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Article: Comparison of clinical effects of two surgical approaches in the treatment of acetabular fractures.

Liu, Bing / Shang, Hongtao / Dong, Guixian / Zhang, Ning / Wang, Shengjie

2023 Volume 39, Issue 4, Page(s) 1057–1061

Abstract: Objective: To determine the clinical effect of lateral rectus abdominis approach and modified Stoppa approach for the surgical treatment of acetabular fractures.: Methods: A retrospective analysis was performed on the case data of 30 patients with ... ...

Abstract	Objective: To determine the clinical effect of lateral rectus abdominis approach and modified Stoppa approach for the surgical treatment of acetabular fractures. Methods: A retrospective analysis was performed on the case data of 30 patients with acetabular fractures admitted to the Department of Orthopaedics of Hengshui City People's Hospital from June 2017 to June 2021. According to the surgical methods, the enrolled patients were divided into the lateral rectus abdominis approach group (observation group) and the modified Stoppa approach group (control group), with 15 patients in each group. Further comparison was made on the incision length, operation time, intraoperative blood loss, length of stay in the hospital, fracture reduction, hip joint function, neurological recovery, and postoperative complications between the two groups. Results: There was no significant difference between the two groups in the length of stay in the hospital, hip joint function score, fracture reduction quality, and excellent-to-good rate of hip joint function ( Conclusion: The clinical effect of the lateral rectus abdominis approach is close to that of the modified Stoppa approach for the surgical treatment of acetabular fracture patients. However, and importantly, surgery through the lateral rectus abdominis approach has less trauma, shorter operation time, lower surgical complications, and good postoperative functional recovery.
Language	English
Publishing date	2023-08-08
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.39.4.6914
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Article: Minimally Invasive Percutaneous Plate Osteosynthesis technique combined with locking compression plates guided by C-Arm X-Ray machine in treatment of tibial metaphyseal fractures: Curative effect and postoperative complications.

Zhang, Xu / Liu, Bin / Wang, Quan / Shang, Hongtao

Pakistan journal of medical sciences

2022 Volume 38, Issue 3Part-I, Page(s) 505–510

Abstract: Objectives: To explore the curative effect of minimally invasive percutaneous plate osteosynthesis (MIPPO) technology combined with locking compression plates (LCP) guided by C-arm X-ray machine in the treatment of tibial metaphyseal fracture and its ... ...

Abstract	Objectives: To explore the curative effect of minimally invasive percutaneous plate osteosynthesis (MIPPO) technology combined with locking compression plates (LCP) guided by C-arm X-ray machine in the treatment of tibial metaphyseal fracture and its impact on the surgical indexes and postoperative complications. Methods: The present study was a retrospective analysis focusing on the clinical data of 104 cases of tibial metaphyseal fracture who were treated surgically in our hospital from February 2019 to February 2021. According to different surgical methods, patients who were treated by using MIPPO technology combined with LCP guided by C-arm X-ray machine were divided into the observation group (n=54), while those who underwent traditional open reduction and internal fixation were classified into the control group (n=50). Further comparison was made on the differences of the curative effect, surgical index (operation time, intraoperative blood loss, incision length, and healing time) and postoperative complications between the two groups. In addition, the differences in ankle function, knee function and quality of life [Medical Outcomes Study 36-item Short-Form Health Survey (MOS SF-36)] were evaluated between the two groups before treatment and 6 months after treatment. Results: The clinical curative effect and total efficacy of the observation group were better than those of the control group (All p<0.05). The operation time, intraoperative blood loss, incision length, and healing time were lower in the observation group when compared to those of the control group (All p<0.05). The total incidence of postoperative complications was also lower in the observation group than that in the control group (p<0.05). In addition, the scores of ankle function, knee function and MOS SF-36 in both groups were higher after 6 months of treatment than those before treatment; besides, the inter-group comparison showed that the scores of ankle function, knee function and MOS SF-36 in the observation group were higher than those in the control group (All p<0.05). Conclusion: MIPPO technology combined with LCP guided by C-arm X-ray machine has a significant curative effect on the treatment of tibial metaphyseal fracture. It can significantly improve the surgical index, reduce postoperative complications, and have an obvious effect on postoperative recovery of ankle function, knee joint function and quality of life.
Language	English
Publishing date	2022-03-23
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.38.3.4757
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Article ; Online: Study on the Grading Model of Hepatic Steatosis Based on Improved DenseNet.

Yang, Ruwen / Zhou, Yaru / Liu, Weiwei / Shang, Hongtao

Journal of healthcare engineering

2022 Volume 2022, Page(s) 9601470

Abstract: To achieve intelligent grading of hepatic steatosis, a deep learning-based method for grading hepatic steatosis was proposed by introducing migration learning in the DenseNet model, and the effectiveness of the method was verified by applying it to the ... ...

Abstract	To achieve intelligent grading of hepatic steatosis, a deep learning-based method for grading hepatic steatosis was proposed by introducing migration learning in the DenseNet model, and the effectiveness of the method was verified by applying it to the practice of grading hepatic steatosis. The results show that the proposed method can significantly reduce the number of model iterations and improve the model convergence speed and prediction accuracy by introducing migration learning in the deep learning DenseNet model, with an accuracy of more than 85%, sensitivity of more than 94%, specificity of about 80%, and good prediction performance on the training and test sets. It can also detect hepatic steatosis grade 1 more accurately and reliably, and achieve automated and more accurate grading, which has some practical application value.
MeSH term(s)	Fatty Liver ; Humans
Language	English
Publishing date	2022-03-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2022/9601470
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Article ; Online: Recent advances on transdermal delivery systems for the treatment of arthritic injuries: From classical treatment to nanomedicines.

Shang, Hongtao / Younas, Ayesha / Zhang, Nan

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

2022 Volume 14, Issue 3, Page(s) e1778

Abstract: Arthritic injuries happen frequently during a lifetime due to accidents, sports, aging, diseases, etc. Such injuries can be cartilage/bone injuries, tendon injuries, ligament injuries, inflammation, pain, and/or synovitis. Oral and injective ... ...

Abstract	Arthritic injuries happen frequently during a lifetime due to accidents, sports, aging, diseases, etc. Such injuries can be cartilage/bone injuries, tendon injuries, ligament injuries, inflammation, pain, and/or synovitis. Oral and injective administration of therapeutics are typically used but cause many side effects. Transdermal administration is an alternative route for safe and efficient delivery. Transdermal formulations of non-steroidal anti-inflammatory drugs have been available on market for years and show promising efficacy in pain relieving, inflammation alleviation, infection control, and so on. Innovative transdermal patches, gels/films, and microneedles have also been widely explored as formulations to deliver therapeutics to combat arthritic injuries. However, transdermal formulations that halt disease progression and promote damage repair are translated slowly from lab bench to clinical applications. One major reason is that the skin barrier and synovial capsule barrier limit the efficacy of transdermal delivery. Recently, many nanocarriers, such as nanoparticles, nanolipids, nanoemulsions, nanocrystals, exosomes, etc., have been incorporated into transdermal formulations to advance drug delivery. The combined transdermal formulations show promising safety and efficacy. Therefore, this review will focus on stating the current development of nanomedicine-based transdermal formulations for the treatment of arthritic injuries. The advances, limitations, and future perspectives in this field will also be provided to inspire future studies and accelerate clinical translational studies. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Biology-Inspired Nanomaterials > Lipid-Based Structures.
MeSH term(s)	Administration, Cutaneous ; Drug Delivery Systems ; Humans ; Inflammation ; Nanomedicine ; Pain
Language	English
Publishing date	2022-02-02
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2502698-7
ISSN	1939-0041 ; 1939-5116
ISSN (online)	1939-0041
ISSN	1939-5116
DOI	10.1002/wnan.1778
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Article ; Online: From traditional to novel treatment of arthritis: a review of recent advances in nanotechnology-based thermal therapy.

Shang, Hongtao / Gu, Huan / Zhang, Nan

Nanomedicine (London, England)

2021 Volume 16, Issue 23, Page(s) 2117–2132

Abstract: Arthritis has been a heavy burden on the economy and society at large. Recently, nanomaterials that can convert near-infrared light into localized heat have demonstrated better targeting to arthritic joints, fewer side effects, ease of combined ... ...

Abstract	Arthritis has been a heavy burden on the economy and society at large. Recently, nanomaterials that can convert near-infrared light into localized heat have demonstrated better targeting to arthritic joints, fewer side effects, ease of combined application with current therapeutics and enhanced efficacy for arthritis treatment. In this review, the authors summarize traditional thermal therapies for arthritis treatment and their molecular mechanisms and discuss the advantages and applications of nanotechnology-based thermal therapies for arthritis treatment. In conclusion, nanotechnology-based thermal therapies are effective alternatives or adjuvant strategies to the current pharmacological treatment of arthritis. Future clinical translation of thermal therapies could benefit from research elucidating their mechanisms and standardizing their parameters to optimize efficacy.
MeSH term(s)	Arthritis/therapy ; Humans ; Infrared Rays ; Nanostructures ; Nanotechnology ; Phototherapy
Language	English
Publishing date	2021-09-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2277839-1
ISSN	1748-6963 ; 1743-5889
ISSN (online)	1748-6963
ISSN	1743-5889
DOI	10.2217/nnm-2021-0182
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Article: Enhanced polyphosphazene membranes for CO2/CH4 separation via molecular design

Zou, Wenhao / Shang, Hongtao / Han, Xiaolong / Zhang, Peng / Cao, Xingzhong / Lu, Ping / Hua, Chao

Journal of membrane science. 2022 Aug. 15, v. 656

2022

Abstract: Developing new robust membrane materials for separating carbon dioxide are getting more and more attention today. In this work, Poly[bis(n-propylamine)phosphazene] (PPA), poly[bis(n-amylamine)phosphazene] (PAA) and poly[bis(n-octylamine)phosphazene] (POA) ...

Abstract	Developing new robust membrane materials for separating carbon dioxide are getting more and more attention today. In this work, Poly[bis(n-propylamine)phosphazene] (PPA), poly[bis(n-amylamine)phosphazene] (PAA) and poly[bis(n-octylamine)phosphazene] (POA) were synthesized and the corresponding composite membranes with polyvinylidene fluoride (PVDF) as supporting membrane were prepared. FT-IR, SEM, NMR, XPS, TGA and positron annihilation lifetime spectroscope (PALS) were used to characterize PPA/PVDF, PAA/PVDF and POA/PVDF composite membranes. The characterization results showed that the prepared membranes had desired structure and the free volume of membranes were increased with increasing the length of side chain of polyphosphazene (PPO). The gas permeation test indicated that PPA/PVDF, PAA/PVDF and POA/PVDF membranes all had good gas permeability and selectivity for CO₂, and as expected, the POA/PVDF membrane had the highest permeability owing to the biggest free volume, meanwhile, the selectivity was basically unchanged.
Keywords	carbon dioxide ; electrons ; permeability
Language	English
Dates of publication	2022-0815
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	194516-6
ISSN	0376-7388
ISSN	0376-7388
DOI	10.1016/j.memsci.2022.120661
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Article ; Online: A macrophage plasma membrane-coated and DNA structured nanomedicine targets to alleviate rheumatoid arthritis via dual inhibition to TNF-α and NF-κB.

Liu, Fenfen / Dong, Zhuolin / Li, Mengru / Sun, Junhong / Hou, Ziye / Younas, Ayesha / Wan, Xiangling / Shang, Hongtao / Zhang, Nan

International journal of pharmaceutics

2023 Volume 642, Page(s) 123188

Abstract: High heterogenicity of rheumatoid arthritis (RA) leads to poor response in many patients. Combined therapies that simultaneously inhibit multiple proinflammatory targets may improve anti-RA efficacy. However, which monotherapies to combine and how to ... ...

Abstract	High heterogenicity of rheumatoid arthritis (RA) leads to poor response in many patients. Combined therapies that simultaneously inhibit multiple proinflammatory targets may improve anti-RA efficacy. However, which monotherapies to combine and how to achieve the combination are critical issues. Here, we design a macrophage plasma membrane-coated and DNA structured nanomedicine to achieve a dual inhibitory therapy to Tumor necrosis factor alpha (TNF-α) and NF-κB. An anti-NF-κB decoy oligodeoxynucleotides (dODN) is first conjugated to a DNA cage with precise numbers and locations (Cage-dODN). Meanwhile, an anti-TNF-α siRNA is anchored to extracted macrophage plasma membrane (siRNA@M). Subsequently, siRNA@M is used to encapsulate Cage-dODN to fabricate siRNA@M(Cage-dODN) (siMCO). The size and zeta potential of siMCO are 63.1 ± 15.7 nm and -20.7 ± 3.8 mV respectively. siMCO shows increased intracellular uptake by inflamed macrophages and enhanced accumulation in inflamed mouse paws. siMCO also reduces pro-inflammatory factors at genetic and protein levels, alleviates arthritic symptoms, and shows no influence to major blood components. These results show that siMCO is a potential targeted, efficient, and safe dual inhibitory therapy for the treatment of inflammatory arthritis. The macrophage plasma membrane can be utilized to improve the targeting, stability, and efficacy of DNA structured nanomedicines.
MeSH term(s)	Mice ; Animals ; Tumor Necrosis Factor-alpha/metabolism ; Signal Transduction ; Nanomedicine ; Tumor Necrosis Factor Inhibitors/metabolism ; Tumor Necrosis Factor Inhibitors/pharmacology ; NF-kappa B/metabolism ; Arthritis, Rheumatoid/pathology ; Macrophages/metabolism ; Cell Membrane/metabolism ; RNA, Small Interfering/metabolism ; DNA/metabolism
Chemical Substances	Tumor Necrosis Factor-alpha ; Tumor Necrosis Factor Inhibitors ; NF-kappa B ; RNA, Small Interfering ; DNA (9007-49-2)
Language	English
Publishing date	2023-06-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2023.123188
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Article ; Online: Polymeric Micelles for the Treatment of Rheumatoid Arthritis.

Yun, Linsen / Shang, Hongtao / Gu, Huan / Zhang, Nan

Critical reviews in therapeutic drug carrier systems

2019 Volume 36, Issue 3, Page(s) 219–238

Abstract: Rheumatoid arthritis (RA) affects around 1% of the world's population and places heavy burdens on patients and society. RA pathogenesis has been studied for centuries, and findings suggest that it is activated by varied factors such as infection, genetic ...

Abstract	Rheumatoid arthritis (RA) affects around 1% of the world's population and places heavy burdens on patients and society. RA pathogenesis has been studied for centuries, and findings suggest that it is activated by varied factors such as infection, genetic activation, and environmental changes, and travels differential pathways in patients, which increases the difficulty of treatment. There is currently no cure for RA. Current treatments inhibit inflammation, protect joints, and suppress immune cells like macrophages and T-lymphocytes. However, these therapies usually have issues of ineffectiveness, drug resistance, and many side effects. The reason is that therapies like methotrexate (MTX), dexamethasone (Dex), and cyclosporine A (CsA) are very lipophilic and have broad distribution in vivo. Micelles are ideal carriers to increase the solubility, bioavailability, half-life, and targeting of these hydrophobic drugs, and thus can be used for RA treatment. In the past decade, micelle-based therapies have become an attractive new strategy for RA treatment. This review summarizes the merits of micelles for RA, the therapeutic targets for RA, and studies that show the recent progress of developed micelles for RA. We compare the composition, performance, potential merits, and limitations of current therapies, and discusses the future directions of advanced and smart micelles for RA.
MeSH term(s)	Animals ; Antirheumatic Agents/administration & dosage ; Antirheumatic Agents/chemistry ; Arthritis, Rheumatoid/drug therapy ; Drug Delivery Systems/methods ; Humans ; Micelles ; Polymers
Chemical Substances	Antirheumatic Agents ; Micelles ; Polymers
Language	English
Publishing date	2019-11-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2012632-3
ISSN	2162-660X ; 0743-4863
ISSN (online)	2162-660X
ISSN	0743-4863
DOI	10.1615/CritRevTherDrugCarrierSyst.2018021833
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Article: Network pharmacology analysis on mechanism of Jian Pi Qing Gan Yin decoction ameliorating high fat diet-induced non-alcoholic fatty liver disease and validated in vivo

Liu, Weiwei / Shang, Jingyu / Deng, Yinxiang / Han, Xiuzhen / Chen, Yugen / Wang, Shuangshuang / Yang, Ruwen / Dong, Fan / Shang, Hongtao

Journal of ethnopharmacology. 2022 Sept. 15, v. 295

2022

Abstract: Jian Pi Qing Gan Yin (JPQGY) has been used clinically to relieve non-alcoholic fatty liver disease (NAFLD) in China for decades; however, the underlying mechanisms of JPQGY remain unclear. We evaluated the effects and mechanisms of JPQGY and hepatic ... ...

Abstract	Jian Pi Qing Gan Yin (JPQGY) has been used clinically to relieve non-alcoholic fatty liver disease (NAFLD) in China for decades; however, the underlying mechanisms of JPQGY remain unclear. We evaluated the effects and mechanisms of JPQGY and hepatic steatosis caused by the middle stage of 13-week-high-fat-diet-induced NAFLD in mice. Different dosages of JPQGY (5.5, 11, and 22 g/kg/day) were administered to NAFLD mice simultaneously. Body weight, body mass index (BMI), and liver lipid- and inflammation-related serum indicators were measured enzymatically. Liver samples were stained with Oil Red O and hematoxylin and eosin (H&E). Next, we performed a network pharmacology analysis and verified eight target genes mapping to NAFLD-related lipid metabolism pathways. The mRNA/protein expression was analyzed by real-time polymerase chain reaction (PCR) and western blotting. JPQGY significantly relieved histological damage (steatosis-inflammation-fibrosis), prevented the downregulation of AMPK and Pparα, and upregulated LXRα, Srebp-1c, F4/80, Nf-κb, and Cyp2e1 in the HFD-induced NAFLD mouse model. The present results suggest that chronic treatment with JPQGY ameliorated HFD-induced NAFLD in mice by targeting the first and second phases of hepatic steatosis by stimulating the AMPK/PPARα pathway and inhibiting the LXRα/Srebp1/Nf-κb pathway. Our findings provide evidence that supports the clinical use of this formula for high-fat diet-induced fatty liver disease.
Keywords	blood serum ; body weight ; eosin ; fatty liver ; high fat diet ; histology ; lipid metabolism ; liver ; mice ; pharmacology ; protein synthesis ; quantitative polymerase chain reaction ; traditional medicine
Language	English
Dates of publication	2022-0915
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115382
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Article ; Online: Effects of probiotics on nonalcoholic fatty liver disease: a systematic review and meta-analysis.

Yang, Ruwen / Shang, Jingyu / Zhou, Yaru / Liu, Weiwei / Tian, Yaozhou / Shang, Hongtao

Expert review of gastroenterology & hepatology

2021 Volume 15, Issue 12, Page(s) 1401–1409

Abstract: Objectives: Several studies have suggested that the gut-liver axis is closely related to nonalcoholic fatty liver disease (NAFLD). This study was designed to conduct a meta-analysis based on a randomized controlled trial (RCT) to systematically evaluate ...

Abstract	Objectives: Several studies have suggested that the gut-liver axis is closely related to nonalcoholic fatty liver disease (NAFLD). This study was designed to conduct a meta-analysis based on a randomized controlled trial (RCT) to systematically evaluate the efficacy of probiotics in the treatment of NAFLD. Methods: This study carried out a literature search of published scientific data (up to April 2021) on probiotic therapies of NAFLD. The quality of the included literature was evaluated, and the corresponding data were extracted using the RevMan5.4 software. Results: A total of 9 randomized clinical trials involving 352 patients with NAFLD were included in this study. Results of the meta-analysisstudy showed that probiotic therapy group have significant reduction in the levels of serum indices: alanine aminotransferase (ALT), aspartate transaminase (AST) and total cholesterol (TC) in comparison with the control group. Probiotic therapy was not associated with changes in body mass index (BMI) homeostasis model assessment of insulin resistance (HOMA-IR) and tumor necrosis factor (TNF) Subgroup analyses of BMI indicated that three or more composite probiotics or probiotic treatment for more than three months can significantly reduce the BMI level. Conclusion: This systematic review and meta-analysis demonstrated that modulating gut microbiota may be utilized as an effective method to improve liver function and reduce blood lipid levels in patients with NAFLD.
MeSH term(s)	Biomarkers/blood ; Body Mass Index ; Gastrointestinal Microbiome ; Humans ; Liver Function Tests ; Non-alcoholic Fatty Liver Disease/therapy ; Probiotics/therapeutic use ; Randomized Controlled Trials as Topic
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-12-08
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review ; Video-Audio Media
ZDB-ID	2481021-6
ISSN	1747-4132 ; 1747-4124
ISSN (online)	1747-4132
ISSN	1747-4124
DOI	10.1080/17474124.2022.2016391
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