume 1153

Abstract: Long-term afforestation strongly changes the soil’s physicochemical and biological properties. However, the underlying mechanism of different tree species driving change in soil nutrients is still unclear in the long-term dryland plantations of the Loess ...

Abstract	Long-term afforestation strongly changes the soil’s physicochemical and biological properties. However, the underlying mechanism of different tree species driving change in soil nutrients is still unclear in the long-term dryland plantations of the Loess Plateau, China. In this study, samples of surface soil (0–20 cm) and woody litter were collected from five plantations (≥50 years) of Caragana korshinskii , Armeniaca sibirica , Populus hopeiensis , Platycladus orientalis , and Pinus tabulaeformis and a natural grassland, and tested for the carbon, nitrogen, phosphorus, and potassium contents, as well as the soil sucrase (SC), urease (UE), and alkaline phosphorus (ALP) activities. We found that soil nutrients, enzyme activities, and the litter’s chemical properties obviously varied among five tree species. C. korshinskii significantly increased the soil’s TC, organic carbon (OC), total nitrogen (TN), available nitrogen (AN), and available potassium (AK) by 28.42%, 56.08%, 57.41%, 107.25%, and 10.29%, respectively, and also increased the soil’s available phosphorus (AP) by 18.56%; while P. orientalis significantly decreased soil TN (38.89%), TP (30.58%), AP (76.39%), TK (8.25%), and AK (8.33%), and also decreased soil OC (18.01%) and AN (1.09%), compared with those in grassland. The C. korshinskii plantation had higher quality litter and soil enzyme activities than the P. orientalis plantation. Moreover, 62.2% of the total variation in soil nutrients was explained by the litter’s chemical properties and soil enzyme activities, and the litter phosphorus (LP) and soil ALP had a more significant and positive impact on soil nutrients. Therefore, tree species, LP, and soil ALP were key factors driving soil nutrient succession in dryland plantations. The significantly positive nitrogen–phosphorus coupling relationship in the “litter–enzyme–soil” system revealed that the improving nitrogen level promoted the phosphorus cycle of the plantation ecosystem. Our results suggest that leguminous tree species are more suitable for dryland afforestation through the regulation of litter quality and soil enzyme activities.
Keywords	drought response ; global warming ; leguminous tree species ; litter quality ; soil properties ; Plant ecology ; QK900-989
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Editorial

Renjie Chai / Hongzhe Li / Tao Yang / Shan Sun / Yongyi Yuan

Frontiers in Cell and Developmental Biology, Vol

Hearing Loss: Mechanisms and Prevention

2022 Volume 10

Keywords	hair cell ; spiral ganglion neurons ; hearing loss ; noise exposure ; gene therapy ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploring Pedestrian Satisfaction in Old and New Town

Liu Han / Dewei Fang / Shan Sun / Lixuan Zhao / Qian Zheng / Jingxu Lan / Xue Wang

Sustainability, Vol 15, Iss 2414, p

An Impact-Asymmetry Analysis

2023 Volume 2414

Abstract: In the context of the global construction of low-carbon cities and residents’ pursuit of healthy living, the improvement in the urban walking environment has gradually been emphasized in the field of planning and transportation research. Using Harbin, ... ...

Abstract	In the context of the global construction of low-carbon cities and residents’ pursuit of healthy living, the improvement in the urban walking environment has gradually been emphasized in the field of planning and transportation research. Using Harbin, China, as an example, this paper combines gradient boosting decision trees (GBDTs) and impact-asymmetry analysis (IAA) methods to explore the differences in residents’ preferences for the pedestrian environment needs in old and new urban areas, analyze the asymmetric relationship between walking environment factors and overall satisfaction, and provide a sound basis for the renewal and reconstruction of the walking environment in old urban areas and the improvement of the walking environment in new urban areas. The factors affecting the pedestrian environment in the old and new urban areas are similar and different, with the aesthetics and safety and the aesthetics and comfort of the pedestrian environment having a greater impact on the old and new urban areas, respectively. According to the results of the IAA, the old city should focus on improving green landscaping, street furniture, the uncivilized behavior of pedestrians, pavement encroachment, barrier-free facilities, and the speed of motor vehicles; the new city should focus on improving the building facade effect, the uncivilized behavior of pedestrians, and green landscaping.
Keywords	pedestrian environment ; satisfaction ; three-factor theory ; gradient boosting decision trees ; impact-asymmetry analysis ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	380
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Simulation of Hemorrhage Pathogenesis in Mice through Dual Stimulation with Dengue Envelope Protein Domain III-Coated Nanoparticles and Antiplatelet Antibody

Te-Sheng Lien / Der-Shan Sun / Wen-Sheng Wu / Hsin-Hou Chang

International Journal of Molecular Sciences, Vol 24, Iss 9270, p

2023 Volume 9270

Abstract: Dengue hemorrhagic fever (DHF) is a severe form of dengue virus (DENV) infection that can lead to abnormal immune responses, endothelial vascular dysfunction, and hemorrhage pathogenesis. The virion-associated envelope protein domain III (EIII) is ... ...

Abstract	Dengue hemorrhagic fever (DHF) is a severe form of dengue virus (DENV) infection that can lead to abnormal immune responses, endothelial vascular dysfunction, and hemorrhage pathogenesis. The virion-associated envelope protein domain III (EIII) is thought to play a role in the virulence of DENV by damaging endothelial cells. However, it is unclear whether EIII-coated nanoparticles simulating DENV virus particles could cause a more severe pathogenesis than soluble EIII alone. This study aimed to investigate whether EIII-coated silica nanoparticles (EIII-SNPs) could elicit greater cytotoxicity in endothelial cells and hemorrhage pathogenesis in mice compared to EIII or silica nanoparticles alone. The main methods included in vitro assays to assess cytotoxicity and in vivo experiments to examine hemorrhage pathogenesis in mice. EIII-SNPs induced greater endothelial cytotoxicity in vitro than EIII or silica nanoparticles alone. Two-hit combined treatment with EIII-SNPs and antiplatelet antibodies to simulate DHF hemorrhage pathogenesis during secondary DENV infections resulted in higher endothelial cytotoxicity than either treatment alone. In mouse experiments, two-hit combined treatment with EIII-SNPs and antiplatelet antibodies resulted in more severe hemorrhage pathogenesis compared to single treatments of EIII, EIII-SNPs, or antiplatelet antibodies alone. These findings suggest that EIII-coated nanoparticles are more cytotoxic than soluble EIII and could be used to develop a tentative dengue two-hit hemorrhage pathogenesis model in mice. Additionally, our results indicated that EIII-containing DENV particles could potentially exacerbate hemorrhage pathogenesis in DHF patients who have antiplatelet antibodies, highlighting the need for further research on the potential role of EIII in DHF pathogenesis.
Keywords	dengue virus ; dengue envelope protein domain III ; dengue hemorrhage fever ; hemorrhage ; antiplatelet antibody ; silica nanoparticles ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exon-intron boundary inhibits m6A deposition, enabling m6A distribution hallmark, longer mRNA half-life and flexible protein coding

Zhiyuan Luo / Qilian Ma / Shan Sun / Ningning Li / Hongfeng Wang / Zheng Ying / Shengdong Ke

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 17

Abstract: Abstract Regional bias of N 6-methyladenosine (m6A) mRNA modification avoiding splice site region, calls for an open hypothesis whether exon-intron boundary could affect m6A deposition. By deep learning modeling, we find that exon-intron boundary ... ...

Abstract	Abstract Regional bias of N 6-methyladenosine (m6A) mRNA modification avoiding splice site region, calls for an open hypothesis whether exon-intron boundary could affect m6A deposition. By deep learning modeling, we find that exon-intron boundary represses a proportion (12% to 34%) of m6A deposition at adjacent exons (~100 nt to splice site). Experiments validate that m6A signal increases once the host gene does not undergo pre-mRNA splicing to produce the same mRNA. Inhibited m6A sites have higher m6A enhancers and lower m6A silencers locally and show high heterogeneity at different exons genome-widely, with only a small proportion (12% to 15%) of exons showing strong inhibition, enabling more stable mRNAs and flexible protein coding. m6A is majorly responsible for why mRNAs with more exons be more stable. Exon junction complex (EJC) only partially contributes to this exon-intron boundary m6A inhibition in some short internal exons, highlighting additional factors yet to be identified.
Keywords	Science ; Q
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Entrepreneurial Passion Matters

Rui Hu / Zuxian Shen / Tae-Won Kang / Li Wang / Peng Bin / Shan Sun

SAGE Open, Vol

The Relationship Between Proactive Personality and Entrepreneurial Intention

2023 Volume 13

Abstract: The multiple mechanisms of entrepreneurial intention are still an open issue, and few have explored whether the relationship between entrepreneurial intention and proactive personality is influenced by entrepreneurial passion. This study aims to reveal ... ...

Abstract	The multiple mechanisms of entrepreneurial intention are still an open issue, and few have explored whether the relationship between entrepreneurial intention and proactive personality is influenced by entrepreneurial passion. This study aims to reveal the mediation role of entrepreneurial passion between proactive personality and entrepreneurial intention with the application of the classic structural equation modeling. A questionnaire survey was conducted on Chinese undergraduates and 647 questionnaires were collected for the further analysis. The main findings shed light on the mechanisms that underpin entrepreneurial passion and contribute to the growing body of knowledge on entrepreneurial intention and will raise implications for both academic entrepreneurial theory and practice.
Keywords	History of scholarship and learning. The humanities ; AZ20-999 ; Social Sciences ; H
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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