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  1. Article ; Online: In vivo

    Potts, Jonathan R / Farahi, Neda / Howard, Mark R / Taylor, Mark R / Heard, Sarah / Shankar, Arun N / Alexander, Graeme J / Chilvers, Edwin R / Verma, Sumita / Peters, A Michael

    Bioscience reports

    2018  Volume 38, Issue 4

    Abstract: The study's aim was to image severe alcoholic hepatitis (SAH) ... ...

    Abstract The study's aim was to image severe alcoholic hepatitis (SAH) using
    MeSH term(s) Acute Disease ; Adult ; Cell Movement ; Female ; Hepatitis, Alcoholic/diagnostic imaging ; Hepatitis, Alcoholic/immunology ; Hepatitis, Alcoholic/pathology ; Humans ; Indium Radioisotopes/analysis ; Liver/diagnostic imaging ; Liver/immunology ; Liver/pathology ; Male ; Middle Aged ; Neutrophil Infiltration ; Neutrophils/immunology ; Neutrophils/pathology ; Radionuclide Imaging
    Chemical Substances Indium Radioisotopes
    Language English
    Publishing date 2018-07-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 764946-0
    ISSN 1573-4935 ; 0144-8463
    ISSN (online) 1573-4935
    ISSN 0144-8463
    DOI 10.1042/BSR20180466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Persistence of Hepatitis C Virus Traces after Spontaneous Resolution of Hepatitis C.

    Chen, Annie Y / Hoare, Matthew / Shankar, Arun N / Allison, Michael / Alexander, Graeme J M / Michalak, Tomasz I

    PloS one

    2015  Volume 10, Issue 10, Page(s) e0140312

    Abstract: Hepatitis C virus (HCV) frequently causes chronic hepatitis, while spontaneous recovery from infection is infrequent. Persistence of HCV after self-limited (spontaneous) resolution of hepatitis C was rarely investigated. The current study aimed to assess ...

    Abstract Hepatitis C virus (HCV) frequently causes chronic hepatitis, while spontaneous recovery from infection is infrequent. Persistence of HCV after self-limited (spontaneous) resolution of hepatitis C was rarely investigated. The current study aimed to assess incidence and robustness of HCV persistence after self-resolved hepatitis C in individuals with normal liver enzymes and undetectable virus by conventional tests. Applying high sensitivity HCV RNA detection approaches, we analyzed plasma and peripheral blood mononuclear cells (PBMC) from individuals with previous hepatitis C infection. Parallel plasma and PBMC from 24 such non-viraemic individuals followed for 0.3-14.4 (mean 6.4) years were examined. Additional samples from 9 of them were obtained 4.5-7.2 (mean 5.9) years later. RNA was extracted from 250 μl plasma and, if HCV negative, from ~5 ml after ultracentrifugation, and from ex vivo stimulated PBMC. PBMC with evidence of HCV replication from 4 individuals were treated with HCV protease inhibitor, telaprevir. HCV RNA was detected in 14/24 (58.3%) plasma and 11/23 (47.8%) PBMC obtained during the first collection. HCV RNA replicative strand was evident in 7/11 (63.6%) PBMC. Overall, 17/24 (70.8%) individuals carried HCV RNA at mean follow-up of 5.9 years. Samples collected 4.5-7.2 years later revealed HCV in 4/9 (44.4%) plasma and 5/9 (55.5%) PBMC, while 4 (80%) of these 5 PBMC demonstrated virus replicative strand. Overall, 6/9 (66.7%) individuals remained viraemic for up to 20.7 (mean 12.7) years. Telaprevir entirely eliminated HCV replication in the PBMC examined. In conclusion, our results indicate that HCV can persist long after spontaneous resolution of hepatitis C at levels undetectable by current testing. An apparently effective host immune response curtailing hepatitis appears insufficient to completely eliminate the virus. The long-term morbidity of asymptomatic HCV carriage should be examined even in individuals who achieve undetectable HCV by standard testing and their need for treatment should be assessed.
    MeSH term(s) Adult ; Aged ; Base Sequence ; Female ; Follow-Up Studies ; Hepacivirus/metabolism ; Hepatitis C, Chronic/blood ; Hepatitis C, Chronic/drug therapy ; Humans ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/virology ; Male ; Middle Aged ; Molecular Sequence Data ; Oligopeptides/administration & dosage ; RNA, Viral/blood ; Remission, Spontaneous ; Time Factors
    Chemical Substances Oligopeptides ; RNA, Viral ; telaprevir (655M5O3W0U)
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0140312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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